Mycobacterium avium subspecies paratuberculosis: A review of current knowledge

Journal of Zoo and Wildlife Medicine

Volumn 32, Issue 3, 2001, Pages 293-304

  Manning, Elizabeth J B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Artiodactylids; Johne's disease; Mycobacterium avium subspecies paratuberculosis; Paratuberculosis; Wildlife

Indexed keywords

ANIMAL; BOVIDS; DOMESTIC ANIMAL; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; MYCOBACTERIUM PARATUBERCULOSIS; PARATUBERCULOSIS; PHYSIOLOGY; REVIEW; WILD ANIMAL; ZOONOSIS;

ANIMALS; ANIMALS, DOMESTIC; ANIMALS, WILD; HUMANS; MYCOBACTERIUM PARATUBERCULOSIS; PARATUBERCULOSIS; RUMINANTS; ZOONOSES;

EID: 0037667217     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: 10.1638/1042-7260(2001)032[0293:maspar]2.0.co;2     Document Type: Review

References (120)

1. Abbas, B., K. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Calif. Vet. J. 383: 787-793.
2. Abel, L., F. O. Sanchez, J. Oberti, N. V. Thuc, L. V. Hoa, V. D. Lap, E. Skamene, P. H. Lagrange, and E. Schurr. 1998. Susceptibility to leprosy is linked to the human NRAMP1 gene. J. Infect. Dis. 177: 133-145.
3. Adams, J. L., M. T. Collins, and C. J. Czuprynski. 1996. Polymerase chain reaction analysis of TNF-α and IL-6 mRNA levels in whole blood from cattle naturally or experimentally infected with Mycobacterium paratuberculosis. Can. J. Vet. Res. 60: 257-262.
4. Adams, J. L., and C. J. Czuprynski. 1995. Ex vivo induction of TNF-α and IL-6 mRNA in bovine whole blood by Mycobacterium paratuberculosis and mycobacterial cell wall components. Microbiol. Pathol. 19: 19-29.
5. Advisory Committee on the Microbiological Safety of Food. 2000. Heat resistance of Mycobacterium avium subsp. paratuberculosis (MAP) in milk at pasteurisation temperatures. http://www.foodstandards.gov.uk/pdf_files/ papers/acm486.pdf ACM/486, 1-7. Accessed 1 September 2000.
6. Allworth, M. B., and D. J. Kennedy. 1999. Progress in national control and assurance programs for ovine Johne's disease in Australia. Proc. Int. Colloq. Paratuberc. 6: 33-38.
7. Alzuherri, H. M., C. J. Woodall, and C. J. Clarke. 1996. Increased intestinal TNF-alpha, IL-1-beta and IL-6 expression in ovine paratuberculosis. Vet. Immunol. Immunopathol. 49: 331-345.
8. Aziz, M., A. Malik, S. M. Abbas, S. Vasenwala, and A. Kalam. 1996. Prognostic evaluation of cell mediated immunity in leprosy and correlation with clinicopathological status of leprosy patients. Indian J. Pathol. Microbiol. 39: 5-12.
9. Beard, P., M. J. Daniels, D. Henderson, A. A. Pirie, K. Rudge, D. Buxton, S. Rhind, A. Greig, M. R. Hutchings, I. McKendrick, K. Stevenson, and J. M. Sharp. 2001. Paratuberculosis infection in nonruminant wildlife in Scotland. J. Clin. Microbiol. 39: 1517-1521.
10. Benedictus, G., J. Verhoeff, Y. H. Schukken, and J. W. Hesselink. 2000. Dutch paratuberculosis programme history, principles and development. Vet. Microbiol. 77: 399-413.
11. Bentley-Hibbert, S. I., X. Quan, T. Newman, K. Huygen, and H. Godfrey. 1999. Pathophysiology of antigen 85 in patients with active tuberculosis: antigen 85 circulates as complexes with fribronectin and immunoglobulin G. Infect. Immun. 67: 581-588.
12. Beutler, B., and A. Cerami. 1989. The biology of cachectin/TNF-α primary mediator of the host response. Annu. Rev. Immunol. 7: 625-655.
13. Billman-Jacobe, H., M. Carrigan, F. Cockram, L. A. Corner, I. J. Gill, J. F. Hill, A. R. Milner, and P. R. Wood. 1992. A comparison of the interferon gamma assay with the absorbed ELISA for the diagnosis of Johne's disease in cattle. Aust. Vet. J. 69: 25-28.
