Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 11, 2002, Pages 3365-3372

  Wu, Bill X ^a   Chen, Yumei ^a   Chen, Ying ^a   Fan, Jie ^a   Rohrer, Baerbel ^a   Crouch, Rosalie K ^a   Ma, Jian xing ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 CIS RETINAL; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; RETINAL; RETINOL; RETINOL OXIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; CELL STRAIN COS1; CELLULAR DISTRIBUTION; DNA DETERMINATION; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EXPRESSED SEQUENCE TAG; GENETIC CONSERVATION; ILLUMINATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOMERISM; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OXIDATION; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TRANS ISOMER; VISION;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, NORTHERN; CATTLE; CLONING, MOLECULAR; COS CELLS; EXPRESSED SEQUENCE TAGS; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; MICE; MOLECULAR SEQUENCE DATA; PIGMENT EPITHELIUM OF EYE; RETINALDEHYDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; VITAMIN A;

EID: 0036845581     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Rando RR. Molecular mechanisms in visual pigment regeneration. Photochem Photobiol. 1992;56:1145-1156.
2. Bok D. Photoreceptor "retinoid pumps" in health and disease. Neuron. 1999;23:412-414.
3. Crouch RK, Chader GJ, Wiggert B, Pepperberg DR. Retinoids and the visual process. Photochem Photobiol. 1996;64:613-621.
4. Schoenlein RW, Peteanu LA, Mathies RA, Shank CV. The first step in vision: Femtosecond isomerization of rhodopsin. Science. 1991;254:412-415.
5. Wald G. Molecular basis of visual excitation. Science. 1968;162:230-239.
6. Bok D. The retinal pigment epithelium: A versatile partner in vision. J Cell Sci Suppl. 1993;17:189-195.
7. Bok D. Processing and transport of retinoids by the retinal pigment epithelium. Eye. 1990;4:326-332.
8. Rando RR. Membrane phospholipids as an energy source in the operation of the visual cycle. Biochemistry. 1991;30:595-602.
9. Chen P, Hao W, Rife L, et al. A photic visual cycle of rhodopsin regeneration is dependent on Rgr. Nat Genet. 2001;28:256-260.
10. Simon A, Hellman U, Wernstedt C, Eriksson U. The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. J Biol Chem. 1995;270:1107-1112.
11. Jang GF, Van Hooser JP, Kuksa V, et al. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene: A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001;276:32456-32465.
12. Pandey S, Blanks JC, Spee C, et al. Cytoplasmic retinal localization of an evolutionary homolog of the visual pigments. Exp Eye Res. 1994;58:605-613.
13. Hao W, Fong HK. The endogenous chromophore of retinal G protein-coupled receptor opsin from the pigment epithelium. J Biol Chem. 1999;274:6085-6090.
14. Yang M, Fong HK. Synthesis of the all-trans retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. J Biol Chem. 2002;277:3318-3324.
15. Chai X, Zhai Y, Popescu G, Napoli JL. Cloning of a cDNA for a second retinol dehydrogenase type II: Expression of its mRNA relative to type I. J Biol Chem. 1995;270:28408-28412.
16. Gough WH, VanOoteghem S, Sint T, Kedishvili NY. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. J Biol Chem. 1998;273:19778-19785.
17. Su J, Chai X, Kahn B, Napoli JL. cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. J Biol Chem. 1998;273:17910-17916.
18. Soref CM, Di YP, Hayden L, et al. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. J Biol Chem. 2001;276:24194-24202.
19. Zhang M, Chen WG, Smith SM, Napoli JL. Molecular characterization of a mouse short-chain dehydrogenase/reductase active with all-trans-retinol in intact cells: mRDH1. J Biol Chem. 2001;276:44083-44090.
20. Haeseleer F, Palczewski K. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000;316:372-383.
21. Ma JX, Zhang D, Laser M, et al. Identification of RPE65 in transformed kidney cells. FEBS Lett. 1999;452:199-204.
22. Ma J, Zhang J, Othersen KL, et al. Expression, purification, and MALDI analysis of RPE65. Invest Ophthalmol Vis Sci. 2001;42:1429-1435.
23. Rohrer B, Stell WK. Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry. Brain Res. 1995;695:110-116.
24. Rohrer B, Korenbrot JI, LaVail MM, et al. Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina. J Neurosci. 1999;19:8919-8930.
25. Redmond TM, Yu S, Lee E, et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998;20:344-3451.
26. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 1986;44:283-292.
27. Persson B, Krook M, Jornvall H. Characteristics of short-chain alcohol dehydrogenases and related enzymes. Eur J Biochem. 1991;200:537-543.
28. Jornvall H, Persson B, Krook M, et al. Short-chain dehydrogenases/reductases (SDR). Biochemistry. 1995;34:6003-6013.
29. Haeseleer F, Huang J, Lebioda L, et al. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces alltrans-retinal. J Biol Chem. 1998;273:21790-21799.
30. Rattner A, Smallwood PM, Nathans J. Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-transretinal to all-trans-retinol. J Biol Chem. 2000;275:11034-11043.
31. Timmers AM, van Groningen-Luyben DA, de Grip WJ. Uptake and isomerization of all-trans retinol by isolated bovine retinal pigment epithelial cells: Further clues to the visual cycle. Exp Eye Res. 1991;52:129-138.
32. Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. Nat Genet. 1999;23:393-394.
33. Wolf G. The regulation of retinoic acid formation. Nutr Rev. 1996;54:182-184.
34. Furr HC, Barua AB, Olson JA. Analytical methods. In: Sporn MB, Roberts AB, Goodman, DS, eds. The Retinoids: Biology, Chemistry and Medicine. 2nd ed. New York: Ravens Press, Ltd.; 1994:179-202.