Ligands for the tyrosine kinase p56(lck) SH2 domain: Discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements

Journal of Medicinal Chemistry

Volumn 42, Issue 10, 1999, Pages 1757-1766

  Beaulieu, Pierre L ^a   Cameron, Dale R ^a   Ferland, Jean Marie ^a   Gauthier, Jean ^a   Ghiro, Elise ^a   Gillard, James ^a   Gorys, Vida ^a   Poirier, Martin ^a   Rancourt, Jean ^a   Wernic, Dominik ^a   Llinas Brunet, Montse ^a   Betageri, Raj ^b   Cardozo, Mario ^b   Hickey, Eugene R ^b   Ingraham, Richard ^b   Jakes, Scott ^b   Kabcenell, Alisa ^b   Kirrane, Tom ^b   Lukas, Susan ^b   Patel, Usha ^b   Proudfoot, John ^b   Sharma, Rajiv ^b   Tong, Liang ^b,c   Moss, Neil ^b   more..

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE DERIVATIVE; PHOSPHATE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HYDROLYSIS; LIGAND BINDING; LIPOPHILICITY; PH; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; LIGANDS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; PROTEIN BINDING; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033587115     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980676t     Document Type: Article

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