Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death

Journal of Nutrition

Volumn 130, Issue 5 SUPPL., 2000, Pages

  Truong Tran, A Q ^a   Ho, L H ^a   Chai, F ^a   Zalewski, P D ^a  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

Author keywords

Apoptosis; Caspase; Disease; Zinc; Zinquin

Indexed keywords

CASPASE; ZINC;

APOPTOSIS; BIOCHEMISTRY; CELL DEATH; CELL LEVEL; CONFERENCE PAPER; CYTOLOGY; GENE CONTROL; HUMAN; NONHUMAN; SUPPLEMENTATION; ZINC DEFICIENCY;

EID: 0034014325     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.5.1459s     Document Type: Conference Paper

References (62)

1. Aggarwal, S. & Gupta, S. (1998) Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95). Fas ligand, Bcl-2, and Bax. J. Immunol. 160: 1627-1637.
2. Aiuchi, T., Mihara, S., Nakaya, M., Masuda, Y., Nakajo, S. & Nakaya, K. (1998) Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. J. Biochem. 124: 300-303.
3. Anderson, A. J., Su, J. H. & Cotman, C. W. (1996) DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16: 1710-1719.
4. Antonucci, A., Baldassarre, A. D., Giacomo, F. D., Stuppia, L. & Palka, G. (1997) Detection of apoptosis in peripheral blood cells of 31 subjects affected by Down syndrome before and after zinc therapy. Ultrastruct. Pathol. 21: 449-452.
5. Barbieri, D., Troiano, L., Grassilli, E., Agnesini, C., Cristofalo, E. A., Monti, D., Capri, M., Cossarizza, A. & Franceschi, C. (1992) Inhibition of apoptosis by zinc: a reappraisal. Biochem. Biophys. Res. Commun. 187: 1256-1261.
6. Budzik, G. P., Hutson, J. M., Ikawa, H. & Donahoe, P. K. (1982) The role of zinc in Müllerian duct regression. Endocrinology 110: 1521-1525.
7. Byar, D. P. (1974) Zinc in male sex accessory organs: distribution and hormonal response. In: Male Accessory Sex Organs (Brandes, D., ed.), pp. 161-172, Academic Press, New York.
8. Chesters, J. K. (1989) Biochemistry of zinc in cell division and tissue growth. In: Zinc in Human Biology (Mills, C. F., ed), pp. 109-118, Springer-Verlag, Heidelberg.
9. Chvapil, M., Zukoski, C. F., Hattler, B. G., Stankova, L., Montgomery, D., Carlso, E. C. & Ludwig, J. C. (1976) Zinc and cells. In: Trace Elements in Human Health and Disease (Prasad, A. S. & Oberleas, D., eds.), Vol. 1, pp. 269-280. Academic Press, New York.
10. Cohen, G., Sun, X.-M., Snowden, R. T., Dinsdale, D. & Skilleter, D. N. (1992) Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286: 331-334.
11. Cohen, J. J. & Duke, R. C. (1993) Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10: 267-293.
12. Cohen, J. J. & Duke, R. C. (1984) Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. lmmunol. 132: 38-42.
13. Coto, J. A., Hadden, E. M., Sauro, M., Zorn, N. & Hadden, J. W. (1992) Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 89: 7752-7756.
14. Cuajungco, M. P. & Lees, G. J. (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol. Dis. 4: 137-169.
15. da Silva, J.J.R.F. & Williams, R.J.P. (1991) Zinc: Lewis acid catalysis and regulation. In: The Biological Chemistry of the Elements (Williams, R.J.P., ed.), pp. 299-318, Clarendon Press, Oxford.
16. Dinsdale, D. & Williams, R. B. (1977) The enhancement by dietary zinc deficiency of the susceptibility of the rat duodenum to colchicine. Br. J. Nutr. 37: 135-142.
17. Duvall, E. & Wyllie, A. H. (1936) Death and the cell. Immunol. Today 7: 115-119.
18. Floersheim, G. L., Christ, A., Koenig, R., Racine, C. & Gudat, F. (1992) Radiation-induced lymphoid tumors and radiation lethality are inhibited by combined treatment with small doses of zinc aspartate and WR 2721. Int. J. Cancer 52: 604-608.
19. Fraker, P. J. & Telford, W. G. (1997) A reappraisal of the role of zinc in life and death decisions of cells. Proc. Soc. Exp. Biol. Med. 215: 229-36.