14. Brown, W. C., A. C. Rice-Ficht, and D. M. Estes. 1998. Bovine type I and type II responses. Vet. Immunol. Immunopathol. 63: 45-55.
15. Buergelt, C. D., and P. E. Ginn. 2000. The histopathologic diagnosis of subclinical Johne's disease in North American bison (Bison bison). Vet. Microbiol. 77: 325-331.
16. Buergelt, C. D., A. W. Layton, P. E. Ginn, M. Taylor, J. M. King, P. L. Habecker, E. Mauldin, R. Whitlock, C. Rossiter, and M. T. Collins. 2000. The pathology of spontaneous paratuberculosis in the North American bison (Bison bison). Vet. Pathol. 37: 428-438.
17. Buergelt, C. D., M. O. Pool, and E. Williams. 1978. Pathological evaluation of paratuberculosis in naturally infected cattle. Vet. Pathol. 15: 196-207.
18. Bull, T. J., I. Pavlik, J. Hermon-Taylor, F. A. El-Zaatari, and M. L. Tizard. 1999. Study of IS900 loci in Mycobacterium avium subsp. paratuberculosis by multiplex PCR screening. Proc. Int. Colloq. Paratuberc. 6: 265-274.
19. Camphausen, R. T., R. L. Jones, and P. J. Brennan. 1985. A glycolipid antigen specific to Mycobacterium paratuberculosis: structure and antigenicity. Proc. Natl. Acad. Sci. USA 82: 3068-3072.
20. Camphausen, R. T., R. L. Jones, and P. J. Brennan. 1988. Antigenic relationship between Mycobacterium paratuberculosis and Mycobacterium avium. Am. J. Vet. Res. 49: 1307-1310.
21. Cetinkaya, B., H. M. Erdogan, and K. L. Morgan. 1997. Relationships between the presence of Johne's disease and farm and management factors in dairy cattle in England. Prev. Vet. Med. 32: 253-266.
22. Chiodini, R. J., and J. Hermon-Taylor. 1993. The thermal resistance of Mycobacterium paratuberculosis in raw milk under conditions simulating pasteurization. J. Vet. Diagn. Invest. 5: 629-631.
23. Chiodini, R. J. and C. A. Rossiter. 1996. Paratuberculosis: a potential zoonosis? In: Sweeney, R. W. (ed.). Paratuberculosis (Johne's Disease). W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 457-467.
24. Clarke, C. J. 1997. The pathology and pathogenesis of paratuberculosis in ruminants and other species. J. Comp. Pathol. 116: 217-261.
25. Clarke, C. J., and C. L. Little. 1996. The pathology of ovine paratuberculosis: gross and histological changes in the intestine. J. Comp. Pathol. 114: 419-437.
26. Colgrove, C. S., C. O. Thoen, B. O. Blackburn, and C. D. Murphy. 1989. Paratuberculosis in cattle: a comparison of three serologic tests with results of fecal culture. Vet. Microbiol. 19: 183-187.
27. Collins, D. M., D. M. Gabric, and G. W. de Lisle. 1989. Identification of a repetitive DNA sequence specific to Mycobacterium paratuberculosis. Fed. Eur. Microbiol. Soc. Lett. 60: 175-178.
28. Collins, M. T. 1996. Diagnosis of paratuberculosis. Vet. Clin. North Am. Food Anim. Pract. 12: 357-371.
29. Collins, M. T. 1997: Mycobacterium paratuberculosis: a potential food-borne pathogen? J. Dairy Sci. 80: 3445-3448.
30. Collins, M. T., K. B. Kenefick, D. C. Sockett, R. S. Lambrecht, J. McDonald, and J. B. Jørgensen. 1990. Enhanced radiometric detection of M. paratuberculosis using filter concentrated bovine fecal specimens. J. Clin. Microbiol. 28: 2514-2519.
31. Collins, M. T., G. Lisby, C. Moser, D. Chicks, S. Christensen, M. Reichelderfer, N. Høiby, B. A. Harms, O. O. Thomsen, U. Skibsted, and V. Binder. 2000. Results of multiple diagnostic tests of Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and in controls. J. Clin. Microbiol. 38: 4373-4381.
32. Condron, R. J., A. F. Hope, P. F. Kluver, S. Jones, and H. W. Millar. 1999. Performance of diagnostic tests to detect ovine Johne's disease. Proc. Int. Colloq. Paratuberc. 6: 503.
33. Cook, W. E., T. E. Cornish, S. Shideler, B. Lasley, and M. T. Collins. 1997. Radiometric culture of Mycobacterium avium paratuberculosis from the feces of rule elk. J. Wildl. Dis. 33: 635-637.
34. Cousins, D. V., R. Whittington, I. Marsh, A. Masters, R. J. Evans, and P. Kluver. 1999. Mycobacteria distinct from Mycobacterium avium subsp. paratuberculosis isolated from the faeces of ruminants possess IS900-like sequences detectable by IS900 polymerase chain reaction: implications for diagnosis. Mol. Cell. Probes 13: 431-442.
35. Cox, J. C., D. P. Drane, S. L. Jones, S. Ridge, and A. R. Milner. 1991. Development and evaluation of a rapid absorbed enzyme immunoassay test for the diagnosis of Johne's disease in cattle. Aust. Vet. J. 68: 157-160.
36. Doyle, T. M. 1958. Foetal infection in Johne's disease. Vet. Rec. 70: 238-241.
37. Dubash, K., W. P. Shulaw, S. Bech-Nielsen, H. F. Stills, and R. D. Selmons. 1996. Evaluation of an agar gel immunodiffusion test kit for detection of antibodies to Mycobacterium paratuberculosis in sheep. J. Am. Vet. Med. Assoc. 208: 401-403.
38. Dumonceau, J. M., A. Van Gossum, M. Adler, P. A. Fonteyne, J. P. Van Vooren, J. Devière, and F. Portaels. 1996. No Mycobacterium paratuberculosis found in Crohn's disease using the polymerase chain reaction. Digest. Dis. Sci. 41: 421-426.
39. Gardner, I. A., S. Heitala, and W. M. Boyce. 1996. Validity of using serological tests for diagnosis of diseases in wild animals. Rev. Sci. Tech. Off. Int. Epizoot. 15: 323-335.
40. Gilot, P., M. De Kessel, M. Coene, and C. Cocito. 1992. Induction of cellular immune reactions by A36, an antigen complex of Mycobacterium paratuberculosis. Comparison of A36 and johnin components. Scand. J. Immunol. 36: 811-821.
41. Gomes, M. S., and R. Appelberg. 1998. Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium. Immunology 95: 165-168.
42. Govoni, G., and P. Gros. 1998. Macrophage NRAMP1 and its role in resistance to microbial infections. Inflammation Res. 47: 277-284.
43. Grant, I. R., H. J. Ball, and M. T. Rowe. 1998. Isolation of Mycobacterium paratuberculosis from milk by immunomagnetic separation. Appl. Environ. Microbiol. 64: 3153-3158.
44. Greig, A., K. Stevenson, D. Henderson, V. Perez, V. Hughes, I. Pavlik, M. E. Hines, I. McKendrick, and J. M. Sharp. 1999. Epidemiological study of paratuberculosis in wild rabbits in Scotland. J. Clin. Microbiol. 37: 1746-1751.
45. Hampe, J., A. Cuthbert, P. J. P. Croucher, M. M. Mirza, S. Mascheretti, S. Fisher, H. Frenzel, K. King, A. Hasselmeyer, A. J. S. MacPherson, S. Bridger, S. van Deventer, A. Forbes, S. Nikolaus, J. E. Lennard-Jones, U. R. Foelsch, M. Krawczak, C. Lewis, S. Schreiber, and C. G. Mathew. 2001. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Nature 357: 1925-1928.
46. Hermon-Taylor, J., T. J. Bull, J. M. Sheridan, J. Cheng, M. L. Stellakis, and N. Sumar. 2000. The causation of Crohn's disease by Mycobacterium avium subspecies paratuberculosis. Can. J. Gastroenterol. 14: 521-539.
47. Horowitz, M. A., G. Harth, B. J. Dillion, and S. Maslesa-Galic. 2000. Recombinant bacillus Calmette-Guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc. Natl. Acad. Sci. USA 97: 13853-13858.
48. Hugot, J. P., M. Chamaillard, H. Zouali, S. Lesage, J. P. Cezard, J. Belaiche, S. Almer, C. Tysk, C. A. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J. F. Colombel, M. Sahbatou, and G. Thomas. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 411: 599-603.
49. Jessup, D. A., and E. Williams. 1999. Paratuberculosis in free-ranging wildlife in North America. In: Fowler, M. E., and R. E. Miller (eds.). Zoo and Wild Animal Medicine. Current Therapy 4. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 616-620.
50. Johnson-Ifearulundu, Y. J., and J. B. Kaneene. 1997. Epidemiology and economic impact of subclinical Johne's disease: a review. Vet. Bull. 67: 437-447.
51. Johnson-Ifearulundu, Y. J., and J. B. Kaneene. 1998. Management-related risk factors for M. paratuberculosis infection in Michigan, USA, dairy herds. Prev. Vet. Med. 37: 41-54.
52. Johnson-Ifearulundu, Y., and J. B. Kaneene. 1999. Distribution and environmental risk factors for paratuberculosis in dairy cattle herds in Michigan. Am. J. Vet. Res. 60: 589-596.
53. Kalis, C. H. J., J. W. Hesselink, and H. W. Barkema. 1999. Long-term use of a killed vaccine does not prevent fecal shedding of Mycobacterim avium subsp. paratuberculosis. Proc. Int. Colloq. Paratuberc. 6: 153-156.
54. Kanazawa, K., Y. Haga, O. Funakoshi, H. Nakajima, A. Munakata, and Y. Yoshida. 1999. Absence of Mycobacterium paratuberculosis DNA in intestinal tissues from Crohn's disease by nested polymerase chain reaction. J. Gastroenterol. 34: 200-206.
55. Kennedy, D. J., and M. B. Allworth. 1999. Progress in national control and assurance programs for bovine Johne's disease in Australia. Proc. Int. Colloq. Paratuberc. 6: 19-26.
56. Keswani, J., and J. F. Frank. 1998. Thermal inactivation of Mycobacterium paratuberculosis in milk. J. Food Protect. 61: 974-978.
57. Koets, A. P., G. Adugna, L. L. G. Janss, H. J. van Weering, C. H. J. Kalis, G. H. Wentink, V. P. M. G. Rutten, and Y. H. Schukken. 2000. Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. J. Dairy Sci. 83: 2702-2708.
58. Koets, A. P., V. P. M. G. Rutten, A. Hoek, D. Bakker, F. van Zijderveld, K. E. Müller, and W. van Eden. 1999. The T(h) 1 to T(h) 2 shift in bovine paratuberculosis and the role of apoptotic cell death. Proc. Int. Colloq. Paratuberc. 6: 585-592.
59. Larsen, A. B. 1981. Mycobacterium paratuberculosis in the semen and genital organs of a semen-donor bull. J. Am. Vet. Med. Assoc. 179: 169-171.
60. Larsen, A. B., R. S. Merkal, and R. C. Cutlip. 1975. Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis. Am. J. Vet. Res. 36: 255-257.
61. Larsen, A. B., R. S. Merkal, and T. H. Vardaman. 1956. Survival time of Mycobacterium paratuberculosis. Am. J. Vet. Res. 13: 549-551.
62. Lovell, R., M. Levi, and J. Francis. 1944. Studies on the survival of Johne's bacilli. J. Comp. Pathol. 54: 120-129.
63. Mackintosh, C. G., T. Qureshi, K. Waldrup, R. E. Labes, K. G. Dodds, and J. F. Griffin. 2000. Genetic resistance to experimental infection with Mycobacterium bovis in red deer (Cervus elaphus). Infect. Immun. 68: 1620-1625.
64. Mackintosh, C. G., M. P. Reichel, J. F. T. Griffin, H. Montgomery, and G. W. de Lisle. 1999. Paratuberculosis and avian tuberculosis in red deer in New Zealand: clinical syndromes and diagnostic tests. Proc. Int. Colloq. Paratuberc. 6: 449-457.
65. Mangold, B. J. 1999. Detection of elevated levels of circulating antigen 85 by dot immunobinding assay in captive wild animals with tuberculosis. J. Zoo Wildl. Med. 30: 477-483.
66. Manning, E. J. B., and M. T. Collins. 1999. Paratuberculosis in zoo animals In: Fowler, M. E., and R. E. Miller (eds.). Zoo and Wild Animal Medicine. Current Therapy 4. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 612-616.
67. Manning, E. J. B., J. A. Kramsky, and M. T. Collins. 1999. Johne's disease diagnosis for non-domestic hoofstock. Proc. Int. Colloq. Paratuberc. 6: 458-461.
