Metabolic flux rates of adenosine in the heart

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 4-5, 2000, Pages 351-363

  Deussen, A ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE KINASE; ADENOSINE PHOSPHATE; ADENOSINE PHOSPHATE DEAMINASE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP; INOSINE; PROTEIN KINASE C; S ADENOSYLHOMOCYSTEINE;

CYTOSOL; DEAMINATION; DEPHOSPHORYLATION; ENDOTHELIUM CELL; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HUMAN; MEMBRANE TRANSPORT; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE TRANSPORT; REVIEW; SMOOTH MUSCLE FIBER;

ADENOSINE; ANIMALS; CELL COMPARTMENTATION; HUMANS; MYOCARDIUM; SPECIES SPECIFICITY;

EID: 0033755843     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000318     Document Type: Review

References (207)

1. Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxia
2. Adenosine deaminase inhibition and myocardial purine release during normoxia and ischaemia
3. Vplyv antytil, spetsifichnykh do sarkolemy kardiomiotsytiv shchuriv, na aktyvnist 5-nukleotydazy
4. Degradation and resynthesis of adenine nucleotides in adult rat heart myocytes
5. Morphometry of exercise-induced right ventricular hypertrophy in the rat
6. Presence of adenosine deaminase on the surface of mononuclear blood cells: Immunochemical localization using light and electron microscopy
7. Activities and some properties of 5'-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine
8. Developmental alterations in 5'-nucleotidase kinetics and lipid composition of rat heart sarcolemma
9. Formation and deamination of adenosine by cardiac muscle enzymes
10. Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase
11. Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow
12. Control of mitochondrial respiration in the heart in vivo
13. Dietary lipids and 5'-nucleotidase activity of rat cell plasma membranes
14. Supply-to-demand ratio for oxygen determines formation of adenosine by the heart
15. Uric acid, the major catabolite of cardiac adenine nucleotides and adenosine, originates in the coronary endothelium
16. The cardiac effects of adenosine
17. Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow
18. A simple assay for ecto-5'-nucleotidase using intact pulmonary artery endothelial cells. Effect of endotoxin-induced cell injury
19. Species differences in adenosine metabolic sites in the heart
20. Adenine nucleotide release from isolated perfused guinea pig hearts and extracellular formation of adenosine
21. S-adenosylhomocysteine hydrolase activity in human myocardium
22. 5'-Nucleotidase activity of isolated mature rat cardiac myocytes
23. Nucleotide ectoenzyme activities of human and Chinese hamster fibroblasts in tissue culture
24. A study of the tissue distribution of adenosine deaminase in six mammal species
25. Influence of mioflazine on canine coronary blood flow and on adenine nucleotide and nucleoside content under normal and ischemic conditions
26. AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. 2. The determination of the degradation pathways using an adenosine deaminase inhibitor
27. Metabolism of adenine nucleotides in human blood
28. Nucleoside influx and efflux in guinea-pig ventricular myocytes. Inhibition by analogues of lidoflazine
29. The deaminases of adenosine and adenylic acid in blood and tissues
30. 5'-Nucleotidase and adenosine deaminase activities in hypertrophied rat heart. The effect of tachycardia
31. 2+-binding and enzyme activities in myocardium from hypothyroid rat
32. Purification and regulation of an AMP-specific cytosolic 5'-nucleotidase from dog heart
33. Immunogold localization of adenosine 5'-monophosphate-specific cytosolic 5'-nucleotidase in dog heart
34. Contribution of cytosolic and membrane-bound 5'-nucleotidases to cardiac adenosine production
35. Dissociation between adenosine release, MVO2, and energy status in working guinea pig hearts
36. Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release
37. Ischemic nucleotide breakdown increases during cardiac development due to drop in adenosine anabolism/catabolism ratio
38. The enzymatic synthesis of S-adenosylhomocysteine from adenosine and homocysteine
39. 2+ regulatory systems and ectonucleotidase activities in rat heart
40. New insights into the mechanism of myocardial adenosine formation
41. Assessment of local tissue adenosine by measurement of S-adenosylhomocysteine (SAH)
42. Contribution of coronary endothelial cells to cardiac adenosine production
43. Formation of S-adenosylhomocysteine in the heart. II. A sensitive index for regional myocardial underperfusion
44. Formation of S-adenosylhomocysteine in the heart. I. An index of free intracellular adenosine
45. Contribution of S-adenosylhomocysteine to cardiac adenosine formation
46. Transmural gradient of adenosine in canine heart during functional hyperemia
47. Formation and salvage of adenosine by macrovascular endothelial cells
48. Quantification of extracellular and intracellular adenosine production: Understanding the transmembranous concentration gradient
49. Abbau freier nucleotide in herz, skeletmuskel, gehirn und leber der ratte bei sauerstoffmangel
50. Monoclonal antibodies against 5'-nucleotidase from chicken gizzard. Evidence for species and tissue specific differences of 5'-nucleotidase
51. The simultaneous determination of cerebrospinal fluid and plasma adenosine deaminase activity as a diagnostic aid in tuberculous meningitis
52. Signal transduction in ischemic preconditioning
53. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth
54. Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway
55. Inhibition of adenosine metabolism increases myocardial interstitial adenosine concentrations and coronary flow
56. Properties of rat heart adenosine kinase
57. Kinetics of adenine nucleotide catabolism in coronary circulation of rats
58. Trypanosoma cruzi: Increased 5'-nucleotidase activity associated with dysfunction of adrenergic receptors in acutely infected albino Swiss mice
59. Vectorial production of adenosine by 5'-nucleotidase in the perfused rat heart
60. A specific inhibitor of heart cytosolic 5'-nucleotidase I attenuates hydrolysis of adenosine 5'-monophosphate in primary rat myocytes
61. Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart
62. Uber den stoffwechsel saureloslicher phosphor-verbindungen in der rattenniere
63. Oral dipyridamole increases plasma adenosine levels in human beings
64. Measurement of plasma adenosine concentration: Methodological and physiological considerations
65. The hydrolysis of extracellular adenine nucleotides by cultured endothelial cells from pig aorta. Feed-forward inhibition of adenosine production at the cell surface
66. The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells. Regulation of adenosine production at the cell surface
67. Inorganic phosphate as regulator of adenosine formation in isolated guinea pig hearts
68. 2 induced effects on purine metabolism in human endothelial cells
69. Cardiac 5'-nucleotidase activity increases with age and inversely relates to recovery from ischemia
70. Downregulation of 5'-nucleotidase in rabbit heart during coronary underperfusion
71. ATP, ADP and AMP in plasma from peripheral venous blood
72. Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells
73. Myocardial adenosine formation during hypoxia: Effects of ecto-5'-nucleotidase inhibition
74. Interstitial adenosine and cellular metabolism during beta-adrenergic stimulation of the in situ rabbit heart
75. Effect of i.v. dipyridamole on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits
76. S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in various tissues of mice given injections of 9-beta-D-arabinofuranosyladenine
77. Metabolism of circulating adenosine by the porcine isolated perfused lung
78. AMP deaminase in piglet cardiac myocytes: Effect on nucleotide metabolism during ischemia
79. Adenosine stimulation of AMP deaminase activity in adult rat cardiac myocytes
80. The PKC activator PMA preconditions rabbit heart in the presence of adenosine receptor blockade: Is 5'-nucleotidase important?
81. Effect of ischemia on adenine nucleotides in cardiac and skeletal muscle
82. Production of AMP and adenosine in the interstitial fluid compartment of the isolated perfused normoxic guinea pig heart
83. Regulation of rat heart cytosol 5'-nucleotidase by adenylate energy charge
84. Injured erythrocytes release adenosine deaminase into the circulation
85. Nitrobenzylthioinosine-sensitive nucleoside transport system: Mechanism of inhibition by dipyridamole
86. Species differences in nucleoside transport. A study of uridine transport and nitrobenzylthioinosine binding by mammalian erythrocytes
87. Enzyme-histochemical identification of lymphatic vessels by light and backscattered image scanning electron microscopy
88. The pathway of decomposition of myoadenylic acid during autolysis in various tissues
89. Alpha 1-adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C
90. Role of activation of protein kinase C in the infarct size-limiting effect of ischemic preconditioning through activation of ecto-5'-nucleotidase
91. Ecto-ATPases and 5'-nucleotidases in the caveolae of smooth muscle. Enzyme-histochemical evidence may indicate a role for caveolae in neurotransmission
92. Subcellular distribution of myocardial 5'-nucleotidase
93. Dipyridamole inhibition of adenosine metabolism in human blood
94. Effects of ions on adenosine binding and enzyme activity of purified S-adenosylhomocysteine hydrolase from bovine kidney
95. Nucleotide and adenosine metabolism in different cell types of human and rat heart
96. 5'-Nucleotidase and adenosine deaminase activities in blood of patients with unstable angina pectoris
97. Calcium in ischemic cell death
