Effect of ventilator-associated pneumonia on mortality and morbidity

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 1, 1996, Pages 91-97

  Papazian, Laurent ^a   Bregeon, Fabienne ^a   Thirion, Xavier ^a   Gregoire, Régine ^a   Saux, Pierre ^a   Denis, Jean Paul ^a   Perin, Gills ^a   Charrel, Juliette ^a   Dumon, Jean François ^a   Affray, Jean Pierre ^a   Gouin, François ^a  

^a HÔPITAL SAINTE MARGUERITE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 9344223929     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.1.8680705     Document Type: Article

References (35)

1. Freeman, J., B. A. Rosner, and J. E. McGowan, Jr. 1979. Adverse effects of nosocomial infection. J. Infect. Dis. 140:732-740.
2. Craig, C. P., and S. Connelly. 1984. Effect of intensive care unit nosocomial pneumonia on duration of stay and mortality. Am. J. Infect. Control 12:233-238.
3. Kollef, M. H. 1993. Ventilator-associated pneumonia: a multivariate analysis. J.A.M.A. 270:1965-1970.
4. Kappstein, F. G., T. Schulgen, U. Beyer, F. Geiger, M. Schumacher, and F. D. Daschner. 1992. Prolongation of hospital stay and extra cost due to ventilator associated pneumonia in an intensive care unit. Eur. J. Clin. Microbiol. Infect. Dis. 11:504-508.
5. Craven, D. E., L. M. Kunches, V. Kilinsky, D. A. Lichtenberg, B. J. Make, and W. R. McCabe. 1986. Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am. Rev. Respir. Dis. 133:792-796.
6. Craven, D. E., L. M. Kunches, D. A. Lichtenberg, N. R. Kollisch, M. A. Barry, T. C. Heeren, and W. R. McCabe. 1988. Nosocomial infection and fatality in medical and surgical intensive care unit patients. Arch. Intern. Med. 148:1161-1168.
7. Rello, J., E. Quitana, V. Ausina, J. Castella, M. Luquin, and G. Prats. 1991. Incidence, etiology and outcome of nosocomial pneumonia in mechanically ventilated patients. Chest 100:439-444.
8. Seidenfeld, J. J., D. F. Pohl, R. C. Bell, G. D. Harris, and W. G. Johanson, Jr. 1986. Incidence, site and outcome of infections in patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 134:12-16.
9. Torres, A., R. Aznar, J. Mariagatell, P. Jimenez, J. Gonzalez, A. Ferrer, R. Celis, and R. Rodriguez-Roisin. 1990. Incidence, risk and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am. Rev. Respir. Dis. 142:523-528.
10. Fagon, J. Y., J. Chastre, A. J. Hance, P. Montravers, A. Novara, and C. Gibert. 1993. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am. J. Med. 94:281-288.
11. Leu, H. S., D. L. Kaiser, M. Mori, R. F. Wooson, and R. P. Wenzel. 1989. Hospital-acquired pneumonia attribute mortality and morbidity. Am. J. Epidemiol. 129:1258-1267.
12. Mc Cabe, W. R., and G. G. Jackson. 1962. Gram negative bacteremia. I. Etiology and ecology. Arch. Intern. Med. 110:847-864.
13. Knaus, W. A., E. A. Draper, D. P. Wagner, and J. E. Zimmerman. 1985. APACHE II: a severity of disease classification system. Crit. Care Med. 13:818-829.
14. Knaus, W. A., E. A. Draper, D. P. Wagner, and J. E. Zimmerman. 1985. Prognosis in acute organ-system failure. Ann. Surg. 202:685-693.
15. Papazian, L., P. Thomas, L. Garbe, I. Guignon, X. Thirion, J. Charrel, C. Bollet, P. Fuentes, and F. Gouin. 1995. Bronchoscopic or blind bronchial sampling techniques for the diagnosis of ventilator-associated pneumonia? Am. J. Respir. Crit. Care Med. 152:1982-1991.
16. Chastre, J., J. Y. Fagon, P. Soler, M. Bornet, Y. Domart, J. L. Touillet, C. Gibert, and A. J. Hance. 1988. Diagnosis of nosocomial bacterial pneumonia in intubated patients undergoing ventilation: comparison of the usefulness of bronchoalveolar lavage and the protected specimen brush. Am. J. Med. 85:499-506.
17. Pham. L. H., C. Brun-Buisson, P. Legrand, A. Rauss, F. Verra, L. Brochard, and F. Lemaire. 1991. Diagnosis of nosocomial bronchopneumonia in mechanically ventilated patients: comparison of a plugged telescoping catheter with the protected specimen brush. Am. Rev. Respir. Dis. 143:1055-1061.
18. SAS User's Guide. 1988. Statistics, version 5 edition, SAS Institute Inc., Cary, NC. 126-154.
19. Fleiss, J. L. 1981. The analysis of data from matched samples. In Statistical Methods for Rates and Proportions, 2nd ed. John Wiley and Sons, New York.
20. Wenzel, R. P., C. A. Osterman, and K. J. Hunting. 1976. Hospital-acquired infections: infection rates by site, service and common procedures in a university hospital. Am. J. Epidemiol. 6:645-650.
21. Fagon, J. Y., J. Chastre, A. J. Hance, M. Guiguet, J. L. Trouillet, Y. Domart, J. Pierre, and C. Gibert. 1988. Detection of nosocomial lung infection in ventilated patients: use of protected specimen brush and quantitative culture techniques in 147 patients. Am. Rev. Respir. Dis. 138:110-116.
22. Chevret, S., M. Hemmer, J. Carlet, and M. Langer. 1993. European cooperative group on nosocomial pneumonia: incidence and risk factors of pneumonia acquired in intensive care units. Intensive Care Med. 19:256-264.
23. Langer, M., M. Cigada, M. Mandelli, P. Mosconi, G. Tognoni, and I.C.U.G.I.C. 1987. Early onset pneumonia: a multicenter study in intensive care units. Intensive Care Med. 13:342-346.
24. Torres, A., M. El-Ebiary, L. Padro, J. Gonzalez, J. Puig De La Bellacasa, J. Ramirez, A. Xaubert, M. Ferrer, and R. Rodriguez-Roisin. 1994. Validation of different techniques for the diagnosis of ventilator-associated pneumonia: comparison with immediate postmortem pulmonary biopsy. Am. J. Respir. Crit. Care Med. 149:324-331.
25. Andrews, C. P., J. J. Coalson, J. D. Smith, and W. G. Johanson. 1981. Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury. Chest 80:254-258.
26. Gross, P. A., H. C. Neu, P. Aswapokee, C. Van Antwerpen, and N. Aswapokee. 1980. Deaths from nosocomial infections and hospital deaths: experience in a university hospital and a community hospital. Am. J. Med. 68:219-223.
27. Celis, R., A. Torres, J. M. Gatell, M. Almeda, R. Rodriguez-Roison, A. Agusti-Vidal. 1988. Nosocomial pneumonia: a multivariate analysis of risk and prognosis. Chest 93:318-324.
28. Britt, M. R., C. J. Schleupner, and S. Matsumna. 1978. Severity of underlying diseases as a predictor of nosocomial infection. J.A.M.A. 239:1047-1051.
29. Blair, P., B. J. Rowlands, K. Lowry, H. Webb, P. Armstrong, and J. Smilie. 1991. Selective decontamination of the digestive tract: a stratified, randomized, prospective study in a mixed intensive care unit. Surgery 110:303-310.
30. Cockerill, F. R., S. R. Muller, J. P. Anhalt, H. M. Marsh, M. B. Farnell, P. Mucha, D. J. Gillespie, D. M. Ilstrup, J. J. Larson-Keller, and R. L. Thompson. 1992. Prevention of infection in critically ill patients by selective decontamination of the digestive tract. Ann. Intern. Med. 117:545-553.
31. Selective Decontamination of the Digestive Tract Trailists' Collaborative Group. 1993. Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. B.M.J. 307:525-532.
32. Berger, M. M., A. Marazzi, J. Freeman, and R. Chioléro. 1992. Evaluation of the consistency of acute physiology and chronic health evaluation (APACHE II) scoring in a surgical intensive care unit. Crit. Care Med. 20:1681-1687.
33. Cerra, F. B., F. Negro, and J. Abrams. 1990. APACHE 11 score does not predict multiple organ failure or mortality in postoperative surgical patients. Arch. Surg. 125:519-522.
34. Knaus, W. A. 1989. Prognosis with mechanical ventilation: the influence of disease, severity of disease, age, and chronic health status on survival from an acute illness. Am. Rev. Respir. Dis. 140:S8-S13.
35. Wagner, D. P., W. A. Knaus, F. E. Harrell, J. E. Zimmerman, and C. Watts. 1994. Daily prognostic estimates for critically ill adults in intensive care units: results from a prospective, multicenter, inception cohort analysis. Crit. Care Med. 22:1359-1372.