The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells

Toxicology and Applied Pharmacology

Volumn 171, Issue 3, 2001, Pages 184-193

  Slim, Rabih ^a   Hammock, Bruce D ^c   Toborek, Michal ^b   Robertson, Larry W ^a   Newman, John W ^c   Morisseau, Christophe H P ^c   Watkins, Bruce A ^d   Saraswathi, Viswanathan ^a   Hennig, Bernhard ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Atherosclerosis; Endothelial cells; Fatty acids; Leukotoxins; Nutrition; Polychlorinated biphenyls

Indexed keywords

1 CYCLOHEXYL 3 DODECYLUREA; 3,3',4,4' TETRACHLOROBIPHENYL; EPOXIDE HYDROLASE; FATTY ACID DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LEUKOTOXIN; LINOLEIC ACID; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; FATTY ACID METABOLISM; NONHUMAN; PULMONARY ARTERY; SWINE; TOXICOKINETICS; VASCULAR ENDOTHELIUM;

EID: 0035869413     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9131     Document Type: Article

References (59)

1. Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos
2. Improved radiolabeled substrates for soluble epoxide hydrolase
3. Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS
4. Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism
5. Physiological importance of ω-3/ω-6 polyunsaturated fatty acids in man. An overview of still unresolved and controversial questions
6. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
7. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase
8. EDHF: A cytochrome P450 metabolite in coronary arteries
9. Cytochrome P450 2C is an EDHF synthase in coronary arteries
10. Atherosclerosis or lipoprotein-induced endothelial dysfunction
11. 13-HPODE and 13-HODE modulate cytokine-induced expression of endothelial cell adhesion molecules differently
12. Endothelial cell gene expression in response to injury
13. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase
14. Metabolism of monoepoxides of methyl linoleate: Bioactivation and detoxification
15. Proposal of leukotoxin, 9,10-epoxy-12-octadecenoate, as a burn toxin
16. Quantitative effects of dietary fat on serum cholesterol in man
17. Fatty acid induced disruption of endothelial barrier function in culture
18. Protection by vitamin E against endothelial cell injury by linoleic acid hydroperoxides
19. Fatty acid-mediated activation of vascular endothelial cells
20. Selective disruption of endothelial barrier function in culture by pure fatty acids and fatty acids derived from animal and plant fats
21. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers
22. Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers
23. Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers
24. Linoleic acid amplifies polychlorinated biphenyl-mediated dysfunction of endothelial cells
25. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells
26. Nutritional implications in vascular endothelial cell metabolism
27. Linoleic acid and linolenic acid: Effect on permeability properties of cultured endothelial cell monolayers
28. Can linoleic acid contribute to coronary artery disease?
29. Origin and function of epoxyeicosatrienoic acids in vascular endothelial cells: More than just endothelium-derived hyperpolarizing factor?
30. Lung injury and pulmonary vascular endothelial cell injury
31. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids
32. Do antioxidants and polyunsaturated fatty acids have a combined association with coronary atherosclerosis?
33. Epoxidation of C18 unsaturated fatty acids by cytochromes P4502C2 and P4502CAA
34. Fatty acid composition in total phospholipids of human coronary arteries in sudden cardiac death
35. Cytokine regulation of endothelial cell function
36. A highly toxic coplanar polychlorinated biphenyl compound suppresses Delta5 and Delta6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver
37. Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations
38. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase
39. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s
40. Potent urea and carbamate inhibitors of soluble epoxide hydrolases
41. Leukotoxin, 9,10-epoxy-12-octadecenoate, as a burn toxin causing adult respiratory distress syndrome
42. Lipid hydroperoxide-induced peroxidation and turnover of endothelial cell phospholipids
43. N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD 36 in human monocyte cells
44. Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
45. The pathogenesis of atherosclerosis: A perspective for the 1990s
46. Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat
47. Epoxides as products of lipid autoxidation in rat lungs
48. Cellular glutathione status modulates PCB-induced stress response and apoptosis in vascular endothelial cells
49. Utilization of arachidonic and linoleic acids by cultured human endothelial cells
50. Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis
51. Linoleic acid and TNF-α cross-amplify oxidative injury and dysfunction of endothelial cells
52. Exposure to polychlorinated biphenyls causes endothelial cell dysfunction
53. Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction
54. Fatty acid-mediated effects on the glutathione redox cycle in cultured endothelial cells
55. Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats
56. Diet and disease, the Israeli paradox: Possible dangers of a high omega-6 polyunsaturated fatty acid diet
57. Role of umbilical vein endothelial cells in hematopoiesis
58. Effect of linoleic acid on endothelial cell inflammatory mediators