20. Frederickson, C. J. (1989) Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31: 145-238.
21. L protein by caspase-3-like proteases. Oncogene 17: 1295-304.
22. Fukamachi, Y., Karasaki, Y., Sugiura, T., Itoh, H., Abe, T., Yamamura, K. and Higashi, K. (1998) Zinc suppresses apoptosis of U937 cells induced by hydrogen peroxide through an increase of the Bcl-2/Bax ratio. Biochem. Biophys. Res. Commun 246: 364-369.
23. Goldberg, E. D., Eshchenko, V. A. & Bovt, V. D. (1990) Diabetogenic activity of chelators in some mammalian species. Endocrinologie 28: 51-55.
24. Janicke, R. U., Sprengart, M. L., Wati, M. R. & Porter, A. G. (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273: 9357-9360.
25. Kamath, N. S., Satyamoorthy. K., Chitnis, M. P. & Advani, S. H. (1989) 1,10-Phenanthroline potentiates cytotoxicity of hydroxyurea in human chronic myeloid leukemia cells. Oncology 46: 193-197.
26. Kasprzak, K. S. & Waalkes, M. P. (1986) The role of calcium, magnesium and zinc in carcinogenesis. Adv. Exp. Med. Biol. 206: 497-515.
27. Kerr, J.F.R., Searle, J., Harmon, B. V. & Bishop, C. J. (1987) Apoptosis. In: Perspectives of Mammalian Cell Death (Potten, C. S., ed.), pp. 93-128, Oxford University Press, Oxford.
28. Kishimoto, S., Iwamoto, S., Masutani, S., Yamamoto, R., Jo, T., Saji, F., Terada, N., Sasaki, Y., Imaoka, S. & Sugiyama, T. (1994) Apoptosis of acinar cells in the pancreas of rats fed on a copper-depleted diet. Exp. Toxicol. Pathol. 45: 489-495.
29. Korsmeyer, S. J., Shutter, J. R., Veis, D. J., Merry, D. E. & Oltvai, Z. N. (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin. Cancer Biol. 327-332.
30. Kuo, I. C., Seitz, B., LaBree, L. & McDonnell, P. J. (1997) Can zinc prevent apoptosis of anterior keratocytes after superficial keratectomy? Cornea 16: 550-555.
31. Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G. & Earnshaw, W. C. (1993) Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J. Cell Biol. 123: 7-22.
32. Levkau, B., Koyama, H., Raines, E. W., Clurman, B. E., Herren, B., Orth, K., Roberts, J. M. and Ross, R. (1998) Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: role of a caspase cascade. Mol. Cell 1: 553-563.
33. Markov, I. G., Berzin, N. I. & Val'dman, A. R (1992) Morphofunctional analysis of zinc-accumulating capacity of digestive system organs. Bull. Eksp. Biol. Med. 113: 324-327.
34. Martin, S. J. & Cotter, T. G. (1990) Specific loss of microtubules in HL-60 cells leads to programmed cell death (apoptosis). Biochem. Soc. Trans. 18: 299-301.
35. Martin. S. J., Mazdai, G., Strain, J. J., Cotter, T. G. & Hannigan, B. M. (1991) Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency. Clin. Exp. Immunol. 83: 338-343.
36. Matsushita, K., Kitagawa, K., Matsuyama, T., Ohtsuki, T., Taguchi, A., Mandai, K., Mabuchi, T., Yagita, Y., Yanagihara, T. & Matsumoto, M. (1996) Effect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus. Brain Res. 743: 362-365.
37. McConkey, D. J. & Orrenius, S. (1997) The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun. 239: 357-366.
38. Mori, H., Matsumoto, Y., Tamada, Y. & Ohashi, M. (1996) Apoptotic cell death in formation of vesicular skin lesions in patients with acquired zinc deficiency. J. Cutan. Pathol. 23: 359-363.
39. Nickolson, V. J. & Veldstra, H. (1972) The influence of various cations on the binding of colchicine by rat brain homogenates: stabilization of intact neurotubules by zinc and cadmium ions. FEBS Lett. 23: 309-314.
40. Pai, L. H. & Prasad, A. S. (1988) Cellular zinc in patients with diabetes mellitus. Nutr. Res. 8: 889-897.
41. Perry, D. K, Smyth, M. J., Stennicke, H. R., Salvesen, G. S., Duriez, P., Pirier, G. G. & Hannun, Y. A. (1997) Zinc is a potent inhibitor of the apoptotic protease caspase-3: a novel target for zinc in the inhibition of apoptosis. J. Biol. Chem. 272: 18530-18533.
