Agonist-specific coupling of a cloned human α1A-adrenoceptor to different second messenger pathways

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 4, 2003, Pages 333-341

  Richardson, Joanna ^a   Chatwin, Heather ^a   Hirasawa, Akira ^b   Tsujimoto, Gozoh ^b   Evans, Peter D ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b NATIONAL CHILDREN S HOSPITAL   (Japan)

Author keywords

1A, 1B and 1D adrenoceptor subtypes; Arachidonic acid; Inositol 1,4,5 trisphosphate; Meta octopamine; Noradrenaline; Para octopamine

Indexed keywords

ADRENERGIC RECEPTOR ALPHA(1A); ADRENERGIC RECEPTOR ALPHA(1B); ADRENERGIC RECEPTOR ALPHA(1D); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ARACHIDONIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL PHOSPHATE; NORADRENALIN; NORFENEFRINE; OCTOPAMINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; HAMSTER; HUMAN; ISOMERISM; METABOLISM; MOLECULAR CLONING; NONHUMAN; PHYSIOLOGY; RADIOASSAY; SECOND MESSENGER; SIGNAL TRANSDUCTION; TIME SERIES ANALYSIS;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ARACHIDONIC ACID; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; GTP-BINDING PROTEINS; HUMANS; INOSITOL PHOSPHATES; ISOMERISM; MOLECULAR STRUCTURE; NOREPINEPHRINE; OCTOPAMINE; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1; SECOND MESSENGER SYSTEMS;

EID: 0038408754     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0703-x     Document Type: Article

References (37)

1. 2A-adrenoceptor. Br J Pharmacol 122:191-198
2. 2. J Biol Chem 272:16069-16072
3. Berg KA, Maayani S, Goldfarb J, Scaramellini C, Left P, Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol Pharrnacol 54:94-104
4. Bonhaus DW, Chang LK, Kwan J, Martin GR (1998) Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses. J Pharrnacol Exp Ther 287:884-888
5. Bradford MM (1976) A rapid sensitive method for the quantitation of protein utilizing the principle of dye-protein binding. Anal Biochem 72:248-254
6. 1B-adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes. FEBS Lett 399:9-13
7. Clarke WP, Bond RA (1998) The elusive nature of intrinsic efficacy. Trends Pharmacol Sci 19:270-276
8. 2 superfamily of signal transduction enzymes. Trends Biochem Sci 22:1-2
9. 2A-adrenergic receptor to multiple second messengers. Soc Neurosci Abstr 21:1613
10. Evans PD, Robb S, Cheek TR, Reale V, Hannan FL, Swales LS, Hall LM, Midgley JM (1995b) Agonist-specific coupling of G-protein-coupled receptors to second messenger systems. Prog Brain Res 106:259-268
11. 1-adrenoceptor classification. Br J Pharmacol 121:1127-1135
12. Garcia-Sainz JA, Vazques-Prado J, del Carmenn Medina L (2000) Alpha-1-adrenoceptors function and phosphorylation. Eur J Pharmacol 389:1-12
13. 2 receptors. Mol Pharmacol 56:1362-1369
14. 1-adrenergic receptor subtypes. Molecular structure, function and signalling. Circ Res 78:737-749
15. Hawes BE, Van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ (1995) Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem 270:17148-17153
16. 1C-adrenergic receptor. Biochem Biophys Res Commun 195:902-909
17. 1-adrenoceptor subtypes. Br J Pharmacol 116:1611-1618
18. 1-adrenergic receptor agonist binding and activation. J Biol Chem 271:6322-6327
19. Kenakin T (1995) Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238
20. Liapakis G, Ballesteros JA, Papachristou S, Chi W, Chen X, Javitch JA (2000) The forgotten serine. J Biol Chem 275:37779-37788
21. 2A-adrenoceptor activation by noradrenaline and epinephrine. Mol Pharmacol 59:1343-1354
22. 1D-adrenergic receptors to multiple signalling pathways is both G protein and cell type specific. Mol Pharmacol 44:784-795
23. Perez DM, Hwa J, Gaivin R, Mathur M, Brown F, Graham RM (1996) Constitutive activation of a single effector pathway: evidence for multiple activation states of a G-protein-coupled receptor. Mol Pharmacol 49:112-122
24. 1-adrenergic receptors: new insights and directions. J Pharmacol Exp Ther 298:403-410
25. 1-adrenergic receptor subtypes. Soc Neurosci Abstr 26:114
26. Robb S, Cheek TR, Hannan FL, Hall LM, Midgley JM, Evans PD (1994) Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. EMBO J 13:1325-1330
27. Ruan Y, Kan H, Parmentier J-H, Fatima S, Allen LF, Malik KU (1998) Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: inhibition by protein kinase A. J Pharmacol Exp Ther 284:576-585
28. 2A-adrenoceptor to adenylyl cyclase. Br J Pharmacol 127:877-886
29. 2-adrenoceptor subtypes. Br J Pharmacol 131:933-941
30. 2-adrenoceptor contributes to agonist binding and receptor activation. Br J Pharmacol 128:272-274
31. Spengler D, Waeber C, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, Journot L (1993) Differential signal transduction by five spliced variants of the PACAP receptor. Nature 365:61-69
32. Strader CD, Candelore MR, Hill WS, Sigal IS, Dixon RAF (1989) Identification of two serine residues involved in agonist activation of the β-adrenergic receptor. J Biol Chem 23:13572-13578
33. 1-adrenoceptor subtype coupling to protein kinase C activation and related signalling pathways. Naunyn-Schmiedebergs Arch Pharmacol 357:100-110
34. 2 contains eight ankyrin motifs. J Biol Chem 272:8567-8575
35. 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists. Mol Pharmacol 40:168-179
36. Williams CM, Couch MW, Thonoor CM, Midgley JM (1987) Isomeric octopamines: their occurrence and functions. J Pharm Pharmacol 39:153-157
37. 1-adrenoceptor subtypes. Eur J Pharmacol 375:261-276