Female development in mammals is regulated by Wnt-4 signalling

Nature

Volumn 397, Issue 6718, 1999, Pages 405-409

  Vainio, Seppo ^a,b   Heikkilä, Minna ^b   Kispert, Andreas ^a,c   Chin, Norman ^a   McMahon, Andrew P ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF OULU   (Finland)

^c MPI Institut für Immunobiologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MUELLERIAN INHIBITING FACTOR; TESTOSTERONE;

ARTICLE; EMBRYO DEVELOPMENT; EMBRYONIC STRUCTURES; GENE MUTATION; MAMMAL; MUELLERIAN DUCT; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT; SIGNAL TRANSDUCTION; TESTOSTERONE SYNTHESIS;

ANIMALS; FEMALE; GENITALIA, FEMALE; GENITALIA, MALE; MALE; MAMMALS; MICE; MORPHOGENESIS; MULLERIAN DUCTS; MUTAGENESIS; OOCYTES; OOGENESIS; PROTO-ONCOGENE PROTEINS; SEX DIFFERENTIATION; SIGNAL TRANSDUCTION; TESTOSTERONE; WNT PROTEINS;

MAMMALIA; WOLFFIA;

EID: 0033521967     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/17068     Document Type: Article

References (41)

1. Burgoyne, P. S. Role of the mammalian Y chromosome in sex determination. Phil. Trans. R. Soc. Lond. B 322, 63-72 (1988).
2. Goodfellow, P. N. & Lovell-Badge, R. SRY and sex determination in mammals. Annu, Rev. Genet. 27, 71-92 (1993).
3. Sinclair, A. H. et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 36, 240-244 (1990).
4. Gubbay, J. et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245-250 (1990).
5. Koopman, P., Gubbay, J., Vivian, N., Goodfellow, P. & Lovell-Badge, R. Male development of chromosomally female mice transgenic for SRY. Nature 351, 117-121 (1991).
6. Palmer, S. J. & Burgoyne, P. S. In situ analysis of fetal, prepubertal and adult XX-XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY. Development 112, 265-268 (1991).
7. Jost, A. Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Recent Prog. Horm. Res. 8, 379-418 (1953).
8. Cate, R. L. et al. Isolation of the bovine and human genes for Müllerian-inhibiting substance and expression of the human gene in animal cells. Cell 45, 685-698 (1986).
9. Behringer, R. R., Finegold, M. J. & Cate, R. L. Müllerian-inhibiting substance function during mammalian sexual development. Cell 79, 415-425 (1994).
10. Bardoni, B. et al. A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal. Nature Genet. 7, 497-501 (1994).
11. Zanaria, E. et al. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372, 635-641 (1994).
12. Muscatelli, F. et al. Mutations in the DAX-1 gene gives rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372, 672-676 (1994).
13. Swain, A., Narvaez, V., Burgoyne, P., Camerino, G. & Lovell-Badge, R. Dax1 antagonizes SRY action in mammalian sex determination. Nature 391, 761-767 (1998).
14. Cadigan, K. M. & Nusse, R. Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286-3305 (1997).
15. Stark, K., Vainio, S., Vassileva, G. & McMahon, A. P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372, 679-683 (1994).
16. McLaren, A. Development of the mammalian gonad: the fate of the supporting cell lineage. BioEssays 13, 151-156 (1991).
17. Buehr, M., Gu, S. & McLaren, A. Mesonephric contribution to testis differentiation in the fetal mouse. Development 117, 273-281 (1993).
18. McLaren, A. Gonad development: assembling the mammalian testis. Curr. Biol. 8, 175-177 (1998).
19. Parr, B. A. & McMahon, A. P. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395, 707-710 (1998).
20. Miller, C. & Sassoon, D. A. Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development 125, 3201-3211 (1998).
21. Münsterberg, A. & Lovell-Badge, R. Expression of the mouse anti-Müllerian hormone gene suggests a role in both male and female sexual differentiation. Development 113, 613-624 (1991).
22. Bitgood, M. J., shen, L. & McMahon, A. P. Sertoli cell signaling by Desert hedgehog regulates the male germ line. Curr. Biol. 6, 298-304 (1996).
23. Morel, Y. et al. Structure-function relationships of 3β-hydroxysteroid dehydrogenase: contribution made by the molecular genetics of 3β-hydroxysteroid dehydrogenase deficiency. Steroids 62, 176-184 (1997).
24. Bitgood, M. J. & McMahon, A. P. Hedgehog and Bmp genes are co-expressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172, 126-138 (1995).
25. Kispert, A., Vainio, S., Shen, L., Rowitch, D. H. & McMahon, A. P. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 122, 3627-3637 (1996).
26. Nordqvist, K. & Lovell-Badge, R. Setbacks on the road to sexual fulfillment. Nature Genet. 7, 7-9 (1994).
27. Andersson, S. et al. Molecular genetics and pathophysiology of 17β-hydroxysteroid dehydrogenase 3 deficiency. J. Clin. Endocrinol. Metab. 81, 130-136 (1996).
28. Nordqvist, K. & Tohonen, V. A mRNA differential display strategy for cloning genes expressed during mouse gonad development. Int. J. Dev. Biol. 41, 627-638 (1997).
29. 17-20 lyase and P450 aromatase in fetal mouse gonads. Endocrinology 135, 262-268 (1994).
30. Mustonen, M. V. J., Poutanen, M. H., Isomaa, V. V., Vihko, P. T. & Vihko, R. K. Cloning of mouse 17β-hydroxysteroid dehydrogenase type 2, and analyzing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues. Biochem. J. 325, 199-205 (1997).
31. Kent, J., Wheatley, S. C., Andrews, J. E., Sinclair, A. H. & Koopman, P. A male-specific role for SOX9 in vertebrate sex determination. Development 122, 2813-2822 (1996).
32. McLaren, A. in Organization of the Early Vertebrate Embryo (eds Zagris, N., Duprat, A. M. & Durston, A. J.) 1-9 (Plenum, New York, 1995).
33. Enders, G. C. & May, J. J. II Developmentally regulated expression of a mouse germ cell nuclear antigen examined from embryonic day 11 to adult in male and female mice. Dev. Biol. 163, 331-340 (1994).
34. Lyet. L. et al. Ontogeny of reproductive abnormalities induced by deregulation of anti-Müllerian hormone expression in transgenic mice. Biol. Reprod. 52, 444-454 (1995).
35. Vigier, B., Watrin, F., Magre, S., Tran, D. & Josso, N. Purified bovine AMH induces a characteristic freemartin effect in fetal rat prospective ovaries exposed to it in vitro. Development 100, 43-55 (1987).
36. Behringer, R. R., Cate, R. L., Froelick, G. J., Palmiter, R. D. & Brinster, R. L. Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance. Nature 345, 167-170 (1990).
37. Luo, X., Ikeda, Y. & Parker, K. L. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490 (1994).
38. Sadovsky, Y. et al. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express p450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of glucocorticoids. Proc. Natl Acad. Sci. USA 92, 10939-10943 (1995).
39. Zamboni, L. & Upadhyay, S. Germ cell differentiation in mouse adrenal glands. J. Exp. Zool. 228, 178-193 (1983).
40. Hogan, B., Beddington, R., Constantini, F. & Lacy, E. Manipulating the Mouse Embryo: A Laboratory Manual 2nd edn. (Cold Spring Harbor Press, New York, 1994).
41. Bishop, C. E., Boursot, P., Baron, B., Bonhomme, F. & Hatat, D. Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musuculus Y chromosome. Nature 315, 70-72 (1985).