Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

American Journal of Clinical Nutrition

Volumn 77, Issue 5, 2003, Pages 1125-1132

  Tholstrup, Tine ^a   Miller, George J ^b   Bysted, Anette ^c   Sandström, Brittmarie ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Factor VII; Men; PAI 1; Plasminogen activator inhibitor type 1; Postprandial lipemia; Saturated fatty acids; Stearic acid; Tissue plasminogen activator; Unsaturated fatty acids

Indexed keywords

BLOOD CLOTTING FACTOR 7; FATTY ACID; LINOLEIC ACID; LIPOPROTEIN LIPASE; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; STEARIC ACID; TISSUE PLASMINOGEN ACTIVATOR; BLOOD CLOTTING FACTOR 7A; LIPID; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNSATURATED FATTY ACID; VOLATILE FATTY ACID;

ADULT; ARTICLE; BLOOD CLOTTING; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FAT INTAKE; FIBRINOLYSIS; HUMAN; HUMAN EXPERIMENT; LIPID DIET; MALE; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; POSTPRANDIAL STATE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; METABOLISM; RANDOMIZED CONTROLLED TRIAL;

ADULT; CROSS-OVER STUDIES; FACTOR VII; FACTOR VIIA; FATTY ACIDS; FATTY ACIDS, UNSATURATED; FATTY ACIDS, VOLATILE; FIBRINOLYSIS; HUMANS; LIPIDS; LIPOPROTEIN LIPASE; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1; POSTPRANDIAL PERIOD; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0037797299     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/77.5.1125     Document Type: Article

References (57)

