Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors

Oncogene

Volumn 22, Issue 8, 2003, Pages 1124-1134

  Zeng, Ping Yao ^a   Rane, Neena ^a   Du, Wei ^b   Chintapalli, Janaki ^c   Prendergast, George C ^c,d  

^a WISTAR INSTITUTE   (United States)

^b DuPont Pharmaceuticals Company   (United States)

^c LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Actin; Rac; Ras; Rho

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ACTIN; ISOPROTEIN; PHOSPHOTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN PRK; PROTEIN RHOB GG; RAC1 PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; EPITHELIUM CELL; FIBROBLAST; GENE ACTIVATION; GENE FUNCTION; GENE INACTIVATION; GROWTH INHIBITION; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; ONCOGENE K RAS; PRENYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION;

ACTINS; ALKYL AND ARYL TRANSFERASES; ANIMALS; BACTERIAL PROTEINS; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EPITHELIAL CELLS; ESCHERICHIA COLI PROTEINS; FARNESYLTRANSTRANSFERASE; FIBROBLASTS; GENES, RAS; INTESTINAL MUCOSA; METHIONINE; MICROFILAMENTS; MODELS, BIOLOGICAL; PROTEIN ISOFORMS; PROTEIN ISOPRENYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; RAC1 GTP-BINDING PROTEIN; RATS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0037468252     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206181     Document Type: Article

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