Studying TGF-β superfamily signaling by knockouts and knockins

Molecular and Cellular Endocrinology

Volumn 180, Issue 1-2, 2001, Pages 39-46

  Chang, Hua ^a   Lau, Anthony L ^a   Matzuk, Martin M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Activins; Angiogenesis; Gonads; Liver; Smad5; Transgenic mice

Indexed keywords

ACTIVIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL EXPERIMENT; CONFERENCE PAPER; EMBRYO; EMBRYO DEVELOPMENT; GONAD; KNOCKOUT MOUSE; LIVER; LIVER DEVELOPMENT; LIVER FUNCTION; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ACTIVINS; ANIMALS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; INHIBINS; MALE; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; SMAD5 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035974428     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00513-5     Document Type: Conference Paper

References (83)

1. Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation
2. Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain
3. Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts
4. FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes
5. Anterior patterning in mouse
6. Insertion of inhbb into the inhba locus rescues the inhba-null phenotype and reveals new activin functions
7. Mechanisms of left-right determination in vertebrates
8. Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice
9. Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor
10. Bone morphogenetic protein-9, a new member of the TGF-beta superfamily
11. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
12. Smad5 is essential for left-right asymmetry in mice
13. Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice
14. Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice
15. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3
16. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
17. Growth differentiation factor-9 is required during early ovarian folliculogenesis
18. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes
19. Paracrine actions of growth differentiation factor-9 in the mammalian ovary
20. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary
21. Oocyte-expressed TGF-beta superfamily members in female fertility
22. Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation
23. Molecular cloning of the mouse activin beta E subunit gene
24. Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
25. Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition
26. Inhibition of activin receptor signaling promotes neuralization in Xenopus
27. Bone morphogenetic proteins: multifunction regulators of vertebrate development
28. Cloning and expression of recombinant human growth/differentiation factor 5
29. Induction of apoptosis in the murine liver with recombinant human activin A
30. Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta
31. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
32. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms
33. Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1
34. Genetic control of extraembryonic cell lineages studied with tetraploid↔diploid chimeric concepti
35. Liver regeneration: a picture emerges from the puzzle
36. Structural analysis of the mouse activin beta C gene
37. Transgenic approaches to study the function of the transforming growth factor-beta superfamily members
38. Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration
39. Stimulation of activin receptor II signaling pathways inhibits differentiation of multiple gastric epithelial lineages
40. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
41. Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua
42. TGF-beta signal transduction
43. Controlling TGF-beta signaling
44. Regulations of ovarian follicle biology from gene knockout mice
45. Identification and analysis of tumor suppressor genes using transgenic mouse models
46. Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
47. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
48. Different phenotypes for mice deficient in either activins or activin receptor type II
49. Functional analysis of activins during mammalian development
50. Multiple defects and perinatal death in mice deficiency in follistatin
51. Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development
52. The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
53. Liver regeneration
54. Stimulation of glucose production by activin-A in isolated rat hepatocytes
55. Embryonic stem cells alone are able to support fetal development in the mouse
56. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
57. Inhibitory effect of transforming growth factor-beta on DNA synthesis of adult rate hepatocytes in primary culture
58. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
59. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
60. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
61. Transgenic mouse models for tumor suppressor genes
62. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry
63. Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sties of vasculogenesis and angiogenesis in early mouse development
64. Structure, chromosomal localization and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene
65. Mice homozygous for a null mutation of activin beta B are viable and fertile
66. Activin induces cell death in hepatocytes in vivo and in vitro
67. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
68. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
69. Smad5 induces ventral fates in Xenopus embryo
70. Intracellular signaling of osteogeneic protein-1 through Smad5 activation
71. Male sterility in transgenic mice expressing activin betaA subunit gene in testis
72. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
73. The inhibin/activin family of hormones and growth factors
74. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction
75. Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells
76. The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult
77. TGF-beta receptors and signalling mechanisms
78. Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
79. Angiogenesis defects and mesenchymal apoptosis in mice lacking Smad5
80. Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes
81. Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth
82. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression