Pharmaceutical strategies to prevent ventilator-associated pneumonia

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 4, 2003, Pages 411-428

  McCroy, Roisin ^a   Jones, David S ^a   Adair, Colin G ^a   Gorman, Sean P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPHOTERICIN B; ANTACID AGENT; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; BIOMATERIAL; CEFOTAXIME; CEFUROXIME; CHLORHEXIDINE; CIPROFLOXACIN; DIGOXIN; DOPAMINE; GENTAMICIN; HISTAMINE H2 RECEPTOR ANTAGONIST; MINOCYCLINE; NORFLOXACIN; PHENYTOIN; POLYMYXIN; QUINOLONE DERIVATIVE; RANITIDINE; RIFAMPICIN; SILICONE; SILVER; SUCRALFATE; SULFADIAZINE SILVER; TEICOPLANIN; TETRACYCLINE; TOBRAMYCIN; UNINDEXED DRUG;

AEROSOL; ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; BIOMEDICAL ENGINEERING; CLINICAL TRIAL; DIAGNOSTIC PROCEDURE; DIGESTIVE TRACT PARAMETERS; DRUG BIOAVAILABILITY; DRUG COST; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG TOXICITY; ENDOTRACHEAL TUBE; EPIDEMIOLOGICAL DATA; GASTROINTESTINAL HEMORRHAGE; HOSPITAL COST; HOSPITAL INFECTION; HUMAN; META ANALYSIS; MORBIDITY; MORTALITY; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PATHOGENESIS; PNEUMONIA; PROPHYLAXIS; REVIEW; RISK FACTOR; STRESS ULCER; SUPERINFECTION; TREATMENT PLANNING;

ANTI-INFECTIVE AGENTS; CROSS INFECTION; DRUG ADMINISTRATION SCHEDULE; EQUIPMENT DESIGN; HUMANS; INFECTION CONTROL; INTENSIVE CARE; INTUBATION, INTRATRACHEAL; META-ANALYSIS; PNEUMONIA, BACTERIAL; RESPIRATION, ARTIFICIAL;

EID: 0038399866     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021035     Document Type: Review

References (151)

1. AbeleHorn, M., Dauber, A., Bauernfeind, A., Russwurm, M., Seyfarth-Metzger, I., Gleich, P., Ruckdeschel, G. (1997) Decrease in nosocomial pneumonia in ventilated patients by selective oropharyngeal decontamination. Intensive Care Med. 23: 187-195
2. Adair, C. G., Gorman, S. P., O'Neill, F. B., McClurg, B., Goldsmith, E. C., Webb, C. H. (1993) Selective decontamination of the digestive tract (SDD) does not prevent the formation of microbial biofilms on endotracheal tubes. J. Antimicrob. Chemother. 31: 689-697
3. Adair, C. G., Gorman, S. P., Feron, B. M., Byers, L. M., Jones, D S., Goldsmith, C. E., Moore, J. E., Kerr, J. R., Curran, M. D., Hogg, G., Webb, C. H., McCarthy, G. J., Milligan, K. R. (1999) Implications of endotracheal tube biofilm for ventilator-associated pneumonia. Intensive Care Med 25: 1072-1076
4. Adair, C. G., Gorman, S. P., Byers, L. M., Jones, D. S., Feron, B., Crowe, M., Webb, H. C., McCarthy, G. J., Milligan, K. R. (2002) Eradication of endotracheal tube biofilm by nebulised gentamicin. Intensive Care Med 28: 426-431
5. Aerdts, S. J., Van Dalen, R., Clasener, H. A., Festen, J., Van Lier, H. J., Vollaard, E. J. (1991) Antibiotic prophylaxis of respiratory tract infection in mechanically ventilated patients: A prospective, blinded, randomised trial of the effect of a novel regimen. Chest 100: 783-791
6. Apte, N. M., Karnad, D. R., Medhekar, T. P., Tilve, G. H., Morye, S., Bhave, G. G. (1992) Gastric colonisation and pneumonia in intubated critically ill patients receiving stress ulcer prophylaxis: A randomised, controlled trial. Crit. Care Med. 20: 590-594
7. Atherton, S., White, D. (1978) The stomach as a source of bacteria colonising the respiratory tract during artificial ventilation. Lancet 2: 968
8. Bach, A., Darby, D., Bottiger, B., Bohrer, H., Motsch, J., Martin, E. (1996) Retention of the antibiotic teicoplanin on a hydromer-coated central venous catheter to prevent bacterial colonisation in postoperative surgical patients. Intensive Care Med. 22: 1066-1069
9. Baker, A. M., Meredith, J. W., Haponik, E. F. (1996) Pneumonia in intubated trauma patients: Microbiology and outcomes. Am. J. Respir. Crit. Care Med. 153: 343-349
10. Beckett, G., Schep, L. J., Crichton, D., Jones, D. S. (1997) Chlorhexidine sorption into and release from dental prosthetic biomaterials. J. Pharm. Pharmacol. 49 (Suppl. 4): 135
11. Ben-Menachem, T., Fogel, R., Patel, R. V., Touchette, M., Zarowitz, B. J., Hadzijahic, N., Divine, G., Verter, J., Bresalier, R. S. (1994) Prophylaxis for stress-related gastric haemorrhage in the medical intensive care unit. Ann. Intern. Med. 121: 568-575
12. Bercault, N., Boulain, T. (2001) Mortality associated with ventilator-associated pneumonia in an adult intensive care unit: A prospective 135 matched-pairs cohort study. Crit Care Med. 29: 2303-2309
13. Bergmans, D. C. J. J., Bonten, M. J. M., Gaillard, C. A., Van Tiel, F. H., Van Der Geest, S., De Leeuw, P. W., Stobberingh, E. E. (1997) Indications for antibiotic use in ICU patients: A one-year prospective surveillance. J. Antimicrob. Chemother. 39: 527-535
14. Bergmans, D. C. J. J., Bonten, M. J. M., Gaillard, C. A., Paling, J. C., Van Der Geest, S., Van Tiel, F. H., Beysens, A. J., De Leeuw, P. W., Stobberingh, E. E. (2001) Prevention of ventilator-associated pneumonia by oral decontamination: A prospective, randomised, double-blind, placebo-controlled study. Am. J. Respir. Crit. Care Med. 164: 382-388
15. Blair, P., Rowlands, B. J., Lowry, K., Webb, H., Armstrong, P., Smilie, J. (1991) Selective decontamination of the digestive tract: A stratified, randomised, prospective study in a mixed intensive care unit. Surgery 110: 303-310
16. Bonten, M. J. M., Bergmans, D. C., Stobberingh, E. E., Van Der Geest, S., De Leeuw, P. W., Van Tiel, F. H., Gaillard, C. A. (1997) Implementation of bronchoscopic techniques in the diagnosis of ventilator-associated pneumonia to reduce antibiotic usage. Am. J. Respir. Crit. Care Med. 156: 1820-1824
17. Bregeon, F., Faucher, M., Roch, A., Gainnier, M., Michelet, P., Saux, P., Thirion, X., Auffray, J. P., Papazian, L. (2001) Influence of prone position on the incidence of VAP and the outcome of ARDS patients. Intensive Care Med 27 (Suppl 2): 175
18. Brun-Buisson, C., Legrand, P., Rauss, A., Richard, C., Montravers, F., Besbes, M., Meakins, J. L., Soussy, C. J., Lemaire, F. (1989) Intestinal decontamination for control of nosocomial multiresistant Gram-negative bacilli: Study of an outbreak in an intensive care unit. Ann. Intern. Med. 110: 873-881
19. Carver, D. E., Steger, K. (1996) Nosocomial pneumonia in mechanically ventilated adult patients: Epidemiology and prevention in 1996. Semin. Respir. Infect. 11: 32-53
20. Celis, R., Torres, A., Gatell, J. M., Almeda, M., Rodriguez-Roisin, R., Agusti-Vidal, A. (1988) Nosocomial pneumonia: A multivariate analysis of risk and prognosis. Chest 93: 319-324
21. Chastre, J., Fagon, J. (1994) Invasive diagnostic testing should be routinely used to manage ventilated patients with suspected pneumonia. Am. J. Respir. Crit. Care Med. 15: 570-574
22. Chastre, J., Fagon, J. Y., Trouillet, J. L. (1995) Diagnosis and treatment of nosocomial pneumonia in patients in intensive care units. Clin. Infect. Dis. 21: 226S-237S
23. Chastre, J., Trouillet, J. L., Vaugnat, A., Joly-Guillou, M. L., Clavier, H., Dombret, M. C., Gibert, C. (1998) Nosocomial pneumonia in patients with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 157: 1165-1172
24. Chien, Y. W. (1992) Novel Drug Delivery Systems. 2nd Edition, Marcel Dekker, New York
25. Cockerill, F. R., Muller, S. R., Anhalt, J. P., Marsh, H. M., Farnell, M. B., Mucha, P., Gillespie, D. J., Ilstrup, D. M., Larsonkeller, J. J., Thompson, R. L. (1992) Prevention of infection in critically ill patients by selective decontamination of the digestive tract. Ann. Interm. Med. 117: 545-553
26. Cook, D. J., Pearl, R. G., Cook, R. J., Guyatt, G. H. (1991a) Incidence of clinically important bleeding in mechanically ventilated patients. J. Intensive Care Med. 6: 167-174
27. Cook, D. J., Laine, L. A., Guyatt, G. H., Raffin, T. (1991b) Nosocomial pneumonia: The role of gastric pH. Chest 100: 7-13
28. Cook, D. J., Fuller, H. D., Guyatt, G. H., Marshall, J. C., Leasa, D., Hall, R., Winton, T. L., Rutledge, F., Todd, T. J. R., Roy, P., Lacroix, J., Griffith, L., Willan, A., Noseworthy, T., Powles, P., Oppenheimer, L., Hewson, J. Lang, J., Lee, H., Guslits, B., Heule, M. (1994) Risk factors for gastrointestinal bleeding in critically ill patients. N. Engl. J. Med. 330: 377-381
29. Cook, D. J., Reeve, B. K., Guyatt, G. H., Heyland, D. K., Griffith, L. E., Buckingham, L., Tryba, M. (1996) Stress ulcer prophylaxis in critically ill patients. J. Am. Med. Assoc. 275: 308-314
30. Cook, D. J., Walter, S., Cook, R. J., Griffith, L. E., Guyatt, G. H., Leasa, D., Jaeschke, R., Brun-Buisson, C. (1998a) The incidence and risk factors for ventilation-associated pneumonia in critically ill patients. Ann. Intern. Med. 129: 433-440
31. Cook, D. J., Guyatt, G., Marshall, J., Leasa, D., Fuller, H., Hall, R., Peters, S., Rutledge, F., Griffith, L., McLellan, A., Wood, G., Kirby, A. (1998b) A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. N. Engl. J. Med. 338: 791-797
32. Cormio, L., La Forgia, P., La Forgia, D., Siitonen, A., Ruutu, M. (1997) Is it possible to prevent bacterial adhesion onto ureteric stents? Urol. Res. 25: 213-216
33. Craven, D. E., Steger, K. A. (1995) Epidemiology of nosocomial pneumonia: New perspectives on an old disease. Chest 108: 1S-16S
34. Craven, D. E., Steger, K. A. (1998) Ventilator-associated bacterial pneumonia: Challenges in diagnosis, treatment and prevention. New Horiz 6: S30-S45.
35. Craven, D. E., Kunches, L. M., Kilinsky, V., Lichtenberg, D. A., Make, B. J., McCabe, W. R. (1986) Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am. Rev. Respir. Dis. 133: 792-796
36. Craven, D. E., Steger, K. A., Barber, T. W. (1991) Preventing nosocomial pneumonia: State of the art and perspectives for the 1990's. Am. J. Med. 91: 44S-53S
37. Cross, A. S., Roup, B. (1981) Role of respiratory assistance devices in endemic nosocomial pneumonia. Am. J. Med. 70: 681-685
38. D'Amico, R., Pifferi, S., Leonetti, C., Torri, V., Tinazzi, A., Liberti, A. (1998) Effectiveness of antibiotic prophylaxis in criticall ill adult patients: Systemic review of randomised controlled trials. Br. Med. J. 316: 1275-1285
39. Darouiche, R. O., Raad, I. I., Heard, S. O., Thornbury, J. I., Wenker, O. C., Gabrielli, A., Berg, J., Khardori, N., Hanna, H., Hachem, R., Haris, R. L., Mayhall, G. (1999) A comparison of two antimicrobial-impregnated central venous catheters. N. Engl. J. Med. 340: 1-8
40. DeRiso, A. J., Ladowski, J. S., Dillon, T. A., Justice, J. W., Peterson, A. C. (1996) Chlorhexidine Gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery. Chest 109: 1556-1561
41. Driks, M. R., Craven, D. E., Celli, B. R., Manning, M., Burke, R. A., Garvin, G. M., Kunches, L. M., Farber, H. W., Wedel, S. A., McCabe, W. R. (1987) Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers. N. Engl. J. Med. 317: 1376-1382
42. Eddleston, J. M., Vohra, A., Scott, P., Tooth, J. A., Pearson, R. C., McCloy, R. F., Morton, A. K., Doran, B. H. (1991) A comparison of the frequency of stress ulceration and secondary pneumonia in sucralfate or ranitidine-treated intensive care unit patients. Crit. Care Med. 19: 1491-1496
43. Eisenberg, J., Pepe, M., Williams-Warren, J., Vasiliev, M., Montgomery, A. B., Smith, A. L., Ramsey, B. W., Borowitz, D., Eigen, H., Hiatt, P., Moss, R., Konstan, M., Schidlow, D., Wilmott, R., Yee, W., Crist, D., Joy, P., McNamra, S., Gray, D., Pitlick, W (1997) A comparison of peak sputum tobramycin concentration in patients with cystic fibrosis using jet and ultrasonic nebuliser systems. Aerosolised tobramycin study group. Chest 111: 955-962
44. Emmerson, A. M., Enstone, J. E., Griffin, M., Kelsey, H. C., Smyth, E. T. M. (1996) The second national prevalence survey of infection in hospitals - Overview of results. J. Hosp. Infect. 32: 175-190
45. Ephgrave, K.S., Kleiman-Wexler, R., Pfaller, M., Both, B. M., Reed, D., Werkmeister, L., Young, S. (1998) Effects of sucralfate vs antacids on gastric pathogens: Results of a double-blind clinical trial. Arch. Surg. 133: 251-257
46. Evans, R. S., Pestotnik, S. L., Classen, D. C., Clemmer, T. P., Weaver, L. K., Orme, J. F., Lloyd, J. F., Burke, J. P. (1998) A computer-assisted management program for antibiotics and other antiinfective agents. N. Engl. J. Med. 338: 232-238
47. Ewig, S., Torres, A., El-Ebiary, M., Fabregas, N., Hernandez, C., Gonzalez, J., Nicolas, J. M., Soto, L. (1999) Bacterial colonisation patterns in mechanically ventilated patients with traumatic and medical head injury incidence, risk factors, and association with ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 159: 188-198
48. Fagon, J. Y., Chastre, J., Domart, Y., Trouillet, J. L., Pierre, J., Darne, C., Gibert, C. (1989) Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Am. Rev. Respir. Dis. 139: 877-884
49. Fagon, J. Y., Chastre, J., Hance, A., Montravers, P., Novara, A., Gilbert, C. (1993) Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay. Am. J. Med. 94: 281-288
50. Fagon, J. Y., Chastre, J., Vuagnat, A., Trouillet, J. L., Novara, A., Gibert, C. (1996) Nosocomial pneumonia and mortality among patients in intensive care units. J. Am. Med. Assoc. 275: 866-869
51. Feeley, T. W., DuMoulin, G. C., Hedley-Whyte, J., Bushnell, L. S., Gilbert, J. P., Feingold, D. S. (1975) Aerosol polymixin and pneumonia in seriously ill patients. N. Engl. J. Med. 293: 471-475
52. Ferrer, M., Torres, A., Gonzalez, J., Puig, J., El-Ebiary, M., Roca, M., Gatell, J. M., Rodriguezroisin, R. (1994) Utility of selective digestive decontamination in mechanically ventilated patients. Ann. Intern. Med. 120: 389-395
53. Flume, P., Klepser, M. E. (2002) The rationale for aerosolised antibiotics. Pharmacotherapy 22: 71S-79S
54. Gabriel, M. M., Mayo, M. S., May, L. L., Simmons, R. B., Ahearn, D. G. (1996) In vitro evaluation of the efficiacy of a silver-coated catheter. Curr. Microbiol. 33: 1-5
55. Gastinne, H., Wolff, M., Delatour, F., Faurisson, F., Chevret, S. (1992) A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. N. Engl. J. Med. 326: 594-599
56. George, D. L. (1995) Epidemiology of nosocomial pneumonia in intensive care unit patients. Clin. Chest. Med. 16: 29-44
57. George, D. L., Falk, P. S., Wunderink, R. G., Leeper, K. V., Meduri, G. U., Steere, E. L., Corbett, C. E., Mayhall, C. G. (1998) Epidemiology of ventilator-acquired pneumonia based on protected bronchoscopic sampling. Am. J. Respir. Crit. Care Med. 158: 1839-1847
58. GoeauBrissonniere, O., Leflon, V., Letort, M., Nicolas, M. H. (1999) Resistance of antibiotic bonded gelatin coated polymer meshes to Staphylococcus aureus in a rabbit subcutaneous pouch model. Biomaterials 20: 229-232
59. Goldman, D. A., Weinstein, R. A., Wenzel, R. P., Tablan, O. C., Duma, R. J., Gaynes, R. P., Schlosser, J., Martrone, W. J. (1996) Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals: A challenge to hospital leadership. J. Am. Med. Assoc. 275: 234-240
60. Gorman, S. P., Jones, D. S. (2003) Complications of urinary devices. In: Wilson, M. (ed.) Medical Implications of Biofilms. Cambridge University Press, UK. In press
61. Gorman, S. P., Adair, C. G., O'Neill, F., Goldsmith, C., Webb, H. (1993) Influence of selective decontamination of the digestive tract on microbial biofilm formation on endotracheal tubes from artificially ventilated patients. Eur. J. Clin. Microbiol. Infect. Dis. 12: 9-17
62. Gorman, S. P., McGovern, J. G., Woolfson, A. D., Adair, C. G., Jones, D. S. (2001) The concomitant development of poly (vinyl chloride)-related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia. Biomaterials 22: 2741-2747
63. Hammond, J., Potgieter, P. D., Saunders, G. L., Ford, A. (1992) Double-blind study of selective decontamination of the digestive tract in intensive care. Lancet 340: 5-9
64. Hanisch, E. W., Encke, A., Naujoks, F., Windolf, J. (1998) A randomised, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia. Am. J. Surg. 176: 453-457
65. Heyland, D. K., Cook, D. J., Jaeschke, R., Griffith, L., Lee, H. N., Guyatt, G. H. (1994) Selective decontamination of the digestive tract: An overview. Chest 105: 1221-1229
66. Heyland, D. K., Cook, D. J., Griffith, L., Keenan, S. P., Brun-Buisson, C. (for the Canadian Critical Care Trials Group) (1999) The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am. J. Respir. Crit. Care. Med. 159: 1249-1256
67. Horan, T. C., Wite, J. W., Jarvis, W. R. (1986) Nosocomial infection surveillance, 1984. MMWR 35: 17SS-29SS
68. Horan, T. C., Culver, D. H., Gaynes, R. P., Jarvis, W. R., Edwards, J. R., Reid, C. R. (1993) Nosocomial infectionsin surgical patients in the United States, January 1986-June 1992. National Nosocomial Infections Surveillance (NNIS) System. Infect. Control Hosp. Epidemiol. 14: 73-80
