2,2′,4,6,6′-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB

Toxicology and Applied Pharmacology

Volumn 189, Issue 1, 2003, Pages 1-10

  Lee, Yong Woo ^a   Park, Hyen Joo ^a   Son, Kwang Won ^a   Hennig, Bernhard ^b,c   Robertson, Larry W ^c   Toborek, Michal ^a,d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspases; CREB; Endothelial cells; Metastasis; PCBs

Indexed keywords

2,2',4,6,6' PENTACHLOROBIPHENYL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYCHLORINATED BIPHENYL DERIVATIVE; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; POLYCHLORINATED BIPHENYL;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL ASSAY; CELL DAMAGE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MICROVASCULATURE; MOLECULAR BIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VASCULAR ENDOTHELIUM; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MICROCIRCULATION; PHYSIOLOGY;

APOPTOSIS; CASPASES; CELL LINE; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; MICROCIRCULATION; POLYCHLORINATED BIPHENYLS;

EID: 0038060729     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00084-X     Document Type: Article

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