Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients

Annals of Internal Medicine

Volumn 129, Issue 6, 1998, Pages 433-440

  Cook, Deborah J ^a   Walter, Stephen D ^b   Cook, Richard J ^c   Griffith, Lauren E ^b   Guyatt, Gordon H ^b   Leasa, David ^d   Jaeschke, Roman Z ^a   Brun Buisson, Christian ^e  

^a ST JOSEPH S HOSPITAL   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

^d LONDON HEALTH SCIENCES CENTRE   (Canada)

^e HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; NEUROMUSCULAR BLOCKING AGENT;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION; BURN; CANADA; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; HEART DISEASE; HUMAN; INCIDENCE; INJURY; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; RISK FACTOR; VENTILATOR;

EID: 0032531113     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-129-6-199809150-00002     Document Type: Article

References (56)

1. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study. EPIC International Advisory Committee. JAMA. 1995;274:639-44.
2. Chevret S, Hemmer M, Carlet J, Langer M. Incidence and risk factors of pneumonia acquired in intensive care units. Results from a multicenter prospective study on 996 patients. European Cooperative Group on Nosocomial Pneumonia. Intensive Care Med. 1993;19:256-64.
3. Alvarez-Lerma F, Palmoar M, Martinez-Pellus AE, et al. Aetiology and diagnostic techniques in intensive care-acquired pneumonia: a Spanish multicenter study. Clin Intensive Care. 1997;8:164-70.
4. Papazian L, Bregeon F, Thirion X, Gregoire R, Saux P, Denis JP, et al. Effect of ventilator-associated pneumonia on mortality and morbidity. Am J Respir Crit Care Med. 1996;154:91-7.
5. Fagon JY, Chastre J, Vuagnat A, Trouillet JL, Novara A, Gibert C. Nosocomial pneumonia and mortality among patients in intensive care units. JAMA. 1996;275:866-9.
6. Craven DE, Kunches LM, Lichtenberg DA, Kollisch NR, Barry MA, Heeren TC, et al. Nosocomial infection and fatality in medical and surgical intensive care unit patients. Arch Intern Med. 1988;148:1161-8.
7. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med. 1993;94:281-8.
8. Cook DJ, De Jonghe B, Brochard L, Brun-Buisson C. Influence of airway management on ventilation associated pneumonia: evidence from randomized trials. JAMA. 1998;279:781-7.
9. Cook DJ, De Jonghe B, Heyland DK. The relation between nutrition and nosocomial pneumonia: Randomized trials in critically ill patients. Crit Care. 1997;1:3-9.
10. Hanson LC, Weber DJ, Rutala WA. Risk factors for nosocomial pneumonia in the elderly. Am J Med. 1992;92:161-6.
11. Cells R, Torres A, Gatell JM, Almela M, Rodriguez-Roisin R, Agusti-Vidal A. Nosocomial pneumonia. A multivariate analysis of risk and prognosis. Chest. 1988;93:318-24.
12. Joshi N, Localio AR, Hamory BH. A predictive risk index for nosocomial pneumonia in the intensive care unit. Am J Med. 1992;93:135-42.
13. Cunnion KM, Weber DJ, Broadhead WE, Hanson LC, Pieper CF, Rutala WA. Risk factors for nosocomial pneumonia: comparing adult critical-care populations. Am J Respir Crit Care Med. 1996;153:158-62.
14. Kropec A, Schulgen G, Just H, Geiger K, Schumacher M, Daschner F. Scoring system for nosocomial pneumonia in ICUs. Intensive Care Med. 1996; 22:1155-61.
15. Mosconi P, Langer M, Cigada M, Mandelli M. Epidemiology and risk factors of pneumonia in critically ill patients. Intensive Care Unit Group for Infection Control. Eur J Epidemiol. 1992;7:320-7.
16. Craven DE, Kunches LM, Kilinsky V, Lichtenberg DA, Make BJ, McCabe WR. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis. 1986;133:792-6.