98. Immunobiology of pleural inflammation: Potential implications for pathogenesis, diagnosis and therapy
99. Steady-state catecholamine stimulation does not increase cytosolic adenosine in canine hearts
100. Adenosine kinetics in canine coronary circulation
101. Release of adenosine and cyclic AMP from coronary endothelium in isolated guinea pig hearts: Relation to coronary flow
102. Comprehensive model of transport and metabolism of adenosine and S-adenosylhomocysteine in the guinea pig heart
103. Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart
104. Ein beitrag zur physiologie der adenylsaure
105. Effect of various types of exercise training on 5'-nucleotidase and adenosine deaminase activities in rat heart: Influence of a single bout of endurance exercise
106. 5'-Adenylic acid deaminase. 3. Properties and kinetic studies
107. The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart
108. Determinants of the S-adenosylhomocysteine (SAH) technique for the local assessment of cardiac free cytosolic adenosine
109. Effect of aging on myocardial adenosine production, adenosine uptake and adenosine kinase activity in rats
110. Simultaneous assay of adenosine deaminase and purine nucleoside phosphorylase activity as possible biochemical means to detect non-Hodgkin lymphomas of the oral cavity
111. Morphometric analysis of the rabbit myocardium after chronic ethanol feeding - Early capillary changes
112. Magnesium activated adenosine formation in intact perfused heart: Predominance of ecto 5'-nucleotidase during hypermagnesemia
113. Surface adenosine deaminase. A novel B-cell marker in chronic lymphocytic leukemia
114. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule
115. Significance of adenosine metabolism of coronary smooth muscle cells
116. Adenosine formation and release from neonatal-rat heart cells in culture
117. Evidence for extracellular deamination of adenosine in the rat heart
118. Absolute rates of adenosine formation during ischaemia in rat and pigeon hearts
119. Intracellular adenosine formation and its carrier-mediated release in cultured embryonic chick heart cells
120. Regulation of extracellular adenosine production by ectonucleotidases of adult rat ventricular myocytes
121. Effect of 5'-deoxy-5'-isobutylthioadenosine on formation and release of adenosine from neonatal and adult rat ventricular myocytes
122. Kinetics of extracellular ATP hydrolysis by microvascular endothelial cells from rat heart
123. Characterization and localization of an ATP diphosphohydrolase activity (EC 3.6.1.5) in sarcolemmal membrane from rat heart
124. A comparison of some leucocyte differentiation markers and the adenosine deaminase and purine nucleoside phosphorylase values in B and T cell leukemias and lymphomas
125. Activation of protein kinase C increases adenosine production in the hypoxic canine coronary artery through the extracellular pathway
126. Inhibition of nitric oxide synthesis increases adenosine production via an extracellular pathway through activation of protein kinase C
127. Adenosine metabolism in microvessels from heart and brain
128. Ecto-5'-nucleotidase is expressed by pericytes and fibroblasts in the rat heart
129. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides
130. Adenosine deaminase (ADA) in leukemia: Clinical value of plasma ADA activity and characterization of leukemic cell ADA
131. Enzymes involved in purine metabolism - A review of histochemical localization and functional implications
132. Turnover of adenosine in plasma of human and dog blood
133. 5'-Nucleotidase from rat heart
134. 5'-Nucleotidase from rat heart membranes. Inhibition by adenine nucleotides and related compounds
135. New perspectives of myocardial adenine nucleotide metabolism
136. Isolation, identification, and continuous culture of coronary endothelial cells from guinea pig hearts
137. The coronary endothelium: A highly active metabolic barrier for adenosine
138. Critical evaluation of the role of ecto-and cytosolic 5'-nucleotidase in adenosine formation
139. The pigeon heart 5-nucleotidase responsible for ischaemia-induced adenosine formation
140. Adenosine production inside rat polymorphonuclear leucocytes
141. The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat
142. Adenosine formation. Evidence for a direct biochemical link with energy metabolism
143. Structure-activity relationship of ligands of human plasma adenosine deaminase-2
144. A1-receptor-mediated effect of adenosine on the release of acetylcholine from the myenteric plexus: Role and localization of ecto-ATPase and 5'-nucleotidase
145. Activation of ecto-5'-nucleotidase by protein kinase C and its role in ischaemic tolerance in the canine heart
146. 2+ in activation of protein kinase C during ischemic preconditioning
147. Tyramine produces interstitial adenosine-mediated activation of ecto-5'-nucleotidase in rat heart in vivo
148. NO and cGMP facilitate adenosine production in rat hearts via activation of ecto-5'-nucleotidase
149. Cardiovascular purinoceptors
150. Solubilization of rat heart sarcolemma 5'-nucleotidase by phosphatidylinositol-specific phospholipase C
151. Subcellular distribution of cardiac 5'-nucleotidase: Alteration of microsomal pool in hypertrophied pig heart
152. Subtypes of nucleoside transport inhibitory sites in heart: A quantitative autoradiographical analysis
153. Heterogeneity of nucleoside transport inhibitory sites in heart: A quantitative autoradiographical analysis
154. Adenosine receptors and nucleoside transport sites in cardiac cells
155. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides
156. Uptake and metabolism of adenosine by pig aortic endothelial and smooth-muscle cells in culture
157. Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture
158. Effects of chronic swimming training on cardiac sarcolemmal function and composition
159. Cardioprotection with ischemic preconditioning and MLA: Role of adenosine-regulating enzymes?
160. Contribution of endothelium and cardiomyocytes to hypoxia-induced adenosine release
161. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel
162. Adenine nucleotide degradation in the rabbit heart
163. Oxidants in mitochondria: From physiology to diseases
164. Apical-basal membrane polarity of membrane phosphatases in isolated capillary endothelium: Alteration in ultrastructural localisation under culture conditions
165. Plasma concentration of adenosine during normoxia and moderate hypoxia in humans
166. The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I
167. Stimulation of alpha 1-adrenoceptors and protein kinase C-mediated activation of ecto-5'-nucleotidase in rat hearts in vivo
168. Role of S-adenosyl-homocysteine hydrolase in adenosine metabolism in mammalian heart
169. Localization of adenosine deaminase and adenosine deaminase complexing protein in rabbit heart. Implications for adenosine metabolism
170. Purification of an adenosine deaminase complexing protein from human plasma
171. Localization of adenosine deaminase and adenosine deaminase complexing protein in rabbit brain
172. Subcellular distribution of adenosine deaminase and adenosine deaminase-complexing protein in rabbit kidney: Implications for adenosine metabolism
173. Different sites of adenosine formation in the heart
174. Cardiac endothelial transport and metabolism of adenosine and inosine
175. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
176. Soluble forms of 5'-nucleotidase in rat and human heart
177. Endothelial nucleotide catabolism and adenosine production
178. Hyperthyroidism increases adenosine transport and metabolism in the rat heart
179. Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells
180. Modulation of purinergic neurotransmission
181. Role of adenosine in adipose tissue circulation
182. Theophylline antagonizes cardiovascular responses to dipyridamole in man without affecting increases in plasma adenosine
183. Regulation of adenosine formation by the heart
184. Quantitative relation between interstitial adenosine concentration and coronary blood flow
185. Adenosine deaminase activity in plasma and blood cells of patients with haematological and autoimmune diseases
186. Inhibition of S-adenosyl-L-homocysteine hydrolase by adrenaline in isolated guinea-pig papillary muscles
187. Kinetics of adenylate metabolism in human and rat myocoardium
188. Adenosine transporters
189. Some enzyme characteristics of spontaneously hypertensive rats myocardium
190. 5'-Nucleotidases in rat heart. Evidence for the occurrence of two soluble enzymes with different substrate specificities
191. Adenosine deaminase isoenzyme levels in patients with human T-cell lymphotropic virus type 1 and human immunodeficiency virus type 1 infections
192. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise
193. Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase
194. Serum adenosine deaminase: Isoenzymes and diagnostic application
195. Adenosine deaminase isoenzymes in typhoid fever
196. Formation and release of nucleosides in the ischemic myocardium. Is the guinea-pig the exception?
197. Existence and role of substrate cycling between AMP and adenosine in isolated rabbit cardiomyocytes under control conditions and in ATP depletion
198. Postnatal changes in enzyme activities of rat myocardial adenine nucleotide catabolic pathway
199. Cerium-induced light-microscopic demonstration of 5'-nucleotidase activity in the lymphatic capillaries of the proximal oesophagus of the rat
200. Regulation of soluble 5'-nucleotidase I from rabbit heart
201. 5'-Nucleotidase I from rabbit heart
202. Steady-state binding of adenine nucleotides ATP, ADP and AMP to rat liver and adipose plasma membranes
203. Plasma adenosine and cardiovascular responses to dipyridamole in fetal sheep
204. Pathways of adenine nucleotide catabolism in primary rat cardiomyocyte cultures