Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: Increased mortality after γδ T cell depletion and no effect of αβ T cell depletion

Gut

Volumn 48, Issue 4, 2001, Pages 489-495

  Hoffmann, J C ^a   Peters, K ^a   Henschke, S ^a   Herrmann, B ^a   Pfister, K ^a   Westermann, J ^b   Zeitz, M ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

T cells; T cells; Experimental colitis; Inflammatory bowel disease; Rat

Indexed keywords

CD2 ANTIGEN; CD4 ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COLITIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; DINITROBENZENES; FEMALE; FLOW CYTOMETRY; IMMUNITY, CELLULAR; INFLAMMATORY BOWEL DISEASES; LYMPHOCYTE DEPLETION; PEROXIDASE; RATS; RATS, INBRED LEW; SEVERITY OF ILLNESS INDEX; SULFONIC ACIDS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0035080601     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.4.489     Document Type: Article

References (41)

1. Immunoregulatory functions for murine intraepithelial lymphocytes: Gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help
2. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells
3. The immunobiology of T cells with invariant gamma delta antigen receptors
4. Gamma/delta and other unconventional T lymphocytes: What do they see and what do they do?
5. + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium
6. Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance
7. + intraepithelial lymphocytes
8. Gamma/delta T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium
9. Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization
10. Gamma delta T cells from tolerized alpha beta T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo, and their interferon-gamma production in vitro
11. Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes
12. Hapten-induced model of chronic inflammation and ulceration in the rat colon
13. Experimental models of inflammatory bowel disease
14. Antibodies to interleukin 12 abrogate established experimental colitis in mice
15. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming ofT helper 1 cells through the inhibition of interleukin 12 secretion
16. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
17. Anti-CD2 (OX34) MoAb treatment of adjuvant arthritic rats: Attenuation of established arthritis, selective depletion of CD4+ T cells, and CD2 down-modulation
18. Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34
19. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy
20. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes
21. Depletion of gamma/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis
22. Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3)
23. Assessment of leukocyte involvement during ischemia and reperfusion of intestine
24. Assay method for myeloperoxidase in human polymorphonuclear leukocytes
25. Cutting edge: Protective response to pulmonary injury requires γδ T lymphocytes
26. Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells
27. Selected Vbeta subset of Th2 type CD4+ T-cells mediate development of colitis in mice with a truncated gamma chain
28. Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor gamma/delta in inflammatory bowel disease
29. Analysis of gamma delta V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry
30. Differences in immunophenotyping of mucosal lymphocytes between ulcerative colitis and Crohn's disease
31. Changes in human mucosal gamma delta T cell repertoire and function associated with the disease process in inflammatory bowel disease
32. Expression of pro-inflammatory cytokines by TCR alpha beta+ and TCR gamma delta+ T cells in an experimental model of colitis
33. Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease
34. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2- deficient mice
35. Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats
36. Crohn's disease stable remission after human immunodeficiency virus infection
37. T lymphocyte reconstitution in athymic rats restores stress-induced reactivation of colitis
38. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
39. Interferongamma receptor deficient mice are not protected against TNBS induced colitis
40. CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization
41. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis