Clonally diverse CTL response to a dominant viral epitope recognizes potential epitope variants

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 4996-5003

  Charini, W A ^a   Kuroda, M J ^a   Schmitz, J E ^a   Beaudry, K R ^a   Lin, W ^a   Lifton, M A ^a   Krivulka, G R ^a   Necker, A ^a   Letvin, N L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; EPITOPE; GAG PROTEIN; PEPTIDE; T LYMPHOCYTE RECEPTOR; TETRAMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGENIC VARIATION; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; IMMUNIZATION; LYMPHOCYTE COUNT; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; RNA REPLICATION; RNA SEQUENCE; RNA VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS INFECTION; VIRUS MUTATION;

EID: 0035500895     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.4996     Document Type: Article

References (28)

1. Definition of an epitope and MHC class I molecule recognized by gagspecific CTLs in SIVmac-infected rhesus monkeys
2. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus
3. The repertoire of CTLs in the recognition of mutant simian immunodeficiency virus variants
4. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
5. A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing
6. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
7. Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection
8. Heterologous and homologous protection against influenza A by DNA vaccination: Optimization of DNA vectors
9. Cytotoxic T lymphocyte and helper T cell responses following HIV polynucleotide vaccination
10. Vaccination of mice and nonhuman primates using HIV-gene-containing DNA
11. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Jg administration
12. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
13. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
14. + lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: Implications for vaccine design and testing
15. The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule
16. Presentation of antigenic peptides by products of the major histocompatibility complex
17. T-cell receptor peptide-MHC interactions: Biological lessons from structural studies
18. Structural basis of T cell recognition
19. Definition of the mamu-A*01 peptide binding specificity: Application to the identification of wild-type and optimized ligands from simian immunodeficiency virus regulatory proteins
20. + T lymphocyte response during primary SIVmac infection
21. Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation
22. Differential signaling by lymphocyte antigen receptors
23. T cell affinity maturation by selective expansion during infection
24. T cells compete for access to antigen-bearing antigen-presenting cells
25. + memory T cells by viral variants
26. Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type I (HIV-1) p24gag epitope by HIV-1-infected children
27. The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes