Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

Infection and Immunity

Volumn 69, Issue 4, 2001, Pages 2045-2053

  Yang, S ^a   Tamai, R ^a   Akashi, S ^a   Takeuchi, O ^a   Akira, S ^a   Sugawara, S ^a   Takada, H ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

22 OXACALCITRIOL; CD14 ANTIGEN; CYTOKINE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; MONOCLONAL ANTIBODY; MURAMYL DIPEPTIDE; TOLL LIKE RECEPTOR 4;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL INFECTION; BACTERIAL MEMBRANE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD14; ANTIGENS, DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DROSOPHILA PROTEINS; DRUG SYNERGISM; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0035078190     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.4.2045-2053.2001     Document Type: Article

References (54)

1. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
2. Toll-like receptors in the induction of the innate immune response
3. Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
4. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
5. Endotoxin-induced antitumor activity in the mouse is highly potentiated by muramyl dipeptide
6. Lipopotysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
7. Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity
8. Bacterial phosphoglycolipids and lipoteichoic acids
9. Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide
10. Preparation and properties of a standardized lipopolysaccharide from Salmonella abortus equi (Novo-Pyrexal)
11. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
12. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
13. Mechanism of gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure
14. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
15. Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway
16. The Toll-receptor family and control of innate immunity
17. Characteristics of 22-oxacalcitriol (OCT) and 2β-(3-hydroxypropoxy)-calcitriol (ED-71)
18. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses
19. Bordetella pertussis tracheal cytotoxin and other muramyl peptides: Distinct structure-activity relationships for respiratory epithelial cytopathology
20. Lipopolysaccharide antagonists
21. The biology of Toll-like receptors
22. Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide
23. Species dependency of in vitro macrophage activation by bacterial peptidoglycans
24. Lack of response of murine peritoneal macrophages to in vitro activation by muramyl dipeptide (MDP). I. Macrophage activation by MDP is species dependent
25. Structural requirements of muramylpeptides for induction of necrosis at sites primed with Mycobacterium tuberculosis in guinea pigs
26. Priming effect of muramyl peptides for induction by lipopolysaccharide of tumor necrosis factor production in mice
27. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
28. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
29. Enhancement of endotoxic shock by N-acetylmuramyl-L-alanyl-(L-seryl)-D-isoglutamine (muramyl dipeptide)
30. Bacterial endotoxins
31. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
32. The interaction of immunomodulator muramyl dipeptide with peripheral 5-HT receptors: Overview of the current state
33. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
34. Muramyl peptides and serotonin intereract at specific binding sites on macrophages and enhance superoxide release
35. Cytokine-inducing glycolipids in the lipoteichoic acid fraction from Enterococcus hirae ATCC 9790
36. Lipoteichoic acids as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner
37. Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture
38. Enhancement of endotoxin lethality and generation of anaphylactoid reactions by lipopolysaccharides in muramyl-dipeptide-treated mice
39. Molecular and structural requirements of lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities
40. Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides
41. Cytokine induction by extracellular products of oral viridans group streptococci
42. Immunopharmacological activities of synthetic muramyl-peptides
43. Muramyl dipeptide and derivatives
44. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
45. Preferentially the S-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
46. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
47. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers
48. Detection of peptidoglycan and endotoxin in dialysate, using silkworm larvae plasma and limulus amebocyte lysate methods
49. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
50. n gene: In vivo evidence for a dominant negative mutation
51. Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes
52. Toll, a new piece in the puzzle of innate immunity
53. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
54. Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2