68. Manning, E. J. B., and M. Ziccardi. 2000. Johne's disease and captive non-domestic hoofstock: prevalence and prevention. Proc. Am. Assoc. Zoo Vet./Int. Assoc. Aquatic Anim. Med. Annu. Meet. 2000: 432-434.
69. Miller, D. S., B. B. Smith, T. Gerros, M. T. Collins, J. Cooley, and J. McClure. 1999. Paratuberculosis in liamas and alpacas. Compend. Cont. Ed. Pract. Vet. 21: S220-S229.
70. Mishina, D., P. Katsel, S. T. Brown, E. C. Gilberts, and R. J. Greenstein. 1996. On the etiology of Crohn's disease. Proc. Natl. Acad. Sci. USA 93: 9816-9820.
71. Momotani, E., D. L. Whipple, A. B. Thiermann, and N. F. Cheville. 1988. Role of M cells and macrophages in the entrance of Mycobacterium paratuberculosis into domes of ileal Peyer's patches in calves. Vet. Pathol. 25: 131-137.
72. Mutharia, L. M., W. Moreno, and M. Raymond. 1997. Analysis of culture filtrate and cell wall-associated antigens of Mycobacterium paratuberculosis with monoclonal antibodies. Infect. Immun. 65: 387-394.
73. Naser, S. A., D. Schwartz, and I. Shafran. 2000. Isolation of Mycobacterium avium subsp. paratuberculosis from breast milk of Crohn's disease patients. Am. J. Gastroenterol. 95: 1094-1095.
74. Ogura, Y., D. K. Bonen, N. Inohara, D. L. Nicolae, F. F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R. H. Duerr, J. P. Achkar, S. R. Brant, T. M. Bayless, B. S. Kirschner, S. B. Hanauer, G. Nunez, and J. H. Cho. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
75. Olsen, I., M. Tryland, H. G. Wiker, and L. J. Reitan. 2001. 1 A.D. AhpC, AhpD and a secreted 14-kilodalton antigen from M. avium ss. paratuberculosis distinguish between paratuberculosis and bovine tuberculosis in an enzyme-linked immunosorbent assay. Clin. Diagn. Lab. Immunol. 8: 797-801.
76. Orme, I. M. 1993. Immunity to mycobacteria. Curr. Opin. Immunol. 5: 5.
77. Patterson, D. S., W. M. Allen, and M. K. Lloyd. 1967. Clinical Johne's as a protein losing enteropathy. Vet. Rec. 81: 717-718.
78. Pavlik, I., J. Bartl, L. Dvorska, P. Svastova, A. du Maine, M. Machackova, W. Y. Ayele, and A. Horvathova. 2000. Epidemiology of paratuberculosis in wild ruminants studied by restriction fragment length polymorphism in the Czech Republic during the period 1995-1998. Vet. Microbiol. 77: 231-251.
79. Pavlik, I., L. Matlova, J. Bartl, P. Svastova, L. Dvorska, and R. Whitlock. 1999. Parallel faecal and organ Mycobacterium avium subsp. paratuberculosis culture showing organism distribution in different breeds of cattle. Proc. Int. Colloq. Paratuberc. 6: 642-656.
80. Payne, J. M., and J. D. Rankin. 1961. The pathogenesis of experimental Johne's disease in calves. Res. Vet. Sci. 2: 167-174.
81. Perez, V., M. J. Garcia, and J. J. Badiola. 1996. Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep. J. Comp. Pathol. 114: 107-122.
82. Perez, V., J. Tellechea, J. M. Corpa, M. Gutierrez, and J. E G. Marin. 1990. Relation between pathologic findings and cellular immune responses in sheep with naturally acquired paratuberculosis. Am. J. Vet. Res. 60: 123-127.
83. Power, C. A., G. Wei, and P. A. Bretscher. 1998. Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by the intravenous, subcutaneous, or intradermal route. Infect. Immun. 66: 5743-5750.
84. Rankin, J. D. 1961. The experimental infection of cattle with Mycobacterium johnei. III. Calves maintained in an infectious environment. J. Comp. Pathol. 71: 10-15.
85. Reichel, M. P., R. Kittelberger, M. E. Penrose, R. M. Meynell, D. Cousins, T. Ellis, L. M. Mutharia, E. A. Sugden, A. H. Johns, and G. W. de Lisle. 1999. Comparison of serological tests and faecal culture for the detection of Mycobacterium avium subsp. paratuberculosis infection in cattle and analysis of the antigens involved. Vet. Microbiol. 66: 135-150.
