Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective α1 adrenoceptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 6, 2003, Pages 1065-1078

  Balle, Thomas ^a,b   Perregaard, Jens ^a   Larsen, Anna K ^a   Ramirez, Martha Teresa ^a   Søby, Karina Krøjer ^a   Liljefors, Tommy ^b   Andersen, Kim ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 3 [1 [2 (2 IMIDAZOLIDINON 1 YL)ETHYL] 4 PIPERIDINYL] N METHYL 1H INDOLE 5 CARBOXAMIDE; 1 (4 FLUOROPHENYL) N METHYL 1H INDOLE 5 CARBOXAMIDE; 1 (FLUOROPHENYL) 1H INDOLE 5 CARBOXYLIC ACID; 1 [2 [4 [1 (4 FLUOROPHENYL) 5 (TRIMETHYLSILYL) 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL] 2 IMIDAZOLIDINONE; 1 [2 [4 [5 AMINOMETHYL 1 (4 FLUOROPHENYL) 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL] 2 IMIDAZOLIDINE; 1 [2 [4 [5 AMINOMETHYL 1 (4 FLUOROPHENYL) 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL] 2 IMIDAZOLIDINONE; 1 [2 [4 [5 DIMETHYLAMINOMETHYL 1 (4 FLUOROPHENYL) 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL] 2 IMIDAZOLIDINONE; 1 [4 [1 (4 FLUOROPHENYL) 5 METHYLAMINOMETHYL 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL 2 IMIDAZOLIDINONE; 1 [4 [1 (4 FLUOROPHENYL) 5,6 METHYLENEDIOXY 1H INDOL 3 YL] 1 PIPERIDINYL]ETHYL 2 IMIDAZOLIDINONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR; AMIDE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; N [1 (4 FLUOROPHENYL) 3 [1 [2 (2 IMIDAZOLIDIN 2 ON 1 YL)ETHYL]PIPERIDIN 4 YL] 1H INDOL 5 YLMETHYL]ACETAMIDE; N,N DIMETHYL 1 (4 FLUOROPHENYL) 1H INDOLE 5 CARBOXAMIDE; N,N DIMETHYL 1 (4 FLUOROPHENYL) 3 [1 [2 (2 IMIDAZOLIDINON 1 YL)ETHYL] 4 PIPERIDINYL] 1H INDOLE 5 CARBOXAMIDE; NEUROLEPTIC AGENT; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SERTINDOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOLECULE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIPSYCHOTIC AGENTS; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; DOPAMINE ANTAGONISTS; HUMANS; IMIDAZOLES; INDICATORS AND REAGENTS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037333874     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00459-5     Document Type: Article

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