α1-Adrenoceptors: Subtypes, signaling, and roles in health and disease

Archives of Medical Research

Volumn 30, Issue 6, 1999, Pages 449-458

  García Sáinz, J Adolfo ^a   Vázquez Prado, José ^a   Villalobos Molina, Rafael ^b  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

1 Adrenergic receptors; 1 Adrenoceptors; G proteins; Signaling

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; MEMBRANE RECEPTOR; MESSENGER RNA; RECEPTOR SUBTYPE;

ADRENERGIC SYSTEM; ENZYME ACTIVATION; GENE EXPRESSION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; NONHUMAN; PROSTATE HYPERTROPHY; REVIEW; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; VASCULAR SMOOTH MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; CARDIOMEGALY; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PROSTATIC HYPERPLASIA; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION;

EID: 0342614935     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-0128(99)00059-7     Document Type: Review

References (119)

1. 1-adrenoceptors: consensus update. Pharmacol Rev 1995;47:267.
2. Lefkowitz R.J., Caron M.G. Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. J Biol Chem. 263:1988;4993.
3. 1-Adrenergic receptor subtypes. Molecular structure, function and signalling. Circ Res. 78:1996;737.
4. 1-Adrenergic receptors subtypes. Annu Rev Pharmacol Toxicol. 34:1994;117.
5. 1-adrenergic receptor. Proc Natl Acad Sci USA. 85:1988;7159.
6. 1-adrenergic subtype. J Biol Chem. 265:1990;8183.
7. 1A-adrenergic receptor, the gene for which is located on human chromosome 5. J Biol Chem. 266:1991;6365.
8. 1D-adrenergic receptor cDNA Mol Pharmacol. 40:1991;876.
9. 1-adrenoceptors in vascular smooth muscle. Br J Pharmacol. 99:1990;197.
10. 1C-adrenoceptor splice variants. FEBS Lett. 363:1995;256.
11. 1A-adrenoceptor isoforms. FEBS Lett. 422:1998;279.
12. 1L-adrenoceptor pharmacology in functional studies. Eur J Pharmacol. 370:1999;337.
13. Okuda-Ashitaka E., Sakamoto K., Ezashi T., Miwa K., Ito S., Hayaishi O. Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype. J Biol Chem. 271:1996;31255.
14. Schöneberg T., Liu J., Wess J. Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor. J Biol Chem. 270:1995;18000.
15. Le Gouill C., Parent J.-L., Caron C.-A., Gaudreau R., Volkov L., Rola-Pleszczynski M., Stanková J. Selective modulation of wild type receptor functions by mutants of G protein-coupled receptors. J Biol Chem. 274:1999;12548.
16. Ulrich A., Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell. 61:1990;203.
17. Conn P.M., Rogers D.C., Stewart J.M., Niedel J., Sheffield T. Conversion of a gonadotropin-releasing hormone antagonist to an agonist. Nature. 296:1982;653.
18. Janovick J.A., Conn M.P. Gonadotropin-releasing hormone agonist provokes homologous receptor microaggregation. an early event in seven-transmembrane receptor mediated signaling Endocrinology. 137:1996;3602.
19. Möhler H., Fritschy J.-M. GABAB receptors make it to the top - as dimers. Trends Pharmacol Sci. 20:1999;87.
20. Hébert T.E., Bouvier M. Structural and functional aspects of G protein-coupled receptor oligomerization. Biochem Cell Biol. 76:1998;1.
21. 1-adrenergic receptor through receptor dimerization. Biochem J. 330:1998;287.
22. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem. 271:1996;16348.
23. Grosse R., Schöneberg T., Schultz G., Gudermann T. Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol Endocrinol. 11:1997;1305.
24. 1-adrenoceptors. Subtypes, signal transduction and regulation. Pharmacol Commun. 6:1995;53.
25. 1A subtype. Eur J Pharmacol 1995;289:81.
26. 1-adrenergic receptor subtypes in human tissues. implications for human adrenergic physiology Mol Pharmacol. 45:1994;171.
27. 1C subtype. Mol Pharmacol. 45:1994;703.
28. 1-adrenoceptor subtypes present in the human prostate. Life Sci. 54:1994;1595.
29. 2 effects of catecholamines. Life Sci. 26:1980;1183.
30. 1-adrenergic action Proc Natl Acad Sci USA. 82:1985;6727.
31. 1-adrenergic responses in rat liver by a cyclic AMP-dependent mechanism. Proc Natl Acad Sci USA. 81:1984;4208.
32. Cotecchia S., Kobilka B.K., Daniel K.W., Nolan R.D., Lapetina E.Y., Caron M.G., Lefkowitz R.J., Regan J.W. Multiple second messenger pathways of α-adrenergic receptor subtypes expressed in eukaryotic cells. J Biol Chem. 265:1990;63.
33. 1D-adrenergic receptors to multiple signaling pathways is both G protein and cells type specific. Mol Pharmacol. 44:1993;784.
34. Perez D., Hwa J., Gaivin R., Mathur M., Brown F., Graham R.M. Constitutive activation of a single effector pathway. evidence for multiple activation states of a G protein-coupled receptor Mol Pharmacol. 49:1996;112.
35. 1-adrenoceptor subtypes. Mol Pharmacol. 50:1996;17.
36. 1-adrenergic receptor subtypes. titration of receptor density and responsiveness with inducible and repressible expression vectors Mol Pharmacol. 50:1996;1376.
37. 2+ J Pharmacol Exp Ther. 289:1999;1376.
38. 1A-Adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in Rat-1 fibroblasts. inhibition by protein kinase A J Pharmacol Exp Ther. 284:1998;576.
39. 1B-adrenergic receptor enhances mitogenesis and tumorigenicity Proc Natl Acad Sci USA. 88:1991;11354.
40. 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. J Biol Chem. 267:1992;1633.
41. 1B-adrenergic receptor by all aminoacid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem. 267:1992;1430.
42. 1-adrenergic receptors is mediated by the α subunits of Gq family. J Biol Chem. 267:1992;25798.
43. 1-adrenergic receptor sequences required for activating different Gα subunits of Gq class of G proteins. J Biol Chem. 270:1995;9828.
44. 2+ entry in rat portal vein myocytes. J Biol Chem 1997:272:5261.
45. 1-adrenoceptor subtype-mediated responses in Fisher 344 rat aorta. Mol Pharmacol. 52:1997;1064.
46. Iñiguez-Lluhi J., Kleuss C., Gilman A.G. The importance of G-protein βγ subunits. Trends Cell Biol. 3:1993;230.
47. 1-adrenergic stimulation in FRTL5 thyroid cells. Proc Natl Acad Sci USA. 83:1986;7201.
48. 1-adrenergic receptor-coupled metabolic activation. J Biol Chem 1993;268:6081.
49. 1-adrenoceptor, Gh family, and phospholipase C. J Biol Chem 1993;268:27398.
50. Nakaoka H., Perez D.M., Baek K.J., Das T., Husain A., Misono K., Im M.-J., Graham R.M. Gh. a GTP-binding protein with transglutaminase activity and receptor signaling function Science. 264:1994;1593.
51. 1-adrenoceptor-coupled Gh family and purification of Gh7 from bovine heart. J Biol Chem 1993;268:27390.
52. 1-adrenergic receptors. J Biol Chem. 273:1998;30033.
53. 1B-adrenergic receptor directly activates Gs in the transfected Chinese hamster ovary cells. Mol Pharmacol. 48:1995;392.
54. 1-adrenergic receptors in Madin-Darby canine cells is independent of PKCα and -ε activation. Mol Pharmacol. 53:1998;221.
55. 1-Adrenergic receptor-mediated activation of phospholipase D in rat cerebral cortex. J Biol Chem. 267:1992;3679.
56. 1-mediated response. J Biol Chem 1990;265:13809.
57. 1-Adrenergic receptor-induced c-fos gene expression in rat aorta and cultured smooth muscle cells. J Clin Invest. 94:1994;210.
58. González-Espinosa C., García-Sáinz J.A. Hormonal modulation of c-fos expression in isolated hepatocytes. Effects of angiotensin II and phorbol myristate acetate on transcription and mRNA degradation. Biochim Biophys Acta. 1310:1996;217.
59. 1- and β-adrenoceptor activation increase c-fos expression in isolated guinea pig hepatocytes. Pharmacol Commun. 7:1996;107.
60. 1-Adrenoceptor subtype activation increases proto-oncogene mRNA levels. Role of protein kinase C. Eur J Pharmacol. 342:1998;311.
61. 1-Adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem. 271:1996;8977.
62. 1D-Adrenergic receptors and mitogen-activated protein kinase mediate increased protein synthesis by arterial smooth muscle. Mol Pharmacol. 51:1997;764.
63. 1B-adrenergic receptor subtype activation of phosphatidylinositol 3-kinase and ras in transfected NIH 3T3 cells. Mol Endocrinol. 13:1999;3.
64. 1A-adrenergic receptor activation of mitogen-activated protein kinase pathways in transfected PC12 Cells. Mol Pharmacol. 55:1999;296.
65. Lefkowitz R.J. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem. 273:1998;18677.
66. Clark R.B., Kunkel M.W., Friedman J., Goka T.J., Johnson J.A. Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells. Proc Natl Acad Sci USA. 85:1988;1442.
67. Houslay M.D. Crosstalk. a pivotal role for protein kinase C in modulating relationships between signal transduction pathways Eur J Biochem. 195:1991;9.
68. Benovic J.L., DeBlasi7 A., Stone W.C., Caron M.G., Lefkowitz R.J. β-Adrenergic receptor kinase. primary structure delineates a multigene family Science. 246:1990;235.
69. 2-adrenergic receptors in response to insulin. J Biol Chem 1992; 267:26017.
70. Ferguson S., Zhang J., Barak L.S., Caron M.G. Pleiotrophic role for GRKs and β-arrestins in receptor regulation. News Physiol Sci. 12:1997;145.
71. 1-adrenergic regulation of hepatocyte metabolism. Biochem Biophys Res Commun. 119:1984;1128.
72. 1-adrenergic receptors for epinephrine. J Biol Chem. 261:1986;520.
73. 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. Proc Natl Acad Sci USA. 82:1985;5651.
74. 1B-adrenergic receptor. J Biol Chem. 269:1994;22887.
75. 1B-adrenergic receptor. J Biol Chem. 271:1996;5049.
76. 1B-adrenergic receptor. J Biol Chem. 272:1997;28712.
77. 1b-adrenoceptors in rat-1 fibroblasts. J Biol Chem. 272:1997;27330.
78. 1b-adrenoceptors induced through activation of bradykinin B2 receptors FEBS Lett. 422:1998;141.
79. 1-adrenergic receptors in bovine aortic membranes. J Pharmacol Exp Ther. 247:1988;196.
80. 1-adrenergic receptors by 4β-phorbol 12-myristate 13-acetate. Biochem J. 305:1995;73.
81. 1B-adrenergic receptor subcellular distribution and function. J Biol Chem. 270:1995;8902.
82. 1-adrenergic receptor internalization in DDT1 MF-2 cells following exposure to agonists plus protein kinase C activators. Mol Pharmacol. 34:1988;340.
83. 1b-adrenoceptor with green fluorescent protein. Mol Endocrinol. 12:1998;1099.
84. 1b-adrenergic receptor mutants display different phosphorylation and internalization features. Mol Pharmacol. 55:1999;339.
85. 1B-adrenoceptors. J Pharmacol Exp Ther. 286:1998;36.
86. 1b-adrenergic receptor by cAMP-dependent protein kinase. Brain Res Bull. 42:1996;427.
87. 1-adrenoceptor subtypes in vitro and in situ. J Biol Chem. 270:1995;30980.
88. 1-Adrenoceptor stimulation causes vascular smooth muscle cell hypertrophy. a possible role for isoprenoid intermediates Eur J Pharmacol. 347:1998;125.
89. 1-adrenergic response. J Clin Invest. 72:1983;732.
90. 1A-adrenergic receptor subtype mediates biochemical, molecular and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 268:1993;15374.
91. 1-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy. J Biol Chem. 270:1995;410.
92. 1-adrenergic receptor and Ras activation is associated with in vitro and in vivo cardiac hypertrophy. J Biol Chem. 272:1997;14057.
93. 1B-adrenoceptors in neonatal rat myocardium. implications in cardiac hypertrophy J Pharmacol Exp Ther. 286:1998;489.
94. 1D. Biochem Biophys Res Commun. 200:1994;1177.
95. 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci USA. 91:1994;10109.
96. 1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 275:1995;1583.
97. 1A subtypes. Eur J Pharmacol. 298:1996;257.
98. 1A-Adrenoceptors mediate contraction in rat renal artery. Eur J Pharmacol. 322:1997;225.
99. 1B-adrenergic receptor and the contribution of this and other subtypes to vascular smooth muscle contraction. analysis with selective ligands and antisense oligonucleotides J Pharmacol Exp Ther. 283:1997;972.
100. 1D-adrenoceptors in rat vasculature. Eur J Pharmacol. 322:1997;221.
101. 1B-adrenoceptor subtype. Br J Pharmacol. 114:1995;745.
102. 1D-adrenoceptors have a role in the pressor response to phenylephrine in the pithed rat. Eur J Pharmacol. 305:1996;173.
103. 1D-Adrenoceptors contribute to the neurogenic vasopressor response in pithed rats. Fundam Clin Pharmacol. 12:1998;584.
104. 1D-adrenoceptors in arteries of normotensive and spontaneously hypertensive rats. Pharmacol Rev Commun. 10:1998;135.
105. Takata Y., Kato H. Adrenoceptors in SRH. alterations in binding characteristics and intracellular signal transduction pathways Life Sci. 58:1996;91.
106. 1D-adrenoceptor protein detectable in rat tissues? Naunyn Schmiedebergs Arch Pharmacol. 355:1997;438.
107. 1-adrenoceptor subtypes in rat myocardium, aorta and other tissues. Br J Pharmacol. 119:1996;269.
108. 1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats. Br J Pharmacol. 126:1999;1534.
109. Hieble J.P., Ruffolo R.R. Jr. The use of α-adrenoceptor antagonists in the pharmacological management of benign prostatic hyperthrophy. an overview Pharmacol Res. 33:1996;145.
110. Lepor H., Tang R., Shapiro E. The α-adrenoceptor subtype mediating the tension of human prostatic smooth muscle. Prostate. 22:1993;301.
111. 1-adrenoceptor subtypes in human and canine prostate membranes. J Pharmacol Exp Ther. 271:1994;1228.
112. 1-adrenergic receptor subtypes in human prostate. J Urol. 150:1993;546.
113. 1C-adrenoceptor in human prostate. cloning, functional expression and localization to specific prostatic cell types Br J Pharmacol. 115:1995;1475.
114. 1-adrenoceptor subtypes in the human prostate. functional and binding studies Br J Urol. 74:1994;572.
115. 1-adrenoceptor antagonist, JTH-601, shows more than 10 times higher affinity for human prostates than arteries. J Urol. 161:1999;1350.
116. Büscher R., Hermann V., Insel P.A. Human adrenoceptor polymorphism. evolving recognition of clinical importance Trends Pharmacol Sci. 20:1999;94.
117. 1-adrenoceptor mediated prostatic smooth muscle contraction. Urol Res. 22:1994;143.
118. Eckert RE, Schreier U, Drescher P, Madsen PO, Derouet H, Becht E, Steffens J, Ziegler M. Regulation of prostatic smooth muscle contractility by second messengers: implications for the conservative treatment of benign prostatic hyperplasia. Urol Int 195;54:6.
119. García-Sáinz J.A. Adrenaline and its receptors. 100 years of research Arch Med Res. 26:1995;205.