86. Ridley, D. S. 1989. The histopathological spectrum of mycobacterioses. In: Ratledge, C., and J. L. Stanford (eds.). The Biology of the Mycobacteria, vol. 2. Immunological and Environmental Aspects. Academic Press, London, U.K. Pp. 129-171.
87. Rothel, J. S., S. L. Jones, L. A. Corner, J. C. Cox, and P. R. Wood. 1990. A sandwich enzyme immunoassay for bovine interferon-gamma and its use for the detection of tuberculosis in cattle. Aust. Vet. J. 67: 134-137.
88. Rowe, M. T., I. R. Grant, L. Dundee, and H. J. Ball. 2000. Heat resistance of Mycobacterium avium subsp. paratuberculosis in milk. Irish J. Agric. Food Res. 39: 203-208.
89. Schroen, C., P. Kluver, W. McDonald, K. Butler, R. Condron, and A. Hope. 1999. Survival of M. paratuberculosis in the Environment. Report to Meat and Livestock Australia. Meat and Livestock Australia, Sydney, Australia.
90. Schulze-Roebbecke, R., and K. Buchholtz. 1992. Heat susceptibility of aquatic mycobacteria. Appl. Environ. Microbiol. 58: 1869-1873.
91. Seitz, S. E., L. E. Heider, W. D. Hueston, S. Bech-Nielsen, M. Rings, and L. Spangler. 1989. Bovine fetal infection with Mycobacterium paratuberculosis. J. Am. Vet. Med. Assoc. 194: 1423-1426.
92. Skamene, E., E. Schurr, and P. Gros. 1998. Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Annu. Rev. Med. 49: 275-287.
93. Slagame, P., J. S. Abrams, and C. Clayberger. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science 254: 279-282.
94. Sockett, D. C., D. J. Carr, and M. T. Collins. 1992. Evaluation of conventional and radiometric fecal culture and a commercial DNA probe for diagnosis of Mycobacterium paratuberculosis infections in cattle. Can. J. Vet. Res. 56: 148-153.
95. Sockett, D. C., T. A. Conrad, C. B. Thomas, and M. T. Collins. 1992. Evaluation of four serological tests for bovine paratuberculosis. J. Clin. Microbiol. 30: 1134-1139.
96. Stabel, J. R. 1999. Transitions in immune response to M. a. paratuberculosis. Proc. Int. Colloq. Paratuberc. 6: 579-584.
97. Stabel, J. R., E. M. Steadham, and C. A. Bolin. 1997. Heat inactivation of Mycobacterium paratuberculosis in raw milk: are current pasteurization conditions effective? Appl. Environ. Microbiol. 63: 4975-4977.
98. Stehman, S. M. 1996. Paratuberculosis in small ruminants, deer, and South American camelids. Vet. Clin. North Am. Food Anim. Pract. 12: 441-455.
99. Steinberg, H. 1981. Johne's disease (Mycobacterium paratuberculosis) in a Jemela topi (Damaliscus lunatus jimela). J. Zoo Anim. Med. 19: 33-41.
100. Streeter, R. N., G. F. Hoffsis, S. Bech-Nielsen, W. P. Shulaw, and M. Rings. 1995. Isolation of Mycobacterium paratuberculosis from colostrum and milk of subclinically infected cows. Am. J. Vet. Res. 56: 1322-1324.
101. Suenaga, K., Y. Yokayama, K. Okazaki, and Y. Yamamoto. 1995. Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease. Am. J. Gastroenterol. 90: 76-80.
102. Sung, N., and M. T. Collins. 1998. Thermal tolerance of Mycobacterium paratuberculosis. Appl. Environ. Microbiol. 64: 999-1005.
103. Sweeney, R. W., R. H. Whitlock, and A. E. Rosenberger. 1992. Mycobacterium paratuberculosis cultured from milk and supramammary lymph nodes of infected asymptomatic cows. J. Clin. Microbiol. 30: 166-171.
104. Sweeney, R. W., R. H. Whitlock, and A. E. Rosenberger. 1992. Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease. Am. J. Vet. Res. 53: 477-480.
