Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

Journal of Neurochemistry

Volumn 85, Issue 4, 2003, Pages 944-956

  Maeda, Tadao ^a   Van Hooser, J Preston ^a   Driessen, Carola A G G ^c   Filipek, Sławomir ^e   Janssen, Jacques J M ^d   Palczewski, Krzysztof ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^e UNIVERSITY OF WARSAW   (Poland)

Author keywords

Photoreceptors; Retina; Retinal G protein coupled receptor; Retinal pigment epithelium; Retinoid cycle; Visual cycle

Indexed keywords

11 CIS RETINAL; 11 CIS RETINOL DEHYDROGENASE; 9 CIS RETINAL; G PROTEIN COUPLED RECEPTOR; OXIDOREDUCTASE; RETINOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ELECTRORETINOGRAPHY; ISOMERISM; MOUSE; NONHUMAN; PHOTOCHEMISTRY; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA; VERTEBRATA;

EID: 0037911521     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01741.x     Document Type: Article

References (56)

1. Ablonczy Z., Crouch R. K., Goletz P. W., Redmond T. M., Knapp D. R., Ma J. X. and Rohrer B. (2002) 11-cis-Retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoiddeficient mouse rod photoreceptors. J. Biol. Chem. 277, 40491-40498.
2. Angers S., Salahpour A. and Bouvier M. (2001) Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells. Life Sci. 68, 2243-2250.
3. Bellingham J., Wells D. J. and Foster R. G. (2003) In silico characterisation and chromosomal localisation of human RRH (peropsin) implications for opsin evolution. BMC Genomics 4, 3.
4. Chen P., Hao W., Rife L., Wang X. P., Shen D., Chen J., Ogden T., Van Boemel G. B., Wu L., Yang M. and Fong H. K. (2001a) A photic visual cycle of rhodopsin regeneration is dependent on Rgr. Nat. Genet. 28, 256-260.
5. Chen P., Lee T. D. and Fong H. K. (2001b) Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin. J. Biol. Chem. 276, 21098-21104.
6. Cideciyan A. V., Haeseleer F., Fariss R. N., Aleman T. S., Jang G. F., Verlinde C. L., Marmor M. F., Jacobson S. G. and Palczewski K. (2000) Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis. Neurosci. 17, 667-678.
7. Dean M. K., Higgs C., Smith R. E., Bywater R. P., Snell C. R., Scott P. D., Upton G. J., Howe T. J. and Reynolds C. A. (2001) Dimerization of G-protein-coupled receptors. J. Med. Chem. 44, 4595-4614.
8. Driessen C. A., Winkens H. J., Hoffmann K., Kuhlmann L. D., Janssen B. P., Van Vugt A. H., Van Hooser J. P., Wieringa B. E., Deutman A. F., Palczewski K., Ruether K. and Janssen J. J. (2000) Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 20, 4275-4287.
9. Ebrey T. and Koutalos Y. (2001) Vertebrate photoreceptors. Prog. Retina Eye Res. 20, 49-94.
10. Filipek S., Teller D. C., Palczewski K. and Stenkamp R. E. (2003) The cyrstallographic model of rhodopsin and its use in studies of other G-protein coupled receptors. Annu. Rev. Biophys. Biomol Struct. 32, 375-397.
11. Fotiadis D., Liang Y., Filipek S., Saperstein D. A., Engel A. and Palczewski K. (2003) Atomic-force microscopy: rhodopsin dimers in native disc membranes. Nature 421, 127-128.
12. Garwin G. G. and Saari J. C. (2000) High-performance liquid chromatography analysis of visual cycle retinoids. Methods Enzymol. 316, 313-324.
13. Haeseleer F., Jang G. F., Imanishi Y., Driessen C. A., Matsumura M., Nelson P. S. and Palczewski K. (2002) Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J. Biol. Chem. 277, 45537-45546.
14. Hao W. and Fong H. K. (1996) Blue and ultraviolet light-absorbing opsin from the retinal pigment epithelium. Biochemistry 35, 6251-6256.
