Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53

European Journal of Immunology

Volumn 31, Issue 6, 2001, Pages 1747-1756

  Dorrell, Lucy ^a   Willcox, Benjamin E ^b   Yvonne Jones, E ^a   Gillespie, Gerry ^b   Njai, Harr ^a   Sabally, Sehu ^b   Jaye, Assan ^a   Degleria, Kati ^b   Rostron, Tim ^a   Lepin, Eric ^b   McMichael, Andrew ^a   Whittle, Hilton ^b   Rowland Jones, Sarah ^a,c  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Cytotoxic T lymphocyte; Epitope; HIV; HLA allele; Motif

Indexed keywords

EPITOPE; GAG PROTEIN; GAMMA INTERFERON; HLA B ANTIGEN; HLA B35 ANTIGEN; HLA B53 ANTIGEN; PROLINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ARTICLE; CAUCASIAN; CONTROLLED STUDY; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG DESIGN; ENZYME LINKED IMMUNOSPOT ASSAY; GAMBIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; IMMUNOASSAY; IMMUNOGENICITY; MOLECULAR RECOGNITION; NEGRO; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; VIRUS INFECTION;

AMINO ACID SEQUENCE; CELL LINE, TRANSFORMED; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; GENE PRODUCTS, GAG; HIV ANTIGENS; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HIV-2; HLA ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 0034974788     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200106)31:6<1747::AID-IMMU1747>3.0.CO;2-L     Document Type: Article

References (39)

1. Anti-HIV cellular immunity: Recent advances towards vaccine design
2. Cytotoxic T lymphocyte epitopes: Implications for HIV vaccines
3. The puzzle of HIV-1 subtypes in Africa
4. Cross-clade T cell recognition of HIV-1
5. Distinct recognition of non-clade B human immunodeficiency virus type 1 epitope by cytotoxic T lymphocytes generated from donors infected in Africa
6. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T lymphocyte responses in infected African and Caucasoid adults and children
7. HIV-1 gag-specific CTL defined with recombinant vaccinia viruses and synthetic peptides
8. MHC ligands and peptide motifs: First listing
9. Molecular analysis of the association of HLA-B53 and resistance to severe malaria
10. Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes
11. Interethnic genetic differentiation in Africa: HLA class I antigens in The Gambia
12. Cytotoxic T cells in HIV-2 seropositive Gambians: Identification of a virus-specific MHC-restricted peptide epitope
13. Specificity and degeneracy in peptide-binding to HLA-B7-like class I molecules
14. + memory cells
15. Quantitation of HIV-1 specific cytotoxic T lymphocytes and plasma load of viral RNA
16. Characterisation of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from SIV
17. Novel cross-restricted, conserved and immunodominant CTL epitopes in slow progressors in HIV-1 infection
18. HLA class I binding motifs derived from random peptide libraries differ at the COOH terminus from those of eluted peptides
19. Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53
20. Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion
21. HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women
22. An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide
23. Counting antigen-specific T cells: A re-evaluation of bystander activation during viral infection
24. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon
25. Epidemiological and immunological implications of the global variability of HIV-1
26. Induction of vigorous cytotoxic T lymphocytes responses by live attenuated simian immunodeficiency virus
27. Design and construction of an experimental HIv-1 vaccine for a year-2000 clinical trial in Kenya
28. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualised using soluble tetrameric major histocompatibility complex class I-peptide complexes
29. Phenotyping: Comprehensive DNA typing for HLA-A, B, C DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilising sequence-specific (PCR-SSP)
30. Phenotypic analysis of antigen-specific T lymphocytes
31. Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
32. Raster3D version 2.0 - A program for photorealistic molecular graphics
33. An altered position of the alpha-2 helix of MHC class I is revealed by the crystal structure of HLA-B*3051
34. AMoRE: An automated package for molecular replacement
35. Crystallography and NMR system: A new software suite for macromolecular structure determination
36. Improved methods of binding protein models in electron density maps and the location of errors in these models