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Volumn 51, Issue 4, 1997, Pages 674-682

Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS[4 (PHTHALIMIDOMETHOXYIMINO METHYL) PYRIDINIUM 1 YL]PROPANE DIBROMIDE; 1,6 HEXAMETHYLENEBIS[DIMETHYL(3 PHTHALIMIDOPROPYL)AMMONIUM BROMIDE]; 4,4' BIS[(2,6 DICHLOROBENZYLOXYIMINO)METHYL] 1,1' PROPANE 1,3 DIYL BIS PYRIDINIUM DIBROMIDE; ALCURONIUM; ATROPINE; DUO 3; GALLAMINE TRIETHIODIDE; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; OBIDOXIME; SCOPOLAMINE METHYL BROMIDE; UNCLASSIFIED DRUG; WDUO 3;

EID: 0038681406     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.4.674     Document Type: Article
Times cited : (62)

References (25)
  • 1
    • 0025875643 scopus 로고
    • Allosteric antagonists of the muscarinic acetylcholine receptor
    • Lee, N. H., and E. E. El-Fakahany. Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem. Pharmacol. 42:199-205 (1991).
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 199-205
    • Lee, N.H.1    El-Fakahany, E.E.2
  • 3
    • 0029055030 scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • Tuček, S., and J. Proška. Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol. Sci. 16:205-212 (1995).
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 205-212
    • Tuček, S.1    Proška, J.2
  • 4
    • 0029126526 scopus 로고
    • Detection, quantitation and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interaction of strychnine and acetylcholine at muscarinic receptors
    • Lazareno, S., and N. J. M. Birdsall. Detection, quantitation and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interaction of strychnine and acetylcholine at muscarinic receptors. Mol. Pharmacol. 48:362-378 (1995).
    • (1995) Mol. Pharmacol. , vol.48 , pp. 362-378
    • Lazareno, S.1    Birdsall, N.J.M.2
  • 5
    • 0030433044 scopus 로고    scopus 로고
    • Search for lead structures to develop new allosteric modulators of muscarinic receptors
    • Tränkle, C., E. Kostenis, U. Burgmer, and K. Mohr. Search for lead structures to develop new allosteric modulators of muscarinic receptors. J. Pharmacol. Exp. Ther. 279:926-933 (1996).
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 926-933
    • Tränkle, C.1    Kostenis, E.2    Burgmer, U.3    Mohr, K.4
  • 6
    • 0027054955 scopus 로고
    • Two allosteric modulators interact at a common site on cardiac muscarinic receptors
    • Ellis, J., and M. Seidenberg. Two allosteric modulators interact at a common site on cardiac muscarinic receptors. Mol. Pharmacol 42:638-641 (1992).
    • (1992) Mol. Pharmacol , vol.42 , pp. 638-641
    • Ellis, J.1    Seidenberg, M.2
  • 7
    • 0028062082 scopus 로고
    • Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors
    • Waelbroeck, M. Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors. Mol. Pharmacol. 46:685-692 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 685-692
    • Waelbroeck, M.1
  • 8
    • 0028840330 scopus 로고
    • Competition between positive and negative allosteric effectors on muscarinic receptors
    • Proška, J., and S. Tuček. Competition between positive and negative allosteric effectors on muscarinic receptors. Mol. Pharmacol. 48:696-702 (1995).
    • (1995) Mol. Pharmacol. , vol.48 , pp. 696-702
    • Proška, J.1    Tuček, S.2
  • 9
    • 0028334668 scopus 로고
    • Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors
    • Botero Cid, H. B., U. Holzgrabe, E. Kostenis, K. Mohr, and C. Tränkle. Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors. J. Med. Chem. 37:1439-1445 (1994).
    • (1994) J. Med. Chem. , vol.37 , pp. 1439-1445
    • Botero Cid, H.B.1    Holzgrabe, U.2    Kostenis, E.3    Mohr, K.4    Tränkle, C.5
  • 10
    • 0000246198 scopus 로고    scopus 로고
    • Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors
    • Kostenis, E., H. B. Botero Cid, U. Holzgrabe, and K. Mohr. Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors. Eur. J. Pharmacol. 314:385-392 (1996).
    • (1996) Eur. J. Pharmacol. , vol.314 , pp. 385-392
    • Kostenis, E.1    Botero Cid, H.B.2    Holzgrabe, U.3    Mohr, K.4
  • 11
    • 0023819931 scopus 로고
    • 3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication
    • 3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol. Toxicol. 63:163-168 (1988).
    • (1988) Pharmacol. Toxicol. , vol.63 , pp. 163-168
    • Jepsen, K.1    Lüllmann, H.2    Mohr, K.3    Pfeffer, J.4
  • 13
    • 0002597710 scopus 로고
    • Molecular modelling and synthesis of potent stabilizers of antagonist binding to M-cholinoceptors
    • Bejeuhr, G., U. Holzgrabe, K. Mohr, U. Sürig, and A. von Petersenn. Molecular modelling and synthesis of potent stabilizers of antagonist binding to M-cholinoceptors. Pharm. Pharmacol. Lett. 2:100-103 (1992).
    • (1992) Pharm. Pharmacol. Lett. , vol.2 , pp. 100-103
    • Bejeuhr, G.1    Holzgrabe, U.2    Mohr, K.3    Sürig, U.4    Von Petersenn, A.5
  • 16
    • 0029094516 scopus 로고
    • Analysis of competitive agonist-antagonist interactions by nonlinear regression
    • Lew, M. J., and J. A. Angus. Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol. Sci. 16:328-337 (1995).
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 328-337
    • Lew, M.J.1    Angus, J.A.2
  • 17
    • 0009644628 scopus 로고
    • Some quantitative uses of drug antagonists
    • Arunlakshana, O., and H. O. Schild. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:48-58 (1959).
    • (1959) Br. J. Pharmacol. , vol.14 , pp. 48-58
    • Arunlakshana, O.1    Schild, H.O.2
  • 20
    • 0030240344 scopus 로고    scopus 로고
    • Conformational analysis, molecular shape comparison, and pharmacophore identification of different allosteric modulators of muscarinic receptors
    • Holzgrabe, U., and A. J. Hopfinger. Conformational analysis, molecular shape comparison, and pharmacophore identification of different allosteric modulators of muscarinic receptors. J. Chem. Inf. Comput. Sci. 36:1018-1024 (1996).
    • (1996) J. Chem. Inf. Comput. Sci. , vol.36 , pp. 1018-1024
    • Holzgrabe, U.1    Hopfinger, A.J.2
  • 21
    • 1842335446 scopus 로고    scopus 로고
    • Comparison of structurally different allosteric modulators of muscarinic receptors by self-organizing neural networks
    • in press
    • Holzgrabe, U., M. Wagener, and J. Gasteiger. Comparison of structurally different allosteric modulators of muscarinic receptors by self-organizing neural networks. J. Mol. Graphics, in press.
    • J. Mol. Graphics
    • Holzgrabe, U.1    Wagener, M.2    Gasteiger, J.3
  • 25
    • 0026980011 scopus 로고
    • 2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase
    • 2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase. J. Pharmacol. Exp. Ther. 263:910-917 (1992).
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 910-917
    • Gerstin Jr., E.H.1    Luong, T.2    Ehlert, F.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.