105. Taylor, R. H., J. O. Falkinham, C. D. Norton, and M. W. LeChevallier. 2000. Chlorine, chloramine, chlorine dioxide, and ozone susceptibility of Mycobacterium avium. Appl. Environ. Microbiol. 66: 1702-1755.
106. Taylor, T. K., C. R. Wilks, and D. S. McQueen. 1981. Isolation of Mycobacterium paratuberculosis from milk of a cow with Johne's disease. Vet. Rec. 109: 532-533.
107. Thorel, M. F., M.-C. Blom-Potar, and N. Rastogi. 1990. Characterization of Mycobacterium paratuberculosis and "wood-pigeon" mycobacteria by isoenzyme profile and selective staining of immunoprecipitates. Res. Microbiol. 141: 551-561.
108. United States Animal Health Association, National Johne's Disease Working Group Certification Subcommittee. 1999. U.S. Voluntary Johne's Disease Herd Status Program for Cattle. http://www.usaha.org/reports/reports01/ r01johnes.html. 26/3/2002.
109. United States Environmental Protection Agency (EPA). 1999. Ultraviolet radiation. In: EPA Guidance Manual. Alternative Disinfectants and Oxidants. EPA, Washington, D.C. Pp. 1-25.
110. van der Giessen, J., L. van Dijk, N. Bleumink-Pluym, T. Eger, J. Haagsma, and B. van der Zeijst. 1995. The spatial distribution of Mycobacterium paratuberculosis in infected cattle. Implications for pathogenesis and diagnosis. Proc. Int. Colloq. Paratuberc. 4: 61-66.
111. Van Kruiningen, H. J. 1999. Lack of support for a common etiology in Johne's disease of animals and Crohn's disease in humans. Inflammatory Bowel Dis. 5: 183-191.
112. Vary, P. H., P. R. Andersen, E. Green, J. Hermon-Taylor, and J. J. McFadden. 1990. Use of highly specific DNA probes and the polymerase chain reaction to detect Mycobacterium paratuberculosis in Johne's disease. J. Clin. Microbiol. 28: 933-937.
113. Walsh, T. F., R. Barbiers, and M. T. Collins. 1995. Enteric Mycobacterium paratuberculosis in a mandrill (Papio sphinx). Proc. Am. Assoc. Zoo Vet./Wildl. Dis. Assoc. Annu. Meet. 1995: 262-264.
114. Whipple, D. L., P. A. Kapke, and P. R. Andersen. 1992. Comparison of a commercial DNA probe test and three cultivation procedures for detection of Mycobacterium paratuberculosis in bovine feces. J. Vet. Diagn. Invest. 4: 23-27.
115. Whitlock, R. H., S. J. Wells, R. W. Sweeney, and J. Van Tiem. 2000. ELISA and fecal culture for paratuberculosis (Johne's disease): sensitivity and specificity of each method. Vet. Microbiol. 77: 387-398.
116. Whittington, R. J., A. F. Hope, D. J. Marshall, C. A. Taragel, and I. Marsh. 2000. Molecular epidemiology of Mycobacterium avium subsp. paratuberculosis: IS900 restriction fragment length polymorphism and IS1311 polymorphism analyses of isolates from animals and a human in Australia. J. Clin. Microbiol. 38: 3240-3248.
117. Whittington, R. J., I. Marsh, E. Choy, and D. Cousins. 2000. Polymorphisms in IS1311, an insertion sequence common to Mycobacterium avium and Mycobacterium avium subsp. paratuberculosis, can be used to distinguish between and within these species. Mol. Cell. Probes 12: 349-358.
118. Whittington, R. J., I. Marsh, S. McAllister, M. J. Turner, D. J. Marshall, and C. A. Fraser. 1999. Evaluation of modified BACTEC 12B radiometric medium and solid media for culture of Mycobacterium avium subsp. paratuberculosis from sheep. J. Clin. Microbiol. 37: 1077-1083.
119. Whittington, R. J., I. Marsh, M. J. Turner, S. McAllister, E. Choy, G. J. Eamens, D. J. Marshall, and S. Ottaway. 1998. Rapid detection of Mycobacterium paratuberculosis in clinical samples from ruminants and in spiked environmental samples by modified BACTEC 12B radiometric culture and direct confirmation by IS900 PCR. J. Clin. Microbiol. 36: 701-707.
120. Wood, P. R., L. A. Corner, and P. Placejett. 1990. Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of γ-interferon. Res. Vet. Sci. 49: 46-49.