17. Torres A, Aznar R, Gatell JM, Jimenez P, Gonzalez J, Ferrer A, et al. Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis. 1990;142:523-8.
18. Kollef M. Ventilator-associated pneumonia: a multivariate analysis. JAMA. 1993;270:1965-70.
19. Elatrous S, Boujdaria R, Merghli S, Ouanes L, Boussarsar M, Nouira S, et al. Incidence and risk factors of ventilator-associated pneumonia: a one-year prospective survey. Clin Intensive Care. 1996;7:276-81.
20. Rello J, Sonora S, Jubert P, Artigas A, Rue M, Valles J. Pneumonia in intubated patients: role of respiratory airway care. Am J Respir Crit Care Med. 1996;154:111-5.
21. Kollef MH, Von Harz B, Prentice D, Shapiro SD, Silver P, St John R, et al. Patient transport from intensive care increases the risk of developing ventilator-associated pneumonia. Chest. 1997;112:765-73.
22. Cook D, Guyatt G, Marshall J, Leasa D, Fuller H, Hall R, et al. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. N Engl J Med. 1998;338:791-7.
23. Niederman MS, Torres A, Summer W. Invasive diagnostic testing is not needed routinely to manage suspected ventilated-associated pneumonia. Am J Respir Crit Care Med. 1994;150:565-9.
24. Chastre J, Fagon JY. Invasive diagnostic testing should be routinely used to manage ventilated patients with suspected pneumonia. Am J Respir Crit Care Med. 1994;150:570-4.
25. CDC definitions for nosocomial infections, 1988. Am Rev Respir Dis. 1989; 139:1058-9.
26. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew RD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143(5 Pt 1):1121-9.
27. Marshall JC, Cook DJ, Christou NV. Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23:1638-52.
28. Timsit JF, Misset B, Renaud B, Goldstein FW, Carlet J. Effect of previous antimicrobial therapy on the accuracy of the main procedures used to diagnose nosocomial pneumonia in patients who are using ventilation. Chest. 1995;108:1036-40.
29. Langer M, Mosconi P, Cigada M, Mandelli M. Long-term respiratory support and risk of pneumonia in critically ill patients. Intensive Care Unit Group of Infection Control. Am Rev Respir Dis. 1989;140:302-5.
30. Huxley EJ, Viroslav J, Gray WR, Pierce AK. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med. 1978; 64:564-8.
31. Braun SR, Levin AB, Clark KL. Role of corticosteroids in the development of pneumonia in mechanically ventilated head-trauma victims. Crit Care Med. 1986;14:198-201.
32. Liberati A, D'Amico R, Pifferi S, Leonetti C, Torri V, Brazzi L, et al. Antibiotic prophylaxis in adult patients treated in intensive care units. In: Douglas R, Bridges-Webb C, Glasziou P, Lozano J, Steinhoff M, Wang E, eds. Acute Respiratory Infections Module of the Cochrane Database of Systematic Reviews. Cochrane Collaboration. Cochrane Library. 1997;3:1-14.
33. Torres A, Serra-Batiles J, Ros E, Piera C, Puig de la Bellacasa J, Cobos A, et al. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med. 1992;116: 540-3.
34. Sirvent JM, Torres A, El-Ebiary M, Castro P, de Batile J, Bonet A. Protective effect of intravenously administered cefuroxime against nosocomial pneumonia in patients with structural coma. Am J Respir Crit Care Med. 1997;155:1729-34.
35. Rello J, Ausina V, Ricart M, Puzo C, Quintana E, Net A, et al. Risk factors for infection by Pseudomonas aeruginosa in patients with ventilator-associated pneumonia. Intensive Care Med. 1994;20:193-8.
36. Atherton ST, White DJ. Stomach as source of bacteria colonizing respiratory tract during artificial respiration. Lancet. 1978;2:968-9.
37. Pingelton SK, Hinthorn DR, Liu C. Enterai nutrition in patients receiving mechanical ventilation. Multiple sources of tracheal colonization include the stomach. Am J Med. 1986;80:827-32.
