Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells

Endocrinology

Volumn 144, Issue 5, 2003, Pages 1832-1841

  Galbiati, Francesca ^a   Polastri, Luca ^a   Thorens, Bernard ^b   Dupraz, Philippe ^b   Fiorina, Paolo ^a   Cavallaro, Ugo ^c   Christofori, Gerhard ^c   Davalli, Alberto M ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; ANTINEOPLASTIC AGENT; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DRUG DERIVATIVE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; I KAPPA B; PROLINE; PROLINEDITHIOCARBAMATE; PROTEIN; SIGNAL PEPTIDE; THIOCARBAMIC ACID DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG EFFECT; GENE EXPRESSION; INSULINOMA; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FAMILY; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG RESISTANCE; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOPHYSIOLOGY; PHOSPHORYLATION; TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCITRIOL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DRUG RESISTANCE; GENE EXPRESSION; I-KAPPA B PROTEINS; INSULINOMA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NF-KAPPA B; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROLINE; PROTEINS; THIOCARBAMATES; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0038071635     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-221014     Document Type: Article

References (59)

1. Campbell MJ, Koeffler HP 1997 Toward therapeutic intervention of cancer by vitamin D compounds. J Natl Cancer Inst 89:182-185
2. Ruszniewski P, Malka D 2000 Hepatic arterial chemoembolization in the management of advanced digestive endocrine tumors. Digestion 62(Suppl 1):79-83
3. Arnold R, Simon B, Wied M 2000 Treatment of neuroendocrine GEP tumors with somatostatin analogues: a review. Digestion 62(Suppl 1):84-91
4. Schott M, Scherbaum WA, Feldkamp J 2000 Drug therapy of endocrine neoplasms: Part II: malignant gastrinomas, insulinomas, glucagonomas, carcinoids and other tumors. Med Klin 95:81-84
5. Ulbrecht JS, Schmeltz R, Aarons JH, Green DA 1986 Insulinoma in 94-year-old woman: long-term therapy with verapamil. Diabetes Care 9:186-188
6. Imanaka S, Matsuda S, Ito K, Matsuoka T, Okada Y 1986 Medical treatment for inoperable insulinoma: clinical usefulness of diphenylhydantoin and diltiazem. Jpn J Clin Oncol 16:65-71
7. Stehouwer CD, Lems WF, Fischer HR, Hackeng WH 1989 Malignant insulinoma: is combined treatment with verapamil and the long-acting somatostatin analogue octreotide (SMS 201-995) more effective than single therapy with either drug? Neth J Med 35:86-94
8. Galbiati F, Polastri L, Grogori S, Freschi M, Casorati M, Cavallaro U, Fiorina P, Bertuzzi F, Zerbi A, Pozza G, Adorini L, Folli F, Christofori G, Davalli AM 2002 Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid β cell tumors. Endocrinology 143:4018-4030
9. Hanahan D 1985 Heritable formation of pancreatic β cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115-122
10. 3 in rat pancreas. Mol Cell Endocrinol 60:109-117
11. 3 and butyrate inducible responses. Proc Natl Acad Sci USA 90:2984-2988
12. 3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10:142-153
13. 3 response elements in the human transforming growth factor β2 gene. Biochemistry 38:2654-2660
14. 3 which mediates rapid activation of protein kinase C. J Bone Miner Res 13:1353-1359
15. 3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltochia. J Biol Chem 269:23750-23756
16. 3 modulation of intracellular calcium during development of skeletal muscle cells in culture. J Cell Biochem 77:200-212
17. 3-induced myeloid cell differentiation is regulated by a vitamin D receptor-phoshatidylinositol 3-kinase signaling complex. J Exp Med 190:1583-1594
18. 3. J Cell Biochem 56:303-306
19. Mosmann T 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63
20. Kocamis H, Gahr Scott A, Batelli L, Hubbs AF, Killefer J 2002 IGF-I, IGF-II and IGF-receptor I and IGF-II protein expression in myostatin knockout mice tissues. Muscle Nerve 26:55-63
21. Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP, Aaranson SA 2000 Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc Natl Acad Sci USA 97:8302-8305
22. Herzig M, Novatchkova M, Christofori G 1999 An unexpected role for p53 in augmenting SV40 large T antigen-mediated tumorigenesis. J Biol Chem 380:203-211
23. Ryan KM, Ernst MK, Rice NR, Vousden KH 2000 Role of NF-κB in p53-mediated programmed cell death. Nature 404:892-896
24. Ladner KJ, Caligiuri MA, Guttridge DC 2003 TNF regulated biphasic activation of NFκB is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem 278:2294-2303
25. Schrek R, Meier B, Mannel DN, Droge W, Baeuerle PA 1992 Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp Med 175:1181-1194
26. Rangan G, Wang Y, Tay YC, Harris D 1999 Inhibition of NFκB activation with antioxidants is correlated cytokine transcription in PTC. Am J Physiol 277: F779-F789
27. Efrat S, Fusco-DeMane D, Lemberg H, Al Emran O, Wang X 1995 Conditional transformation of a pancreatic β cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc Natl Acad Sci USA 92:3576-3580
28. Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B 1999 Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. Gene Ther 6:1160-1169
29. Xie SP, Pirianov G, Colston KW 1999 Vitamin D analogues suppress IGF-I signaling and promote apoptosis in breast cancer cells. Eur J Cancer 35:1717-1723
30. Colston KW, Perks CM, Xie SP, Hally JMP 1998 Growth inhibiting of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3. J Endocrinol 20:157-162
31. Razen F, Yong XF, Huynh H, Pollak M 1997 Antiproliferative action of vitamin D-related compounds and insulin-like growth factor binding protein 5 accumulation. J Natl Cancer Inst 89:652-656
32. Gautier J, Minshull J, Lalika M, Glotzer M, Maller JL 1990 Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60:487-494
33. El-Deiry WS, Tokino T, Velculescu VE, Leny DB, Parsans R, Trent JM, Lin D, Mircer WE, Kinzler KW, Vogelstein B 1993 WAF 1, a particular mediator of p53 tumor suppression. Cell 75:817-825
34. Krause, K, Wasner M, Reinhard W, Haugwitz V, Dahna CL, Mossner J, Engeland K 2000 The tumor suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res 28:4410-4418
35. Levine AJ 1997 p53 the cellular gatekeeper for growth and division. Cell 88:323-331
36. Ko LJ, Prives C 1996 P53 puzzle and paradigm. Genes Dev 10:1054-1072
37. Ludlow JW 1993 Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. FASEB J 7:866-871
38. Shieh SY, Ikeda M, Taya Y, Prives C 1997 DNA-damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334
39. Huang C, Mai WY, Maxiner A, Sun Y, Dang Z 1999 p38 kinase mediates UV-induced phosphorylation p53 protein at serine 389. J Biol Chem 276:12229-12235
40. Fuchs SY, Adler V, Pincus MR, Ronai Z 1998 MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci USA 18:10541-10546
41. Lamm GL, Christofori G 1998 Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells. Cancer Res 58:801-807
42. 3 induces programmed cell death in a rat glioma cell line. J Neurosci Res 46:540-550
43. Mathiasen IS, Lademann U, Jaattela M 1999 Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. Cancer Res 59:4848-4856
44. Diaz GD, Paraskeva C, Thomas MG, Binderup L, Hague A 2000 Apoptosis is induced by the active metabolite of vitamin D3 and its analog EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res 60:2304-2312
45. Chen F, Catranova F, Shi X 2001 New insight into the role of nuclear factor-κB in cell growth regulation. Am J Pathol 159:387-397
46. Smirnov AS, Ruzov AS, Budanov AV, Prokhortchouk AV, Ivanov AV, Prokhortchouk EB 2001 High constitutive leveI of NFκB is crucial for viability of adenocarcinoma cells. Cell Death Differ 8:621-630
47. Gunawardena K, Murray DK, Swope RE, Meikle AW 2002 Inhibition of nuclear factor κ-B induced apoptosis following treatment with tumor necrosis factor a and an antioxidant in human prostate cancer cells. Cancer Detect Prev 26:229-237
48. O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC 2000 P53-independent induction of GADD 45 and GADD 153 in mouse lungs exposed to hyperoxia. Am J Physiol 278:L552-L559
49. Harris MH, Thompson CB 2000 The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 7:1182-1191
50. Kaelin Jr WG 1999 Choosing anticancer drug targets in the postgenomic era. J Cancer Inst 104:1503-1506
51. Liu X, Bhalla K, Naekyung Kim C, Ibrado AM, Cai J, Deng TI, Jones DP, Wong X 1997 Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondrial. Science 275:1129-1132
52. 3 and its analog EB 1089. Int J Oncol 13:137-143
53. Nickerson T, Huynh H 1999 Vitamin D analogue EB 1089-induced prostate regression is associated with increased gene expression of insulin-like growth factor binding proteins. J Endocrinol 160:223-229
54. Tietelman G, Alpert S, Hanahan D 1988 Proliferation, senescence, and neoplastic progression of b cells in hyperplastic pancreatic islets. Cell 52:97-105
55. Christofori G, Naik P, Hanahan D 1994 A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369:414-418
56. 3. Diabetologia 37:552-558
57. 3 analog and cyclosporine. Transplantation 65:1225-1232
58. 3. Curr Opin Nephrol Hypertens 4:313-318
59. George M, Ayuso E, Casellas A, Costa C, Christophe JD, Bosh F 2002 B cell expression of IGF-I leads to recovery from type 1 diabetes. J Clin Invest 109:1153-1163