메뉴 건너뛰기




Volumn 12, Issue 3, 2003, Pages 255-269

Sexy transgenes: The impact of gene transfer and gene inactivation technologies on the understanding of mammalian sex determination

Author keywords

Gene regulation; Genetic disorders; Mammals; Sex determination; Transgenesis

Indexed keywords

ANIMALS; ANIMALS, GENETICALLY MODIFIED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TRANSFER TECHNIQUES; GONADS; HUMANS; MALE; MICE; MICE, KNOCKOUT; SEX DETERMINATION (GENETICS);

EID: 0038057457     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023392407143     Document Type: Review
Times cited : (5)

References (75)
  • 1
    • 0036277895 scopus 로고    scopus 로고
    • Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner
    • Achermann JC, Ozisik G, Ito M, Orun UA, Harmanci K, Gurakan B et al. (2002) Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. J Clin Endocrinol Metab 87: 1829-1833.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1829-1833
    • Achermann, J.C.1    Ozisik, G.2    Ito, M.3    Orun, U.A.4    Harmanci, K.5    Gurakan, B.6
  • 2
    • 0037205229 scopus 로고    scopus 로고
    • Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc
    • Ahmad SM and Baker BS (2002) Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc. Cell 109: 651-661.
    • (2002) Cell , vol.109 , pp. 651-661
    • Ahmad, S.M.1    Baker, B.S.2
  • 3
    • 0032705186 scopus 로고    scopus 로고
    • Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development
    • Arango NA, Lovell-Badge R and Behringer RR (1999) Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell 99: 409-419.
    • (1999) Cell , vol.99 , pp. 409-419
    • Arango, N.A.1    Lovell-Badge, R.2    Behringer, R.R.3
  • 4
    • 0001320592 scopus 로고
    • The genetic sex on intersexual goats and a probable linkage with the gene for homlessness
    • Asdell SA (1944) The genetic sex on intersexual goats and a probable linkage with the gene for homlessness. Science 99: 124.
    • (1944) Science , vol.99 , pp. 124
    • Asdell, S.A.1
  • 6
    • 0031930042 scopus 로고    scopus 로고
    • Origin of the metazoan phyla: Molecular clocks confirm paleontological estimates
    • Ayala FJ and Rzhetsky A (1998) Origin of the metazoan phyla: molecular clocks confirm paleontological estimates. Proc Natl Acad Sci USA 95: 606-611.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 606-611
    • Ayala, F.J.1    Rzhetsky, A.2
  • 8
    • 0027957103 scopus 로고
    • A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal
    • Bardoni B, Zanaria E, Guioli S, Floridia G, Worley KC, Tonini G et al. (1994) A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nat Genet 7: 497-501.
    • (1994) Nat Genet , vol.7 , pp. 497-501
    • Bardoni, B.1    Zanaria, E.2    Guioli, S.3    Floridia, G.4    Worley, K.C.5    Tonini, G.6
  • 9
    • 0028103739 scopus 로고
    • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
    • Barnes JD, Crosby JL, Jones CM, Wright CV and Hogan BL (1994) Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol 161: 168-178.
    • (1994) Dev Biol , vol.161 , pp. 168-178
    • Barnes, J.D.1    Crosby, J.L.2    Jones, C.M.3    Wright, C.V.4    Hogan, B.L.5
  • 10
    • 0025312139 scopus 로고
    • Abnormal sexual development in transgenic mice chronically expressing mullerian inhibiting substance
    • Behringer RR, Cate RL, Froelick GJ, Palmiter RD and Brinster RL (1990) Abnormal sexual development in transgenic mice chronically expressing mullerian inhibiting substance. Nature 345: 167-170.
    • (1990) Nature , vol.345 , pp. 167-170
    • Behringer, R.R.1    Cate, R.L.2    Froelick, G.J.3    Palmiter, R.D.4    Brinster, R.L.5
  • 11
    • 0028172159 scopus 로고
    • Mullerian-inhibiting substance function during mammalian sexual development
    • Behringer RR, Finegold MJ and Cate RL (1994) Mullerian-inhibiting substance function during mammalian sexual development. Cell 79: 415-425.
    • (1994) Cell , vol.79 , pp. 415-425
    • Behringer, R.R.1    Finegold, M.J.2    Cate, R.L.3
  • 14
  • 15
    • 0033662409 scopus 로고    scopus 로고
    • A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse
    • Bishop CE, Whitworth DJ, Qin Y, Agoulnik AI, Agoulnik IU, Harrison WR et al. (2000) A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet 26: 490-494.