38. Bonten MJ, Gaillard CA, de Leeuw PW, Stobberingh EE. Role of colonization of the upper intestinal tract in the pathogenesis of ventilator associated pneumonia. Clin Infect Dis. 1997;24:309-19.
39. Rouby JJ, Laurent P, Gosnach M, Cambau E, Lamas G, Zouaoui A, et al. Risk factors and clinical relevance of nosocomial maxillary sinusitis in the critically ill. Am J Respir Crit Care Med. 1994;150:776-83.
40. Salord F, Gaussorgues P, Marti-Flich J, Sirodot M, Allimant C, Lyonnet D, et al. Nosocomial maxillary sinusitis during mechanical ventilation: a prospective comparison of orotracheal versus the nasotracheal route for intubation. Intensive Care Med. 1990;16:390-3.
41. Michelson A, Kamp HD, Schuster B. [Sinusitis in long-term intubated, intensive care patients; nasal versus oral intubation]. Anaesthesist. 1991;40: 100-4.
42. Holzapfel L, Chevret S, Madinier G, Ohen F, Demingeon G, Coupry A, et al. Influence of long-term oro-or nasotracheal intubation on nosocomial maxillary sinusitis and pneumonia: results of a prospective, randomized, clinical trial. Crit Care Med. 1993;21:1132-8.
43. Rouby JJ, Laurent P, Gosnach M, Cambeau E, Lamas G, Zouaoui A, et al. Risk factors and clinical relevance of nosocomial maxillary sinusitis in the critically ill. Am Rev Respir Crit Care Med. 1994;150:776-83.
44. Montecalvo MA, Steger KA, Farber HW, Smith BF, Dennis RC, Fitzpatrick GF, et al. Nutritional outcome and pneumonia in critical care patients randomized to gastric versus jejunal tube feedings. The Critical Care Research Team. Crit Care Med. 1992;20:1377-87.
45. Heyland D, Mandell LA. Gastric colonization by gram-negative bacilli and nosocomial pneumonia in the intensive care unit patient. Evidence for causation. Chest. 1992;101:87-93.
46. Ibanez J, Penafiel A, Raurich JM, Marse P, Jorda R, Mata F. Gastroesophageal reflux in intubated patients receiving enterai nutrition: effect of supine and semirecumbent positions. JPEN J Parenter Enterai Nutr. 1992;16: 419-22.
47. Orozco-Levi M, Torres A, Ferrer M, Piera C, el-Ebiary M, de la Bellacasa JP, et al. Semirecumbent position protects from pulmonary aspiration but not completely from gastroesophageal reflux in mechanically ventilated patients. Am J Respir Crit Care Med. 1996;152(4 Pt 1):1387-90.
48. Cook DJ, Kollef MH. Risk factors for ICU-acquired pneumonia. JAMA. 1998; 279:1605-6.
49. Cook DJ, King D. How accurate are physician estimates of length of ICU stay and mechanical ventilation? The Canadian Critical Care Trials Group. Am J Respir Crit Care Med. 1994;149:A640.
50. Rello J, Ricart M, Ausina V, Net A, Prats G. Pneumonia due to Haemophilus influenzae among mechanically ventilated patients. Incidence, outcome, and risk factors. Chest. 1992;102:1562-5.
51. Baraibar J, Correa H, Mariscal D, Gallego M, Valles J, Rello J. Risk factors for infection by Acinetobacter baumannii in intubated patients with nosocomial pneumonia. Chest. 1997;112:1050-4.
52. Kollef MH, Silver P, Murphy DM, Trovillion E. The effect of late-onset ventilator-associated pneumonia in determining patient mortality. Chest. 1995;108:1655-62.
53. Timsit JF, Chevret S, Valcke J, Misset B, Renaud B, Goldstein FW, et al. Mortality of nosocomial pneumonia in ventilated patients: influence of diagnostic tools. Am J Respir Crit Care Med. 1996;154:116-23.
54. Crouch Brewer S, Wunderink RG, Jones CB, Leeper KV Jr. Ventilator-associated pneumonia due to Pseudomonas aeruginosa. Chest. 1996;109: 1019-29.
55. Rello J, Ausina V, Ricart M, Castella J, Prats G. Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia. Chest. 1993;104:1230-5.
56. Laupacis A, Sekar N, Stiell IG. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA. 1997;277:488-94.