메뉴 건너뛰기




Volumn 79, Issue 3, 2003, Pages 78-85

Genetic basis of glioma progression

Author keywords

EGFR; Genetic pathway; Glioblastoma; MGMT; SV40; TP53

Indexed keywords

SIMIAE; SIMIAN VIRUS 40;

EID: 0037525200     PISSN: 03862208     EISSN: None     Source Type: Journal    
DOI: 10.2183/pjab.79B.78     Document Type: Review
Times cited : (2)

References (76)
  • 1
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • Watanabe, K , Tachibana, O., Sato, K., Yonekawa, Y., Kleihues, P , and Ohgaki, H. (1996) Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol. 6, 217-224.
    • (1996) Brain Pathol. , vol.6 , pp. 217-224
    • Watanabe, K.1    Tachibana, O.2    Sato, K.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 2
    • 0030778862 scopus 로고    scopus 로고
    • Amplification and overexpression of MDM2 in primary (de novo) glioblastomas
    • Biernat, W., Kleihues, P., Yonekawa, Y., and Ohgaki, H (1997) Amplification and overexpression of MDM2 in primary (de novo) glioblastomas. J. Neuropathol. Exp. Neurol. 56, 180-185.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 180-185
    • Biernat, W.1    Kleihues, P.2    Yonekawa, Y.3    Ohgaki, H.4
  • 3
    • 0030881477 scopus 로고    scopus 로고
    • Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
    • Biernat, W., Tohma, Y., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (1997) Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 94, 303-309.
    • (1997) Acta Neuropathol. , vol.94 , pp. 303-309
    • Biernat, W.1    Tohma, Y.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 5
    • 0033968345 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas
    • Fujisawa, H., Reis, R. M., Nakamura, M., Colella, S., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (2000) Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas. Lab. Invest. 80, 65-72
    • (2000) Lab. Invest. , vol.80 , pp. 65-72
    • Fujisawa, H.1    Reis, R.M.2    Nakamura, M.3    Colella, S.4    Yonekawa, Y.5    Kleihues, P.6    Ohgaki, H.7
  • 8
    • 0035133842 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RB1 gene in glioblastomas
    • Nakamura, M., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (2001) Promoter hypermethylation of the RB1 gene in glioblastomas Lab Invest 81, 77-82.
    • (2001) Lab. Invest. , vol.81 , pp. 77-82
    • Nakamura, M.1    Yonekawa, Y.2    Kleihues, P.3    Ohgaki, H.4
  • 9
    • 0034795045 scopus 로고    scopus 로고
    • Promoter hypermethylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G·C→A·T mutations of the TP53 tumor suppressor gene
    • Nakamura, M., Watanabe, T., Yonekawa, Y , Kleihues, P., and Ohgaki, H (2001) Promoter hypermethylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G·:C→A·T mutations of the TP53 tumor suppressor gene. Carcinogenesis 22, 1715-1719.
    • (2001) Carcinogenesis , vol.22 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 12
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W. G. (1998) ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 14
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E. E., and Collins, V. P. (1993) Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53, 2736-2739.
    • (1993) Cancer Res. , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 16
    • 7144261725 scopus 로고    scopus 로고
    • The class III variant of the epidermal growth factor receptor (EGFRvIII): Characterization and utilization as an immunotherapeutic target
    • Wikstrand, C. J., Reist, C. J., Archer, G. E., Zalutsky, M. R., and Bigner, D. D. (1998) The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. J. Neurovirol. 4, 148-158
    • (1998) J. Neurovirol. , vol.4 , pp. 148-158
    • Wikstrand, C.J.1    Reist, C.J.2    Archer, G.E.3    Zalutsky, M.R.4    Bigner, D.D.5
  • 17
    • 0034575691 scopus 로고    scopus 로고
    • EGFRvIII as a promising target for antibody-based brain tumor therapy
    • Kuan, C. T., Wikstrand, C. J., and Bigner, D. D. (2000) EGFRvIII as a promising target for antibody-based brain tumor therapy. Brain Tumor Pathol 17, 71-78
    • (2000) Brain Tumor Pathol. , vol.17 , pp. 71-78
    • Kuan, C.T.1    Wikstrand, C.J.2    Bigner, D.D.3
  • 18
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa, N., Ekstrand, A J., James C. D , and Collins, V P. (1990) Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas Proc Natl Acad. Sci. U. S. A. 87, 8602-8606.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 19
    • 0029146954 scopus 로고
    • EGFR gene amplification-rearrangement in human glioblastomas
    • Schwechheimer, K , Huang, S., and Cavenee, W. K. (1995) EGFR gene amplification-rearrangement in human glioblastomas. Int. J. Cancer 62, 145-148.
    • (1995) Int. J. Cancer , vol.62 , pp. 145-148
    • Schwechheimer, K.1    Huang, S.2    Cavenee, W.K.3
  • 20
    • 0032979933 scopus 로고    scopus 로고
    • Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2-7 gene deletion in human glioblastomas
    • Worm, K., Dabbagh, P., and Schwechheimer, K (1999) Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2-7 gene deletion in human glioblastomas. Hum. Pathol. 30, 222-227.
    • (1999) Hum. Pathol. , vol.30 , pp. 222-227
    • Worm, K.1    Dabbagh, P.2    Schwechheimer, K.3
  • 22
    • 0029992049 scopus 로고    scopus 로고
    • Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q
    • Albarosa, R., Colombo, B. M., Roz, L., Magnani, I., Pollo, B , Cirenei, N., Giani, C., Conti, A. M. F., DiDonato, S., and Finocchiaro, G. (1996) Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q. Am. J. Hum. Genet. 58, 1260-1267
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1260-1267
    • Albarosa, R.1    Colombo, B.M.2    Roz, L.3    Magnani, I.4    Pollo, B.5    Cirenei, N.6    Giani, C.7    Conti, A.M.F.8    DiDonato, S.9    Finocchiaro, G.10
  • 25
    • 0031967883 scopus 로고    scopus 로고
    • Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
    • Ichimura, K., Schmidt, E. E , Miyakawa, A , Goike, H. M., and Collins, V. P (1998) Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer 22, 9-15.
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 9-15
    • Ichimura, K.1    Schmidt, E.E.2    Miyakawa, A.3    Goike, H.M.4    Collins, V.P.5
  • 28
    • 0032566064 scopus 로고    scopus 로고
    • Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas
    • Maier, D., Zhang, Z., Taylor, E., Hamou, M. F., Gratzl, O , Van Meir, E. G., Scott, R. J., and Merlo, A. (1998) Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Oncogene 16, 3331-3335.
    • (1998) Oncogene , vol.16 , pp. 3331-3335
    • Maier, D.1    Zhang, Z.2    Taylor, E.3    Hamou, M.F.4    Gratzl, O.5    Van Meir, E.G.6    Scott, R.J.7    Merlo, A.8
  • 31
    • 0032788101 scopus 로고    scopus 로고
    • Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with LOH on chromosome 10q25-qter
    • Fujisawa, H , Kurrer, M., Reis, R. M., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (1999) Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with LOH on chromosome 10q25-qter Am. J Pathol. 155, 387-394.
    • (1999) Am. J. Pathol. , vol.155 , pp. 387-394
    • Fujisawa, H.1    Kurrer, M.2    Reis, R.M.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 32
    • 0034671669 scopus 로고    scopus 로고
    • Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays
    • Huang, H , Colella, S., Kurrer, M., Yonekawa, Y., Kleihues, P., and Ohgaki, H (2000) Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. Cancer Res. 60, 6868-6874.
    • (2000) Cancer Res. , vol.60 , pp. 6868-6874
    • Huang, H.1    Colella, S.2    Kurrer, M.3    Yonekawa, Y.4    Kleihues, P.5    Ohgaki, H.6
  • 35
    • 0034998193 scopus 로고    scopus 로고
    • Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    • Hui, A. B , Lo, K. W , Yin, X. L., Poon, W. S., and Ng, H K. (2001) Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab. Invest. 81, 717-723.
    • (2001) Lab. Invest. , vol.81 , pp. 717-723
    • Hui, A.B.1    Lo, K.W.2    Yin, X.L.3    Poon, W.S.4    Ng, H.K.5
  • 36
    • 0026580876 scopus 로고
    • Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene
    • Brustle, O , Ohgaki, H , Schmitt, H. P., Walter, G. F., Ostertag, H., and Kleihues, P. (1992) Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene. Cancer 69, 2385-2392
    • (1992) Cancer , vol.69 , pp. 2385-2392
    • Brustle, O.1    Ohgaki, H.2    Schmitt, H.P.3    Walter, G.F.4    Ostertag, H.5    Kleihues, P.6
  • 37
    • 0014587529 scopus 로고
    • Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?
    • Li, F. P , and Fraumeni, J. F., Jr. (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann. Intern Med 71, 747-752.
    • (1969) Ann. Intern. Med. , vol.71 , pp. 747-752
    • Li, F.P.1    Fraumeni Jr., J.F.2
  • 39
    • 0031031049 scopus 로고    scopus 로고
    • Tumors associated with p53 germline mutations: A synopsis of 91 families
    • Kleihues, P , Schauble, B., zur Hausen, A., Esteve, J , and Ohgaki, H. (1997) Tumors associated with p53 germline mutations: a synopsis of 91 families. Am. J. Pathol. 150, 1-13.
    • (1997) Am. J. Pathol. , vol.150 , pp. 1-13
    • Kleihues, P.1    Schauble, B.2    Zur Hausen, A.3    Esteve, J.4    Ohgaki, H.5
  • 41
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava, S , Zou, Z. Q., Pirollo, K., Blattner, W. A , and Chang, E. H (1990) Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome Nature 348, 747-749
    • (1990) Nature , vol.348 , pp. 747-749
    • Srivastava, S.1    Zou, Z.Q.2    Pirollo, K.3    Blattner, W.A.4    Chang, E.H.5
  • 44
    • 0028556276 scopus 로고
    • p53 and the Li-Fraumeni syndrome
    • Malkin, D. (1994) p53 and the Li-Fraumeni syndrome. Biochim. Biophys. Acta 1198, 197-213.
    • (1994) Biochim. Biophys. Acta , vol.1198 , pp. 197-213
    • Malkin, D.1
  • 48
    • 0022361679 scopus 로고
    • SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumors in transgenic mice
    • Palmiter, R. D., Chen, H. Y , Messing, A., and Brinster, R. L (1985) SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumors in transgenic mice. Nature 316, 457-460.
    • (1985) Nature , vol.316 , pp. 457-460
    • Palmiter, R.D.1    Chen, H.Y.2    Messing, A.3    Brinster, R.L.4
  • 49
    • 0028226013 scopus 로고
    • A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen
    • Eibl, R. H., Kleihues, P., Jat, P. S., and Wiestler, O. D (1994) A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen. Am. J. Pathol. 144, 556-564.
    • (1994) Am. J. Pathol. , vol.144 , pp. 556-564
    • Eibl, R.H.1    Kleihues, P.2    Jat, P.S.3    Wiestler, O.D.4
  • 50
    • 6544255873 scopus 로고    scopus 로고
    • Animal models of tumors of the nervous system
    • (eds. Berger, M., and Wilson, Ch.). W B. Saunders, Cambridge, MA
    • Kleihues, P., Wiestler, O. D., Ohgaki, H., and Aguzzi, A. (1998) Animal models of tumors of the nervous system. In The Gliomas (eds. Berger, M., and Wilson, Ch.). W B. Saunders, Cambridge, MA, pp. 124-133.
    • (1998) The Gliomas , pp. 124-133
    • Kleihues, P.1    Wiestler, O.D.2    Ohgaki, H.3    Aguzzi, A.4
  • 51
    • 0031606399 scopus 로고    scopus 로고
    • BK and JC human polyomaviruses and Simian virus 40: Natural history of infection in humans, experimental oncogenicity, and association with human tumors
    • Barbanti-Brodano, G., Martini, F., De Mattei, M., Lazzarin, L., Corallini, A., and Tognon, M. (1998) BK and JC human polyomaviruses and Simian virus 40: natural history of infection in humans, experimental oncogenicity, and association with human tumors Adv Virus Res 50, 69-99.
    • (1998) Adv. Virus Res. , vol.50 , pp. 69-99
    • Barbanti-Brodano, G.1    Martini, F.2    De Mattei, M.3    Lazzarin, L.4    Corallini, A.5    Tognon, M.6
  • 52
    • 0030671131 scopus 로고    scopus 로고
    • Simian virus 40, poliovaccines and human tumors: A review of recent developments
    • Carbone, M., Rizzo, P., and Pass, H. I. (1997) Simian virus 40, poliovaccines and human tumors: a review of recent developments. Oncogene 15, 1877-1888.
    • (1997) Oncogene , vol.15 , pp. 1877-1888
    • Carbone, M.1    Rizzo, P.2    Pass, H.I.3
  • 53
    • 0020038652 scopus 로고
    • Role of viruses in the induction of primary intracranial tumors
    • Walsh, J. W., Zimmer, S. G., and Perdue, M. L (1982) Role of viruses in the induction of primary intracranial tumors. Neurosurgery 10, 643-662.
    • (1982) Neurosurgery , vol.10 , pp. 643-662
    • Walsh, J.W.1    Zimmer, S.G.2    Perdue, M.L.3
  • 54
    • 0025115324 scopus 로고
    • SV40 T antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts
    • Ray, F. A , Peabody, D S., Cooper, J. L., Cram, L. S., and Kraemer, P. M. (1990) SV40 T antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts J. Cell Biochem. 42, 13-31.
    • (1990) J. Cell Biochem. , vol.42 , pp. 13-31
    • Ray, F.A.1    Peabody, D.S.2    Cooper, J.L.3    Cram, L.S.4    Kraemer, P.M.5
  • 55
    • 0033585417 scopus 로고    scopus 로고
    • Cell and molecular biology of simian virus 40: Implications for human infections and disease
    • Butel, J. S., and Lednicky, J. A (1999) Cell and molecular biology of simian virus 40: implications for human infections and disease. J. Natl. Cancer Inst. 91, 119-134.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 119-134
    • Butel, J.S.1    Lednicky, J.A.2
  • 56
    • 0026053363 scopus 로고
    • Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells
    • Stewart, N., and Bacchetti, S. (1991) Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology 180, 49-57.
    • (1991) Virology , vol.180 , pp. 49-57
    • Stewart, N.1    Bacchetti, S.2
  • 57
    • 0032958518 scopus 로고    scopus 로고
    • Identification in human brain tumors of DNA sequences specific for SV40 large T antigen
    • Huang, H., Reis, R., Yonekawa, Y., Lopes, J M., Kleihues, P., and Ohgaki, H. (1999) Identification in human brain tumors of DNA sequences specific for SV40 large T antigen. Brain Pathol 9, 33-44.
    • (1999) Brain Pathol. , vol.9 , pp. 33-44
    • Huang, H.1    Reis, R.2    Yonekawa, Y.3    Lopes, J.M.4    Kleihues, P.5    Ohgaki, H.6
  • 60
    • 0030722275 scopus 로고    scopus 로고
    • Investigation of human urine for genomic sequences of the primate polyomaviruses simian virus 40, BK virus, and JC virus
    • Shah, K. V., Daniel, R. W., Strickler, H. D., and Goedert, J J. (1997) Investigation of human urine for genomic sequences of the primate polyomaviruses simian virus 40, BK virus, and JC virus J. Infect Dis. 176, 1618-1621.
    • (1997) J. Infect Dis. , vol.176 , pp. 1618-1621
    • Shah, K.V.1    Daniel, R.W.2    Strickler, H.D.3    Goedert, J.J.4
  • 61
    • 0017240246 scopus 로고
    • Human exposure to SV40 review and comment
    • Shah, K , and Nathanson, N. (1976) Human exposure to SV40 review and comment. Am. J. Epidemiol. 103, 1-12
    • (1976) Am. J. Epidemiol. , vol.103 , pp. 1-12
    • Shah, K.1    Nathanson, N.2
  • 62
    • 0025616927 scopus 로고
    • SV40 and human brain tumors
    • Geissler, E. (1990) SV40 and human brain tumors Prog. Med. Virol 37, 211-222.
    • (1990) Prog. Med. Virol. , vol.37 , pp. 211-222
    • Geissler, E.1
  • 63
    • 0029805877 scopus 로고    scopus 로고
    • Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue
    • Pepper, C., Jasani, B , Navabi, H., Wynford-Thomas, D , and Gibbs, A. R. (1996) Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue. Thorax 51, 1074-1076.
    • (1996) Thorax , vol.51 , pp. 1074-1076
    • Pepper, C.1    Jasani, B.2    Navabi, H.3    Wynford-Thomas, D.4    Gibbs, A.R.5
  • 64
    • 0000145173 scopus 로고
    • Excretion of vacuolating SV-40 virus (Papova Virus Group) after ingestion as a contaminant of oral poliovaccine
    • Melnick, J. L., and Stinebaugh, S. (1962) Excretion of vacuolating SV-40 virus (Papova Virus Group) after ingestion as a contaminant of oral poliovaccine. Proc Soc Exp Biol. Med. 109, 965-968.
    • (1962) Proc. Soc. Exp. Biol. Med. , vol.109 , pp. 965-968
    • Melnick, J.L.1    Stinebaugh, S.2
  • 65
    • 0034654630 scopus 로고    scopus 로고
    • More about: Cell and molecular biology of Simian Virus 40: Implications for human infections and disease
    • Ohgaki, H , Huang, H., Haltia, M., Vainio, H., and Kleihues, P. (2000) More about: Cell and molecular biology of Simian Virus 40: Implications for human infections and disease J Natl. Cancer Inst 92, 495-496.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 495-496
    • Ohgaki, H.1    Huang, H.2    Haltia, M.3    Vainio, H.4    Kleihues, P.5
  • 67
    • 0016715086 scopus 로고
    • Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea
    • Margison, G. P., and Kleihues, P. (1975) Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N- nitrosourea. Biochem. J. 148, 521-525.
    • (1975) Biochem. J. , vol.148 , pp. 521-525
    • Margison, G.P.1    Kleihues, P.2
  • 68
    • 0016042235 scopus 로고
    • Persistence of O6-ethylguanine in rat-brain DNA- correlation with nervous system-specific carcinogenesis by ethylnitrosourea
    • Goth, R., and Rajewsky, M. F. (1974) Persistence of O6-ethylguanine in rat-brain DNA- correlation with nervous system-specific carcinogenesis by ethylnitrosourea Proc. Natl. Acad Sci. U. S. A 71, 639-643.
    • (1974) Proc. Natl. Acad Sci. U. S. A. , vol.71 , pp. 639-643
    • Goth, R.1    Rajewsky, M.F.2
  • 69
    • 0030874380 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • 6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell Biol. 17, 5612-5619.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 70
    • 0030823671 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase gene
    • 6-methylguanine-DNA methyltransferase gene. Cancer Res 57, 3672-3677.
    • (1997) Cancer Res. , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 71
    • 0033557903 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59, 793-797.
    • (1999) Cancer Res. , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 73
    • 0028218474 scopus 로고
    • Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
    • Ohshima, H , and Bartsch, H. (1994) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis Mutat. Res. 305, 253-264.
    • (1994) Mutat. Res. , vol.305 , pp. 253-264
    • Ohshima, H.1    Bartsch, H.2
  • 74
    • 0028181446 scopus 로고
    • Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine
    • Bentivegna, S. S., and Bresnick, E. (1994) Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine. Cancer Res 54, 327-329.
    • (1994) Cancer Res. , vol.54 , pp. 327-329
    • Bentivegna, S.S.1    Bresnick, E.2
  • 75
    • 0034028030 scopus 로고    scopus 로고
    • 6-alkylguanine by alkyltransferases
    • 6-alkylguanine by alkyltransferases Mutat Res. 462, 83-100.
    • (2000) Mutat Res. , vol.462 , pp. 83-100
    • Pegg, A.E.1
  • 76
    • 0021196260 scopus 로고
    • Chemical neuro-oncogenesis: Role of structural DNA modifications, DNA repair and neural target cell population
    • Kleihues, P., and Rajewsky, M F. (1984) Chemical neuro-oncogenesis: role of structural DNA modifications, DNA repair and neural target cell population. Prog Exp. Tumor Res. 27, 1-16.
    • (1984) Prog. Exp. Tumor Res. , vol.27 , pp. 1-16
    • Kleihues, P.1    Rajewsky, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.