    • (2000) Nat Genet , vol.26 , pp. 490-494
    • Bishop, C.E.1    Whitworth, D.J.2    Qin, Y.3    Agoulnik, A.I.4    Agoulnik, I.U.5    Harrison, W.R.6
  • 16
    • 0032786946 scopus 로고    scopus 로고
    • Sry requires a CAG repeat domain for male sex determination in Mus musculus
    • Bowles J, Cooper L, Berkman J and Koopman P (1999) Sry requires a CAG repeat domain for male sex determination in Mus musculus. Nat Genet 22: 405-408.
    • (1999) Nat Genet , vol.22 , pp. 405-408
    • Bowles, J.1    Cooper, L.2    Berkman, J.3    Koopman, P.4
  • 17
    • 0034669139 scopus 로고    scopus 로고
    • Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators
    • Bowles J, Schepers G and Koopman P (2000) Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 227: 239-255.
    • (2000) Dev Biol , vol.227 , pp. 239-255
    • Bowles, J.1    Schepers, G.2    Koopman, P.3
  • 18
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi MR (1989) Altering the genome by homologous recombination. Science 244: 1288-1292.
    • (1989) Science , vol.244 , pp. 1288-1292
    • Capecchi, M.R.1
  • 19
    • 0036550063 scopus 로고    scopus 로고
    • Sex with two SOX on: SRY and SOX9 in testis development
    • Clarkson MJ and Harley VR (2002) Sex with two SOX on: SRY and SOX9 in testis development. Trends Endocrinol Metab 13: 106-111.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 106-111
    • Clarkson, M.J.1    Harley, V.R.2
  • 20
    • 0035937405 scopus 로고    scopus 로고
    • Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    • Colvin JS, Green RP, Schmahl J, Capel B and Ornitz DM (2001) Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104: 875-889.
    • (2001) Cell , vol.104 , pp. 875-889
    • Colvin, J.S.1    Green, R.P.2    Schmahl, J.3    Capel, B.4    Ornitz, D.M.5
  • 21
    • 0342445418 scopus 로고    scopus 로고
    • Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta
    • Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ et al. (1999) Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286: 2328-2331.
    • (1999) Science , vol.286 , pp. 2328-2331
    • Couse, J.F.1    Hewitt, S.C.2    Bunch, D.O.3    Sar, M.4    Walker, V.R.5    Davis, B.J.6
  • 22
    • 0035131812 scopus 로고    scopus 로고
    • The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
    • Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P et al. (2001) The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 27: 159-166.
    • (2001) Nat Genet , vol.27 , pp. 159-166
    • Crisponi, L.1    Deiana, M.2    Loi, A.3    Chiappe, F.4    Uda, M.5    Amati, P.6
  • 23
    • 0031796252 scopus 로고    scopus 로고
    • Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene
    • De Santa Barbara P, Bonneaud N, Boizet B, Desclozeaux M, Moniot B, Sudbeck P et al. (1998) Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol Cell Biol 18: 6653-6665.
    • (1998) Mol Cell Biol , vol.18 , pp. 6653-6665
    • De Santa Barbara, P.1    Bonneaud, N.2    Boizet, B.3    Desclozeaux, M.4    Moniot, B.5    Sudbeck, P.6
  • 25
    • 0028180838 scopus 로고
    • Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system
    • Fujii T, Pichel JG, Taira M, Toyama R, Dawid IB and Westphal H (1994) Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev Dyn 199: 73-83.
    • (1994) Dev Dyn , vol.199 , pp. 73-83
    • Fujii, T.1    Pichel, J.G.2    Taira, M.3    Toyama, R.4    Dawid, I.B.5    Westphal, H.6
  • 26
    • 0030922218 scopus 로고    scopus 로고
    • The nuclear receptor SF- 1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo
    • Giuili G, Shen WH and Ingraham HA (1997) The nuclear receptor SF- 1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo. Development 124: 1799-1807.
    • (1997) Development , vol.124 , pp. 1799-1807
    • Giuili, G.1    Shen, W.H.2    Ingraham, H.A.3
  • 28
    • 0035839099 scopus 로고    scopus 로고
    • Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
    • Hammes A, Guo JK, Lutsch G, Leheste JR, Landrock D, Ziegler U et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106: 319-329.
    • (2001) Cell , vol.106 , pp. 319-329
    • Hammes, A.1    Guo, J.K.2    Lutsch, G.3    Leheste, J.R.4    Landrock, D.5    Ziegler, U.6
  • 29
    • 0035506747 scopus 로고    scopus 로고
    • Wnts and the female reproductive system
    • Heikkila M, Peltoketo H and Vainio S (2001) Wnts and the female reproductive system. J Exp Zool 290: 616-623.