15. Hao W. and Fong H. K. (1999) The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium. J. Biol. Chem. 274, 6085-6090.
16. Hao W., Chen P. and Fong H. K. (2000) Analysis of chromophore of RGR: retinal G-protein-coupled receptor from pigment epithelium. Methods Enzymol. 316, 413-422.
17. Hara-Nishimura I., Matsumoto T., Mori H., Nishimura M., Hara R. and Hara T. (1990) Cloning and nucleotide sequence of cDNA for retinochrome, retinal. FEBS Lett. 271, 106-110.
18. Hetling J. R. and Pepperberg D. R. (1999) Sensitivity and kinetics of mouse rod flash responses determined in vivo. J. Physiol. Lond. 516, 593-609.
19. Jang G. F., McBee J. K., Alekseev A. M., Haeseleer F. and Palczewski K. (2000) Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J. Biol. Chem. 275, 28128-28138.
20. Jang G. F., Van Hooser J. P., Kuksa V., McBee J. K., He Y. G., Janssen J. J., Driessen C. A. and Palczewski K. (2001) Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted rdh5 gene. A model for the human hereditary disease fundus albipunctatus. J. Biol. Chem. 276, 32456-32465.
21. Jiang M., Pandey S. and Fong H. K. (1993) An opsin homologue in the retina and pigment epithelium. Invest. Ophthalmol. Vis. Sci. 34, 3669-3678.
22. Koyanagi M., Terakita A., Kubokawa K. and Shichida Y. (2002) Amphioxus homologs of Go-coupled rhodopsin and peropsin having 11-cis- and all-trans-retinals as their chromophores. FEBS Lett. 531, 525-528.
23. Kuksa V., Bartl F., Maeda T., Jang G. F., Ritter E., Heck M., Van Hooser J. P., Liang Y., Filipek S., Gelb M. H., Hofmann K. P. and Palczewski K. (2002) Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J. Biol. Chem. 277, 42315-42324.
24. Lyubarsky A. L., Chen C., Simon M. I. and Pugh E. N. Jr (2000) Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J. Neurosci. 20, 2209-2217.
25. Maeda T., Maeda A., Maruyama I., Ogawa K. I., Kuroki Y., Sahara H., Sato N. and Ohguro H. (2001) Mechanisms of photoreceptor cell death in cancer-associated retinopathy. Invest. Ophthalmol. Vis. Sci. 42, 705-712.
26. McBee J. K., Palczewski K., Baehr W. and Pepperberg D. R. (2001a) Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog. Retin. Eye Res. 20, 469-529.
27. McBee J. K., Van Hooser J. P., Jang G. F. and Palczewski K. (2001b) Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J. Biol. Chem. 276, 48483-48493.
28. Mirzadegan T., Benk G., Filipek S. and Palczewski K. (2003) Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin. Biochemistry 42, 2759-2767.
29. Morimura H., Saindelle Ribeaudeau F., Berson E. L. and Dryja T. P. (1999) Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. Nat. Genet. 23, 393-394.
30. Okada T., Ernst O. P., Palczewski K. and Hofmann K. P. (2001) Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem. Sci. 26, 318-324.
31. Overton M. C. and Blumer K. J. (2000) G-protein-coupled receptors function as oligomers in vivo. Curr. Biol. 10, 341-344.
32. Palczewski K., Van Hooser J. P., Garwin G. G., Chen J., Liou G. I. and Saari J. C. (1999) Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry 38, 12012-12019.
33. Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., Le Trong I., Teller D. C., Okada T., Stenkamp R. E., Yamamoto M. and Miyano M. (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745.
34. Pandey S., Blanks J. C., Spee C., Jiang M. and Fong H. K. (1994) Cytoplasmic retinal localization of an evolutionary homolog of the visual pigments. Exp. Eye Res. 58, 605-613.
35. Pepperberg D. R. and Crouch R. K. (2001) An illuminating new step in visual-pigment regeneration. Lancet 358, 2098-2099.
36. 2+-binding proteins in the retina. Trends Neurosci. 19, 547-554.
37. Pugh E. N. Jr, Nikonov S. and Lamb T. D. (1999) Molecular mechanisms of vertebrate photoreceptor light adaptation. Curr. Opin. Neurobiol. 9, 410-418.
38. Rattner A., Sun H. and Nathans J. (1999) Molecular genetics of human retinal disease. Annu. Rev. Genet 33, 89-131.
39. Redmond T. M. and Hamel C. P. (2000) Genetic analysis of RPE65: from human disease to mouse model. Methods Enzymol. 316, 705-724.
40. Redmond T. M., Yu S., Lee E., Bok D., Hamasaki D., Chen N., Goletz P., Ma J. X., Crouch R. K. and Pfeifer K. (1998) Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat. Genet. 20, 344-351.
41. Rios C. D., Jordan B. A., Gomes I. and Devi L. A. (2001) G-proteincoupled receptor dimerization: modulation of receptor function. Pharmacol. Ther. 92, 71-87.
42. Saari J. C., Garwin G. G., Van Hooser J. P. and Palczewski K. (1998) Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vis. Res. 38, 1325-1333.
43. Seeliger M. W., Grimm C., Stahlberg F., Friedburg C., Jaissle G., Zrenner E., Guo H., Reme C. E., Humphries P., Hofmann F., Biel M., Fariss R. N., Redmond T. M. and Wenzel A. (2001) New views on RPE65 deficiency: the rod system is the source ofvision in a mouse model of Leber congenital amaurosis. Nat. Genet. 29, 70-74.
44. Shen D., Jiang M., Hao W., Tao L., Salazar M. and Fong H. K. (1994) A human opsin-related gene that encodes a retinaldehyde-binding protein. Biochemistry 33, 13117-13125.
45. Shichida Y. and Imai H. (1998) Visual pigment: G-protein-coupled receptor for light signals. Cell Mol. Life Sci. 54, 1299-1315.
46. Stecher H., Gelb M. H., Saari J. C. and Palczewski K. (1999) Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J. Biol. Chem. 274, 8577-8585.
47. Sun H., Gilbert D. J., Copeland N. G., Jenkins N. A. and Nathans J. (1997) Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc. Natl Acad. Sci. USA 94, 9893-9898.
48. Teller D. C., Okada T., Behnke C. A., Palczewski K. and Stenkamp R. E. (2001) Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 40, 7761-7772.
49. Terakita A., Yamashita T. and Shichida Y. (2000) Highly conserved glutamic acid in the extracellular IV-V loop in rhodopsins acts as the counterion in retinochrome, a member of the rhodopsin family [in process citation]. Proc. Natl Acad. Sci. USA 97, 14263-14267.
50. Van Hooser J. P., Garwin G. G. and Saari J. C. (2000a) Analysis of visual cycle in normal and transgenic mice. Methods Enzymol. 316, 565-575.
51. Van Hooser J. P., Aleman T. S., He Y. G., Cideciyan A. V., Kuksa V., Pittler S. J., Stone E. M., Jacobson S. G. and Palczewski K. (2000b) Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc. Natl Acad. Sci. USA 97, 8623-8628.
52. Van Hooser J. P., Liang Y., Maeda T., Kuksa V., Jang G. F., He Y. G., Rieke F., Fong H. K., Detwiler P. B. and Palczewski K. (2002) Recovery of visual functions in a mouse model of Leber congenital amaurosis. J. Biol. Chem. 277, 19173-19182.
53. Wu B. X., Chen Y., Fan J., Rohrer B., Crouch R. K. and Ma J. X. (2002) Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest. Ophthalmol. Vis. Sci. 43, 3365-3372.
54. Yamamoto H., Simon A., Eriksson U., Harris E., Berson E. L. and Dryja T. P. (1999) Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Nat. Genet. 22, 188-191.
55. Yang M. and Fong H. K. (2002) Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. J. Biol. Chem. 277, 3318-3324.
56. Znoiko S. L., Crouch R. K., Moiseyev G. and Ma J. X. (2002) Identification of the RPE65 protein in mammalian cone photoreceptors. Invest. Ophthalmol. Vis. Sci. 43, 1604-1609.