69. Ibrahim, E. H., Ward, S., Sherman, G., Kollef, M. H. (2000) A comparative analysis of patients with early-onset versus late-onset nosocomial pneumonia (NP) in the ICU setting. Chest 117: 1434-1442
70. Jacobs, S., Foweraker, J. E., Roberts, S. E. (1992) Effectiveness of selective decontamination of the digestive tract in an ICU with a policy encouraging a low gastric pH. Clin. Intensive Care 3: 52-58
71. Jarvis, W. R., Edwards, J. R., Culver, D. H., Hughes, J. M., Horan, T., Emori, T. G., Banerjee, S., Tolson, J., Henderson, T., Gaynes, R. P., Martone, W. J. (1991) Nosocomial infection rates in adult and paediatric intensive care units in the United States: National Nosocomial Infections Surveillance System. Am. J. Med. 91: 185S-191S
72. Jimenez, P., Torres, A., Rodriguez-Roisin, R., Delabelacasa, J. P., Aznar, R., Gatell, J. M., Agustividal, A. (1989) Incidence and aetiology of pneumonia acquired during mechanical ventilation. Crit. Care Med. 17: 882-885
73. Jones, C. R., Handley, P. S., Robson, G. D., Eastwood, I. M., Greenhalgh, M. (1996) Biocides incorporated into plasticised polyvinyl chloride reduce adhesion of Pseudomonas fluorescens B1146 and substratum hydrophobicity. J. Appl. Bacteriol. 81: 553-560
74. Jones, D. S., McGoven, J. G., Woolfson, A. D., Adair, C. G., Gorman, S. P. (2002) Physicochemical characterisation of hexetidine impregnated endotracheal tube poly (vinylchloride) and resistance to adherence of respiratory bacterial pathogens. Pharm. Res. 19: 818-824
75. Jones, D. S., McMeel, S., Adair, C. G., Gorman, S. P. (2003) Characterisation and evaluation of novel surfactant bacterial anti-adherent coatings for endotracheal tubes designed for the prevention of ventilator associated pneumonia. J. Pharm. Pharmacol. 55: 43-52
76. Kerver, A. J. H., Rommes, J. H., Mevissen-Verhage, E. A., Hulstaert, P. F., Vos, A., Verhoef, J., Wittebol, P. (1988) Prevention of colonisation and infection in critically ill patients: A prospective randomised study. Crit. Care Med. 16: 1087-1093
77. Kohnen, W., Schaper, J., Klien, O., Tieke, B., Jansen, B. (1998) A silicone ventricular catheter coated with a combination of rifampin and trimethoprim for the prevention of cathether-related infections. Zentralbl. Bakteriol. 287: 147-156
78. Klastersky, J., Huysman, E., Weertz, D. (1974) Endotracheally administered gentamicin for prevention of infection of the respiratory tract in patients with tracheostomy: A double-blind study. Chest 65: 650-654
79. Klick, J. M., DuMoulin, G. C., Hedley-Whyte, J. (1975) Prevention of Gram-negative bacillary pneumonia using polymycin aerosol as prophylaxis. J. Clin. Invest. 55: 514-519
80. Kollef, M. H. (1993) Ventilator-associated pneumonia: A multivariate analysis. J. Am. Med. Assoc. 270: 1965-1970
81. Kollef, M. H. (1994) The role of selective digestive tract decontamination on mortality and respiratory tract infections: A meta-analysis. Chest 105: 1101-1108
82. Kollef, M. H. (1999) The prevention of ventilator-associated pneumonia. N. Engl. J. Med. 340: 627-634
83. Kollef, M. H., Sharpless, L., Vlasnik, J., Plasque, C., Murphy, D., Fraser, V. J. (1997a) The impact of nosocomial infections on patients outcomes following cardiac surgery. Chest 112: 666-675
84. Kollef, M. H., Vlasnik, J., Sharpless, L., Pasque, C., Murphy, D., Fraser, V. (1997b) Scheduled change of antibiotic classes: A strategy to decrease the incidence of ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 156: 1040-1048
85. Korinek, A. M., Laisne, M. J., Nicols, M. H., Raskine, L., Deroin, V., Sanson-Lepors, M. J. (1993) Selective decontamination of the digestive tract in neurosurgical intensive care unit patients: A double-blind, randomised, placebo-controlled study. Crit. Care Med. 21: 1466-1473
86. Laggner, A. N., Lenz, K. L., Base, W., Druml, W., Schneeweiss, B., Grimm, G. (1989) Prevention of upper gastro intestinal bleeding in long term ventilated patients. Sucralfate versus ranitidine. Am. J. Med. 86: 81-84
87. Le Conte, P., Potel, G., Clementi, E., Legra, A., Villers, D., Bironneau, E., Cousson, J., Baron, D. (2000) Administration d'aerosols de tobramycine chez des patients ayant une pneumopathi nosocomiale: Etude preliminaire. Presse Med. 29: 76-78.
88. Lingnau, W., Berger, J., Javorsky, F., Lejeune, P., Mutz, N., Benzer, H. (1997) Selective intestinal decontamination in multiple trauma patients; Prospective, controlled trial. J. Trauma 42: 687-694
89. Louria, D. B., Kanimski, T. (1962) The effects of four antimicrobial drug regimens on sputum superinfection in hospitalised patients. Am. Rev. Respir. Dis. 85: 649-665
90. Maier, R. V., Mitchell, D., Gentilello, L. (1994) Optimal therapy for stress gastritis. Ann. Surg. 220: 353-360
91. Maki, D. G., Stolz, S. M., Wheeler, S., Mermel, L. A. (1997) Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. Ann. Intern. Med. 127: 257-266
92. Mandell, L. A., Marrie, T. J., Niederman, M. S. and the Canadian Hospital Acquired Pneumonia Consensus Conference Group (1993) Initial antimicrobial treatment of hospital acquired pneumonia in adults: A conference report. Can. J. Infect. Dis. 4: 317-321
93. Mendelman, P. M., Smith, A. L., Levy, J., Weber, A., Ramsey, B., Davis, R. L. (1985) Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum. Am. Rev. Respir. Dis. 132: 761-767
94. Messori, A., Trippoli, S., Vaiani, M., Corrado, A. (2000) Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: Meta-analysis of randomised controlled trials. Br. Med. J. 321: 1-7
95. Metz, C. A., Livingston, D. H., Smith, J. S., Larson, G. M., Wilson, T. H. (1993) Impact of multiple risk factors and ranitidine prophylaxis on the development of stress-related upper gastrointestinal bleeding. Crit. Care Med. 21: 1844-1849
96. Morgan, W. J., Butler, S. M., Johnson, C. A., Colin, A. A., FitzSimmons, S. C., Geller, D. E., Konstan, M. W., Light, M. J., Rabin, H. R., Regelmann, W. E., Schidlow, D. V., Stokes, D., C., Wohl, M. E. B., Kaplowitz, H., Wyatt, M. M., Stryker, S. (1999) Epidemiologic study of cystic fibrosis: Design and implementation of a prospective, multicenter, observational study of patients with cystic fibrosis in the U. S. and Canada. Paediatr. Pulmonol. 138: 699-704
97. Mustafa, N. A., Akturk, G., Ozen, I., Koksal, I., Erciyes, N., Solak, M. (1995) Acute stress bleeding prophylaxis with sucralfate versus ranitidine and increase of secondary pneumonia in intensive care unit patients. Intensive Care Med. 21: 287
98. Nathens, A. B., Marshall, J. C. (1999) Selective decontamination of the digestive tract in surgical patients. A systemic review of the evidence. Arch. Surg. 134: 170-176
99. National Audit Office (2000) The Management and Control of Hospital Acquired Infection in Acute NHS Trusts in England. HMSO, London
100. Niedermann, M., Torres, A., Summer, W. (1994) Invasive diagnostic testing is not needed routinely to manage suspect ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 150: 565-569
101. Ollendorf, D., Rello, J., Kollef, M., Vera-Ilonch, M., Bellm, L., Redman, R., Oster, G. (2001) Epidemiology and outcomes of ventilator-associated pneumonia (VAP) in a large US database. Intensive Care Med. 27: S192
102. Palmer, L. B., Smaldone, G. C., Simon, S. R., O'Riordan, T. G., Cuccia, A. (1998) Aerosolized antibiotics in mechanically ventilated patients: Delivery and reponse. Crit. Care Med. 26: 31-39
103. Palomar, M., Alvarez-Lerma, F., Jorda, R., Bermejo, B. (1997) Prevention of nosocomial infection in mechanically ventilated patients: Selective decontamination versus sucralfate. Clin. Intensive Care 8: 228-235
104. Papazian, L., Bregeon, F., Thirion, X., Gregorie, R., Saux, P., Denis, J. P., Perin, G., Charrel, J., Dumon, J. F., Affray, J. P., Gouin, F. (1996) Effect of ventilator-associated pneumonia on mortality and morbidity. Am. J. Respir. Crit. Care Med. 154: 91-97
105. Pemberton, L. B., Ross, V., Cuddy, P., Kremer, H., Fessler, T., McGurk, E. (1996) No difference in catheter sepsis between standard and antiseptic central venous catheters. Arch. Surg. 131: 986-989
106. Pickworth, K. K., Falcone, R. E., Hoogeboom, J. E., Santanello, S. A. (1993) Occurrence of nosocomial pneumonia in mechanically ventilated trauma patients: A comparison of sucralfate and ranitidine. Crit. Care Med. 21: 1856-1862
107. Pingleton, S. K., Fagon, J. Y., Leeper, K. V. (1992) Patient selection for clinical investigation of ventilator-associated pneumonia: Criteria for evaluating diagnostic techniques. Chest 102: 553S-556S