    • (2001) J Exp Zool , vol.290 , pp. 616-623
    • Heikkila, M.1    Peltoketo, H.2    Vainio, S.3
  • 30
    • 0035907372 scopus 로고    scopus 로고
    • The human sex-determining gene SRY is a direct target of WT1
    • Hossain A and Saunders GF (2001) The human sex-determining gene SRY is a direct target of WT1. J Biol Chem 276: 16817-16823.
    • (2001) J Biol Chem , vol.276 , pp. 16817-16823
    • Hossain, A.1    Saunders, G.F.2
  • 31
    • 0025136766 scopus 로고
    • An immunoassay to detect human mullerian inhibiting substance in males and females during normal development
    • Hudson PL, Dougas I, Donahoe PK, Cate RL, Epstein J, Pepinsky RB et al. (1990) An immunoassay to detect human mullerian inhibiting substance in males and females during normal development. J Clin Endocrinol Metab 70: 16-22.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 16-22
    • Hudson, P.L.1    Dougas, I.2    Donahoe, P.K.3    Cate, R.L.4    Epstein, J.5    Pepinsky, R.B.6
  • 32
    • 0027295482 scopus 로고
    • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
    • Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP and Parker KL (1993) Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7: 852-860.
    • (1993) Mol Endocrinol , vol.7 , pp. 852-860
    • Ikeda, Y.1    Lala, D.S.2    Luo, X.3    Kim, E.4    Moisan, M.P.5    Parker, K.L.6
  • 35
    • 0030851322 scopus 로고    scopus 로고
    • Clinical aspects and molecular genetics of the persistent mullerian duct syndrome
    • Josso N, Picard JY, Imbeaud S, di Clemente N and Rey R (1997) Clinical aspects and molecular genetics of the persistent mullerian duct syndrome. Clin Endocrinol (Oxf) 47: 137-144.
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 137-144
    • Josso, N.1    Picard, J.Y.2    Imbeaud, S.3    Di Clemente, N.4    Rey, R.5
  • 38
    • 0033011523 scopus 로고    scopus 로고
    • Sry and Sox9: Mammalian testis-determining genes
    • Koopman P (1999) Sry and Sox9: mammalian testis-determining genes. Cell Mol Life Sci 55: 839-856.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 839-856
    • Koopman, P.1
  • 39
  • 41
    • 0026665062 scopus 로고
    • Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I
    • Lala DS, Rice DA and Parker KL (1992) Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6: 1249-1258.
    • (1992) Mol Endocrinol , vol.6 , pp. 1249-1258
    • Lala, D.S.1    Rice, D.A.2    Parker, K.L.3
  • 42
    • 0028303959 scopus 로고
    • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    • Luo X, Ikeda Y and Parker KL (1994) A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77: 481-490.
    • (1994) Cell , vol.77 , pp. 481-490
    • Luo, X.1    Ikeda, Y.2    Parker, K.L.3
  • 43
    • 0026621796 scopus 로고
    • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • Matzuk MM, Finegold MJ, Su JG, Hsueh AJ and Bradley A (1992) Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360: 313-319.
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.G.3    Hsueh, A.J.4    Bradley, A.5
  • 44
    • 0029144102 scopus 로고
    • Synergistic effects of inhibins and mullerian-inhibiting substance on testicular tumorigenesis
    • Matzuk MM, Finegold MJ, Mishina Y, Bradley A and Behringer RR (1995) Synergistic effects of inhibins and mullerian-inhibiting substance on testicular tumorigenesis. Mol Endocrinol 9: 1337-1345.
    • (1995) Mol Endocrinol , vol.9 , pp. 1337-1345
    • Matzuk, M.M.1    Finegold, M.J.2    Mishina, Y.3    Bradley, A.4    Behringer, R.R.5
  • 45
    • 0027466437 scopus 로고
    • A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development
    • McElreavey K, Vilain E, Abbas N, Herskowitz I and Fellous M (1993) A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development. Proc Natl Acad Sci 90: 3368-3372.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 3368-3372
    • McElreavey, K.1    Vilain, E.2    Abbas, N.3    Herskowitz, I.4    Fellous, M.5
  • 46
    • 0024854249 scopus 로고
    • Mullerian inhibiting substance is present in testes of dogs with persistent mullerian duct syndrome
    • Meyers-Wallen VN, Donahoe PK, Ueno S, Manganaro TF and Patterson DF (1989) Mullerian inhibiting substance is present in testes of dogs with persistent mullerian duct syndrome. Biol Reprod 41: 881-888.
