Antigen-induced mucosal T cell activation is followed by Th1 T cell suppression in continuously fed ovalbumin TCR-transgenic mice

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3478-3486

  Marth, Thomas ^a   Ring, Sabine ^b   Schulte, Dirk ^a   Klensch, Nicole ^b   Strober, Warren ^b   Kelsall, Brian L ^a   Stallmach, Andreas ^a   Zeitz, Martin ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

IFN ; IL 10; IL 12; Oral tolerance; Peyer's patch

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; OVALBUMIN; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; MUCOSA; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE ACTIVATION; TH1 CELL; TRANSGENIC MOUSE;

ANIMALS; CYTOKINES; FEMALE; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; PEYER'S PATCHES; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES; TH1 CELLS;

EID: 0034529318     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2000012)30:12<3478::AID-IMMU3478>3.0.CO;2-A     Document Type: Article

References (36)

1. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
2. Oral tolerance
3. Oral tolerance in experimental autoimmune uveoretinitis: Distinct mechanisms of resistance are induced by low dose versus high dose feeding protocols
4. Oral tolerance in experimental autoimmune encephalitis. III. Evidence for clonal anergy
5. Peripheral deletion of antigen-reactive T cells in oral tolerance
6. Antigen-driven bystander suppression after oral administration of antigen
7. Oral tolerance to myelin basic protein induces regulatory TGFβ secreting cells in Peyer's patches of SJL mice
8. High dose oral tolerance in ovalbumin TCR-transgenic mice: Systemic neutralization of interleukin-12 augments TGFβ secretion and T cell apoptosis
9. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
10. Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II antigen
11. Experimental granulomatous colitis in mice is abrogated by induction of TGFβ mediated oral tolerance
12. Th2 cells are subject to high dose oral tolerance and are not essential for its induction
13. Orally induced peripheral nonresposiveness is maintained in the absence of functional Th1 or Th2 cells
14. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalitis
15. Reciprocal IFN-γ and TGFβ responses regulate the occurrence of mucosal inflammation
16. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model
17. The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation
18. Antigen-specific T cell activation and proliferation during oral tolerance induction
19. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen
20. Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-γ signaling pathway
21. IFN-γ receptor deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance
22. Lack of orally induced systemic unresponsiveness in IFN-γ knockout mice
23. Peripheral tolerance of Th2 lymphocytes induced by continuous feeding of ovalbumin
24. Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance
25. + T cells: IL-4 and IFN-γ have opposing effects, while TGFβ positively regulates its own production
26. Induction of autoimmune diabetes by oral administration of autoantigen
27. Regulation of TGFβ production by IL-12
28. + T cells that secrete IFN-γ and IL-5
29. + T cells with specific reactivity against astrovirus isolated from normal human small intestine
30. Selective induction of Th2 cells in murine Peyer's patches by oral immunization
31. Stimulation of antigen-specific T and B cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant
32. The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant
33. Energy and exhaustion are independent mechanisms of peripheral T cell tolerance
34. Anti-IL-10 treatment does not block either the induction or the maintenance of orally induced tolerance to OVA
35. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis
36. + T cell subset inhibits antigen-specific T cell responses and prevents colitis