Modulation of MCF-7 breast cancer cell signal transduction by linoleic acid and conjugated linoleic acid in culture

Anticancer Research

Volumn 20, Issue 2 A, 2000, Pages 669-676

  Park, Yongsoon ^a   Allen, Kenneth G D ^b   Shultz, Terry D ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Cell growth; Membrane fatty acids; Phospholipase C; Prostaglandin E2; Protein kinase C

Indexed keywords

EPIDERMAL GROWTH FACTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LINOLEIC ACID; PHOSPHOLIPASE C; PROSTAGLANDIN E2; PROTEIN KINASE C;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL STRAIN MCF 7; CONJUGATE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID COMPOSITION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; CELL MEMBRANE; CULTURE MEDIA, SERUM-FREE; CYTOSOL; DINOPROSTONE; EPIDERMAL GROWTH FACTOR; FATTY ACIDS; FEMALE; HUMANS; KINETICS; LINOLEIC ACID; LINOLEIC ACIDS; LINOLEIC ACIDS, CONJUGATED; MEMBRANE LIPIDS; PHOSPHOLIPASE C; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034052414     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ip C, Carter CA, Ip MM: Requirement of essential fatty acid for mammary tumorigenesis in the rat. Cancer Res 45: 1997-2001, 1985.
2. Cohen LA, Thompson DO, Maeura Y, Choi K, Blank ME, Rose DP: Dietary fat and mammary cancer. I. Promoting effects of different dietary fats on N-nitrosomethylurea-induced rat mammary tumorigenesis. J Natl Cancer Inst 77: 33-42, 1986.
3. Hubbard NE, Erickson KL: Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. Cancer Res 47: 6171-6175, 1987.
4. Ip C, Scimeca JA, Thompson HJ: Conjugated linoleic acid. Cancer 74: 1050-1054, 1994.
5. Ha YL, Grimm NK, Pariza MW: Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J Agric Food Chem 37: 75-81, 1989.
6. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW: Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Comp Anal 5: 185-197, 1992.
7. Lin H, Boylston TD, Chang MJ, Luedecke LO, Shultz TD: Survey of the conjugated linoleic acid contents of dairy products. J Dairy Sci 78: 2358-2365, 1995.
8. Huang YC, Luedecke LO, Shultz TD: Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men. Nutr Res 14: 373-386, 1994.
9. McGuire MK, Park YS, Behre RA, Harrison LY, Shultz TD, McGuire MA: Conjugated linoleic acid concentration of human milk and infant formula. Nutr Res 17: 1277-1283, 1997.
10. Pariza MW, Hargraves WA: A beef derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene. Carcinogenesis 6: 591-593, 1985.
11. Ha YL, Storkson J, Pariza MW: Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res 50: 1097-1101, 1990.
12. Ip C, Chin SF, Scimeca JA, Pariza MW: Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 51: 6119-6124, 1991.
13. Ip C, Briggs SP, Haegele AD, Thompson HJ, Storkson J, Scimeca JA: The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. Carcinogenesis 17: 1045-1050, 1996.
14. Belury MA, Bird C, Wu B: Dietary conjugated dienoic linoleate modulation of phorbol ester-elicited tumor promotion in mouse skin. Proc Am Assoc Cancer Res 36: A596 (abstr), 1995.
15. Shultz TD, Chew BP, Seaman WR: Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res 12: 2143-2146, 1992.
16. Shultz TD, Chew BP, Seaman WR, Luedecke LO: Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett 63: 125-133, 1992.
17. Cunningham DC, Harrison LY, Shultz TD: Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. Anticancer Res 17: 197-204, 1997.
18. Cave WT Jr: Dietary n-3 polyunsaturated fatty acid effects on animal tumorigenesis. FASEB J 5: 2160-2166, 1991.
19. Sylvester PW, Birkenfeld HP, Hosick HL, Briski KP: Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. Exp Cell Res 214: 145-153, 1994.
20. Awad AB, Ntanois FY, Fink CS, Horvath PJ: Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells. Prost Leuk Ess Fatty Acids 5: 293-302, 1996.
21. Liu KL, Belury MA: Conjugated linoleic acid modulation of phorhol ester-induced events in murine keratinocytes. Lipids 32: 725-730, 1997.
22. Lanson M, Besson P, Bougnoux P: Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to 1GF-1. J Lipid Mediators Cell Signal 16: 189-197, 1997.
23. Spector AA, Burns CP: Biological and therapeutic potential of membrane lipid modification in tumors. Cancer Res 47: 4529-4537, 1987.
24. Bandyopadhyay GK, Hwang S, Imagawa W, Nandi S: Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. Prost Leuk Ess Fatty Acids 48: 71-78, 1993.
25. Bonorden W, Storkson J, Lui W, Albright K, Pariza M: Fatty acid inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phospholipase C activity. FASEB J 5: A3580 (abstr), 1991.
26. Rando RR: Regulation of protein kinase C activity by lipids. FASEB J 2: 2348-2355, 1988.
27. Merrill AH Jr, Schroeder JJ: Lipid modulation of cell function. Ann Rev Nutr 13: 539-559, 1993.
28. Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614, 1992.
29. Lo HH, Bartek GA, Fischer SM: In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites. Lipids 29: 547-553, 1944.
30. Rose DP, Connolly JM: Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture. Cancer Res 50: 7139-7144, 1990.
31. Earashi M, Noguchi M, Kinoshita K, Tanaka M: Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line. Oncology 52: 150-155, 1995.
32. Noguchi M, Earashi M, Minami M, Miyazaki I, Tanaka M, Sasaki T: Effects of piroxicam and esculetin on the MDA-MB-231 human breast cancer cell line. Prost Leuk Ess Fatty Acids 53: 325-329, 1995.
33. Iversen SA, Cawood P, Madigan MJ, Lawson AM, Dormandy TL: A diene-conjugated isomer of linoleic acid, 18:2 (9,11), in human plasma phospholipids. Life Chem Rept 3: 45-48, 1985.
34. Ohta A, Mayo MC, Kramer N, Lands WEM: Rapid analysis of fatty acids in plasma lipids. Lipids 25: 742-747, 1990.
35. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917, 1959.
36. Bolt MJG, Bissonnette BM, Wali RK, Hartmann SC, Brasitus TA: Characterization of phosphoinositide-specific phospholipase C in rat colonocyte membranes. Biochem J 292: 271-276, 1993.
37. Recce MS, Allen KGD, Mathias MM, Harris MA: Prostaglandins in selected reproductive tissues in preterm and full term gestations. Prost Leuk Ess Fatty Acids 55: 303-307, 1996.
38. SAS/STAT User's Guide version 6: 2. SAS Institute Inc, Cary, NC, 1989.
39. Rose DP, Connolly JM: Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. Biochem Biophys Res Comm 164: 277-283, 1989.
40. Durgam VR, Fernandes G: The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Lett 116: 121-130, 1997.
41. Begin ME, Ells G, Horrobin DF: Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation. J Natl Cancer Inst 80: 188-194, 1988.
42. Freter CE, Lippman MC, Cheville A, Zinn S, Gelmann EP: Alterations in phosphoinositide metabolism associated with 17 ß-estradiol and growth factor treatment of MCF-7 breast cancer cells. Mol Endocrinol 2: 159-166, 1988.
43. Balakrishnan A, Cramer S, Bandyopadhyay GK, Imagawa W, Yang J, Elias J, Beattie CW, Das Gupta TK, Nandi S: Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. Cancer Res 49: 857-862, 1989.
44. Lee PP, Ip MM: Regulation of proliferation of rat mammary tumor cells by inhibitors of cyclooxygenase and lipoxygenase. Prost Leuk Ess Fatty Acids 45: 21-31, 1992.
45. Snyder DS, Castro R, Desforges JF: Antiproliferative effects of lipooxygenase inhibitors on malignant human hematopoietic cell lines. Exp Hematol 17: 6-9, 1989.
46. Grammatikos SI, Subbaiah PV, Victor TA, Miller WM: n-3 and n-6 fatty acid processing and growth effects in neoplastic and noncancerous human mammary epithelial cell lines. Br J Cancer 70: 219-227, 1994.
47. Peto R, Roe FJC, Lee PN, Levy L, Clack J: Cancer and ageing in mice and men. Br J Cancer 32: 411-426, 1975.