RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

Neoplasia

Volumn 2, Issue 5, 2000, Pages 418-425

  Van Golen, Kenneth L ^a   Wu, Zhi Fen ^a   Qiao, Xiao Tan ^a   Bao, Li Wei ^a   Merajver, Sofia D ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

Angiogenesis; Angiogenic factors; Human mammary epithelial cells; Inflammatory breast cancer; RhoC GTPase

Indexed keywords

ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 6; INTERLEUKIN 8; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULOTROPIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; METASTASIS; PHENOTYPE; PRIORITY JOURNAL;

ADENOCARCINOMA; ADENOSINE DIPHOSPHATE RIBOSE; ADP RIBOSE TRANSFERASES; ANIMALS; AORTA; BOTULINUM TOXINS; BREAST; BREAST NEOPLASMS; CELL LINE, TRANSFORMED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL GROWTH FACTORS; EPITHELIAL CELLS; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOSOMES; LYMPHOKINES; MEMBRANE FUSION; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; RHO GTP-BINDING PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034518232     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900115     Document Type: Article

References (52)

1. Inflammatory breast cancer. The experience of the surveillance, epidemiology, and end results (SEER) program
2. Inflammatory breast cancer: A review
3. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype
4. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
5. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
6. Rho GTPases control polarity, protrusion, and adhesion during cell movement
7. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia
8. Impact of oncogenes in tumor angiogenesis: Mutant ki-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
9. Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
10. Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells
11. erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line
12. Human breast cancer cell lines as models of growth regulation and disease progression
13. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells
14. Human papilloma virus DNAs immortalize normal epithelial cells and reduce their growth factor requirements
15. Growth of microvessels in serumfree matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro
16. Inflammatory breast cancer: Clinical syndrome and molecular determinants
17. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
18. Molecular determinants of angiogenesis in cancer metastasis
19. Angiogenesis and breast cancer
20. Angiogenesis inhibitors generated by tumors
21. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo
22. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
23. Expression of androgen receptor and growth factors in premalignant lesions of the prostate
24. Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro
25. VEGF, BFGF and EGF in the angiogenesis of human melanoma xenografts
26. Angiogenic growth factors in preinvasive breast disease
27. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
28. Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells
29. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C.
30. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
31. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
32. The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers
33. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
34. Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
35. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
36. Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
37. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
38. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signaling pathways
39. Rho proteins: Targets for bacterial toxins
40. The small GTPases Ras, Rac and Cdc42 transcriptionally regulate expression of human fibroblast growth factor 1
41. Interleukin 6 induces the expression of vascular endothelial growth factor
42. Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts
43. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
44. Basic fibroblast growth factor in human melanoma
45. Production of VEGF and expression of the VEGF receptors Flt - 1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours
46. Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer
47. Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue
48. Spontaneous production of interleukin-8 by human lung cancer cells and its augmentation by tumor necrosis factor alpha and interleukin-1 at protein and mRNA levels
49. Role of interleukin-8 in tumor growth and metastasis of human melanoma