    • (1989) Biol Reprod , vol.41 , pp. 881-888
    • Meyers-Wallen, V.N.1    Donahoe, P.K.2    Ueno, S.3    Manganaro, T.F.4    Patterson, D.F.5
  • 47
    • 0029658831 scopus 로고    scopus 로고
    • Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation
    • Mishina Y, Rey R, Finegold MJ, Matzuk MM, Josso N, Cate RL et al. (1996) Genetic analysis of the Mullerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev 10: 2577-2587.
    • (1996) Genes Dev , vol.10 , pp. 2577-2587
    • Mishina, Y.1    Rey, R.2    Finegold, M.J.3    Matzuk, M.M.4    Josso, N.5    Cate, R.L.6
  • 49
    • 0025950803 scopus 로고
    • Expression of the mouse anti-mullerian hormone gene suggests a role in both male and female sexual differentiation
    • Münsterberg A and Lovell-Badge R (1991) Expression of the mouse anti-mullerian hormone gene suggests a role in both male and female sexual differentiation. Development 113: 613-624.
    • (1991) Development , vol.113 , pp. 613-624
    • Münsterberg, A.1    Lovell-Badge, R.2
  • 51
    • 0014517234 scopus 로고
    • The problem of the bovine freemartin
    • Ono S (1969) The problem of the bovine freemartin. J Reprod Fertil Suppl 7(Suppl 7): 53-61.
    • (1969) J Reprod Fertil Suppl , vol.7 , Issue.SUPPL. 7 , pp. 53-61
    • Ono, S.1
  • 54
    • 0032531820 scopus 로고    scopus 로고
    • Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a
    • Parr BA and McMahon AP (1998) Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395: 707-710.
    • (1998) Nature , vol.395 , pp. 707-710
    • Parr, B.A.1    McMahon, A.P.2
  • 55
    • 0033358653 scopus 로고    scopus 로고
    • Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: Evidence for an extended control region
    • Pfeifer D, Kist R, Dewar K, Devon K, Lander ES, Birren B et al. (1999) Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet 65: 111-124.
    • (1999) Am J Hum Genet , vol.65 , pp. 111-124
    • Pfeifer, D.1    Kist, R.2    Dewar, K.3    Devon, K.4    Lander, E.S.5    Birren, B.6
  • 57
    • 0034668046 scopus 로고    scopus 로고
    • Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation
    • Raymond CS, Murphy MW, O'Sullivan MG, Bardwell VJ and Zarkower D (2000) Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev 14: 2587-2595.
    • (2000) Genes Dev , vol.14 , pp. 2587-2595
    • Raymond, C.S.1    Murphy, M.W.2    O'Sullivan, M.G.3    Bardwell, V.J.4    Zarkower, D.5
  • 58
    • 0029316784 scopus 로고
    • Genome engineering: The new mouse genetics
    • Rossant J and Nagy A (1995) Genome engineering: the new mouse genetics. Nat Med 1: 592-594.
    • (1995) Nat Med , vol.1 , pp. 592-594
    • Rossant, J.1    Nagy, A.2
  • 59
    • 0028905544 scopus 로고
    • Requirement for Lim1 in head-organizer function
    • Shawlot W and Behringer RR (1995) Requirement for Lim1 in head-organizer function. Nature 374: 425-430.
    • (1995) Nature , vol.374 , pp. 425-430
    • Shawlot, W.1    Behringer, R.R.2
  • 60
    • 0033118412 scopus 로고    scopus 로고
    • Mammalian sex determination: A molecular drama
    • Swain A and Lovell-Badge R (1999) Mammalian sex determination: a molecular drama. Genes Dev 13: 755-767.
    • (1999) Genes Dev , vol.13 , pp. 755-767
    • Swain, A.1    Lovell-Badge, R.2
  • 61
    • 0029912474 scopus 로고    scopus 로고
    • Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function
    • Swain A, Zanaria E, Hacker A, Lovell-Badge R and Camerino G (1996) Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nat Genet 12: 404-409.
    • (1996) Nat Genet , vol.12 , pp. 404-409
    • Swain, A.1    Zanaria, E.2    Hacker, A.3    Lovell-Badge, R.4    Camerino, G.5
  • 63
    • 0034333215 scopus 로고    scopus 로고
    • Mammalian intersexes. Deciphering the sex determination cascade
    • Vaiman D and Pailhoux E (2000) Mammalian intersexes. Deciphering the sex determination cascade. Trends Genet 16: 488-494.
    • (2000) Trends Genet , vol.16 , pp. 488-494
    • Vaiman, D.1    Pailhoux, E.2
  • 64
    • 0033521967 scopus 로고    scopus 로고
    • Female development in mammals is regulated by Wnt-4 signalling
    • Vainio S, Heikkila M, Kispert A, Chin N and McMahon AP (1999) Female development in mammals is regulated by Wnt-4 signalling. Nature 397: 405-409.
    • (1999) Nature , vol.397 , pp. 405-409
    • Vainio, S.1    Heikkila, M.2    Kispert, A.3    Chin, N.4    McMahon, A.P.5
  • 65
    • 0032231944 scopus 로고    scopus 로고
    • Swyer syndrome and 46,XY partial gonadal dysgenesis associated with 9p deletions in the absence of monosomy-9p syndrome
    • Veitia RA, Nunes M, Quintana-Murci L, Rappaport R, Thibaud E, Jaubert F et al. (1998) Swyer syndrome and 46,XY partial gonadal dysgenesis associated with 9p deletions in the absence of monosomy-9p syndrome. Am J Hum Genet 63: 901-905.
    • (1998) Am J Hum Genet , vol.63 , pp. 901-905
    • Veitia, R.A.1    Nunes, M.2    Quintana-Murci, L.3    Rappaport, R.4    Thibaud, E.5    Jaubert, F.6
  • 67
    • 0031876652 scopus 로고    scopus 로고
    • Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Mullerian inhibiting substance promoter
    • Viger RS, Mertineit C, Trasler JM and Nemer M (1998) Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Mullerian inhibiting substance promoter. Development 125: 2665-2675.
    • (1998) Development , vol.125 , pp. 2665-2675
    • Viger, R.S.1    Mertineit, C.2    Trasler, J.M.3    Nemer, M.4
  • 68
    • 0017298904 scopus 로고
    • Les premieres manifestations du freemartinisme chez le foetus de veau ne dependent pas du chimerisme chromosomique XX/XY
    • Vigier B, Locatelli A, Prepin J, Mesnil du Buisson F and Jost A (1976) Les premieres manifestations du freemartinisme chez le foetus de veau ne dependent pas du chimerisme chromosomique XX/XY. CR Acad Sci Paris 282: 1355-1358.
    • (1976) CR Acad Sci Paris , vol.282 , pp. 1355-1358
    • Vigier, B.1    Locatelli, A.2    Prepin, J.3    Mesnil Du Buisson, F.4    Jost, A.5
  • 69
    • 0023266218 scopus 로고
    • Purified bovine AMH induces a characteristic freemartin effect in rat prospective ovaries exposed to it in vitro
    • Vigier B, Warin F, Magre S, Tran D and Josso N (1987) Purified bovine AMH induces a characteristic freemartin effect in rat prospective ovaries exposed to it in vitro. Development 100: 43-55.
    • (1987) Development , vol.100 , pp. 43-55
    • Vigier, B.1    Warin, F.2    Magre, S.3    Tran, D.4    Josso, N.5
  • 70
    • 0028589588 scopus 로고
    • Autosomal sex reversal and campomelic dysplasia are caused by mutations in and round the SRY-related gene SOX9
    • Wagner W, Wirth J, Meyer J, Zabel B, Held M, Zimmer J et al. (1994) Autosomal sex reversal and campomelic dysplasia are caused by mutations in and round the SRY-related gene SOX9. Cell 79: 1111-1120.
    • (1994) Cell , vol.79 , pp. 1111-1120
    • Wagner, W.1    Wirth, J.2    Meyer, J.3    Zabel, B.4    Held, M.5    Zimmer, J.6
  • 71
    • 0027306801 scopus 로고
    • Rapid sequence evolution of the mammalian sex-determining gene SRY
    • Whitfield LS, Lovell-Badge R and Goodfellow PN (1993) Rapid sequence evolution of the mammalian sex-determining gene SRY. Nature 364: 713-715.
    • (1993) Nature , vol.364 , pp. 713-715
    • Whitfield, L.S.1    Lovell-Badge, R.2    Goodfellow, P.N.3
  • 72
    • 0037099299 scopus 로고    scopus 로고
    • The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
    • Wilhelm D and Englert C (2002) The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. Genes Dev 16: 1839-1851.
    • (2002) Genes Dev , vol.16 , pp. 1839-1851
    • Wilhelm, D.1    Englert, C.2
  • 73
  • 75
    • 0028558750 scopus 로고
    • An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
    • Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W et al. (1994) An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372: 635-641.
    • (1994) Nature , vol.372 , pp. 635-641
    • Zanaria, E.1    Muscatelli, F.2    Bardoni, B.3    Strom, T.M.4    Guioli, S.5    Guo, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.