The gut as an organ of immunology

International Journal of Colorectal Disease

Volumn 18, Issue 3, 2003, Pages 181-187

  Wittig, Bianca M ^a   Zeitz, M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Chronic inflammatory bowel disease; Gut associated immune system; Oral tolerance

Indexed keywords

BACTERIAL ANTIGEN; CYTOKINE;

CELIAC DISEASE; CELL INFILTRATION; CHRONIC INFLAMMATION; CLONAL ANERGY; CYTOKINE PRODUCTION; ENTERITIS; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INTESTINE LYMPHATIC TISSUE; INTESTINE MUCOSA; LYMPH FOLLICLE; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; MUCOSA CELL; PEYER PATCH; PRIORITY JOURNAL; REVIEW; TH1 CELL; TH2 CELL;

EID: 0038480148     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-002-0444-1     Document Type: Review

References (59)

1. Peyer JC (1677) Exercitatio anatomico-medica de glandulis intestinorum. Schaffhausen
2. Griebel PJ, Hein WR (1996) Expanding the role of Peyer's patches in B-cell ontogeny. Immunol Today 17:30
3. Cornes JS (1965) Number, size and distribution of Peyer's patches in human small intestine. Gut 6:225
4. Zarember KA, Godowski PJ (2002) Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168:554
5. Kelsall BL (1999) Subset of dendritic cells in the Peyer's patch. In: Stallmach A, Zeitz M, Strober W, MacDonald TT, Lochs H (eds) Induction and modulation of gastrointestinal inflammation. Kluwer, Dordrecht, p 24
6. Brandtzaeg P, Farstad IN, Helgeland L (1998) Phenotypes of T cells in the gut. Chem Immunol 71:1
7. Zeitz M, Quinn TC, Graeff AS (1988) Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venerum proctitis in non-human primates. Gastroenterology 94:353
8. Targan SR, Deem RL, Liu M, Wang S, Nel A (1995) Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 154:664
9. Boirivant M, Fuss I, Fiocchi C, Klein J, Strober W (1996) Hypoproliferative human lamina propria T cells retain their capacity to secrete lymphokines when stimulated via the CD2/CD28 accessory signaling pathway. Proc Assoc Am Physiol 108:55
10. James SP, Kwan WC, Sneller MC (1990) T cells in inductive and effector compartments of the intestinal mucosal immune system of nonhuman primates differ in lymphokine mRNA expression, lymphokine utilization, and regulatory function. J Immunol 144:1251
11. James SP, Fiocchi C, Graeff AS, Strober W (1986) Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytotoxic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients. Gastroenterology 91:1483
12. Schieferdecker HL, Ullrich R, Weiss-Breckwoldt AN, Schwartling R, Stein H, Roecken EO, Zeitz M (1990) The HML-1 antigen of intestinal lymphocytes is an activation antigen. J Immunol 144:2541
13. Schieferdecker HL, Ullrich R, Hirseland H, Zeitz M (1992) T cell differentiation antigens on lymphocytes in human intestinal lamina propria. J Immunol 149:2816
14. London SD, Rubin DH (1999) Functional role of mucosal cytotoxic lymphocytes. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR (eds) Mucosal immunology, vol 1. Academic Press, San Diego, p 643
15. Deusch K, Lüling F, Reich K, Classen M, Wagner H, Pfeffer K (1991) A major fraction of human intraepithelial lymphocytes simultaneously expresses the gd T cell receptor, the CD8 accessory molecule and preferentially uses the Vd1 gene segment. Eur J Immunol 21:1053
16. Lundqvist C, Melgar S, Yeung MMW, Hammarstrom S, Hammarstrom M (1995) Intraepithelial lymphocytes, evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 7:1473
17. Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB (1994) Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and an integrin, alphaEbeta7. Nature 372:190
18. Boismenu R, Havran WL (1994) Modulation of epithelial cell growth by intraepithelial gd T cells. Science 266:1253
19. Hoffmann JC, Peters K, Henschke S, Herrmann B, Pfister K, Westermann J, Zeitz M (2001) Role of T lymphocytes in rat 2: 4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after gammadelta T cell depletion and no effect of alphabeta T cell depletion. Gut 48:489
20. Mayer L, Posnett DN, Kunkel HG (1985) Human malignant T cells capable of inducing an immunoglobulin class switch. J Exp Med 161:134
21. Weiner HL (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18:335
22. Chen Y, Inobe JI, Weiner HL (1997) Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell Immunol 178:62
23. Kelsall BL, Ehrhardt RO, Strober W (1994) Peyer's patch dendritic cells: phenotypic characterization by FACS analysis and in vitro primary and secondary T cell responses using a TCR-transgenic mouse model. J Cell Biochem [Suppl 18D]
24. Marth T, Strober W, Kelsall B (1996) High dose oral tolerance in ovalbumin TCR-transgeneic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J Immunol 157:2348
25. Chen Y, Inobe JI, Marks P, Gonnella P, Kuchroo VK, Weiner HL (1995) Peripheral deletion of antigen-reactive T-cells in oral tolerance. Nature 376:177
26. Finkelmann FD, Lees A, Birnbaum R, Gause WC, Morris SC (1996) Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 157:1406
27. Viney JL, Mowat AMI, O'Malley J, Williamson E, Farger N (1998) Expanding dendritic cells in vivo enhances the induction of oral tolerance. J Immunol 160:5815
28. Dippold W, Wittig B, Schwaeble W, Mayet W, Meyer zum Büschenfelde KH (1993) Expression of the intercellular adhesion molecule 1 (ICAM-1, CD54) in colonic epithelial cells. Gut 34:1593
29. Bloom S, Simmons D, Jewell DP (1995) Adhesion molecules intercellular adhesion molecules-1 (ICAM-1), ICAM-3, and B7 are not expressed by epithelium in normal and inflamed colon. Clin Exp Immunol 101:157
30. Spahn TW, Fontana A, Faria AMC, Slavin AJ, Eugster H-P, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL (2001) Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur J Immunol 1:1278
31. Braunstein J, Qiao L, Autschbach F, Schürmann G, Meuer S (1997) T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 41:215
32. Autschbach F, Braunstein J, Helmke B, Zuna I, Schürmann G, Niemir ZI, Wallich R, Otto HF, Meuer SC (1998) In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol 153:121
33. Strobel S, Mowat AM (1998) Immune responses to dietary antigens: oral tolerance. Immunol Today 19:173
34. Marth T, Ring S, Schulte D, Klensch N, Strober W, Kelsall B, Stallmach A, Zeitz M (2000) Antigen-induced mucosal T-cell activation is followed by Th1 T cell suppression in continuously fed ovalbumin TCR-transgenic mice. Eur J Immunol 30:3478
35. Fuss IJ, Neurath N, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W (1996) Disparate CD4+ lamina propria lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157:1261
36. Carol M, Lambrechts A, Van Gossum A, Libin M, Goldman M, Mascart-Lemone F (1998) Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes. Gut 42:643
37. Nagata S, McKenzie C, Pender SLF, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, Monteleone G, MacDonald TT (2000) Human Peyer's patch T cells are sensitized to dietary antigen and display a T cell type 1 cytokine profile. J Immunol 165:5315
38. Dalton DK, Haynes L, Chu C-Q, Swain SL, Wittmer S (2000) Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med 192:117
39. MacDonald TT, Monteleone G (2001) IL12 and Th1 immune response in human Peyer's patches. Trends Immunol 22:244
40. Qiao L, Braunstein J, Golling M, Schürmann G, Autschbach F, Möller P, Meuer S (1996) Differential regulation of human T cell responsiveness by mucosal versus blood monocytes. Eur J Immunol 26:922
41. Rogler G, Hausmann M, Spottl T, Vogl D, Aschenbrenner E, Andus T, Falk W, Schölmerich J, Gross V (1999) T-cell costimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa. Eur J Gastroenterol Hepatol 11:1105
42. Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383:787
43. Noelle RJ, Roy M, Sheperd DM, Stamenkovic I, Ledbetter JA, Arruffo A (1992) A novel ligand on activated T helper cells binds CD40 and transduces the signal for the cognate activation of B cells. Proc Natl Acad Sci USA 89:6550
44. Wittig BM, Johansson B, Zöller M, Schwärzler C, Günthert U (2000) Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44v7. J Exp Med 191:2053
45. Wittig B, Schwärzler C, Föhr N, Günthert U, Zöller M (1998) Curative treatment of an experimentally induced colitis by a CD44 variant v7-specific antibody. J Immunol 161:1069
46. Wittig B, Seiter S, Schmidt DS, Zuber M, Neurath M, Zöller M (1999) Selective upregulation of CD44 variant isoforms on peripheral blood leukocytes in patients with chronic inflammatory bowel disease and other systemic autoimmune diseases. Lab Invest 79:747
47. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH (1995) B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707
48. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA (1997) CD28 costimulation promotes the production of Th2 cytokines. J Immunol 158:658
49. Strober W, Neurath M (1996) Immunological diseases of the gastrointestinal tract. In: Rich RR, Fleisher TA, Schwartz BD, Schearer WT, Strober W (eds) Clinical immunology, vol 2. Mosby, St Louis, p 1401
50. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797
51. Zeitz M (1990) Immunoregulatory abnormalities in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2:246
52. Stallmach A, Marth T, Adrian N, Wittig BM, Ecker KW, Schilling M, Zeitz M (2002) Increased expression of interleukin-12 receptor beta (2) on lamina propria mononuclear cells of patients with active Crohn's disease. Int J Colorectal Dis 17:303
53. Strober W, Ludviksson BR, Fuss IJ (1998) The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn's disease. Ann Intern Med 128:848
54. Wirtz S, Neurath MF (2000) Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease. Int J Colorectal Dis 15:144
55. Duchmann R, Schmitt E, Knolle P, Meyer zum Büschenfelde KH, Neurath M (1996) Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 26:934
56. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Büschenfelde KH (1995) Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102:448
57. Hugot JP, Zouali H, Thomas G (1999) Etiology of inflammatory bowel diseases. Int J Colorectal Dis 14:2
58. Schottelius AJ, Baldwin ASJ (1999) A role for transcription factor NF-kappa B in intestinal inflammation. Int J Colorectal Dis 14:18
59. Wittig BM, Duchmann R, Stallmach A, Zeitz M (2001) Modulation von Zytokinen bei chronisch entzündlichen Darmerkrankungen. Internist (Berl) 42:47