SIR2 and aging - The exception that proves the rule

Trends in Genetics

Volumn 17, Issue 7, 2001, Pages 391-392

  Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; BODY REGIONS; DETERIORATION; EVOLUTION; GENE CONTROL; GENE MUTATION; HEALTH CARE; HUMAN; LIFESPAN; MOLECULAR GENETICS; PHYSICAL DEVELOPMENT; PRIORITY JOURNAL;

EID: 0035399711     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02339-3     Document Type: Review

References (24)

1. Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae
2. Divergent roles of RAS1 and RAS2 in yeast longevity
3. Three mutants that extend both mean and maximum lifespan of the nematode, Caenorhabditis elegans, define the age-1 gene
4. A C. elegans mutant that lives twice as long as wild type
5. Determination of life span in Caenorhabditis elegans by four clock genes
6. Extended life-span and stress resistance in the Drosophila mutant methuselah
7. Extended life-span conferred by cotransporter gene mutations in Drosophila
8. Dwarf mice and the ageing process
9. shc adaptor protein controls oxidative stress response and lifespan in mammals
10. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
11. Extrachromosomal rDNA circles - A cause of aging in yeast
12. Increased dosage of a sir-2 gene extends lifespan in C. elegans
13. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapauses in Caenorhabditis elegans
14. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
15. The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
16. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
17. Transcriptional silencing and longevity protein SIR 2 is an NAD-dependent histone deacetylase
18. +-dependent protein deacetylase activity in the Sir2 protein family
19. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
20. Sir2 links chromatin silencing, metabolism, and aging
21. Lifespan extension by calorie restriction in S. cerevisiae requires NAD and SIR2
22. Genes that regulate both development and longevity in Caenorhabditis elegans