Arbekacin is actively secreted in the rat intestine via a different efflux system from P-glycoprotein

European Journal of Pharmaceutical Sciences

Volumn 19, Issue 2-3, 2003, Pages 133-140

  Saitoh, Hiroshi ^a   Arashiki, Yuji ^a   Oka, Ayako ^a   Oda, Masako ^a   Hatakeyama, Yuko ^a   Kobayashi, Michiya ^a   Hosoi, Kaoru ^b  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Active efflux system; Aminoglycoside antibiotics; Arbekacin transport; Caco 2 cells; LLC PK1 cells; Rat intestine

Indexed keywords

ABSORPTION; BIOLOGICAL ORGANS; GLUCOSE; MONOLAYERS; PROTEINS;

GLYCOPROTEINS;

ANTIBIOTICS;

3 METHYLGLUCOSE; AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CYCLOSPORIN A; DIBEKACIN; DRUG DERIVATIVE; GENTAMICIN; GLUCOSE; GLYCOPROTEIN P; GUANIDINE; HABEKACIN; MULTIDRUG RESISTANCE PROTEIN; PROBENECID; STREPTOMYCIN; TETRYLAMMONIUM; VERAPAMIL;

ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL STRAIN CACO 2; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; HUMAN CELL; ILEUM; IN VITRO STUDY; INTESTINE MUCOSA; JEJUNUM; MALE; METABOLISM; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; SECRETION; SEROSA; SMALL INTESTINE; SMALL INTESTINE ABSORPTION; SWINE;

EID: 0038182033     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00072-1     Document Type: Article

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