Anti-oxidant properties of N-acetyl-L-cysteine do not improve the immune resistance of mice fed dietary lipids to Listeria monocytogenes infection

Clinical Nutrition

Volumn 22, Issue 3, 2003, Pages 313-319

  Puertollano, M A ^a   De Pablo, M A ^a   Alvarez De Cienfuegos G ^a  

^a UNIVERSITY OF JAÉN   (Spain)

Author keywords

Dietary lipids; Immunomodulation; Lipid peroxidation; Listeria monocytogenes; N acetyl L cysteine

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; COCONUT OIL; FISH OIL; NITROBLUE TETRAZOLIUM; OLIVE OIL; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL IMMUNITY; CELL VIABILITY; CONTROLLED STUDY; FAT INTAKE; IMMUNOMODULATION; LISTERIA MONOCYTOGENES; LISTERIOSIS; LOW FAT DIET; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; SPLEEN; SURVIVAL; TREATMENT OUTCOME;

EID: 0038173667     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(03)00031-1     Document Type: Article

References (39)

1. Calder P C. Fat chance of immunomodulation. Immunol Today 1998; 19: 244-247
2. de Pablo M A, Álvarez de Cienfuegos G. Modulatory effects of dietary lipids on immune system functions. Immunol Cell Biol 2000; 78: 31-39
3. Endres S, Ghorbani R, Kelley V E et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989; 320: 265-271
4. Arrington J L, Chapkin R S, Switzer K C, Morris J S, McMurray D N. Dietary n-3 polyunsaturated fatty acids modulate purified murine T-cell subset activation. Clin Exp Immunol 2001; 125: 499-507
5. Yaqoob P, Newsholme E A, Calder P C. Inhibition of natural killer cell activity by dietary lipids. Immunol Lett 1994; 41: 241-247
6. Calder P C, Bond J A, Harvey D J, Gordon S, Newsholme E A. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochem J 1990; 269: 807-814
7. Harbige L S. Dietary n-6 and n-3 fatty acids in immunity and autoimmune disease. Proc Nutr Soc 1998; 57: 555-562
8. de Pablo M A, Puertollano M A, Alvarez de Cienfuegos G. Immune cell functions, lipids and host natural resistance. FEMS Immunol Med Microbiol 2000; 29: 323-328
9. de Pablo M A, Puertollano M A, Galvez A, Ortega E, Gaforio J J, Álvarez de Cienfuegos G. Determination of natural resistance of mice fed dietary lipids to experimental infection induced by Listeria monocytogenes. FEMS Immunol Med Microbiol 2000; 27: 127-133
10. Fritsche K L, Shahbazian L M, Feng C, Berg J N. Dietary fish oil reduces survival and impairs bacterial clearance in C3H/Hen mice challenged with Listeria monocytogenes. Clin Sci 1997; 92: 95-101
11. Chang H R, Dullo A G, Vladoianu I R, Piguet P F, Arsenijevic D, Girardier L, Pechere J C. Fish oil decreases natural resistance of mice to infection with Salmonella typhimurium. Metabolism 1992; 41: 1-2
12. Peck M D, Alexander J W, Ogle C K, Babcock G F. The effect of dietary fatty acids on response to Pseudomonas infection in burned mice. J Trauma 1990; 30: 445-452
13. Paul K P, Leichsenring M, Pfisterer M et al. Influence of n-6 and n-3 polyunsaturated fatty acids on the resistance to experimental tuberculosis. Metabolism 1997; 46: 619-624
14. Byleveld P M, Pang, G T, Clancy R L, Roberts D C K. Fish oil feeding delays influenza virus clearance and impairs production of interferon-γ and virus-specific immunoglobulin A in the lungs of mice. J Nutr 1999; 129: 328-335
15. Byleveld P M, Pang G T, Clancy R L, Roberts D C K. Fish oil feeding enhances lymphocyte proliferation but impairs virus-specific T lymphocyte cytotoxicity in mice following challenge with influenza virus. Clin Exp Immunol 2000; 119: 287-292
16. Turnock L, Cook M, Steinberg H, Czuprynski C. Dietary supplementation with conjugated linoleic acid does not alter the resistance of mice to Listeria monocytogenes infection. Lipids 2001; 36: 135-138
17. Bjornsson S, Hardardottir I, Gunnarsson E, Haraldsson A. Dietary fish oil supplementation increases survival in mice following Klebsiella pneumoniae infection. Scand J Infect Dis 1997; 29: 491-493
18. Ziment I. Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother 1988; 42: 513-519
19. Mosmann T. Rapid colorimetric assay for cellular growth, survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63
20. Witz G, Czerniecki B J. Tumor promoters differ in their ability to stimulate superoxide anion radical production by murine peritoneal exudate cells following in vivo administration. Carcinogenesis 1988; 10: 807-811
21. Kremer J M, Lawrence D A, Jubiz W, DiGiacomo R, Rynes R, Bartholomew L E, Sherman M. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990; 33: 810-820
22. Bittiner S B, Tucker W F G, Cartwright I, Bleehen S S. A double blind, randomised, placebo-controlled trial of fish oil in psoriasis. Lancet 1988; i: 378-380
23. Yang M, Pariza M W, Cook M E. Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse. Immunopharmacol Immunotoxicol 2000; 22: 433-449
24. Fritsche K L, Cassity N A, Huang S C. Dietary (n-3) fatty acid and vitamin E interactions in rats: effects on vitamin E status, immune cell prostaglandin E production and primary antibody response. J Nutr 1992; 122: 1009-1018
25. Muller F, Svardal A M, Nordoy I, Berge R K, Aukrust P, Froland S S. Virological and immunological effects of antioxidant treatment in patients with HIV infection. Eur J Clin Invest 2000; 30: 905-914
26. De Rosa S C, Zaretsky M D, Dubs J G et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000; 30: 915-929
27. Villa P, Ghezzi P. Effect of N-acetyl-L-cysteine on sepsis in mice. Eur J Pharmacol 1995; 292: 341-344
28. Villa P, Saccani A, Sica A. Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense. J Infect Dis 2002; 185: 1115-1120
29. Heller A R, Groth G, Heller S C, Breitkreutz R, Nebe T, Quintel M, Koch T. N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients. Crit Care Med 2001; 29: 272-276
30. Rocksen D, Lilliehöök B, Larsson R, Johansson T, Bucht A. Differential anti-inflammatory and anti-oxidative effects of desamethaxone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol 2000: 122: 249-256
31. Terada S, Tarizawa M, Yamamoto S, Ezaki O, Itakura H, Akagawa K S. Suppressive mechanisms of EPA on human T cell proliferation. Microbiol Immunol 2001; 45: 473-481
32. Aihara M, Dobashi K, Akiyama M, Naruse I, Nakazawa T, Mori M. Effects of N-acetylcysteine and ambroxol on the production of IL-12 and IL-10 in human alveolar macrophages. Respiration 2000; 67: 662-671
33. Puertollano M A, de Pablo M A, Alvarez de Cienfuegos G. Immunomodulatory effects of dietary lipids alter host natural resistance of mice to Listeria monocytogenes infection. FEMS Immunol Med Microbiol 2001; 32: 47-52
34. Puertollano M A, de Pablo M A, Alvarez de Cienfuegos G. Relevance of dietary lipids as modulators of immune functions in cells infected with Listeria monocytogenes. Clin Diagn Lab Immunol 2002; 9: 352-357
35. Godfrey RW, Wilder MS. Generation of oxygen species and virulence of Listeria monocytogenes. Infect Immun 1985; 47: 837-839
36. Hashimoto S, Nomoto K, Yokokura T. The role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. Scand J Immunol 1986; 24: 429-436
37. Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M. N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappa B inhibition. J Immunol 1999; 162: 2569-2574
38. Victor VM, Guayerbas N, Garrote D, Del Rio M, De la Fuente M. Modulation of murine macrophage function by N-acetylcysteine in a model of endotoxic shock. Biofactors 1999; 10: 347-357
39. Victor VM, De la Fuente M. N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress. Free Radic Res 2002; 36: 33-45