42. Prasad, A. S., Fitzgerald, J. T., Hess, J. W., Kaplan, J., Pelen, F. & Dardenne, M. (1993) Zinc deficiency in elderly patients. Nutrition 9: 218-224.
43. Record, I. R., Tulsi, R. S., Dreosti, I. E. & Fraser, F. J. (1985) Cellular necrosis in zinc-deficient rat embryos. Teratology 32: 397-405.
44. Rogers, J. M., Taubeneck, M. W., Daston, G. P., Sulik, K. K., Zucker, R. M., Elstein, K. H., Jankowski, M. A. & Keen, C. L. (1995) Zinc deficiency causes apoptosis but not cell cycle alterations in organogenesis-stage rat embryos: effect of varying duration of deficiency. Teratology 52: 149-159.
45. Solomons, N. W. (1988) Zinc and copper. In: Modern Nutrition in Health and Disease, 7th ed. (Shils, M. E. & Young, V. R., eds.), pp. 238-262. Lea & Febiger, Philadelphia, PA.
46. Song, M. K., Heng, M. C., Rolandelli, R., Ament, M. E. & Heng, M. K. (1993) Possible link between zinc intake and colon cancer. J. Natl. Cancer Inst. 85: 667-669.
47. Srinivasula, S. M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, R. C., Wang, L., Trapani, J. A., Tomaselli, K. J., Litwack, G. & Alnemri, E. S. (1996) The ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J. Biol. Chem. 271: 27099-27010.6.
48. Stennicke, H. R. & Salvesen, G. S. (1997) Biochemical characteristics of caspases-3, -6, -7, and -8. J. Biol. Chem. 272: 25719-25723.
49. Sunderman, F. W. (1995) The influence of zinc on apoptosis. Ann. Clin. Lab. Sci. 25: 134-142.
50. Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernandes-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H. & Earnshaw, W. C (1996). Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc. Natl. Acad. Sci. U.S.A. 93: 8395-8400.
51. Thornberry, N. A. & Lazebnik, Y. (1998) Caspases: enemies within. Science (Washington, DC) 281: 1312-1316.
52. Treves, S., Trentini, P. L., Ascanelli, M., Bucci, G. & Di Virgilio, F. (1994) Apoptosis is dependent on intracellular zinc and independent of intracellular calcium in lymphocytes. Exp. Cell Res. 211: 339-343.
53. Vallee, B. L. & Falchuk, K. H. (1993) The biochemical basis of zinc physiology. Physiol. Rev. 73: 79-118.
54. 2+ salts. Int. J. Immunopharmac. 12: 445-457.
55. Wyllie, A. H. (1997) Apoptosis: an overview. Br. Med. Bull. 53: 451-465.
56. Zalewski, P. D. (1996) A review: zinc and immunity: implications for growth, survival and function of lymphoid cells. J. Nutr. Immun. 4: 39-101.
57. Zalewski, P. D. & Forbes, I. J. (1993) Intracellular zinc and the regulation of apoptosis. In: Programmed Cell Death: The Cellular and Molecular Biology of Apoptosis (Lavin, M. & Watters, D., eds.), pp. 73-86, Harwood Academic Publishers, Melbourne.
58. Zalewski, P. D., Forbes, I. J. & Betts, W. H. (1993) Correlation of apoptosis with change in intracellular labile Zn, using Zinquin, a new specific fluorescent probe for zinc. Biochem. J. 296: 403-408.
59. Zalewski, P. D., Forbes, I. J. & Giannakis, C. (1991) Physiological role for zinc in prevention of apoptosis (gene-directed death). Biochem. Int. 24: 1093-1101.
60. Zalewski, P. D., Forbes, I. J., Seamark, R. F., Borlinghaus, R., Betts, W. H., Lincoln, S. F. & Ward, A. D. (1994b) Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin. Chem. Biol. 153-161.
61. Zalewski, P. D., Jian, X., Soon, L.L.L., Breed, W. G., Seamark, R. F., Lincoln, S. F., Ward, A. D. & Sun, F.-Z. (1996) Changes in distribution of labile zinc in mouse spermatozoa during maturation in the epididymis assessed by the fluorophore Zinquin. Reprod. Fertil. Dev. 8: 1097-1105.
62. Zalewski, P. D., Millard, S. H., Forbes, I. J., Kapaniris, O., Slavotinek, A. & Betts, W. H. (1994a) Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc. J. Histochem. Cytochem. 42: 877-884.