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344981 New compound, CEP-1347, demonstrates potential for halting the progression of Parkinson's disease. Positive results seen in Parkinson's disease models. Cephalon Inc Press Release 1999 October 27
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The neuroprotective effects of CEP-1347 in a primate model of MPTP-induced chronic progressive parkinsonism
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0037899953
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CEP-1347, an inhibitor in the JNK pathway, protects against in vitro toxicity of malonate
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345793; Abs 332.6
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345793 CEP-1347, an inhibitor in the JNK pathway, protects against in vitro toxicity of malonate. Eberhardt O, Saporito MS, Topka H, Schulz JB Abstr Soc Neurosci 1999 25 Pt 1 Abs 332.6
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CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults
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349382 CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA J Neurochem 1999 73 5 1901-1912
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18
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0033029823
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CEP-1347/KT-7515, an inhibitor of c-Jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
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349385 CEP-1347/KT-7515, an inhibitor of c-Jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. Saporito MS, Brown EM, Miller MS, Carswell S J Pharmacol Exp Ther 1999 288 2 421-427
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CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo
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349390
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349390 CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo. Glicksman MA, Chiu AY, Dionne CA, Harty M, Kaneko M, Murakata C, Oppenheim RW, Prevette D, Sengelaub DR, Vaught JL, Neff NT J Neurobiol 1998 35 4 361-370
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377450 Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J J Neurosci 2000 20 1 43-50
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0037899950
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387420; Abs 10.6
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0037561881
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CEP-1347/KT7515 rescues rat dorsal root ganglia from gp120IIIB-induced apoptosis
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Drug development pipeline: [Sertindole, NC-531, Alzheimer's treatment with Gerolymatos, TV-1203, Almotriptan, CEP-1347, zonisamide]
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CEP-1347, an inhibitor of the c-Jun N-terminal kinase pathway has antiociceptive activity in phase II of the rat formalin model
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428035; Abs 615.8
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428035 CEP-1347, an inhibitor of the c-Jun N-terminal kinase pathway has antiociceptive activity in phase II of the rat formalin model. Clas DM, Aimone LD, Fiocchi E, Miller MS Abstr Soc Neurosci 2001 27 2 Abs 615.8
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CEP-1347 improves the survival of grafted dopaminergic neurons
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Cephalon reports that data show that CEP-1347 increased success of brain cell transplantation in models of Parkinson's disease
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429353 Cephalon reports that data show that CEP-1347 increased success of brain cell transplantation in models of Parkinson's disease. Cephalon Inc Press Release 2001 November 14
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Cephalon and H Lundbeck initiate clinical trial in patients with early stage Parkinson's disease
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