Traceless solid-phase synthesis of 2-aminothiazoles: Receptor tyrosine kinase inhibitors with dual selectivity for tie-2 and VEGFR-2

Angewandte Chemie - International Edition

Volumn 41, Issue 24, 2002, Pages 4757-4761

  Stieber, Frank ^b,d   Mazitschek, Ralph ^e   Soric, Natascha ^e   Giannis, Athanassios ^a   Waldmann, Herbert ^b,c  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

^d Semaia Pharmaceuticals GmbHandCoKG   (Germany)

^e UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Combinatorial chemistry; Heterocycles; Inhibitors; Solid phase synthesis

Indexed keywords

DRUG PRODUCTS; ENZYME INHIBITION; ENZYMES; SYNTHESIS (CHEMICAL);

SOLID-PHASE SYNTHESIS;

ORGANIC COMPOUNDS;

2-AMINOTHIAZOLE; AMINOTHIAZOLE; ENZYME INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RECEPTOR PROTEIN TYROSINE KINASES; THIAZOLE DERIVATIVE; TIE 2 RECEPTOR TYROSINE KINASE; TIE-2 RECEPTOR TYROSINE KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; ENZYME SPECIFICITY; IC 50; METHODOLOGY; SOLID; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; SUBSTRATE SPECIFICITY; THIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 0038480375     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200290040     Document Type: Article

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