-
1
-
-
0036739952
-
On inventing reactions for atom economy
-
Trost B.M. On inventing reactions for atom economy. Acc Chem Res. 35:2002;695-705.
-
(2002)
Acc Chem Res
, vol.35
, pp. 695-705
-
-
Trost, B.M.1
-
2
-
-
0026418434
-
The atom economy: A search for synthetic efficiency
-
Trost B.M. The atom economy: a search for synthetic efficiency. Science. 254:1991;1471-1477.
-
(1991)
Science
, vol.254
, pp. 1471-1477
-
-
Trost, B.M.1
-
3
-
-
0035477024
-
Directed evolution of an enantioselective enzyme through combinatorial multiple-cassette mutagenesis
-
Reetz M.T., Wilensek S., Zha D., Jaeger K.-E. Directed evolution of an enantioselective enzyme through combinatorial multiple-cassette mutagenesis. Angew Chem Int Ed Engl. 40:2001;3589-3591.
-
(2001)
Angew Chem Int Ed Engl
, vol.40
, pp. 3589-3591
-
-
Reetz, M.T.1
Wilensek, S.2
Zha, D.3
Jaeger, K.-E.4
-
4
-
-
0033834791
-
Directed evolution of an enantioselective lipase
-
Liebeton K., Zonta A., Schimossek K., Nardini M., Lang D., Dijkstra B.W., Reetz M.T., Jaeger K.-E. Directed evolution of an enantioselective lipase. Chem Biol. 7:2000;709-718.
-
(2000)
Chem Biol
, vol.7
, pp. 709-718
-
-
Liebeton, K.1
Zonta, A.2
Schimossek, K.3
Nardini, M.4
Lang, D.5
Dijkstra, B.W.6
Reetz, M.T.7
Jaeger, K.-E.8
-
5
-
-
0037025911
-
Directed evolution of selective enzymes and hybrid catalysts
-
Reetz M.T. Directed evolution of selective enzymes and hybrid catalysts. Tetrahedron. 58:2002;6595-6602.
-
(2002)
Tetrahedron
, vol.58
, pp. 6595-6602
-
-
Reetz, M.T.1
-
6
-
-
0033976143
-
Directed evolution of enantioselective enzymes for organic chemistry
-
Jaeger K.-E., Reetz M.T. Directed evolution of enantioselective enzymes for organic chemistry. Curr Opin Chem Biol. 4:2000;68-73.
-
(2000)
Curr Opin Chem Biol
, vol.4
, pp. 68-73
-
-
Jaeger, K.-E.1
Reetz, M.T.2
-
7
-
-
0037170944
-
Amino acids and peptides as asymmetric organocatalysts
-
Jarvo E.R., Miller S.J. Amino acids and peptides as asymmetric organocatalysts. Tetrahedron. 58:2002;2481-2495.
-
(2002)
Tetrahedron
, vol.58
, pp. 2481-2495
-
-
Jarvo, E.R.1
Miller, S.J.2
-
9
-
-
18744388834
-
Evaluation of a two-stage screening procedure in the combinatorial search for serine protease-like activity
-
The above two articles describe a truely combinatorial approach to the problem of artficial, biomimetic esterase activity. The authors were able to identify - by bulk screening and recursive deconvolution - peptidosteroid structures in which both the formation and the hydrolysis of the so-called acyl-intermediate of serine hydrolases is accelerated
-
Madder A., Li L., De Muynck H., Farcy N., Van Haver D., Fant F., Vanhoenacker G., Sandra P., Davis A.P., De Clercq P.J. Evaluation of a two-stage screening procedure in the combinatorial search for serine protease-like activity. J Comb Chem. 4:2002;552-562 The above two articles describe a truely combinatorial approach to the problem of artficial, biomimetic esterase activity. The authors were able to identify - by bulk screening and recursive deconvolution - peptidosteroid structures in which both the formation and the hydrolysis of the so-called acyl-intermediate of serine hydrolases is accelerated.
-
(2002)
J Comb Chem
, vol.4
, pp. 552-562
-
-
Madder, A.1
Li, L.2
De Muynck, H.3
Farcy, N.4
Van Haver, D.5
Fant, F.6
Vanhoenacker, G.7
Sandra, P.8
Davis, A.P.9
De Clercq, P.J.10
-
10
-
-
0344428136
-
Discovery of peptide-zirconium complexes that mediate phosphate hydrolysis by batch screening of a combinatorial undecapeptide library
-
Berkessel A., Hérault D.A. Discovery of peptide-zirconium complexes that mediate phosphate hydrolysis by batch screening of a combinatorial undecapeptide library. Angew Chem Int Ed Engl. 38:1999;102-105.
-
(1999)
Angew Chem Int Ed Engl
, vol.38
, pp. 102-105
-
-
Berkessel, A.1
Hérault, D.A.2
-
11
-
-
0001708325
-
Combinatorial de novo synthesis of catalysts: How much of a hit-structure is needed for activity?
-
Two novel assays for the site-selective bulk screening of combinatorial libraries for phosphodiester cleavage are presented. The oligopeptide hits discovered in this study were analyzed for the minimal catalytically active substructure, the 'minimal catalophore'. It was found in one example that just a fraction of the overall structure was sufficient for catalytic activity. This result raises the question whether there may be other oligomeric catalysts that can be truncated to the 'minimal catalophore'
-
Berkessel A., Riedl R. Combinatorial de novo synthesis of catalysts: how much of a hit-structure is needed for activity? J Comb Chem. 2:2000;215-219 Two novel assays for the site-selective bulk screening of combinatorial libraries for phosphodiester cleavage are presented. The oligopeptide hits discovered in this study were analyzed for the minimal catalytically active substructure, the 'minimal catalophore'. It was found in one example that just a fraction of the overall structure was sufficient for catalytic activity. This result raises the question whether there may be other oligomeric catalysts that can be truncated to the 'minimal catalophore'.
-
(2000)
J Comb Chem
, vol.2
, pp. 215-219
-
-
Berkessel, A.1
Riedl, R.2
-
12
-
-
0035886866
-
A new screen for combinatorial catalysis; On-bead testing in agarose gel
-
This article describes the use of agarose gels for the immobilization of bead-bound libraries. As a result, site-selective detection of hydrolase activity becomes possible by a pH-sensitive probe present in the gel
-
Müller M., Mathers T.W., Davis A.P. A new screen for combinatorial catalysis; on-bead testing in agarose gel. Angew Chem Int Ed Engl. 40:2001;3813-3815 This article describes the use of agarose gels for the immobilization of bead-bound libraries. As a result, site-selective detection of hydrolase activity becomes possible by a pH-sensitive probe present in the gel.
-
(2001)
Angew Chem Int Ed Engl
, vol.40
, pp. 3813-3815
-
-
Müller, M.1
Mathers, T.W.2
Davis, A.P.3
-
13
-
-
84985609389
-
Synthetic enzyme: Highly stereoselective epoxidation of chalcone in the three-phase system toluene-water-poly-(S)-alanine
-
Juliá S., Masana J., Vega J.C. Synthetic enzyme: highly stereoselective epoxidation of chalcone in the three-phase system toluene-water-poly-(S)-alanine. Angew Chem Int Ed Engl. 19:1980;929-930.
-
(1980)
Angew Chem Int Ed Engl
, vol.19
, pp. 929-930
-
-
Juliá, S.1
Masana, J.2
Vega, J.C.3
-
14
-
-
37049095864
-
Synthetic enzymes. Part 2. Catalytic asymmetric epoxidation by means of polyamino-acids in a triphase system
-
Juliá S, Guixer J, Masana J, Rocas J, Colonna S, Annuziata R, Molinari H: Synthetic enzymes. Part 2. Catalytic asymmetric epoxidation by means of polyamino-acids in a triphase system. J Chem Soc Perkin Trans 1982:1317-1324.
-
(1982)
J Chem Soc Perkin Trans
, pp. 1317-1324
-
-
Juliá, S.1
Guixer, J.2
Masana, J.3
Rocas, J.4
Colonna, S.5
Annuziata, R.6
Molinari, H.7
-
15
-
-
0030998044
-
Preparation of polyamino acid catalysts for use in Juliá asymmetric epoxidation
-
Bentley P.A., Kroutil W., Littlechild J.A., Roberts S.M. Preparation of polyamino acid catalysts for use in Juliá asymmetric epoxidation. Chirality. 9:1997;198-202.
-
(1997)
Chirality
, vol.9
, pp. 198-202
-
-
Bentley, P.A.1
Kroutil, W.2
Littlechild, J.A.3
Roberts, S.M.4
-
16
-
-
0035969617
-
Highly enantioselective enone epoxidation catalyzed by short solid phase-bound peptides: Dominant role of peptide helicity
-
This article defines the minimal structural requirement for activity and enantioselectivity in the Juliá-Colonna epoxidation. Based on experimentation and calculations, a mechanistic proposal was put forward: catalysis and selectivity result from the binding of both the enone and hydroperoxide to the N-terminus of a helical peptide stretch
-
Berkessel A., Gasch N., Glaubitz K., Koch C. Highly enantioselective enone epoxidation catalyzed by short solid phase-bound peptides: dominant role of peptide helicity. Org Lett. 3:2001;3839-3842 This article defines the minimal structural requirement for activity and enantioselectivity in the Juliá-Colonna epoxidation. Based on experimentation and calculations, a mechanistic proposal was put forward: catalysis and selectivity result from the binding of both the enone and hydroperoxide to the N-terminus of a helical peptide stretch.
-
(2001)
Org Lett
, vol.3
, pp. 3839-3842
-
-
Berkessel, A.1
Gasch, N.2
Glaubitz, K.3
Koch, C.4
-
17
-
-
0037000505
-
Asymmetric epoxidation of α,β-unsaturated ketones catalyzed by poly(amino acids)
-
Lauret C., Roberts S.M. Asymmetric epoxidation of α,β-unsaturated ketones catalyzed by poly(amino acids). Aldrichimica Acta. 35:2002;47-51.
-
(2002)
Aldrichimica Acta
, vol.35
, pp. 47-51
-
-
Lauret, C.1
Roberts, S.M.2
-
18
-
-
0017998510
-
4-Dialkylaminopyridines as highly active acylation catalysts
-
Höfle G., Steglich W., Vorbrüggen H. 4-Dialkylaminopyridines as highly active acylation catalysts. Angew Chem Int Ed Engl. 17:1978;569-583.
-
(1978)
Angew Chem Int Ed Engl
, vol.17
, pp. 569-583
-
-
Höfle, G.1
Steglich, W.2
Vorbrüggen, H.3
-
19
-
-
0034354748
-
Asymmetric catalysis of acyl transfer by Lewis acids and nucleophiles. A review
-
Spivey A.C., Maddaford A. Asymmetric catalysis of acyl transfer by Lewis acids and nucleophiles. A review. Org Prep Proc Int. 32:2000;331-365.
-
(2000)
Org Prep Proc Int
, vol.32
, pp. 331-365
-
-
Spivey, A.C.1
Maddaford, A.2
-
20
-
-
0032564916
-
Kinetic resolution of alcohols catalyzed by tripeptides containing the N-alkylimidazole substructure
-
Miller S.J., Copeland G.T., Papaioannou N., Horstmann T.E., Ruel E.M. Kinetic resolution of alcohols catalyzed by tripeptides containing the N-alkylimidazole substructure. J Am Chem Soc. 120:1998;1629-1630.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 1629-1630
-
-
Miller, S.J.1
Copeland, G.T.2
Papaioannou, N.3
Horstmann, T.E.4
Ruel, E.M.5
-
21
-
-
0000089981
-
Minimal acylase-like peptides. Conformational control of absolute stereospecificity
-
Copeland G.T., Jarvo E.R., Miller S.J. Minimal acylase-like peptides. Conformational control of absolute stereospecificity. J Org Chem. 63:1998;6784-6785.
-
(1998)
J Org Chem
, vol.63
, pp. 6784-6785
-
-
Copeland, G.T.1
Jarvo, E.R.2
Miller, S.J.3
-
22
-
-
0001625628
-
A His-Pro-Aib peptide that exhibits an Asx-Pro-turn-like structure
-
Blank J.T., Guerin D.J., Miller S.J. A His-Pro-Aib peptide that exhibits an Asx-Pro-turn-like structure. Org Lett. 2:2000;1247-1249.
-
(2000)
Org Lett
, vol.2
, pp. 1247-1249
-
-
Blank, J.T.1
Guerin, D.J.2
Miller, S.J.3
-
23
-
-
0033596302
-
A biomimetic approach to asymmetric acyl transfer catalysis
-
Jarvo E.R., Copeland G.T., Papaioannou N., Bonitatebus P.J. Jr., Miller S.J. A biomimetic approach to asymmetric acyl transfer catalysis. J Am Chem Soc. 121:1999;11638-11643.
-
(1999)
J Am Chem Soc
, vol.121
, pp. 11638-11643
-
-
Jarvo, E.R.1
Copeland, G.T.2
Papaioannou, N.3
Bonitatebus P.J., Jr.4
Miller, S.J.5
-
24
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-
0036603597
-
Proton-activated fluorescence as a tool for simultaneous screening of combinatorial chemical reactions
-
•]). This presents an overview
-
•]). This presents an overview.
-
(2002)
Curr Opin Chem Biol
, vol.6
, pp. 333-338
-
-
Evans, C.A.1
Miller, S.J.2
-
25
-
-
0035838880
-
Fluorescence-based screening of asymmetric acylation catalysts through parallel enantiomer analysis. Identification of a catalyst for tertiary alcohol resolution
-
Jarvo E.R., Evans C.A., Copeland G.T., Miller S.J. Fluorescence-based screening of asymmetric acylation catalysts through parallel enantiomer analysis. Identification of a catalyst for tertiary alcohol resolution. J Org Chem. 66:2001;5522-5527.
-
(2001)
J Org Chem
, vol.66
, pp. 5522-5527
-
-
Jarvo, E.R.1
Evans, C.A.2
Copeland, G.T.3
Miller, S.J.4
-
26
-
-
0034807976
-
Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence-based activity assay: An approach to kinetic resolution of secondary alcohols of broad structural scope
-
6 peptide library, using the 'sensor-on-the-bead' approach, affords catalysts for the enantioselective acylation of non-hydrogen bonding secondary alcohols
-
6 peptide library, using the 'sensor-on-the-bead' approach, affords catalysts for the enantioselective acylation of non-hydrogen bonding secondary alcohols.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 6496-6502
-
-
Copeland, G.T.1
Miller, S.J.2
-
27
-
-
0033526393
-
A chemosensor-based approach to catalyst discovery in solution and on solid support
-
Copeland G.T., Miller S.J. A chemosensor-based approach to catalyst discovery in solution and on solid support. J Am Chem Soc. 121:1999;4306-4307.
-
(1999)
J Am Chem Soc
, vol.121
, pp. 4306-4307
-
-
Copeland, G.T.1
Miller, S.J.2
-
28
-
-
0035904415
-
Discovery of a catalytic asymmetric phosphorylation through selection of a minimal kinase mimic: A concise total synthesis of D-myo-inositol-1-phosphate
-
••]
-
••].
-
(2001)
J Am Chem Soc
, vol.123
, pp. 10125-10126
-
-
Sculimbrene, B.R.1
Miller, S.J.2
-
29
-
-
0037010024
-
Enantio-divergence in small-molecule catalysis of asymmetric phosphorylation: Concise total synthesis of the enantiomeric D-myo-inositol-1-phosphate and D-myo-inositol-3-phosphate
-
The above two articles demonstrate the combinatorial approach by which peptide catalysts for the enantioselective phosphorylation of myo-inositol were found. This is the first example of a small-peptide kinase mimetic
-
Sculimbrene B.R., Morgan A.J., Miller S.J. Enantio-divergence in small-molecule catalysis of asymmetric phosphorylation: concise total synthesis of the enantiomeric D-myo-inositol-1-phosphate and D-myo-inositol-3-phosphate. J Am Chem Soc. 124:2002;11653-11656 The above two articles demonstrate the combinatorial approach by which peptide catalysts for the enantioselective phosphorylation of myo-inositol were found. This is the first example of a small-peptide kinase mimetic.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 11653-11656
-
-
Sculimbrene, B.R.1
Morgan, A.J.2
Miller, S.J.3
-
30
-
-
0034675660
-
Asymmetric conjugate addition of azide to α,β-unsaturated carbonyl compounds catalyzed by simple peptides
-
Horstmann T.E., Guerin D.J., Miller S.J. Asymmetric conjugate addition of azide to α,β-unsaturated carbonyl compounds catalyzed by simple peptides. Angew Chem Int Ed Engl. 39:2000;3635-3638.
-
(2000)
Angew Chem Int Ed Engl
, vol.39
, pp. 3635-3638
-
-
Horstmann, T.E.1
Guerin, D.J.2
Miller, S.J.3
-
31
-
-
0037070622
-
Asymmetric azidation-cycloaddition with open-chain peptide-based catalysts. A sequential enantioselective route to triazoles
-
Guerin D.J., Miller S.J. Asymmetric azidation-cycloaddition with open-chain peptide-based catalysts. A sequential enantioselective route to triazoles. J Am Chem Soc. 124:2002;2134-2136.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 2134-2136
-
-
Guerin, D.J.1
Miller, S.J.2
-
32
-
-
0035793657
-
Recent developments in catalytic asymmetric Strecker-type reactions
-
Yet L. Recent developments in catalytic asymmetric Strecker-type reactions. Angew Chem Int Ed Engl. 40:2001;875-877.
-
(2001)
Angew Chem Int Ed Engl
, vol.40
, pp. 875-877
-
-
Yet, L.1
-
33
-
-
0003554758
-
Schiff base catalysts for the asymmetric Strecker reaction indentified and optimized from parallel synthetic libraries
-
Sigman M.S., Jacobsen E.N. Schiff base catalysts for the asymmetric Strecker reaction indentified and optimized from parallel synthetic libraries. J Am Chem Soc. 120:1998;4901-4902.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 4901-4902
-
-
Sigman, M.S.1
Jacobsen, E.N.2
-
35
-
-
0034704642
-
Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quarternary amino acids
-
Vachal P., Jacobsen E.N. Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quarternary amino acids. Org Lett. 2:2000;867-870.
-
(2000)
Org Lett
, vol.2
, pp. 867-870
-
-
Vachal, P.1
Jacobsen, E.N.2
-
36
-
-
0037189898
-
Structure-based analysis and optimization of a highly enantioselective catalyst for the Strecker reaction
-
This article decribes the development of the most selective and broadly applicable catalyst available to date for the asymmetric addition of HCN to imines (i.e. the asymmetric Strecker reaction)
-
Vachal P., Jacobsen E.N. Structure-based analysis and optimization of a highly enantioselective catalyst for the Strecker reaction. J Am Chem Soc. 124:2002;10012-10014 This article decribes the development of the most selective and broadly applicable catalyst available to date for the asymmetric addition of HCN to imines (i.e. the asymmetric Strecker reaction).
-
(2002)
J Am Chem Soc
, vol.124
, pp. 10012-10014
-
-
Vachal, P.1
Jacobsen, E.N.2
-
37
-
-
0034599407
-
IR-thermographic screening of thermoneutral or endothermic transformations: The ring-closing olefin metathesis reaction
-
Reetz M.T., Becker M.H., Liebl M., Fürstner A. IR-thermographic screening of thermoneutral or endothermic transformations: the ring-closing olefin metathesis reaction. Angew Chem Int Ed Engl. 39:2000;1236-1239.
-
(2000)
Angew Chem Int Ed Engl
, vol.39
, pp. 1236-1239
-
-
Reetz, M.T.1
Becker, M.H.2
Liebl, M.3
Fürstner, A.4
-
38
-
-
0035001299
-
Infrared-thermographic screening of the activity and enantioselectivity of enzymes
-
Reetz M.T., Hermes M., Becker M.H. Infrared-thermographic screening of the activity and enantioselectivity of enzymes. Appl Microbiol Biotech. 55:2001;531-536.
-
(2001)
Appl Microbiol Biotech
, vol.55
, pp. 531-536
-
-
Reetz, M.T.1
Hermes, M.2
Becker, M.H.3
-
39
-
-
0037858846
-
Discovery of novel homogeneous lanthanide catalysts by IR-thermography: Epoxide opening with alcohols and Baeyer-Villiger oxidations with hydrogen peroxide
-
in press
-
Berkessel A, Ashkenazi E, Andreae MRM: Discovery of novel homogeneous lanthanide catalysts by IR-thermography: epoxide opening with alcohols and Baeyer-Villiger oxidations with hydrogen peroxide. Appl Catal A General 2003, in press.
-
(2003)
Appl Catal A General
-
-
Berkessel, A.1
Ashkenazi, E.2
Andreae, M.R.M.3
-
40
-
-
0037090667
-
New methods for the high-throughput screening of enantioselective catalysts and biocatalysts
-
Reetz M.T. New methods for the high-throughput screening of enantioselective catalysts and biocatalysts. Angew Chem Int Ed Engl. 41:2002;1335-1338.
-
(2002)
Angew Chem Int Ed Engl
, vol.41
, pp. 1335-1338
-
-
Reetz, M.T.1
-
41
-
-
0035801625
-
Color indicators of molecular chirality based on doped liquid crystals
-
Van Delden R.A., Feringa B.L. Color indicators of molecular chirality based on doped liquid crystals. Angew Chem Int Ed Engl. 40:2001;3198-3200.
-
(2001)
Angew Chem Int Ed Engl
, vol.40
, pp. 3198-3200
-
-
Van Delden, R.A.1
Feringa, B.L.2
-
42
-
-
0035900973
-
Reaction microarrays: A method for rapidly determining the enantiomeric excess of thousands of samples
-
Korbel G.A., Lalic G., Shair M.D. Reaction microarrays: a method for rapidly determining the enantiomeric excess of thousands of samples. J Am Chem Soc. 123:2001;361-362.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 361-362
-
-
Korbel, G.A.1
Lalic, G.2
Shair, M.D.3
-
43
-
-
0034669263
-
A polymeric and fluorescent gel for combinatorial screening of catalysts
-
This article describes the use of gels for the immobilization of bead-bound libraries. As a result, site-selective detection of acylase activity becomes possible by a fluorescence probe present in the gel, and not on the individual beads
-
Harris R.F., Nation A.J., Copeland G.T., Miller S.J. A polymeric and fluorescent gel for combinatorial screening of catalysts. J Am Chem Soc. 122:2000;11270-11271 This article describes the use of gels for the immobilization of bead-bound libraries. As a result, site-selective detection of acylase activity becomes possible by a fluorescence probe present in the gel, and not on the individual beads.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 11270-11271
-
-
Harris, R.F.1
Nation, A.J.2
Copeland, G.T.3
Miller, S.J.4
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