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Volumn 11, Issue 4, 1999, Pages 466-474

Host genetic influences on HIV-1 pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR;

EID: 0033179134     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)80078-8     Document Type: Article
Times cited : (93)

References (129)
  • 3
    • 0023028190 scopus 로고
    • The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
    • Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R: The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986, 47:333-348.
    • (1986) Cell , vol.47 , pp. 333-348
    • Maddon, P.J.1    Dalgleish, A.G.2    McDougal, J.S.3    Clapham, P.R.4    Weiss, R.A.5    Axel, R.6
  • 4
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW: A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996, 85:1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3    Smyth, R.J.4    Samson, M.5    Peiper, S.C.6    Parmentier, M.7    Collman, R.G.8    Doms, R.W.9
  • 6
    • 0029821869 scopus 로고    scopus 로고
    • A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains
    • Berson JF, Long D, Doranz GJ, Rucker J, Jirik FR, Doms RW: A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J Virol 1996, 70:6288-6295.
    • (1996) J Virol , vol.70 , pp. 6288-6295
    • Berson, J.F.1    Long, D.2    Doranz, G.J.3    Rucker, J.4    Jirik, F.R.5    Doms, R.W.6
  • 11
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein-coupled receptor
    • Feng Y, Broder C, Kennedy PE, Berger EA: HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 1996, 272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.2    Kennedy, P.E.3    Berger, E.A.4
  • 15
    • 0031575431 scopus 로고    scopus 로고
    • Change in coreceptor use correlates with disease progression in HIV-1 infected individuals
    • Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR: Change in coreceptor use correlates with disease progression in HIV-1 infected individuals. J Exp Med 1997, 185:621-628.
    • (1997) J Exp Med , vol.185 , pp. 621-628
    • Connor, R.I.1    Sheridan, K.E.2    Ceradini, D.3    Choe, S.4    Landau, N.R.5
  • 17
    • 0029987361 scopus 로고    scopus 로고
    • Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes
    • Chesebro B, Wehrly K, Nishio J, Perryman S: Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes. J Virol 1996, 70:9055-9059.
    • (1996) J Virol , vol.70 , pp. 9055-9059
    • Chesebro, B.1    Wehrly, K.2    Nishio, J.3    Perryman, S.4
  • 18
    • 0031025113 scopus 로고    scopus 로고
    • Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor
    • Cheng-Mayer C, Liu R, Landau NR, Stamatatos L: Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor. J Virol 1997, 71:1657-1661.
    • (1997) J Virol , vol.71 , pp. 1657-1661
    • Cheng-Mayer, C.1    Liu, R.2    Landau, N.R.3    Stamatatos, L.4
  • 19
    • 0030896676 scopus 로고    scopus 로고
    • Role of CCR5 in infection of primary macrophages and lymphocytes by M-tropic strains of HIV: Resistance to patient-derived and prototype isolates resulting from the δccr5 mutation
    • Rana S, Besson G, Cook DG, Rucker J, Smyth RJ, Yi Y, Turner JD, Guo H-H, Du J-G, Peiper SC et al.: Role of CCR5 in infection of primary macrophages and lymphocytes by M-tropic strains of HIV: Resistance to patient-derived and prototype isolates resulting from the δccr5 mutation. J Virol 1997, 71:3219-3227.
    • (1997) J Virol , vol.71 , pp. 3219-3227
    • Rana, S.1    Besson, G.2    Cook, D.G.3    Rucker, J.4    Smyth, R.J.5    Yi, Y.6    Turner, J.D.7    Guo, H.-H.8    Du, J.-G.9    Peiper, S.C.10
  • 21
    • 0032889037 scopus 로고    scopus 로고
    • Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates
    • Albright AV, Shieh JT, Itoh T, Lee B, Pleasure D, O'Connor MJ, Doms RW, Gonzalez-Scarano F: Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. J Virol 1999, 73:205-213. This paper describes the dominance of CCR5 as the HIV-1 entry coreceptor in tissues of the central nervous system. CCR3 and CXCR4 were shown to be minor coreceptors. Tissues were obtained from adults with AIDS dementia syndrome in distinction to He et al. [20] who used fetal tissues and demonstrated a more significant role for CCR3.
    • (1999) J Virol , vol.73 , pp. 205-213
    • Albright, A.V.1    Shieh, J.T.2    Itoh, T.3    Lee, B.4    Pleasure, D.5    O'Connor, M.J.6    Doms, R.W.7    Gonzalez-Scarano, F.8
  • 22
    • 0030769920 scopus 로고    scopus 로고
    • Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
    • Sallusto F, Mackay CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997, 277:2005-2007.
    • (1997) Science , vol.277 , pp. 2005-2007
    • Sallusto, F.1    Mackay, C.R.2    Lanzavecchia, A.3
  • 24
    • 0033008471 scopus 로고    scopus 로고
    • Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?
    • Zhang Y, Moore JP: Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry? J Virol 1999, 73:3443-3448. This paper convincingly demonstrated that coreceptor utilization assays performed using transduced cell lines do not always predict coreceptor utilization on primary human target cells. The dominance of CCR5 and CXCR4 as the major HIV-1 entry coreceptors was re-affirmed by the well-controlled experiments in this paper.
    • (1999) J Virol , vol.73 , pp. 3443-3448
    • Zhang, Y.1    Moore, J.P.2
  • 25
    • 0031710044 scopus 로고    scopus 로고
    • Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro
    • Zhang YJ, Dragic T, Cao Y, Kostrikis L, Kwon DS, Littman DR, Kewal-Ramani VN, Moore JP: Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro. J Virol 1998, 72:9337-9344.
    • (1998) J Virol , vol.72 , pp. 9337-9344
    • Zhang, Y.J.1    Dragic, T.2    Cao, Y.3    Kostrikis, L.4    Kwon, D.S.5    Littman, D.R.6    Kewal-Ramani, V.N.7    Moore, J.P.8
  • 26
    • 0031775146 scopus 로고    scopus 로고
    • Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus
    • Chen Z, Kwon D, Jin Z, Monard S, Telfer P, Jones MS, Lu CY, Aguilar RF, Ho DD, Marx PA: Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus. J Exp Med 1998, 188:2057-2065. Marx and his team elegantly related geologic partitioning and subsequent speciation of West African mangabey monkeys associated with specific CCR2B polymorphisms to the evolution of phylogenetically distinct simian immunodeficiency viruses with radically different coreceptor utilization profiles.
    • (1998) J Exp Med , vol.188 , pp. 2057-2065
    • Chen, Z.1    Kwon, D.2    Jin, Z.3    Monard, S.4    Telfer, P.5    Jones, M.S.6    Lu, C.Y.7    Aguilar, R.F.8    Ho, D.D.9    Marx, P.A.10
  • 28
    • 0030751948 scopus 로고    scopus 로고
    • Expression cloning of new receptors used by simian and human immunodeficiency viruses
    • Deng H, Unutmaz D, Kewal-Ramani VN, Littman DR: Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997, 388:296-300.
    • (1997) Nature , vol.388 , pp. 296-300
    • Deng, H.1    Unutmaz, D.2    Kewal-Ramani, V.N.3    Littman, D.R.4
  • 29
    • 0032582016 scopus 로고    scopus 로고
    • Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins
    • Edinger AL, Hoffman TL, Sharron M, Lee B, O'Dowd B, Doms RW: Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins. Virology 1998, 249:367-378.
    • (1998) Virology , vol.249 , pp. 367-378
    • Edinger, A.L.1    Hoffman, T.L.2    Sharron, M.3    Lee, B.4    O'Dowd, B.5    Doms, R.W.6
  • 31
    • 0031008794 scopus 로고    scopus 로고
    • STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
    • Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM: STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 1997, 185:2015-2023.
    • (1997) J Exp Med , vol.185 , pp. 2015-2023
    • Liao, F.1    Alkhatib, G.2    Peden, K.W.3    Sharma, G.4    Berger, E.A.5    Farber, J.M.6
  • 32
    • 0030749247 scopus 로고    scopus 로고
    • Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection
    • Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N et al.: Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med 1997, 186:405-411.
    • (1997) J Exp Med , vol.186 , pp. 405-411
    • Farzan, M.1    Choe, H.2    Martin, K.3    Marcon, L.4    Hofmann, W.5    Karlsson, G.6    Sun, Y.7    Barrett, P.8    Marchand, N.9    Sullivan, N.10
  • 33
    • 0030831545 scopus 로고    scopus 로고
    • Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses
    • Rucker J, Edinger AL, Sharron M, Samson M, Lee B, Berson JF, Yi Y, Margulies B, Collman RG, Doranz BJ et al.: Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses. J Virol 1997, 71:8999-9007.
    • (1997) J Virol , vol.71 , pp. 8999-9007
    • Rucker, J.1    Edinger, A.L.2    Sharron, M.3    Samson, M.4    Lee, B.5    Berson, J.F.6    Yi, Y.7    Margulies, B.8    Collman, R.G.9    Doranz, B.J.10
  • 35
    • 2642678444 scopus 로고    scopus 로고
    • The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins
    • Pleskoff O, Treboute C, Alizon M: The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins. J Virol 1998, 72:6389-6397.
    • (1998) J Virol , vol.72 , pp. 6389-6397
    • Pleskoff, O.1    Treboute, C.2    Alizon, M.3
  • 36
    • 17544397389 scopus 로고    scopus 로고
    • The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1
    • Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf ME, Gerard N et al.: The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. J Virol 1998, 72:6113-6118.
    • (1998) J Virol , vol.72 , pp. 6113-6118
    • Choe, H.1    Farzan, M.2    Konkel, M.3    Martin, K.4    Sun, Y.5    Marcon, L.6    Cayabyab, M.7    Berman, M.8    Dorf, M.E.9    Gerard, N.10
  • 37
    • 0031662094 scopus 로고    scopus 로고
    • An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus
    • Edinger AL, Hoffman TL, Sharron M, Lee B, Yi Y, Choe W, Kolson DL, Mitrovic B, Zhou Y, Faulds D et al.: An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol 1998, 72:7934-7940.
    • (1998) J Virol , vol.72 , pp. 7934-7940
    • Edinger, A.L.1    Hoffman, T.L.2    Sharron, M.3    Lee, B.4    Yi, Y.5    Choe, W.6    Kolson, D.L.7    Mitrovic, B.8    Zhou, Y.9    Faulds, D.10
  • 39
    • 0032482753 scopus 로고    scopus 로고
    • The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells
    • Owman C, Garzino-Demo A, Cocchi F, Popovic M, Sabirsh A, Gallo RC: The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells. Proc Natl Acad Sci USA 1998, 95:9530-9534.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9530-9534
    • Owman, C.1    Garzino-Demo, A.2    Cocchi, F.3    Popovic, M.4    Sabirsh, A.5    Gallo, R.C.6
  • 40
    • 0030035550 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α
    • Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J Biol Chem 1996, 271:17161-17166.
    • (1996) J Biol Chem , vol.271 , pp. 17161-17166
    • Raport, C.J.1    Gosling, J.2    Schweickart, V.L.3    Gray, P.W.4    Charo, I.F.5
  • 41
    • 0029986131 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a new human CC-chemokine receptor gene
    • Sampson M, Labbe O, Mollereau C, Vassart G, Parmentier M: Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996, 35:3362-3367.
    • (1996) Biochemistry , vol.35 , pp. 3362-3367
    • Sampson, M.1    Labbe, O.2    Mollereau, C.3    Vassart, G.4    Parmentier, M.5
  • 44
    • 0030451775 scopus 로고    scopus 로고
    • Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates
    • Jansson M, Popovic M, Karlsson A, Cocchi F, Rossi P, Albert J, Wigzell H: Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates. Proc Natl Acad Sci USA 1996, 93:15382-15387.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15382-15387
    • Jansson, M.1    Popovic, M.2    Karlsson, A.3    Cocchi, F.4    Rossi, P.5    Albert, J.6    Wigzell, H.7
  • 46
    • 0029955497 scopus 로고    scopus 로고
    • The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    • Cocchi F, De Vico AL, Garzino-Demo A, Cara A, Gallo RC, Lusso P: The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med 1996, 2:1244-1247.
    • (1996) Nat Med , vol.2 , pp. 1244-1247
    • Cocchi, F.1    De Vico, A.L.2    Garzino-Demo, A.3    Cara, A.4    Gallo, R.C.5    Lusso, P.6
  • 47
    • 0030946755 scopus 로고    scopus 로고
    • HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5
    • Farzan M, Choe H, Martin KA, Sun Y, Sidelko M, Mackay CR, Gerard NP, Sodroski J, Gerard C: HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem 1997, 272:6854-6857.
    • (1997) J Biol Chem , vol.272 , pp. 6854-6857
    • Farzan, M.1    Choe, H.2    Martin, K.A.3    Sun, Y.4    Sidelko, M.5    Mackay, C.R.6    Gerard, N.P.7    Sodroski, J.8    Gerard, C.9
  • 52
    • 0029985197 scopus 로고    scopus 로고
    • + T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1
    • + T lymphocytes from two multiply exposed, uninfected individuals resist infection with primary non-syncytium-inducing isolates of human immunodeficiency virus type 1. J Virol 1996, 70:8758-8764.
    • (1996) J Virol , vol.70 , pp. 8758-8764
    • Connor, R.I.1    Paxton, W.A.2    Sheridan, K.E.3    Koup, R.A.4
  • 54
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
    • Haemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
    • Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E et al.: Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Haemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996, 273:1856-1862.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3    Huttley, G.A.4    Smith, M.W.5    Allikmets, R.6    Goedert, J.J.7    Buchbinder, S.P.8    Vittinghoff, E.9    Gomperts, E.10
  • 58
    • 8244227329 scopus 로고    scopus 로고
    • Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk
    • Zimmerman PA, Buckler-White A, Alkhatib G, Spalding T, Kubofcik J, Combadiere C, Weissman D, Cohen O, Rubbert A, Lam G et al.: Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997, 3:23-36.
    • (1997) Mol Med , vol.3 , pp. 23-36
    • Zimmerman, P.A.1    Buckler-White, A.2    Alkhatib, G.3    Spalding, T.4    Kubofcik, J.5    Combadiere, C.6    Weissman, D.7    Cohen, O.8    Rubbert, A.9    Lam, G.10
  • 59
    • 0031969955 scopus 로고    scopus 로고
    • The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression
    • Paxton WA, Kang S, Koup RA: The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. AIDS Res Hum Retroviruses 1998, 14:S89-S92. This paper confirmed the association of the CCR5Δ32 allele with reduced HIV-1 transmission risk and delayed disease progression in a large cohort of homosexual males.
    • (1998) AIDS Res Hum Retroviruses , vol.14
    • Paxton, W.A.1    Kang, S.2    Koup, R.A.3
  • 60
    • 0031051739 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for the CCR5 deletion allele
    • Biti R, Ffrench R, Young J, Bennetts B, Stewart G, Liang T: HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat Med 1997, 3:252-253.
    • (1997) Nat Med , vol.3 , pp. 252-253
    • Biti, R.1    Ffrench, R.2    Young, J.3    Bennetts, B.4    Stewart, G.5    Liang, T.6
  • 62
    • 0030976601 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for CCR5 delta 32
    • Seroco Study Group
    • Theodorou I, Meyer L, Magierowska M, Katlama C, Rouzioux C: HIV-1 infection in an individual homozygous for CCR5 delta 32. Seroco Study Group. Lancet 1997, 349:1219-1220.
    • (1997) Lancet , vol.349 , pp. 1219-1220
    • Theodorou, I.1    Meyer, L.2    Magierowska, M.3    Katlama, C.4    Rouzioux, C.5
  • 64
    • 0033545475 scopus 로고    scopus 로고
    • HIV-1 infection in a heterosexual man homozygous for CCR-5δ32
    • Heiken H, Bastisch I, Schmidt RE: HIV-1 infection in a heterosexual man homozygous for CCR-5δ32. AIDS 1999, 13:529-530.
    • (1999) AIDS , vol.13 , pp. 529-530
    • Heiken, H.1    Bastisch, I.2    Schmidt, R.E.3
  • 65
    • 0032968822 scopus 로고    scopus 로고
    • An HIV-1 infected individual homozygous for the CCR-5 δ32 allele and the SDF-1 3′A allele
    • Kuipers H, Workman C, Dyer W, Geczy A, Sullivan J, Oelrichs R: An HIV-1 infected individual homozygous for the CCR-5 δ32 allele and the SDF-1 3′A allele. AIDS 1999, 13:433-434.
    • (1999) AIDS , vol.13 , pp. 433-434
    • Kuipers, H.1    Workman, C.2    Dyer, W.3    Geczy, A.4    Sullivan, J.5    Oelrichs, R.6
  • 66
    • 17144454549 scopus 로고    scopus 로고
    • Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
    • Goh WC, Markee J, Akridge RE, Meldorf M, Musey L, Karchmer T, Krone M, Collier A, Corey L, Emerman M, McElrath MJ: Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis 1999, 179:548-557.
    • (1999) J Infect Dis , vol.179 , pp. 548-557
    • Goh, W.C.1    Markee, J.2    Akridge, R.E.3    Meldorf, M.4    Musey, L.5    Karchmer, T.6    Krone, M.7    Collier, A.8    Corey, L.9    Emerman, M.10    McElrath, M.J.11
  • 67
    • 17544384752 scopus 로고    scopus 로고
    • Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32
    • Michael NL, Nelson JA, Kewal-Ramani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC II, Littman DR et al.: Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. J Virol 1998, 72:6040-6047. This first characterization of HIV-1 coreceptor utilization from an individual homozygous for the CCR5Δ32 allele revealed restriction to CXCR4 without 'minor HIV-1 coreceptor' utilization, calling into question the physiologic relevance of these proteins and it demonstrated that persistent CXCR4 usage is not uniformly associated with accelerated disease progression.
    • (1998) J Virol , vol.72 , pp. 6040-6047
    • Michael, N.L.1    Nelson, J.A.2    Kewal-Ramani, V.N.3    Chang, G.4    O'Brien, S.J.5    Mascola, J.R.6    Volsky, B.7    Louder, M.8    White G.C. II9    Littman, D.R.10
  • 68
    • 0028027078 scopus 로고
    • The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression
    • Richman DD, Bozzette SA: The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression. J Infect Dis 1994, 169:968-974.
    • (1994) J Infect Dis , vol.169 , pp. 968-974
    • Richman, D.D.1    Bozzette, S.A.2
  • 69
    • 0033057961 scopus 로고    scopus 로고
    • HIV-1 entry inhibitors: Evading the issue
    • Michael NL, Moore JP: HIV-1 entry inhibitors: evading the issue. Nat Med 1999, 5:740-742.
    • (1999) Nat Med , vol.5 , pp. 740-742
    • Michael, N.L.1    Moore, J.P.2
  • 71
    • 0031908903 scopus 로고    scopus 로고
    • Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients
    • Malo A, Rommel F, Bogner J, Gruber R, Schramm W, Goebel FD, Riethmuller G, Wank R: Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients. Immunobiology 1998, 198:485-488.
    • (1998) Immunobiology , vol.198 , pp. 485-488
    • Malo, A.1    Rommel, F.2    Bogner, J.3    Gruber, R.4    Schramm, W.5    Goebel, F.D.6    Riethmuller, G.7    Wank, R.8
  • 72
    • 0031962506 scopus 로고    scopus 로고
    • Distribution of CCR-5 delta32 allele in Argentinian children at risk of HIV-1 infection: Its role in vertical transmission
    • Mangano A, Prada F, Roldan A, Picchio G, Bologna R, Sen L: Distribution of CCR-5 delta32 allele in Argentinian children at risk of HIV-1 infection: Its role in vertical transmission. AIDS 1998, 12:109-110.
    • (1998) AIDS , vol.12 , pp. 109-110
    • Mangano, A.1    Prada, F.2    Roldan, A.3    Picchio, G.4    Bologna, R.5    Sen, L.6
  • 73
    • 0032573896 scopus 로고    scopus 로고
    • CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children
    • French Pediatric HIV Infection Study Group
    • Misrahi M, Teglas JP, N'Go N, Burgard M, Mayaux MJ, Rouzioux C, Delfraissy JF, Blanche S: CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group. JAMA 1998, 279:277-280.
    • (1998) JAMA , vol.279 , pp. 277-280
    • Misrahi, M.1    Teglas, J.P.2    N'Go, N.3    Burgard, M.4    Mayaux, M.J.5    Rouzioux, C.6    Delfraissy, J.F.7    Blanche, S.8
  • 76
    • 0031874343 scopus 로고    scopus 로고
    • Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression
    • Mummidi S, Ahuja SS, Gonzalez E, Anderson SA, Santiago EN, Stephan KT, Craig FE, O'Connell P, Tryon V, Clark RA et al.: Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med 1998, 4:786-793. Mummidi et al. confirmed the association of CCR2B64I with delayed disease progression in African-American, but not Caucasian, US military personnel but found no such association with CCR5Δ32. In distinct contrast to [115•], they found and association of SDF-1 3′A with accelerated, not delayed, disease progression. CCR5 promoter polymorphisms were described but without clear association with pathogenesis.
    • (1998) Nat Med , vol.4 , pp. 786-793
    • Mummidi, S.1    Ahuja, S.S.2    Gonzalez, E.3    Anderson, S.A.4    Santiago, E.N.5    Stephan, K.T.6    Craig, F.E.7    O'Connell, P.8    Tryon, V.9    Clark, R.A.10
  • 77
    • 0030798652 scopus 로고    scopus 로고
    • CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status
    • Hoffman TL, MacGregor RR, Burger H, Mick R, Doms RW, Collman RG: CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. J Infect Dis 1997, 176:1093-1096.
    • (1997) J Infect Dis , vol.176 , pp. 1093-1096
    • Hoffman, T.L.1    MacGregor, R.R.2    Burger, H.3    Mick, R.4    Doms, R.W.5    Collman, R.G.6
  • 80
    • 6844240236 scopus 로고    scopus 로고
    • The δCCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in northeast Europe
    • Libert F, Cochaus P, Beckman G, Samson M, Aksenova M, Cao A, Czeizel A, Claustres M, de la Rua C, Ferrari M et al.: The δCCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in northeast Europe. Hum Mol Genet 1998, 7:399-406. These two papers [80•,81•] present lines of evidence for the recent fixation of the CCR5Δ32 allele in Caucasian populations in Northwest Europe around the time of the fourteenth Century bubonic plague epidemic. The fascinating - but unproven - theory suggests that the CCR5Δ32 allele provided a selective advantage for individuals exposed to the etiologic agent of plague, Yersinia pestis.
    • (1998) Hum Mol Genet , vol.7 , pp. 399-406
    • Libert, F.1    Cochaus, P.2    Beckman, G.3    Samson, M.4    Aksenova, M.5    Cao, A.6    Czeizel, A.7    Claustres, M.8    De La Rua, C.9    Ferrari, M.10
  • 82
    • 0030894132 scopus 로고    scopus 로고
    • 32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes
    • Rappaport J, Cho YY, Hendel H, Schwartz EJ, Schachter F, Zagury JF: 32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes. Lancet 1997, 349:922-923.
    • (1997) Lancet , vol.349 , pp. 922-923
    • Rappaport, J.1    Cho, Y.Y.2    Hendel, H.3    Schwartz, E.J.4    Schachter, F.5    Zagury, J.F.6
  • 84
    • 0031445262 scopus 로고    scopus 로고
    • Genetic polymorphism of CCR5 gene and HIV disease: The heterozygous (CCR5/δccr5) genotype is neither essential nor sufficient for protection against disease progression
    • Morawetz RA, Rizzardi GP, Glauser D, Rutschmann O, Hirschel B, Perrin L, Opravil M, Flepp M, Overbeck J, Glauser MP et al.: Genetic polymorphism of CCR5 gene and HIV disease: The heterozygous (CCR5/δccr5) genotype is neither essential nor sufficient for protection against disease progression. Eur J Immunol 1997, 12:3223-3227.
    • (1997) Eur J Immunol , vol.12 , pp. 3223-3227
    • Morawetz, R.A.1    Rizzardi, G.P.2    Glauser, D.3    Rutschmann, O.4    Hirschel, B.5    Perrin, L.6    Opravil, M.7    Flepp, M.8    Overbeck, J.9    Glauser, M.P.10
  • 85
    • 0031686773 scopus 로고    scopus 로고
    • A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness
    • Wilkinson DA, Operskalski EA, Busch MP, Mosley JW, Koup RA: A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness. J Infect Dis 1998, 178:1163-1166.
    • (1998) J Infect Dis , vol.178 , pp. 1163-1166
    • Wilkinson, D.A.1    Operskalski, E.A.2    Busch, M.P.3    Mosley, J.W.4    Koup, R.A.5
  • 86
    • 0032932463 scopus 로고    scopus 로고
    • No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users
    • Schinkel J, Langendam MW, Coutinho RA, Krol A, Brouwer M, Schuitemaker H: No evidence for an effect of the CCR5 delta32/+ and CCR2b 64I/+ mutations on human immunodeficiency virus (HIV)-1 disease progression among HIV-1-infected injecting drug users. J Infect Dis 1999, 179:825-831.
    • (1999) J Infect Dis , vol.179 , pp. 825-831
    • Schinkel, J.1    Langendam, M.W.2    Coutinho, R.A.3    Krol, A.4    Brouwer, M.5    Schuitemaker, H.6
  • 87
    • 0032565314 scopus 로고    scopus 로고
    • Reduced HIV-1 infectibility of CD4+ lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of β-chemokines
    • Paxton WA, Liu R, Kang S, Wu L, Gingeras TR, Landau NR, Mackay CR, Koup RA: Reduced HIV-1 infectibility of CD4+ lymphocytes from exposed-uninfected individuals: Association with low expression of CCR5 and high production of β-chemokines. Virology 1998, 244:66-73.
    • (1998) Virology , vol.244 , pp. 66-73
    • Paxton, W.A.1    Liu, R.2    Kang, S.3    Wu, L.4    Gingeras, T.R.5    Landau, N.R.6    Mackay, C.R.7    Koup, R.A.8
  • 88
  • 90
    • 0032493007 scopus 로고    scopus 로고
    • MT-2 tropism and CCR5 genotype strongly influence disease progression in HIV-1 infected individuals
    • Bratt G, Leandersson A-C, Albert J, Sandstrom E, Wahren B: MT-2 tropism and CCR5 genotype strongly influence disease progression in HIV-1 infected individuals. AIDS 1998, 12:729-736. These authors confirmed the dominant association of the CCR5Δ32 allele with delayed disease progression in individuals whose HIV-1 primarily utilized CCR5 and not CXCR4 as originally proposed in [88,89].
    • (1998) AIDS , vol.12 , pp. 729-736
    • Bratt, G.1    Leandersson, A.-C.2    Albert, J.3    Sandstrom, E.4    Wahren, B.5
  • 91
    • 17344366561 scopus 로고    scopus 로고
    • Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age
    • Buseyne F, Janvier G, Teglas JP, Ivanoff S, Burgard M, Bui E, Mayaux MJ, Blanche S, Rouzioux C, Riviere Y: Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age. J Infect Dis 1998, 178:1019-1023.
    • (1998) J Infect Dis , vol.178 , pp. 1019-1023
    • Buseyne, F.1    Janvier, G.2    Teglas, J.P.3    Ivanoff, S.4    Burgard, M.5    Bui, E.6    Mayaux, M.J.7    Blanche, S.8    Rouzioux, C.9    Riviere, Y.10
  • 92
    • 17044452367 scopus 로고    scopus 로고
    • HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
    • Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, Montagnier L, Virelizier JL, Arenzana-Seisdedos F, Beretta A: HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet 1998, 351:14-18. A single individual resistant to R5 HIV-1 was reported who carried a single allele each of CCR5Δ32 and a rarer CCRS-inactivating polymorphism termed CCR5m303. This observation is sentinel to other, as yet undiscovered, genetic associations with HIV pathogenesis.
    • (1998) Lancet , vol.351 , pp. 14-18
    • Quillent, C.1    Oberlin, E.2    Braun, J.3    Rousset, D.4    Gonzalez-Canali, G.5    Metais, P.6    Montagnier, L.7    Virelizier, J.L.8    Arenzana-Seisdedos, F.9    Beretta, A.10
  • 95
    • 0032402255 scopus 로고    scopus 로고
    • CXCR4 polymorphisms and HIV-1 pathogenesis
    • Martin MP, Carrington M, Dean M, O'Brien SJ, Sheppard HW, Wegner SA, Michael NL: CXCR4 polymorphisms and HIV-1 pathogenesis. J Acquir Immune Defic Syndr Hum Retrovirol 1998, 19:430. The virtual lack of genetic polymorphisms in the entire CXCR4 transcription unit was demonstrated in a large group of HIV-1-infected individuals with divergent rates of HIV disease progression and HIV-1-uninfected individuals with variable risk behaviors for HIV transmission. These data underscore the more central role for CXCR4 in normal human physiology compared with CCR5 and may predict greater clinical toxicity with pharmacological inhibition of the former receptor.
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.19 , pp. 430
    • Martin, M.P.1    Carrington, M.2    Dean, M.3    O'Brien, S.J.4    Sheppard, H.W.5    Wegner, S.A.6    Michael, N.L.7
  • 96
    • 0032549021 scopus 로고    scopus 로고
    • Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1
    • Wegner SA, Ehrenberg PK, Chang G, Dayhoff DE, Sleeker AL, Michael NL: Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J Biol Chem 1998, 273:4754-4760.
    • (1998) J Biol Chem , vol.273 , pp. 4754-4760
    • Wegner, S.A.1    Ehrenberg, P.K.2    Chang, G.3    Dayhoff, D.E.4    Sleeker, A.L.5    Michael, N.L.6
  • 97
    • 18244415985 scopus 로고    scopus 로고
    • CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: Lack of association with mutations other than CCR5-Delta32
    • Cohen OJ, Paolucci S, Bende SM, Daucher M, Moriuchi H, Moriuchi M, Cicala C, Davey RT Jr, Baird B, Fauci AS: CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: Lack of association with mutations other than CCR5-Delta32. J Virol 1998, 72:6215-6217.
    • (1998) J Virol , vol.72 , pp. 6215-6217
    • Cohen, O.J.1    Paolucci, S.2    Bende, S.M.3    Daucher, M.4    Moriuchi, H.5    Moriuchi, M.6    Cicala, C.7    Davey R.T., Jr.8    Baird, B.9    Fauci, A.S.10
  • 98
    • 0032507962 scopus 로고    scopus 로고
    • Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    • Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998, 393:595-599.
    • (1998) Nature , vol.393 , pp. 595-599
    • Zou, Y.R.1    Kottmann, A.H.2    Kuroda, M.3    Taniuchi, I.4    Littman, D.R.5
  • 100
    • 0028012561 scopus 로고
    • Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes
    • Loetscher M, Geiser T, O'Reilly T, Zwahlen R, Baggiolini M, Moser B: Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 1994, 269:232-237.
    • (1994) J Biol Chem , vol.269 , pp. 232-237
    • Loetscher, M.1    Geiser, T.2    O'Reilly, T.3    Zwahlen, R.4    Baggiolini, M.5    Moser, B.6
  • 101
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression
    • Haemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort, ALIVE Study
    • Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobsen LP, Kaslow R et al.: Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Haemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort, ALIVE Study. Science 1997, 277:959-965.
    • (1997) Science , vol.277 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3    Winkler, C.4    Huttley, G.A.5    Lomb, D.A.6    Goedert, J.J.7    O'Brien, T.R.8    Jacobsen, L.P.9    Kaslow, R.10
  • 102
    • 0031915155 scopus 로고    scopus 로고
    • A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation
    • Kostrikis LG, Huang Y, Moore JP, Wolinsky SM, Zhang L, Guo Y, Deutch L, Phair J, Neumann AU, Ho DD: A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med 1998, 4:350-353. Kostrikis et al. confirmed the association of the CCR2B64I allele with delayed disease progression in seroincident (duration of HIV infection more precisely known) but not seroprevalent (duration of HIV infection less certain) cohorts, providing a plausible explanation for the disparate conclusions of [88] and [101].
    • (1998) Nat Med , vol.4 , pp. 350-353
    • Kostrikis, L.G.1    Huang, Y.2    Moore, J.P.3    Wolinsky, S.M.4    Zhang, L.5    Guo, Y.6    Deutch, L.7    Phair, J.8    Neumann, A.U.9    Ho, D.D.10
  • 105
    • 0032104091 scopus 로고    scopus 로고
    • Chemokine receptor CCR2b 64I polymorphism and its relation to CD4 counts and disease progression in a Danish cohort of HIV-infected individuals
    • Eugen-Olsen J, Iversen AKN, Benfield TL, Koppelhus U, Garred P: Chemokine receptor CCR2b 64I polymorphism and its relation to CD4 counts and disease progression in a Danish cohort of HIV-infected individuals. J Acquir Immune Defic Syndr Hum Retrovirol 1998, 18:110-116.
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.18 , pp. 110-116
    • Eugen-Olsen, J.1    Iversen, A.K.N.2    Benfield, T.L.3    Koppelhus, U.4    Garred, P.5
  • 106
    • 0031837534 scopus 로고    scopus 로고
    • Genetic effects on HIV disease progression
    • Ioannidis JPA, O'Brien TR, Rosenberg PS, Contopoulos-Ioannidis DG, Goedert JJ: Genetic effects on HIV disease progression. Nat Med 1998, 4:536-537. The first results of a formal meta-analysis of the association of the CCR5Δ32 and CCR2B64I alleles with delayed HIV disease progression confirmed both associations but demonstrated a more statistically robust association for CCR5Δ32. This publication has since spawned an impressive international collaboration between the authors and virtually every group that has contributed to this literature. This far-sighted process will undoubtedly be the final word for the association of genetic polymorphisms with HIV pathogenesis.
    • (1998) Nat Med , vol.4 , pp. 536-537
    • Ioannidis, J.P.A.1    O'Brien, T.R.2    Rosenberg, P.S.3    Contopoulos-Ioannidis, D.G.4    Goedert, J.J.5
  • 108
    • 0031851757 scopus 로고    scopus 로고
    • Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4
    • Lee B, Doranz BJ, Rana S, Yi Y, Mellado M, Frade JM, Martinez AC, O'Brien SJ, Dean M, Collman RG, Doms RW: Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4. J Virol 1998, 72:7450-7458. These papers [107•,108•] collectively provide evidence for the lack of association of CCR2B64I with CCR2B coreceptor activity, expression of CCR2B, CCR5 or CXCR4 and susceptibility to infection with R5 or X4 HIV-1. Subtle associations of CCR2B ligand binding with subsequent attenuated responsiveness of CCR5 and CXCR4 to their cognate ligands were reported by Lee et al. [108•].
    • (1998) J Virol , vol.72 , pp. 7450-7458
    • Lee, B.1    Doranz, B.J.2    Rana, S.3    Yi, Y.4    Mellado, M.5    Frade, J.M.6    Martinez, A.C.7    O'Brien, S.J.8    Dean, M.9    Collman, R.G.10    Doms, R.W.11
  • 109
    • 0032511573 scopus 로고    scopus 로고
    • CCR5 promoter polymorphism and HIV-1 disease progression
    • Multicenter AIDS Cohort Study (MACS)
    • McDermott DH, Zimmerman PA, Guignard F, Kleeberger CA, Leitman SF, Murphy PM: CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet 1998, 352:866-870. These papers [109••,110••] describe CCR5 promoter polymorphisms that are associated with accelerated HIV disease progression in the absence of the moderating influence of so-called 'protective' alleles such as CCR5Δ32, CCR2B64I or SDF-1 3′A. Although McDermott et al. [109••] suggested an association of the disease-accelerating CCR5 promoter allele with increased CCR5 promoter activity in a neoplastic cell line model, Martin et al. [110••] could demonstrate no association with CCR5 or CXCR4 expression nor susceptibility to HIV-1 infection in primary human T cells.
    • (1998) Lancet , vol.352 , pp. 866-870
    • McDermott, D.H.1    Zimmerman, P.A.2    Guignard, F.3    Kleeberger, C.A.4    Leitman, S.F.5    Murphy, P.M.6
  • 111
    • 0031963655 scopus 로고    scopus 로고
    • Gene organization and promoter function for CC chemokine receptor 5 (CCR5)
    • Guignard F, Combadiere C, Tiffany HL, Murphy PM: Gene organization and promoter function for CC chemokine receptor 5 (CCR5). J Immunol 1998, 160:985-992.
    • (1998) J Immunol , vol.160 , pp. 985-992
    • Guignard, F.1    Combadiere, C.2    Tiffany, H.L.3    Murphy, P.M.4
  • 112
    • 0031307855 scopus 로고    scopus 로고
    • Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry
    • Moriuchi H, Moriuchi M, Fauci AS: Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry. J Immunol 1997, 159:5441-5449.
    • (1997) J Immunol , vol.159 , pp. 5441-5449
    • Moriuchi, H.1    Moriuchi, M.2    Fauci, A.S.3
  • 114
    • 0030679633 scopus 로고    scopus 로고
    • The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons
    • Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK: The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem 1997, 272:30662-30671.
    • (1997) J Biol Chem , vol.272 , pp. 30662-30671
    • Mummidi, S.1    Ahuja, S.S.2    McDaniel, B.L.3    Ahuja, S.K.4
  • 115
    • 7144225541 scopus 로고    scopus 로고
    • Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant
    • ALIVE study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC)
    • Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D et al.: Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science 1998, 279:389-393. Winkler et al. first described the SDF-1 3′A allele and its association with delayed disease progression in this large study of multiple HIV infected cohorts.
    • (1998) Science , vol.279 , pp. 389-393
    • Winkler, C.1    Modi, W.2    Smith, M.W.3    Nelson, G.W.4    Wu, X.5    Carrington, M.6    Dean, M.7    Honjo, T.8    Tashiro, K.9    Yabe, D.10
  • 116
    • 0029099521 scopus 로고
    • Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
    • Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T: Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995, 28:495-500.
    • (1995) Genomics , vol.28 , pp. 495-500
    • Shirozu, M.1    Nakano, T.2    Inazawa, J.3    Tashiro, K.4    Tada, H.5    Shinohara, T.6    Honjo, T.7
  • 117
    • 0032543538 scopus 로고    scopus 로고
    • The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection
    • van Rij RP, Broersen S, Goudsmit J, Coutinho RA, Scuitemaker H: The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection. AIDS 1998, 12:F85-F90. van Rij et al., in agreement with [76•], demonstrated an association of SDF-1 3′A with accelerated - not delayed - disease progression as reported by Winkler et al. [115•]. These results underscore the need for the formal meta-analysis program described in [106••].
    • (1998) AIDS , vol.12
    • Van Rij, R.P.1    Broersen, S.2    Goudsmit, J.3    Coutinho, R.A.4    Scuitemaker, H.5
  • 119
    • 0030006049 scopus 로고    scopus 로고
    • Population biology of antigen presentation by MHC class I molecules
    • Parham P, Ohta T: Population biology of antigen presentation by MHC class I molecules. Science 1996, 272:67-74.
    • (1996) Science , vol.272 , pp. 67-74
    • Parham, P.1    Ohta, T.2
  • 120
    • 0032426345 scopus 로고    scopus 로고
    • Natural selection at major histocompatibility complex loci of vertebrates
    • Hughes AL, Yeager M: Natural selection at major histocompatibility complex loci of vertebrates. Annu Rev Genet 1998, 32:415-435. This review delineates the impressive evidence for selective forces acting at the MHC, which controls the presentation of peptides to the immune system.
    • (1998) Annu Rev Genet , vol.32 , pp. 415-435
    • Hughes, A.L.1    Yeager, M.2
  • 121
    • 0029942925 scopus 로고    scopus 로고
    • Correlates of protective viruses damaging to HIV infection
    • Zinkernagel RM, Hengartner H: Correlates of protective viruses damaging to HIV infection. Science 1996, 272:1362.
    • (1996) Science , vol.272 , pp. 1362
    • Zinkernagel, R.M.1    Hengartner, H.2
  • 122
    • 0016842119 scopus 로고
    • Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex
    • Doherty PC, Zinkernagel RM: Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex. Nature 1975, 256:50-52.
    • (1975) Nature , vol.256 , pp. 50-52
    • Doherty, P.C.1    Zinkernagel, R.M.2
  • 125
    • 0031229976 scopus 로고    scopus 로고
    • Heterozygote advantage for HLA class-II type in hepatitis B virus infection
    • Published erratum appears in Nat Genet 1998, 18:88
    • Thursz MR, Thomas HC, Greenwood BM, Hill AV: Heterozygote advantage for HLA class-II type in hepatitis B virus infection. Nat Genet 1997, 17:11-12. [Published erratum appears in Nat Genet 1998, 18:88.]
    • (1997) Nat Genet , vol.17 , pp. 11-12
    • Thursz, M.R.1    Thomas, H.C.2    Greenwood, B.M.3    Hill, A.V.4
  • 127
    • 0033548497 scopus 로고    scopus 로고
    • HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage
    • Carrington M, Nelson GW, Martin MP, Kissner T, Vlahov D, Goedert JJ, Kaslow R, Buchbinders, Hoots K, O'Brien SJ: HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage. Science 1999, 283:1748-1752. Carrington et al. definitively demonstrate the association of HLA alleles B35 and Cw4 with accelerated disease progression. This paper is notable for its rigor in confirming the specificity of the former observation to the HLA locus itself and not just to the general region of the human genome in which it resides.
    • (1999) Science , vol.283 , pp. 1748-1752
    • Carrington, M.1    Nelson, G.W.2    Martin, M.P.3    Kissner, T.4    Vlahov, D.5    Goedert, J.J.6    Kaslow, R.7    Hoots, K.8    O'Brien, S.J.9
  • 129
    • 0032950189 scopus 로고    scopus 로고
    • Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals
    • Magierowska M, Theodorou I, Debre P, Sanson F, Autran B, Riviere Y, Charron D, Costagliola D: Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood 1999, 93:936-941.
    • (1999) Blood , vol.93 , pp. 936-941
    • Magierowska, M.1    Theodorou, I.2    Debre, P.3    Sanson, F.4    Autran, B.5    Riviere, Y.6    Charron, D.7    Costagliola, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.