Greater CD8+ TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection

Journal of Immunology

Volumn 171, Issue 1, 2003, Pages 307-316

  Ross Lopes, A ^a   Jaye, Assan ^b   Dorrell, Lucy ^b,c   Sabally, Sehu ^b   Alabi, Abraham ^b   Jones, Nicola A ^d   Flower, Darren R ^d   De Groot, Anne ^e   Newton, Phillipa ^a   Monica Lascar, R ^a   Williams, Ian ^a   Whittle, Hilton ^b   Bertoletti, Antonio ^a   Borrow, Persephone ^d   Maini, Mala K ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d EDWARD JENNER INST FOR VACC RES   (United Kingdom)

^e BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; HLA ANTIGEN; HLA B57 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CLONAL VARIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0037868245     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.1.307     Document Type: Article

References (52)

1. Kanki, P. J., K. U. Travers, S. MBoup, C. C. Hsieh, R. G. Marlink, A. Gueye-NDiaye, T. Siby, I. Thior, M. Hernandez-Avila, J. L. Sankale, et al. 1994. Slower heterosexual spread of HIV-2 than HIV-1. Lancet 343:943.
2. Adjorlolo-Johnson, G., K. M. De Cock, E. Ekpini, K. M. Vetter, T. Sibailly, K. Brattegaard, D. Yavo, R. Doorly, J. P. Whitaker, L. Kestens, et al. 1994. Prospective comparison of mother-to-child transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast. J. Am. Med. Assoc. 272:462.
3. Poulsen, A. G., P. Aaby, O. Larsen, H. Jensen, A. Naucler, I. M. Lisse, C. B. Christiansen, F. Dias, and M. Melbye, 1997. Nine-year HIV-2-associated mortality in an urban community in Bissau, West Africa. Lancet 349:911.
4. Schramm, B., M. L. Penn, E. H. Palacios, R. M. Grant, F. Kirchhoff, and M. A. Goldsmith. 2000. Cytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1. J. Virol. 74:9594.
5. Berry, N., K. Ariyoshi, S. Jaffar, S. Sabally, T. Corrah, R. Tedder, and H. Whittle. 1998. Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection. J. Hum. Virol. 1:457.
6. Popper, S. J., A. D. Sarr, A. Gueye-Ndiaye, S. Mboup, M. E. Essex, and P. J. Kanki. 2000. Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo. J. Virol. 74:1554.
7. McMichael, A. J., and S. L. Rowland-Jones. 2001. Cellular immune responses to HIV. Nature 410:980.
8. Moore, C. B., M. John, I. R. James, F. T. Christiansen, C. S. Witt, and S. A. Mallal. 2002. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296:1439.
9. O'Connor, D. H., T. M. Allen, T. U. Vogel, P. Jing, I. P. DeSouza, E. Dodds, E. J. Dunphy, C. Melsaether, B. Mothe, H. Yamamoto, et al. 2002. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat. Med. 8:493.
10. Gotch, F., S. N. McAdam, C. E. Allsopp, A. Gallimore, J. Elvin, M. P. Kieny, A. V. Hill, A. J. McMichael, and H. C. Whittle. 1993. Cytotoxic T cells in HIV2 seropositive Gambians: identification of a virus-specific MHC-restricted peptide epitope. J. Immunol. 151:3361.
11. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
12. Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19:395.
13. Buseyne, F., and Y. Riviere. 2001. The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes. Int. Immunol. 13:941.
14. Nanda, N. K., K. K. Arzoo, and E. E. Sercarz. 1992. In a small multideterminant peptide, each determinant is recognized by a different Vβ gene segment. J. Exp. Med. 176:297.
15. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403.
16. Douek, D. C., M. R. Betts, J. M. Brenchley, B. J. Hill, D. R. Ambrozak, K. L. Ngai, N. J. Karandikar, J. P. Casazza, and R. A. Koup. 2002. A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J. Immunol. 168:3099.
17. Maini, M. K., N. Gudgeon, L. R. Wedderbum, A. B. Rickinson, and P. C. Beverley. 2000. Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype. J. Immunol. 165:5729.
18. Bjorkman, P. J., M. A. Saper, B. Samraoui, W. S. Bennett, J. L. Strominger, and D. C. Wiley. 1987. Structure of the human class I histocompafibility antigen, HLA-A2. Nature 329:506.
19. Berman, H. M., T. N. Bhat, P. E. Boume, Z. Feng, G. Gilliland, H. Weissig, and J. Westbrook. 2000. The Protein Data Bank and the challenge of structural genomics. Nat. Struct. Biol. 7(Suppl):957.
20. Sali, A., and T. L. Blundell. 1993. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234:779.
21. Stuber, G., S. Modrow, P. Hoglund, L. Franksson, J. Elvin, H. Wolf, K. Karre, and G. Klein. 1992. Assessment of major histocompatibility complex class I interaction with Epstein-Barr virus and human immunodeficiency virus peptides by elevation of membrane H-2 and HLA in peptide loading-deficient cells. Eur. J. Immunol. 22:2697.
22. + T cells in chronic HIV infection are antigen specific. J. Exp. Med. 188:785.
23. Argaet, V. P., C. W. Schmidt, S. R. Burrows, S. L. Silins, M. G. Kurilla, D. L. Doolan, A. Suhrbier, D. J. Moss, E. Kieff, T. B. Suclley, and I. S. Misko. 1994. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 180:2335.
24. Maini, M. K., S. Reignat, C. Boni, G. S. Ogg, A. S. King, F. Malacame, G. J. Webster, and A. Bertoletti. 2000. T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection. Eur. J Immunol. 30:3067.
25. Kalams, S. A., R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. D'Aquila, J. T. Kumick, and B. D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus I envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
26. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia, 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917.
27. Pantaleo, G., J. F. Demarest, T. Schacker, M. Vaccarezza, O. J. Cohen, M. Daucher, C. Graziosi, S. S. Schnittman, T. C. Quinn, G. M. Shaw, et al. 1997. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc. Natl. Acad. Sci. USA 94:254.
28. Campos-Lima, P. O., V. Levitsky, M. P. Imreh, R. Gavioli, and M. G. Masucci. 1997. Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 186:83.
29. Horwitz, M. S., Y. Yanagi, and M. B. Oldstone. 1994. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity. J. Virol. 68:352.
30. + T cells with a predominant Vβ usage during the primary immune response to HIV. Nature 370:463.
31. Gotch, F. 1998. Cross-clade T cell recognition of HIV. 1. Curr. Opin. Immunol. 10:388.
32. Brander, C., K. E. Hartman, A. K. Trocha, N. G. Jones, R. P. Johnson, B. Korber, P. Wentworth, S. P. Buchbinder, S. Wolinsky, B. D. Walker, and S. A. Kalams. 1998. Lack of strong immune selection pressure by the immunodominant, HLAA*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. J. Clin. Invest. 101:2559.
33. Dorrell, L., T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. 1999. Distinct recognition of nonclade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa. J. Virol. 73:1708.
34. McAdam, S., P. Kaleebu, P. Krausa, P. Goulder, N. French, B. Collin, T. Blanchard, J. Whitworth, A. McMichael, and F. Gotch. 1998. Cross-clade recognition of p55 by cytotoxic T lymphocytes in HIV-1 infection. AIDS 12:571.
35. Durali, D., J. Morvan, F. Letoumeur, D. Schmitt, N. Guegan, M. Dalod, S. Saragosti, D. Sicard, J. P. Levy, and E. Gomard. 1998. Cross-reactions between the cytotoxic T-lymphocyte responses of human immunodeficiency virusinfected African and European patients. J. Virol. 72:3547.
36. Nixon, D. F., S. Huet, J. Rothbard, M. P. Kieny, M. Delchambre, C. Thiriart, C. R. Rizza, F. M. Gotch, and A. J. McMichael. 1990. An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. AIDS 4:841.
37. Gillespie, G. M., R. Kaul, T. Dong, H. B. Yang, T. Rostron, J. J. Bwayo, P. Kiama, T. Peto, F. A. Plummer, A. J. McMichael, and S. L. Rowland-Jones. 2002. Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57. AIDS 16:961.
38. Bertoletti, A., F. Cham, S. McAdam, T. Rostron, S. Rowland-Jones, S. Sabally, T. Corrah, K. Ariyoshi, and H. Whittle. 1998. Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. J. Virol. 72:2439.
39. Buseyne, F., M. L. Chaix, C. Rouzioux, S. Blanche, and Y. Riviere. 2001. Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children. J. Virol. 75:4941.
40. Dorrell, L., B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, et al. 2001. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-I gag through HLA-B53. Eur. J. Immunol. 31:1747.
41. Rowland-Jones, S., J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, et al. 1995. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat. Med. 1:59.
42. Busch, D. H., and E. G. Pamer. 1999. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:701.
43. + T lymphocyte population. J. Immunol. 166:4525.
44. Whittle, H. C., K. Ariyoshi, and S. Rowland-Jones. 1998. HIV-2 and T cell recognition. Curr. Opin. Immunol. 10:382.
45. + T cell responses associated with control of viremia. Science 278:1447.
46. Charini, W. A., M. J. Kuroda, J. E. Schmitz, K. R. Beaudry, W. Lin, M. A. Lifton, G. R. Krivulka, A. Necker, and N. L. Letvin. 2001. Clonally diverse CTL response to a dominant viral epitope recognizes potential epitope variants. J. Immunol. 167:4996.
47. van der Loeff, M. F., P. Aaby, K. Aryioshi, T. Vincent, A. A. Awasana, C. Da Costa, L. Pembrey, F. Dias, E. Harding, H. A. Weiss, and H. C. Whittle. 2001. HIV-2 does not protect against HIV-1 infection in a rural community in Guinea-Bissau. AIDS 15:2303.
48. Putkonen, P., L. Walther, Y. J. Zhang, S. L. Li, C. Nilsson, J. Albert, P. Biberfeld, R. Thorstensson, and G. Biberfeld. 1995. Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine. Nat. Med. 1:914.
49. Putkonen, P., B. Makitalo, D. Bottiger, G. Biberfeld, and R. Thorstensson. 1997. Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission. J. Virol. 71:4981.
50. Klenerman, P., and R. M. Zinkemagel. 1998. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 394:482.
51. Nowak, M. A., R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. Bangham, et al. 1995. Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 375:606.
52. Barouch, D. H., J. Kunstman, M. J. Kuroda, J. E. Schmitz, S. Santra, F. W. Peyerl, G. R. Krivulka, K. Beaudry, M. A. Lifton, D. A. Gorgone, et al. 2002. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415:335.