Selective decontamination of the digestive tract in multiple trauma patients: A prospective double-blind, randomized, placebo-controlled study

Chest

Volumn 109, Issue 3, 1996, Pages 765-772

  Quinio, Bertrand ^a   Albanèse, Jacques ^a   Bues Charbit, Martine ^a   Viviand, Xavier ^a   Martin, Claude ^a  

^a HÔPITAL NORD   (France)

Author keywords

bacterial colonization; coagulase negative Staphylococcus; critical illness; nosocomial infections; selective decontamination of the digestive tract; topical antibiotics; trauma patients

Indexed keywords

ADULT; ARTICLE; BACTERIAL COLONIZATION; BRONCHOPNEUMONIA; FEMALE; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; INFECTIOUS COMPLICATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0029871633     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.109.3.765     Document Type: Article

References (33)

1. Stoutenbeek CP, Van Saene HKF, Miranda DR, et al. The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients. Intensive Care Med 1984; 10:185-92
2. Aerdts SJA, Clasener HAL, Van Dalen D, et al. Prevention of bacterial colonization of the respiratory tract and stomach of mechanically ventilated patients by a novel regimen of selective decontamination in combination with initial systemic cefotaxime. J Antimicrob Chemother 1990; 26:59-76
3. Hammond JMJ, Potgieter PD, Saunders GL, et al. Double-blind study of selective decontamination of the digestive tract in intensive care. Lancet 1992; 340:5-9
4. Mackie DP, Van Hertum WAJ, Schumburg T, et al. Prevention of infection in burns: preliminary experience with selective decontamination of the digestive tract in patients with extensive injuries. J Trauma 1992; 32:570-75
5. Tetteroo GWM, Wagenwoort JHT, Castelein A, et al. Selective decontamination to reduce Gram-negative colonization and infections after oesophageal resection. Lancet 1990; 335:704-07
6. Gastinne H, Wolff M, Delatour F, et al. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. N Engl J Med 1992; 326: 594-99
7. Korinek AM, Laisne MJ, Nicolas MH, et al. Selective decontamination of the digestive tract in neurosurgical intensive care unit patients: a double-blind, randomized, placebo-controlled study. Crit Care Med 1993; 21:1466-73
8. Nardi G, Valentinis U, De Monte A, et al. Epidemiological impact of prolonged systematic use of topical SDD on bacterial colonization of the tracheobronchial tree and antibiotic resistance. Intensive Care Med 1993; 19:273-78
9. Redriguez-Roldan JM, Altuna-Cuesta A, Lopez A, et al. Prevention of nosocomial lung infection in ventilated patients: use of an antimicrobial pharyngeal nonabsorbable paste. Crit Care Med 1990; 18:1239-42
10. Armstrong PJ, Barr JG, Webb CH, et al. Epidemiology of Pseudomonas aeruginosa in an intensive care unit using selective decontamination of the digestive tract. J Hosp Infect 1992; 20: 199-208
11. Daschner F. Emergence of resistance during selective decontamination of the digestive tract. Eur J Clin Microbiol Dis 1992; 11:1-3
12. Humphrey H, Winter R, Pick A. The effect of selective decontamination of the digestive tract on gastrointestinal enterococcal colonization in ITU patients. Intensive Care Med 1992; 18:459-63
13. Nau R, Rüchel R, Mergerian H, et al. Emergence of antibiotic-resistant bacteria during selective decontamination of the digestive tract. J Antimicrob Chemother 1990; 25:881-83
14. Craven DE, Kunches LM, Kilinsky V, et al. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986; 133:792-96
15. Fagon JY, Chastre J, Hance AJ, et al. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 1993; 94:281-88
16. Kollef MH. Ventilator-associated pneumonia: a multivariate analysis. JAMA 1993; 270:1965-70
17. Torres A, Aznar R, Gattel JM, et al. Incidence risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 1990; 142:523-28
18. Rello J, Quintana E, Ausina V, et al. Incidence, etiology and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 1991; 100:439-44
19. Rello J, Ricart M, Ausina V, et al. Pneumonia due to Haemophilus influenzae among mechanically ventilated patients: incidence, outcome, and risk factors. Chest 1992; 102:1562-65
20. Rello J, Ausina V, Castella J, et al. Nosocomial respiratory tract infections in multiple trauma patients: influence of level of consciousness with implications for therapy. Chest 1992; 102:525-29
21. Liberati A, Brazzi L. Effect of selective decontamination of the digestive tract upon mortality. Réan Urg 1992; 1(3bis):521-25
22. Selective Decontamination of the Digestive Tract Trialists' Collaborative Group. Meta-analysis of randomized controlled trials of selective decontamination of the digestive tract. BMJ 1993; 307: 525-32
23. Rocha LA, Martin MJ, Pita S, et al. Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract. Intensive Care Med 1992; 18:398-404
24. Jacobs S, Foweraker JE, Roberts SK. Effectiveness of selective decontamination of the digestive tract (SDD) in an ICU with a policy encouraging a low gastric pH. Clin Intensive Care 1992; 3:52-8
25. Ulrich C, Harinck-de Weerd JK, Bakker NC, et al. Selective decontamination of the digestive tract with norfloxacin in the prevention of ICU-acquired infections: a prospective randomized study. Intensive Care Med 1989; 15:423-31
26. Ledingham IM, Alcock SR, Eastaway AT, et al. Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime, and microbiological surveillance for prevention of acquired infection in intensive care. Lancet 1988; 1:785-90
27. Stoutenbeek CP, Van Saene HKF, Miranda DR, et al. The effect of orophraryngeal decontamination using topical nonansorbable antibiotics on the evidence of nosocomial respiratory tract infections in multiple trauma patients. J Trauma 1987; 27:357-64
28. Hammond JMJ, Potgieter PD, Saunders GL, et al. Selective decontamination of the digestive tract in multiple trauma patients - is there a role?: results of a prospective, double-blind, randomized trial. Crit Care Med 1994; 22:33-9
29. Stoutenbeek CP, Van Saene HKF, Miranda DH, et al. A new technique of infection prevention in the intensive care unit by selective decontamination of the digestive tract. Acta Anaesthesiol Belg 1983; 3:209-21
30. Mandelli M, Mosconi P, Langer M, et al. Prevention of pneumonia in an intensive care unit: a randomized multi-center clinical trial. Crit Care Med 1989; 17:501-05
31. Armstrong PJ, Barr JG, Webb CH, et al. Epidemiology of Pseudomonas aeruginosa in intensive care unit using selective decontamination of the digestive tract. J Hosp Infect 1992; 20:199-208
32. Daschner F. Emergence of resistance during selective decontamination of the digestive tract. Eur J Clin Microbiol Dis 1992; 11:1-3
33. Stoutenbeek CP, Van Saene HKF, Zandstra DF. The effect of oral non-absorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit. J Antimicrob Chemoter 1987; 19:513-20