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Volumn 101, Issue 11, 1998, Pages 2559-2566

Lack of strong immune selection pressure by the immunodominant, HLA- A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection

Author keywords

AIDS; Antigen processing; Escape; Immunodominance; Variant

Indexed keywords

EPITOPE;

EID: 0032102284     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2405     Document Type: Article
Times cited : (147)

References (67)
  • 3
    • 0028041344 scopus 로고
    • Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
    • Borrow, P., H. Lewicki, B.H. Hahn, G.M. Shaw, and M.B.A. Oldstone. 1994. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103-6110.
    • (1994) J. Virol. , vol.68 , pp. 6103-6110
    • Borrow, P.1    Lewicki, H.2    Hahn, B.H.3    Shaw, G.M.4    Oldstone, M.B.A.5
  • 5
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R.A., J.T. Safrit, Y. Cao, C.A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D.D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 9
    • 0030997137 scopus 로고    scopus 로고
    • Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: Evidence for HLA class 1-restricted triggering of cytolytic and noncytolytic mechanisms
    • Yang, O.O., S.A. Kalams, A. Trocha, H. Cao, A. Luster, R.P. Johnson, and B.D. Walker. 1997. Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class 1-restricted triggering of cytolytic and noncytolytic mechanisms. J. Virol. 71:3120-3128.
    • (1997) J. Virol. , vol.71 , pp. 3120-3128
    • Yang, O.O.1    Kalams, S.A.2    Trocha, A.3    Cao, H.4    Luster, A.5    Johnson, R.P.6    Walker, B.D.7
  • 10
    • 16944365445 scopus 로고    scopus 로고
    • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
    • Borrow, P., H. Lewicki, X. Wei, M.S. Horwitz, N. Peffer, H. Meyers, J.A. Nelson, J.E. Gairin, B.H. Hahn, M.B. Oldstone, and G.M. Shaw. 1997. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3:205-211.
    • (1997) Nat. Med. , vol.3 , pp. 205-211
    • Borrow, P.1    Lewicki, H.2    Wei, X.3    Horwitz, M.S.4    Peffer, N.5    Meyers, H.6    Nelson, J.A.7    Gairin, J.E.8    Hahn, B.H.9    Oldstone, M.B.10    Shaw, G.M.11
  • 11
    • 0027787423 scopus 로고
    • The fastest genome evolution ever described: HIV variation in situ
    • Wain-Hobson, S. 1993. The fastest genome evolution ever described: HIV variation in situ. Curr. Opin. Gen. Devel. 3:878-883.
    • (1993) Curr. Opin. Gen. Devel. , vol.3 , pp. 878-883
    • Wain-Hobson, S.1
  • 14
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis and therapy
    • Coffin, J.M. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis and therapy. Science. 267:483-488.
    • (1995) Science , vol.267 , pp. 483-488
    • Coffin, J.M.1
  • 15
    • 0027979442 scopus 로고
    • Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: Recognition of autologous virus sequences within a conserved immunodominant epitope
    • Safrit, J.T., C.A. Andrews, T. Zhu, D.D. Ho, and R.A. Koup. 1994. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J. Exp. Med. 179:463-472.
    • (1994) J. Exp. Med. , vol.179 , pp. 463-472
    • Safrit, J.T.1    Andrews, C.A.2    Zhu, T.3    Ho, D.D.4    Koup, R.A.5
  • 18
    • 0027057504 scopus 로고
    • Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag
    • Chen, Z.W., L. Shen, M.D. Miller, S.H. Ghim, A.L. Hughes, and N.L. Letvin. 1992. Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. J. Immunol. 149:4060-4066.
    • (1992) J. Immunol. , vol.149 , pp. 4060-4066
    • Chen, Z.W.1    Shen, L.2    Miller, M.D.3    Ghim, S.H.4    Hughes, A.L.5    Letvin, N.L.6
  • 19
    • 0031973577 scopus 로고    scopus 로고
    • Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3ζ, the signaling chain of the T cell receptor complex
    • In press
    • Trimble, L.A., and J. Lieberman. 1998. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3ζ, the signaling chain of the T cell receptor complex. Blood. In press.
    • (1998) Blood
    • Trimble, L.A.1    Lieberman, J.2
  • 23
    • 0029878348 scopus 로고    scopus 로고
    • Genetic diversity of HLA-A2: Evolutionary and functional significance
    • Browning, M., and P. Krausa. 1996. Genetic diversity of HLA-A2: evolutionary and functional significance. Immunol. Today. 17:165-170.
    • (1996) Immunol. Today , vol.17 , pp. 165-170
    • Browning, M.1    Krausa, P.2
  • 25
    • 0025924977 scopus 로고
    • Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of the HLA-A2 subtype polymorphism
    • Castano, A.R., and J.A. Lopez de Castro. 1991. Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of the HLA-A2 subtype polymorphism. Immunogenetics. 34:281-285.
    • (1991) Immunogenetics. , vol.34 , pp. 281-285
    • Castano, A.R.1    De Lopez Castro, J.A.2
  • 27
    • 37049106853 scopus 로고
    • Procedures for solid-phase peptide synthesis using N-fluorenylmethoxycarbonylamino-acids on polyamid supports. Synthesis of substance P and of acyl carrier protein
    • Atherton, E., C.J. Logan, and R.C. Sheppard. 1981. Procedures for solid-phase peptide synthesis using N-fluorenylmethoxycarbonylamino-acids on polyamid supports. Synthesis of substance P and of acyl carrier protein. Chem. Soc. Perkin Trans. 1:538-546.
    • (1981) Chem. Soc. Perkin Trans. , vol.1 , pp. 538-546
    • Atherton, E.1    Logan, C.J.2    Sheppard, R.C.3
  • 28
    • 0026335733 scopus 로고
    • An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein
    • Tsomides, T.J., B.D. Walker, and H.N. Eisen. 1991. An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA. 88:11276-11280.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 11276-11280
    • Tsomides, T.J.1    Walker, B.D.2    Eisen, H.N.3
  • 29
    • 0028067568 scopus 로고
    • Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1 (HIV-1)
    • Tsomides, T.J., A. Aldovini, R.P. Johnson, B.D. Walker, R.A. Young, and H.N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1 (HIV-1). J. Exp. Med. 180:1283-1293.
    • (1994) J. Exp. Med. , vol.180 , pp. 1283-1293
    • Tsomides, T.J.1    Aldovini, A.2    Johnson, R.P.3    Walker, B.D.4    Young, R.A.5    Eisen, H.N.6
  • 30
    • 0030071441 scopus 로고    scopus 로고
    • Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor
    • Harrer, E., T. Harrer, P. Barbosa, M. Feinberg, R.P. Johnson, S. Buchbinder, and B.D. Walker. 1996. Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. J. Infect. Dis. 173:476-179.
    • (1996) J. Infect. Dis. , vol.173 , pp. 476-1179
    • Harrer, E.1    Harrer, T.2    Barbosa, P.3    Feinberg, M.4    Johnson, R.P.5    Buchbinder, S.6    Walker, B.D.7
  • 31
    • 0002708340 scopus 로고
    • HIV-1-specific cytotoxic T lymphocytes
    • A. Aldovini and B.D. Walker, editors. Stockton Press, New York
    • Walker, B.D. 1990. HIV-1-specific cytotoxic T lymphocytes. In Techniques in HIV Research. A. Aldovini and B.D. Walker, editors. Stockton Press, New York. 201.
    • (1990) Techniques in HIV Research , pp. 201
    • Walker, B.D.1
  • 32
    • 0028323247 scopus 로고
    • Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire
    • Kalams, S.A., R.P. Johnson, A.K. Trocha, M.J. Dynan, H.S. Ngo, R.T. DAquila, J.T. Kurnick, and B.D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261-1271.
    • (1994) J. Exp. Med. , vol.179 , pp. 1261-1271
    • Kalams, S.A.1    Johnson, R.P.2    Trocha, A.K.3    Dynan, M.J.4    Ngo, H.S.5    Daquila, R.T.6    Kurnick, J.T.7    Walker, B.D.8
  • 34
    • 0020067009 scopus 로고
    • The evaluation of limiting dilution assays
    • de St. Groth, F. 1982. The evaluation of limiting dilution assays. J. Immunol. Methods. 49:11-23.
    • (1982) J. Immunol. Methods , vol.49 , pp. 11-23
    • De St. Groth, F.1
  • 35
    • 0004698682 scopus 로고
    • Assays based on quantal responses. 3rd ed
    • Charles Griffen & Co. LTD., London
    • Finney, D.I. 1978. Assays based on quantal responses. 3rd ed. In Statistical Method in Biological Assay. Charles Griffen & Co. LTD., London. 371-403.
    • (1978) Statistical Method in Biological Assay , pp. 371-403
    • Finney, D.I.1
  • 38
    • 0025787509 scopus 로고
    • HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells
    • Johnson, R.P., A. Trocha, L. Yang, G.P. Mazzara, D.L. Panicali, T.M. Buchanan, and B.D. Walker. 1991. HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells. J. Immunol. 147:1512-1521.
    • (1991) J. Immunol. , vol.147 , pp. 1512-1521
    • Johnson, R.P.1    Trocha, A.2    Yang, L.3    Mazzara, G.P.4    Panicali, D.L.5    Buchanan, T.M.6    Walker, B.D.7
  • 40
    • 0004510030 scopus 로고    scopus 로고
    • The HLA class I restricted CTL response in HIV infection: Systematic identification of optimal epitopes
    • C.B.B. Korber, B. Walker, R. Koup, J. Moore, B. Haynes, G. Meyers, editors. Los Alamos National Laboratory: Theoretical Biology and Biophysics, Los Alamos, NM
    • Brander, C., and B.D. Walker. 1996. The HLA class I restricted CTL response in HIV infection: systematic identification of optimal epitopes. In HIV Molecular Immunology Database. C.B.B. Korber, B. Walker, R. Koup, J. Moore, B. Haynes, G. Meyers, editors. Los Alamos National Laboratory: Theoretical Biology and Biophysics, Los Alamos, NM.
    • (1996) HIV Molecular Immunology Database
    • Brander, C.1    Walker, B.D.2
  • 42
    • 14844341454 scopus 로고
    • CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef
    • Hadida, F., G. Haas, N. Zimmermann, A. Hosmalin, R. Spohn, A. Samri, G. Jung, P. Debre, and B. Autran. 1995. CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef. J. Immunol. 154: 4174-4186.
    • (1995) J. Immunol. , vol.154 , pp. 4174-4186
    • Hadida, F.1    Haas, G.2    Zimmermann, N.3    Hosmalin, A.4    Spohn, R.5    Samri, A.6    Jung, G.7    Debre, P.8    Autran, B.9
  • 43
    • 0028979084 scopus 로고
    • Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein
    • Dupuis, M., S.K. Kundu, and T.C. Merigan. 1995. Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein. J. Immunol. 155:2232-2239.
    • (1995) J. Immunol. , vol.155 , pp. 2232-2239
    • Dupuis, M.1    Kundu, S.K.2    Merigan, T.C.3
  • 44
    • 0027403718 scopus 로고
    • Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease
    • Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249-256.
    • (1993) J. Exp. Med. , vol.177 , pp. 249-256
    • Carmichael, A.1    Jin, X.2    Sissons, P.3    Borysiewicz, L.4
  • 45
    • 0029935149 scopus 로고    scopus 로고
    • T cell receptor (TCR) usage and fine specificity of HIV-1-specific cytotoxic T lymphocyte (CTL) clones: Analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant
    • Kalams, S.A., R.P. Johnson, M.J. Dynan, K.E. Hartman, T. Harrer, E. Harrer, A.K. Trocha, W.A. Blattner, S.P. Buchbinder, and B.D. Walker. 1996. T cell receptor (TCR) usage and fine specificity of HIV-1-specific cytotoxic T lymphocyte (CTL) clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant. J. Exp. Med. 183:1669-1679.
    • (1996) J. Exp. Med. , vol.183 , pp. 1669-1679
    • Kalams, S.A.1    Johnson, R.P.2    Dynan, M.J.3    Hartman, K.E.4    Harrer, T.5    Harrer, E.6    Trocha, A.K.7    Blattner, W.A.8    Buchbinder, S.P.9    Walker, B.D.10
  • 47
    • 0028086591 scopus 로고
    • Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope
    • Bertoletti, A., A. Costanzo, F.V. Chisari, M. Levrero, M. Artini, A. Sette, A. Penna, T. Giuberti, F. Fiaccadori, and C. Ferrari. 1994. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J. Exp. Med. 180:933-943.
    • (1994) J. Exp. Med. , vol.180 , pp. 933-943
    • Bertoletti, A.1    Costanzo, A.2    Chisari, F.V.3    Levrero, M.4    Artini, M.5    Sette, A.6    Penna, A.7    Giuberti, T.8    Fiaccadori, F.9    Ferrari, C.10
  • 48
    • 0028145416 scopus 로고
    • Virus escape from CTL recognition
    • Koup, R.A. 1994. Virus escape from CTL recognition. J. Exp. Med. 180: 779-782.
    • (1994) J. Exp. Med. , vol.180 , pp. 779-782
    • Koup, R.A.1
  • 51
    • 0030898038 scopus 로고    scopus 로고
    • Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses on two human histocompatibility leukocyte antigen identical siblings with HLA-A*0201 are influenced by epitope mutation
    • Goulder, P.J.R., A.K. Sewell, D.G. Lalloo, D.A. Price, J.A. Whelan, J. Evans, G.P. Taylor, G. Luzzi, P. Giangrande, R.E. Phillips, and A.J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses on two human histocompatibility leukocyte antigen identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185:1423-1433.
    • (1997) J. Exp. Med. , vol.185 , pp. 1423-1433
    • Goulder, P.J.R.1    Sewell, A.K.2    Lalloo, D.G.3    Price, D.A.4    Whelan, J.A.5    Evans, J.6    Taylor, G.P.7    Luzzi, G.8    Giangrande, P.9    Phillips, R.E.10    McMichael, A.J.11
  • 52
    • 0014828908 scopus 로고
    • An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
    • Wu, T.T., and E.A. Kabat. 1970. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp. Med. 132:211-250.
    • (1970) J. Exp. Med. , vol.132 , pp. 211-250
    • Wu, T.T.1    Kabat, E.A.2
  • 54
    • 0028123067 scopus 로고
    • Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein
    • Couillin, I., B. Culmann-Penciolelli, E. Gomard, J. Choppin, J.-P. Levy, J.-G. Guillet, and S. Saragosti. 1994. Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein. J. Exp. Med. 180:1129-1134.
    • (1994) J. Exp. Med. , vol.180 , pp. 1129-1134
    • Couillin, I.1    Culmann-Penciolelli, B.2    Gomard, E.3    Choppin, J.4    Levy, J.-P.5    Guillet, J.-G.6    Saragosti, S.7
  • 56
    • 0027304399 scopus 로고
    • Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules
    • Ruppert, J., J. Sidney, E. Celis, R.T. Kubo, H.M. Grey, and A. Sette. 1993. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell. 74:929-937.
    • (1993) Cell , vol.74 , pp. 929-937
    • Ruppert, J.1    Sidney, J.2    Celis, E.3    Kubo, R.T.4    Grey, H.M.5    Sette, A.6
  • 57
    • 0029064432 scopus 로고
    • Identification of HIV-protein derived CTL epitopes for their potential use as synthetic vaccine
    • Brander, C., W.J. Pichler, and G. Corradin. 1995. Identification of HIV-protein derived CTL epitopes for their potential use as synthetic vaccine. Clin. Exp. Immunol. 101:107-113.
    • (1995) Clin. Exp. Immunol. , vol.101 , pp. 107-113
    • Brander, C.1    Pichler, W.J.2    Corradin, G.3
  • 58
    • 0023874251 scopus 로고
    • Human cytomegalovirus-specific cytotoxic T cells: Their precursor frequency and stage specificity
    • Borysiewicz, L.K., S. Graham, J.K. Hickling, P.D. Mason, and J.G. Sissons. 1988. Human cytomegalovirus-specific cytotoxic T cells: their precursor frequency and stage specificity. Eur. J. Immunol. 18:269-275.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 269-275
    • Borysiewicz, L.K.1    Graham, S.2    Hickling, J.K.3    Mason, P.D.4    Sissons, J.G.5
  • 60
    • 0029006397 scopus 로고
    • The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus
    • Klenerman, P., U.C. Meier, R.E. Phillips, and AJ. McMichael. 1995. The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus. Eur. J. Immunol. 25: 1927-1931.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1927-1931
    • Klenerman, P.1    Meier, U.C.2    Phillips, R.E.3    McMichael, A.J.4
  • 61
    • 0027340164 scopus 로고
    • A TH1 to Th2 switch is a critical step in the etiology of HIV infection
    • Clerici, M., and G.M. Shearer. 1993. A TH1 to Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today. 14:107-110.
    • (1993) Immunol. Today , vol.14 , pp. 107-110
    • Clerici, M.1    Shearer, G.M.2
  • 62
    • 0028968217 scopus 로고
    • Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
    • Niedermann, G., S. Butz, H.G. Ihlenfeldt, R. Grimm, M. Lucchiari, H. Hoschutzky, G. Jung, B. Maier, and K. Eichmann. 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity. 2:289-299.
    • (1995) Immunity , vol.2 , pp. 289-299
    • Niedermann, G.1    Butz, S.2    Ihlenfeldt, H.G.3    Grimm, R.4    Lucchiari, M.5    Hoschutzky, H.6    Jung, G.7    Maier, B.8    Eichmann, K.9
  • 63
    • 0029974597 scopus 로고    scopus 로고
    • Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
    • Neisig, A., R. Wubbolts, X. Zang, C. Melief, and J. Neefjes, 1996. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. J. Immunol. 156:3196-3206.
    • (1996) J. Immunol. , vol.156 , pp. 3196-3206
    • Neisig, A.1    Wubbolts, R.2    Zang, X.3    Melief, C.4    Neefjes, J.5
  • 64
    • 0028676237 scopus 로고
    • Substrate specificity of allelic variants of the TAP peptide transporter
    • Heemels, M., and H.L. Ploegh. 1994. Substrate specificity of allelic variants of the TAP peptide transporter. Immunity. 1:775-784.
    • (1994) Immunity , vol.1 , pp. 775-784
    • Heemels, M.1    Ploegh, H.L.2
  • 65
    • 0027223877 scopus 로고
    • MHC-linked LMP gene products specifically alter pcptidasc activities of the proteasome
    • Driscoll, J., M.G. Brown, D. Finlay, and J.J. Monaco. 1993. MHC-linked LMP gene products specifically alter pcptidasc activities of the proteasome. Nature. 365:262-264.
    • (1993) Nature , vol.365 , pp. 262-264
    • Driscoll, J.1    Brown, M.G.2    Finlay, D.3    Monaco, J.J.4
  • 67
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A.S., A.U. Neumann, M. Markowitz, J.M. Leonard, and D.D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5


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