High constitutive level of NF-κB is crucial for viability of adenocarcinoma cells

Cell Death and Differentiation

Volumn 8, Issue 6, 2001, Pages 621-630

  Smirnov, A S ^a   Ruzov, A S ^a   Budanov, A V ^b   Prokhortchouk, A V ^a   Ivanov, A V ^b   Prokhortchouk, E B ^a  

^a INSTITUTE OF GENE BIOLOGY   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Adenocarcinoma cell lines; Apoptosis; NF B constitutive level; P53

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; PROTEIN P53; PYRROLIDINE DITHIOCARBAMATE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TUMOR NECROSIS FACTOR;

ADENOCARCINOMA; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL LINE; CELL MOTILITY; CELL NUCLEUS; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; GROWTH REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TISSUE;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLOW CYTOMETRY; GIANT CELLS; I-KAPPA B PROTEINS; MICE; NF-KAPPA B; PROLINE; PROTEIN BINDING; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-MYC; THIOCARBAMATES; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0034960297     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400853     Document Type: Article

References (40)

1. Aberrant rel/nfkb genes and activity in human cancer
2. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
3. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
4. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
5. Identification and characterization of an IkappaB kinase
6. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
7. The NF-kappa B and I kappa B proteins: New discoveries and insights
8. NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules
9. Signal transduction through NF-kappa B
10. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappa B control
11. NF-kappa B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
12. TNF-and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappa B
13. Suppression of TNF-alpha-induced apoptosis by NF-kappa B
14. NF-kappa B functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
15. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum
16. Constitutive NF-kappa B activity in neurons
17. Inhibition of NF-kappa B/Rel induces apoptosis of murine B cells
18. Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes
19. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
20. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells
21. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappa B
22. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
23. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors
24. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappa B and Myc/Max
25. p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300
26. Transcriptional cross talk between NF-kappa B and p53
27. Requirement of NF-kappa B activation to suppress p53-independent apoptosis induced by oncogenic Ras
28. Vestnik USSR Acad
29. Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo
30. A kappaB-related binding site is an integral part of the mts 1 gene composite enhancer element located in the first intron of the gene
31. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
32. The kappaB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1
33. Metastasis-associated Mts1 (S100A4) protein modulates protein kinase C phosphorylation of the heavy chain of nonmuscle myosin
34. Constitutive activation of NF-kappa B causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates
35. Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes
36. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells
37. Role of NF-kB in p53-mediated programmed cell death
38. Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells
39. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells