A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor α (PPARα) versus liver X receptor

Journal of Biological Chemistry

Volumn 278, Issue 4, 2003, Pages 2403-2410

  Thomas, Jeffrey ^a   Bramlett, Kelli S ^a   Montrose, Chahrzad ^a   Foxworthy, Patricia ^a   Eacho, Patrick I ^a   McCann, Denis ^a   Cao, Guoqing ^a   Kiefer, Anton ^a   McCowan, Jeff ^a   Yu, Kuo Long ^a   Grese, Timothy ^a   Chin, William W ^a   Burris, Thomas P ^a   Michael, Laura F ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; ESTERS; FATTY ACIDS; LIPIDS; OXIDATION;

CHEMICAL SWITCHES;

GENES;

ABC TRANSPORTER; ANTILIPEMIC AGENT; BEZAFIBRATE; BEZAFIBRIC ACID; CLOFIBRATE; CLOFIBRIC ACID; COMPLEMENTARY DNA; FENOFIBRATE; FENOFIBRIC ACID; FIBRIC ACID DERIVATIVE; GEMFIBRATE; GEMFIBROZIL; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; RECEPTOR; RNA; UNCLASSIFIED DRUG; ABCA PROTEIN, AEROMONAS SALMONICIDA; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; CARRIER PROTEIN; CELL RECEPTOR; DNA BINDING PROTEIN; HYPOCHOLESTEROLEMIC AGENT; LIGAND; SULFONAMIDE; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL CULTURE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG SPECIFICITY; FATTY ACID OXIDATION; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; LIGAND BINDING; LIPID METABOLISM; LIPOGENESIS; LIVER CELL CARCINOMA; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; ANIMAL; CELL CULTURE; CHEMICAL MODEL; DOSE RESPONSE; GENETIC TRANSFECTION; IC 50; LIVER; METABOLISM; MOUSE; PATHOLOGY; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCINTILLATION COUNTING; TIME; TRANSACTIVATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTILIPEMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CARRIER PROTEINS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; LIPID METABOLISM; LIVER; MICE; MODELS, CHEMICAL; PROCETOFEN; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCINTILLATION COUNTING; SULFONAMIDES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037462729     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209629200     Document Type: Article

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