108. Pizzo, P. A. (1990) Current issues in the antibiotic primary management of the febrile neutropenic cancer patient. J. Hosp. Infect. 15: 41-48
109. Plowman, R., Craves, N., Griffin, M., Roberts, J., Swan, A., Cookson, B., Taylor, L. (2000) The Socio Economic Burden of Hospital Acquired Infection. Public Health Laboratory Service, London
110. Prod'hom, G., Leuenberger, P., Koerfer, J., Blum, A., Chiolero, R., Schaller, M. D., Perret, C., Spinnler, O., Blondel, J., Siegrist, H., Saghafi, L., Blanc, D., Francioli, P. (1994) Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer: A randomised controlled trial. Ann. Intern. Med. 120: 653-662
111. Pugin, J., Auckenthaler, R., Lew, D. P., Suter, P. M. (1991) Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: A randomised, placebo-controlled, double-blind clinical trial. J. Am. Med. Assoc. 265: 2704-2710
112. Quinio, B., Albanese, J., Bues-Charbit, M., Viviand, X., Martin, C. (1996) Selective decontamination of the digestive tract in multiple trauma patients. A prospective-blind, randomised, placebo-controlled study. Chest 109: 765-772
113. Raad, I., Buzaid, A., Rhyne, J., Hachem, R., Darouiche, R., Safar, H., Albitar, M., Sherertz, R. J. (1997a) Minocycline and ethylenediaminetetraacetate for the prevention for recurrent vascular catheter infections. Clin. Infect. Dis. 25: 149-151
114. Raad, I., Darouiche, R., Dupuis, J., Abi-Said, D., Gabrielli, A., Hachem, R., Wall, M., Harris, R., Jones, J., Buzaid, A., Robertson, C., Sheaq, S., Curling, P., Burke, T., Ericsson, C. (1997b) Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonisation and bloodstream infections: A randomized, double-blind trial. Ann. Intern. Med. 127: 267-274
115. Ramsey, B. W., Burns, J., Smith, A. (1997) Safety and efficacy of tobramycin solution for inhalation in patients with cystic fibrosis: The results of two phase placebo controlled clinical trials. Paediatr. Pulmonol. 14: 137-138
116. Reid, G., Sharma, S., Advikolanu, K., Tieszer, C. (1994) Effects of ciprofloxacin, norfloxacin and ofloxacin on in vitro adhesion and survival of Pseudomonas aeruginosa AK1 on urinary catheters. Antimicrob. Agents Chemother. 38: 1490-1495
117. Rello, J., Ausina, V., Ricart, M., Castella, J., Prats, G. (1993) Impact of previous antimicrobial therapy on aetiology and outcome of ventilator-associated pneumonia. Chest 104: 1230-1235
118. Rello, J., Diaz, E., Roque, M., Valles, J. (1999) Risk factors for developing pneumonia within 48 hours of intubation. Am. J. Respir. Crit. Care Med. 159: 1742-1746
119. Richards, M. J., Edwards, J. R., Culver, D. H., Gaynes, R. P. (1999) Nosocomial infections in medical intensive care units in the United States. Crit. Care Med. 27: 887-892
120. Rocha, L. A., Martin, M. J., Pita, S., Paz, J., Seco, C., Margusino, L., Villanueva, R., Duran, M. T. (1992) Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract: A randomised, double-blind, placebo-controlled study. Intensive Care Med. 18: 398-404
121. Roder, B. L., Nielsen, S. L., Magnussen, P., Enquist, A., Frimodtmoller, N. (1993) Antibiotic usage in an intensive care unit in a Danish university hospital. J. Antimicrob. Chemother. 32: 633-642
122. Rodriguez-Roldan, J. M., Altuna-Cuesta, A., Lopez, A., Carrillo, A., Garcia, J., Leon, J., Martinezpellus, A. J. (1990) Prevention of nosocomial lung infection in ventilated patients: Use of an antimicrobial pharyngeal nonabsorbable paste. Crit. Care Med. 18: 1239-1242
123. Sanchez Garcia, M., Cambronero Galache, J. A., Lopez Diaz, J., Cerda Cerda, E., Rubio Blasco, J., Gomez Aguinaga, M. A. (1998) Effectiveness and cost of selective decontamination of the digestive tract in critically ill intubated patients: A randomised, double-blind, placebo-controlled, multicenter trial. Am. J. Respir. Crit. Care 158: 908-916
124. Schierholz, J. M., Jansen, B., Jaenicke, L., Pulverer, G. (1994) In vitro efficacy of an antibiotic-releasing silicone ventricle catheter to prevent shunt infection. Biomaterials 15: 996-1000
125. Sherertz, R. J. (1997) Selected thoughts on the development of new medical devices. Curr. Opin. Infect. Dis. 10, 330-334
126. Selective Decontamination of the Digestive Tract Trialists Collaboration Group (1993) Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. Br. Med. J. 307: 525-532
127. Singh, N., Falestiny, M. N., Rogers, P., Reed, M. J., Pularski, J., Norris, R., Yu, V. L. (1998) Pulmonary infiltrates in the surgical ICU. Chest 114: 1129-1136
128. Singh, N., Rogers, P., Atwood, C. W., Wagener, M. M., Yu, V. L. (2000) Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. Am. J. Respir. Crit. Care Med. 162: 505-511
129. Sirvent, J. M., Torres, A., El-Ebiary, M., Castro, P., De Batlle, J., Bonet, A. (1997) Protective effect of intravenously administered cefuroxime against nosocomial pneumonia in patients with structural coma. Am. J. Respir. Crit Care Med. 155: 1729-1734
130. Sleyfer, D. T., Mulder, N. H., De Vries-Hospers, H. G., Fidler, V. (1980) Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur. J. Cancer 16: 859-869
131. Stickler, D. J. (1996) Bacterial biofilms and the encrustation of urethral catheters. Biofouling 9: 293-305
132. Stoutenbeek, C. P., Van Saene, H. K. F., Miranda, D. R., Zandstra, D. F. (1984) The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med. 10: 185-192
133. Thomason, M. H., Payseur, E. S., Hakenewerth, A. M., Norton, J. H., Mehta, B., Reeves, R., MooreSwartz, M. W., Robbins, P. I. (1996) Nosocomial pneumonia in ventilated trauma patients during stress ulcer prophylaxis with sucralfate, antacid and ranitidine. J. Trauma 41: 503-508
134. Torres, A., Aznar, R., Gatell, J., Jimenez, P., Gonzalez, J., Ferrer, A., Celis, R., Rodriguezroisin, R. (1990) Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am. Rev. Respir. Dis. 142: 523-528
135. 2-antagonists for stress ulcer prophylaxis: A meta-analysis on efficacy and pneumonia rate. Crit. Care Med. 19: 942-949
136. Tryba, M., Cook, D. (1997) Current guidelines on stress ulcer prophylaxis. Drugs 54: 581-596
137. Tryba, M., Mantey-Stiers, F. (1987) Antibacterial action of sucralfate in human gastric juice. Am. J. Med. 83: 3S-11S
138. Tunney, M. M., Gorman, S. P., Patrick, S. (1996) Infection associated with medical devices. Rev. Med. Microbiol. 74: 195-205
139. Ulrich, C., Harinck-De Weerd, J. E., Bakker, N. C., Jacz, K., Doornbos, L., De Ridder, V. A. (1989) Selective decontamination of the digestive tract with norfloxacin in the prevention of ICU-acquired infections: A prospective randomised study. Intensive Care Med. 15: 424-431
140. Unertl, K., Ruckdeschel, G., Selbmann, H. K., Jensen, U., Forst, H., Lenhart, F. P., Peter, K. (1987) Prevention of colonisation and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis. Intensive Care Med. 13: 106-113
141. Van Der Waaij, D., Berghuis-De Vries, J. M. and Lekkerkerk-Van Der Wees, J. E. (1971) Colonisation resistance of the digestive tract in conventional and antibiotic-treated mice. J. Hyg. 69: 405-411
142. Van Nieuwenhoven, C. A., Buskens, E., Van Tiel, F. H., Bonten, M. J. M. (2001) Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patients. J. Am. Med. Assoc. 286: 335-340
143. Van Saene, H. K. F., Baines, P. B. (1999) The prevention of ventilator-associated pneumonia. N. Engl. J. Med. 341: 293-294
144. Vandenbroucke-Grauls, C. M., Vandenbrouke, J. P. (1991) Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet 338: 859-862
145. Villers, B., Espaze, E., Coste-Burel, M., Giauffret, F., Ninin, E., Nicolas, F., Richet, H. (1998) Nosocomial Acinetobacter baumannii infections: Microbiological and clinical epidemiology. Ann. Intern. Med. 129: 182-189
146. Vincent, J. L. (1999) Prevention of nosocomial bacterial pneumonia. Thorax 54: 544-549
147. Vincent, J. L., Bihari, D. J., Suter, P. M., Bruining, H. A., White, J., Nicolas-Chanoin, M. H., Wolff, M., Spencer, R. C., Hemmer, M. (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC) study. J. Am. Med. Assoc. 274: 639-644
148. Whalen, R. L., Cai, C., Thompson, L. M., Sarrasin, M. J., Dempsey, D. J., Bowen, M. A. (1997) An infection inhibiting urinary catheter material. ASAOI J. 43: M843-M847
149. Wiener, J., Itokazu, G., Nathan, C., Kabins, S. A., Weinstein, R. A. (1995) A randomised, double-blind, placebo-controlled trial of selective decontamination in a medical-surgical intensive care unit. Clin. Infect. Dis. 20: 861-867
150. Winter, R., Humphreys, H., Pick, A., Macgowan, A. P., Willatts, S. M., Speller, D. C. E. (1992) A controlled trial of selective decontamination of the
151. Wunderink, R. G. (1998) Attributable mortality of ventilator-associated pneumonia. Sepsis 1: 211-221