A3 receptors in cortical neurons: Pharmacological aspects and neuroprotection during hypoxia

Drug Development Research

Volumn 58, Issue 4, 2003, Pages 420-427

  Lewerenz, A ^a   Hentschel, S ^a   Vissiennon, Z ^a   Michael, S ^a   Nieber, K ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

A3 receptor; Cortex; Hypoxia; Pyramidal cells; Synaptic potentials

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 PHENYLETHYNYL) N ETHYLCARBOXAMIDE; 2 CHLORO 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 3 PROPYL 3 ETHYL 5 [(ETHYLTHIO)CARBONYL] 2 PHENYL 4 PROPYL 3 PYRIDINECARBOXYLATE; 6 ETHYL 4 PROPYL 2 PHENYL 3 PYRIDINECARBOXYLIC ACID 5 THIOCARBOXYLIC ACID 5 ETHYL 3 PROPYL ESTER; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

BINDING AFFINITY; BRAIN HYPOXIA; BRAIN ISCHEMIA; CINGULATE GYRUS; CONFERENCE PAPER; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; GENE IDENTIFICATION; MOLECULAR CLONING; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOPHYSIOLOGY; PYRAMIDAL NERVE CELL; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SYNAPSE; SYNAPTIC TRANSMISSION;

EID: 0037712610     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10187     Document Type: Conference Paper

References (62)

1. 3 receptors in rat brain. Mol Pharmacol 48:1038-1045.
2. 3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: studies hi human astroglioma cells. Biochem Biophys Res Commun 241:297-304.
3. 3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line. J Pharmacol Exp Ther 276:837-845.
4. Allgaier C, Hertting C, Kugelgen OV. 1987. The adenosine receptor-mediated inhibition of noradrenaline release possibly involves an N-protein and is increased by alpha 2-autoreceptor blockade. Br J Pharmacol 90:403-412.
5. Bachevalier J, Meunier M. 1996. Cerebral ischemia: are the memory deficits associated with hippocampal cell loss? Hippocampus 6:553-560.
6. Baraldi PG, Cacciari B, Romagnoli R, Merighi S, Varani K, Borea PA, Spalluto G. 2000. A(3) adenosine receptor ligands: history and perspectives. Med Res Rev 20:103-128.
7. Bernaudin M, Nouvelot A, MacKenzie ET, Petit E. 1998. Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia. Exp Neurol 150:30-39.
8. Brand A, Vissiennon Z, Eschke D, Nieber K. 2001. Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons. Neuropharmacology 40:85-95.
9. Coelho JE, de Mendonca A, Ribeiro JA. 2000. Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices. Brain Res 869:158-165.
10. 3 receptors: modulation of synaptic plasticity in the rat hippocampus. Neurosci Lett 302:53-57.
11. 2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus. J Neurochem 63:207-214.
12. Cunha RA, Ribeiro JA, Sebastiao AM. 1994b. Purinergic modulation of the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ectonucleotidases. Eur J Neurosci 6:33-42.
13. 3 receptors in rat brain. Soc Neurosci Abstr 19:42.
14. de Mendonca A, Ribeiro JA. 1993. Adenosine inhibits the NMDA receptor-mediated excitatory postsynaptic potential in the hippo-campus. Brain Res 606:351-356.
15. Deussen A. 2000. Metabolic flux rates of adenosine in the heart. Naunyn Schmiedebergs Arch Pharmacol 362:351-363.
16. Dunwiddie TV, Haas HL. 1985. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: evidence for a presynaptic site of action. J Physiol 369:365-377.
17. 1 receptor-mediated responses in rat hippo-campus. J Neurosci 17:607-614.
18. Dunwiddie TV, Masino SA. 2001. The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci 24:31-55.
19. Eschke D, Brand A, Scheibler P, Hess S, Eger K, Allgaier C, Nieber K. 2001. Effect of an adenosine A(1) receptor agonist and a novel pyrimidoindole on membrane properties and neurotransmitter release in rat cortical and hippocampal neurons. Neurochem Int 38:391-398.
20. Fleidervish IA, Gebhardt C, Astman N, Gutnick MJ, Heinemann U. 2001. Enhanced spontaneous transmitter release is the earliest consequence of neocortical hypoxia that can explain the disruption of normal circuit function. J Neurosci 21:4600-4608.
21. Fredholm BB, Dunwiddie TV. 1988. How does adenosine inhibit transmitter release? Trends Pharmacol Sci 9:130-134.
22. Fredholm BB. 1997. Adenosine and neuroprotection. Int Rev Neurobiol 40:259-280.
23. i by activation of adenosine receptors subtypes: a comparative study on human monocytes and macrophages. Naunyn-Schmiedebergs Arch Pharmacol 365:R32-115.
24. 3-selective adenosine agonists. J Med Chem 37:636-646.
25. Garcia de Arriba S, Franke H, Pissarek M, Nieber K, Illes P. 1999. Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia. Neurosci Lett 273:13-16.
26. Gessi S, Varani K, Merighi S, Cattabriga E, Iannotta V, Leung E, Baraldi PG, Borea PA. 2002. A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study. Mol Pharmacol 61:415-424.
27. 3 receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons. Rest Neurol Neurosci (in press).
28. 3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett 336:57-60.
29. 3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci 19:184-191.
30. Jacobson KA, Ravi RG, Nandanan E, Kim HS, Moro S, Kim YC, Lee K, Barak D, Marquez VE, Ji XD. 2001. Ribose modified nucleosides and nucleotides as ligands for purine receptors. Nucleosides Nucleotides Nucleic Acids 20:333-341.
31. 3-adenosine receptors: Drug Dev Res 33:51-59.
32. 3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 360:103-108.
33. Klotz KN. 2000. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol 362:382-391.
34. Kohno Y, Sei Y, Koshiba M, Kim HO, Jacobson KA. 1996. Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists. Biochem Biophys Res Commun 219:904-910.
35. 3 adenosine receptors on human eosinophils elevates intracellular calcium. Blood 88:3569-3574.
36. Latini S, Bordoni F, Pedata F, Corradetti R. 1999. Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices. Br J Pharmacol 127:729-739.
37. Lee JE, Bokoch G, Liang BT. 2001. A novel cardioprotective role of RhoA: new signaling mechanism for adenosine. FASEB J 15:1886-1894.
38. 3 adenosine receptor with widespread tissue distribution. Mol Pharmacol 44:524-532.
39. 3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci 15:298-306.
40. 2B adenosine receptors. Life Sci 62:1519-1524.
41. Mager R, Ferroni S, Schubert P. 1990. Adenosine modulates a voltage-dependent chloride conductance in cultured hippocampal neurons. Brain Res 532:58-62.
42. Meyerhof W, Müller-Brechlin R, Richter D. 1991. Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Lett 284:155-160.
43. Müller CE, Scior T. 1993. Adenosine receptors and their modulators. Pharm Acta Helv 68:77-111.
44. Müller CE. 2000. Adenosine receptor ligands-recent developments part I. Agonists. Curr Med Chem 7:1269-1288.
45. 1 adenosine receptors and their ligands: overview and recent developments. Farmaco 56:77-80.
46. Nieber K, Sevcik J, Illes P. 1995. Hypoxic changes in rat locus coeruleus neurons in vitro. J Physiol 486(Pt 1):33-46.
47. Nieber K. 1999. Hypoxia and neuronal function under in vitro conditions. Pharmacol Ther 82:71-86.
48. 3 adenosine receptor. Evidence for a G-protein-coupled receptor kinase-mediated mechanism. J Biol Chem 270:29607-29613.
49. Phillis JW, Song D, O'Regan MH. 1997. Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cortex. Brain Res 758:9-15.
50. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
51. 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 268:16887-16890.
52. Ribeiro JA. 1995. Purinergic inhibition of neurotransmitter release in the central nervous system. Pharmacol Toxicol 77:299-305.
53. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB. 1992. Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol Sci 13:439-445.
54. 3 adenosine receptor variant. FEBS Lett 382:125-129.
55. 3 adenosine receptor. Proc Natl Acad Sci USA 90:10365-10369.
56. Stiles GL. 1992. Adenosine receptors. J Biol Chem 267:6451-6454.
57. Vazquez E, Sanchez-Prieto J. 1997. Presynaptic modulation of glutamate release targets different calcium channels in rat cerebrocortical nerve terminals. Eur J Neurosci 9:2009-2018.
58. 1 receptor agonist or antagonist in cerebral ischemia. Eur J Pharmacol 256:161-167.
59. 3 receptor stimulation and cerebral ischemia. Eur J Pharmacol 263:59-67.
60. Wallman-Johansson A, Fredholm BB. 1994. Release of adenosine and other purines from hippocampal slices stimulated electrically or by hypoxia/hypoglycemia. Effect of chlormethiazole. Life Sci 55:721-728.
61. 3-subtype adenosine receptor is highly expressed in rat vascular smooth muscle cells: its role in attenuating adenosine-induced increase in cAMP. Microvasc Res 54:243-252.
62. 3 adenosine receptor. Proc Natl Acad Sci USA 89:7432-7436.