Peptidyl aldehydes as reversible covalent inhibitors of Src homology 2 domains

Biochemistry

Volumn 42, Issue 17, 2003, Pages 5159-5167

  Park, Junguk ^a   Fu, Hua ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDES;

ALDEHYDES; CATALYST ACTIVITY; ENZYME INHIBITION; MEMBRANES; MUTAGENESIS; SURFACE PLASMON RESONANCE;

PROTEINS;

ALDEHYDE; ARGININE; CARBON 13; CINNAMALDEHYDE; ENAMINE; GUANIDINE DERIVATIVE; HYDROGEN; IMINE; N [2 [4 (3 OXO 1 PROPENYL)PHENOXY]ACETYL]GLYCYLGLUTAMINYLGLUTAMINE; PEPTIDYL ALDEHYDE DERIVATIVE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; COVALENT BOND; MEMBRANE PERMEABILITY; MOLECULAR INTERACTION; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SRC HOMOLOGY DOMAIN;

ALDEHYDES; ARGININE; BINDING SITES; CATALYTIC DOMAIN; CLONING, MOLECULAR; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MOLECULAR WEIGHT; PEPTIDES; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SRC HOMOLOGY DOMAINS;

EID: 0037657546     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034076u     Document Type: Article

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