The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain

Archives of Biochemistry and Biophysics

Volumn 414, Issue 2, 2003, Pages 232-243

  Xu, Liwen ^a   Simoni, Robert D ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Degradation; ER membrane bound protein; HMGal; HMGR; SCAP; Sterol regulated degradation

Indexed keywords

BETA GALACTOSIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEMBRANE PROTEIN; PHENYLALANINE; PROTEIN; PROTEIN HMGAL; REGULATOR PROTEIN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; COMPETITION; ENZYME ANALYSIS; ENZYME DEGRADATION; ESCHERICHIA COLI; MUTAGENESIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; WILD TYPE;

ESCHERICHIA COLI;

EID: 0037763809     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(03)00168-1     Document Type: Article

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