1. Dubois C, Beaumier G, Juhel C, et al. Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. Am J Clin Nutr 1998;67:31-8.
2. Silveira A, Karpe F, Blombäck M, Steiner G, Walldius G, Hamsten A. Activation of coagulation factor VII during alimentary lipemia. Arterioscler Thromb 1994;14:60-9.
3. Byrne CD, Wareham NJ, Martensz ND, Humphries SE, Metcalfe JC, Grainger DJ. Increased PAI activity and PAI-1 antigen occurring with an oral fat load: associations with PAI-1 genotype and plasma active TGF-beta levels. Atherosclerosis 1998;140:45-53.
4. Broijersen A, Karpe F, Hamsten A, Goodall AH, Hjemdahl P. Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. Atherosclerosis 1998;137:107-13.
5. Connor WE, Poole JCF. The effect of fatty acids on the formation of thrombi. Q J Exp Physiol 1961;46:1-7.
6. Connor W. The acceleration of thrombus formation by certain fatty acids. J Clin Invest 1962;41:1199-205.
7. Botti RE, Ratnoff OD. The clot-promoting effect of soaps of long-chain saturated fatty acids. J Clin Invest 1963;42:1569-77.
8. Sanders TAB, Miller GJ, de Grassi T, Yahia N. Postprandial activation of coagulant factor VII by long-chain dietary fatty acids. Thromb Haemost 1996;76:369-71.
9. Roche HM, Zampelas A, Jackson KG, Williams CM, Gibney MJ. The effect of test meal monounsaturated fatty acid: saturated fatty acid ratio on postprandial lipid metabolism. Br J Nutr 1998;79:419-24.
10. Tholstrup T, Marckmann P, Jespersen J, Sandström B. Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. Am J Clin Nutr 1994;59:371-7.
11. Tholstrup T, Andreasen K, Sandström B. Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men. Am J Clin Nutr 1996;64:168-76.
12. Mennen L, de Maat M, Meijer G, et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition. A randomized controlled trial. Arterioscler Thromb Vasc Biol 1998;18:599-603.
13. Kleman LP, Finley JW, Leveille GA. Estimation of the absorption coefficient of stearic acid in SALATRIM. J Agric Food Chem 1994;42:484-8.
14. Sakr SW, Attia N, Haourigui M, et al. Fatty acid composition of an oral load affects chylomicron size in human subjects. Br J Nutr 1997;77:19-31.
15. Sanders TAB, de Grassi T, Miller GJ, Morrissey JH. Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). Atherosclerosis 2000;149:413-20.
16. Mitropoulos KA, Esnouf MP. The autoactivation of factor XII in the presence of long-chain saturated fatty acids - a comparison with the potency of sulphatides and dextran sulphate. Thromb Haemost 1991;66:446-52.
17. Mitropoulos KA, Miller GJ, Martin JC, Reeves BEA, Cooper J. Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. Arterioscler Thromb 1994;14:214-22.
18. Meade TW, Ruddock V, Stirling Y, Chakrabarti R, Miller GJ. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwich Park Heart Study. Lancet 1993;342:1076-9.
19. Folsom AR, Wu KK, Rosamund WD, Sharrett A, Richey PH, Chambles LE. Prospective study of hemostatic factors and coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997;96:1102-8.
20. Junker R, Heinrich J, Schulte H, van de Loo J, Assmann G. Coagulation factor VII and the risk of coronary heart disease in healthy men. Arterioscler Thromb Vasc Biol 1997;17:1539-44.
21. Tracy RP, Arnold AM, Ettinger W, Fried L, Meilahn E, Savage P. The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly: results from the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 1999;19:1776-83.
22. Cooper JA, Miller GJ, Bauer KA, et al. Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease. Circulation 2000;102:2816-22.
23. Astrup T. The haemostatic balance. Thrombos Diath Haemorrh 1958;2:347-57.
24. Nossel HL. Relative proteolysis of the fibrinogen chain by thrombin and plasmin as a determinant of thrombosis. Nature 1998;291:165-7.
25. Bauer KA, Kass BL, Cate H, Hawiger JJ, Rosenberg RD. Factor IX is activated in vivo by the tissue factor mechanism. Blood 1990;76:731-6.
26. Kohler HP, Grant PJ. Plasminogen-activator inhibitor type I and coronary artery disease. N Engl J Med 2000;342:1792-801.
27. Hamsten A, Walldius G, Dahlén G, Johansson B, Faire UD. Serum lipoproteins and apolipoproteins in young male survivors of myocardial infarction. Atherosclerosis 1986;59:223-35.
28. Geppert A, Beckmann R, Graf S, et al. Tissue-type plasminogen activator and type-1 plasminogen activator inhibitor in patients with coronary heart disease - relations to clinical variables and cardiovascular risk factors. Fibrinolysis 1995;9:109-13.
29. De Bono D. Significance of raised plasma concentrations of tissueplasminogen activator and plasminogen activator inhibitor in patients at risk from ischemic heart disease. Br Heart J 1994;71:504-17.
30. Nilsson L, Gafvels M, Musakka L, et al. VLDL activation of plasminogen activator inhibitor-1 (PAI-1) expression: involvement of the VLDL receptor. J Lipid Res 1999;40:913-9.
31. Banfi C, Risé P, Musssoni L, Galli C, Tremoli E. Linoleic acid enhances the secretion of plasminogen activator inhibitor type 1 by HepG2 cells. J Lipid Res 1997;38:860-9.
32. Constantino M, Merskey C, Kudzma DJ, Zucker MB. Increased activity of vitamin K-dependent clotting factors in human hyperlipoproteinaemia - association with cholesterol and triglyceride levels. Thromb Haemost 1977;38:465-74.
33. Tholstrup T, Sandström B, Bysted A, Hølmer G. Effect of six dietary fatty acids on postprandial lipid profile, plasma free fatty acids, lipoprotein lipase and cholesterol ester transfer activities in healthy young men. Am J Clin Nutr 2001;73:198-208.
34. Haraldsdóttir J, Holm L, Jensen JH, Møller A. Dietary habits in Denmark 1985. 1. Main results. Soeborg, Denmark: National Food Agency, 1986:1-152. (Publication 136.)
35. Marckmann P, Sandström B, Jespersen J. Fasting blood coagulation and fibrinolysis of young adults unchanged by reduction in dietary fat content. Arterioscler Thromb 1992;12:201-5.
36. Thomson JM, ed. Blood coagulation and haemostasis. A practical guide. 3rd ed. New York: Churchill Livingstone, 1985.
37. Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993;81:734-44.
38. Tholstrup T, Marckmann P, Hermansen JE, Hølmer G, Sandström B. Effect of modified dairy fat on fasting and postprandial haemostatic variables in healthy young men. Br J Nutr 1999;82:105-13.
39. Larsen LF, Bladbjerg EM, Jespersen J, Marckmann P. Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII. Arterioscler Thromb Vasc Biol 1997;17:2904-9.
40. Kapur R, Hoffman CJ, Bhushan V, Hultin MB. Postprandial elevation of activated factor VII in young adults. Arterioscler Thromb Vasc Biol 1996;16:1327-32.
41. Roche HM, Gibney MJ. Postprandial coagulation factor VII activity: the effect of monounsaturated fatty acids. Br J Nutr 1997;77:537-49.
42. Oakley FR, Sanders TAB, Miller GJ. Postprandial effects of an oleic acid-rich oil compared with butter on clotting factor VII and fibrinolysis in healthy men. Am J Clin Nutr 1998;68:1202-7.
43. Salomaa V, Rasi V, Pekkanen J, et al. The effects of saturated fat and n-6 polyunsaturated fat on postprandial lipemia and hemostatic activity. Atherosclerosis 1993;103:1-11.
44. Sanders TAB, Oakley FR, Cooper JA, Miller GJ. Influence of a stearic acid-rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects. Am J Clin Nutr 2001;73:715-21.
45. Mitropoulos KA, Miller GJ, Watts GF, Durrington PN. Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency. Atherosclerosis 1992;95:119-25.
46. Radcliffe R, Bagdasarian A, Colman R, Nemerson Y. Activation of bovine factor VII by Hageman factor fragments. Blood 1977;50:611-7.
47. Mitropoulos KA, Reeves BEA, Miller GJ. The activation of factor VII in citrated plasma by charged long-chain saturated fatty acids at the interface of large triglyceride-rich lipoprotein. Blood Coagul Fibrinolysis 1993;4:943-51.
48. Kjalke M, Silveira A, Hamsten A, Hedner U, Ezban M. Plasma lipoproteins enhance tissue factor-independent factor VII activation. Arterioscler Thromb Vasc Biol 2000;20:1835-41.
49. Miller GJ, Martin JC, Mitropoulos KA, et al. Activation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency. Blood 1996;87:4187-96.
50. Silveira A, Karpe F, Johnsson H, Bauer KA, Hamsten A. In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway. Arterioscler Thromb Vasc Biol 1996;16:1333-9.
51. Miller GJ, Cooke CJ, Nanjee MN, et al. Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia. Thromb Haemost 2002;87:477-82.
52. Andreotti F, Davies GJ, Hackett DR, et al. Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden cardiac death and stroke. Am J Cardiol 1988;62:635-7.
53. Byberg L, Vessby B, Lithell H. Unsaturated, but not saturated, dietary fatty acids are associated with plasminogen activator inhibitor-1 (PAI-1) activity in men. Atherosclerosis 2000;151:18 (abstr MoP1:W2).
54. Byberg L, Smedman A, Vessby B, Lithell H. Plasminogen activator inhibitor-1 and relations to fatty acid composition in the diet and in the serum cholesterol esters. Arterioscler Thromb Vasc Biol 2001;21:2086-92.
55. Mussoni L, Mannucci L, Sirtori M, et al. Hypertriglyceridemia and regulation of fibrinolytic activity. Arterioscler Thromb 1992;12:19-27.
56. Muller H, Seljeflot I, Solvoll K, Pedersen JI. Partially hydrogenated soybean oil reduces postprandial tPA activity compared with palm oil. Atherosclerosis 2001;155:467-76.
57. Marckmann P, Sandström B, Jespersen J. Dietary effects on circadian fluctuation in human blood coagulation factor VII and fibrinolysis. Atherosclerosis 1993;101:225-34.