Decreased stimulation of CD4+ T cell proliferation and IL-2 production by highly enriched populations of HIV-infected dendritic cells

Journal of Immunology

Volumn 170, Issue 8, 2003, Pages 4260-4266

  Kawamura, Tatsuyoshi ^a   Gatanaga, Hiroyuki ^a   Borris, Debra L ^a   Connors, Mark ^b   Mitsuya, Hiroaki ^a   Blauvelt, Andrew ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CYTOKINE; GLYCOPROTEIN GP 120; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; PROTEIN P70;

ARTICLE; CELL CULTURE; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0037446635     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.8.4260     Document Type: Article

References (51)

1. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767.
2. Turville, S. G., P. U. Cameron, J. Arthos, K. MacDonald, G. Clark, D. Hart, and A. L. Cunningham. 2001. Bitter-sweet symphony: defining the role of dendritic cell gp120 receptors in HIV infection. J. Clin. Virol. 22:229.
3. Pohlmann, S., F. Baribaud, and R. W. Doms. 2001. DC-SIGN and DC-SIGNR: helping hands for HIV. Trends Immunol. 22:643.
4. Knight, S. C. 2001. Dendritic cells and HIV infection; immunity with viral transmission versus compromised cellular immunity? Immunobiology 204:614.
5. Geijtenbeek, T. B., A. Engering, and Y. Van Kooyk. 2002. DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J. Leukocyte Biol. 71:921.
6. Piguet, V., and A. Blauvelt. 2002. Essential roles for dendritic cells in the pathogenesis and potential treatment of HIV disease. J. Invest. Dermatol. 119:365.
7. Macatonia, S. E., R. Lau, S. Patterson, A. J. Pinching, and S. C. Knight. 1989. Suppression of immune responses by dendritic cells infected with HIV. Immunology 67:285.
8. Macatonia, S. E., R. Lau, S. Patterson, A. J. Pinching, and S. C. Knight. 1990. Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 71:38.
9. Macatonia, S. E., M. Gompels, A. J. Pinching, S. Patterson, and S. C. Knight. 1992. Antigen presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection. Immunology 75:576.
10. Cameron, P. U., P. S. Freudenthal, J. M. Barker, S. Gezelter, K. Inaba, and R. M. Steinman. 1992. Dendritic cells exposed to human immunodeficiency virus type-I transmit a vigorous cytopathic infection to CD4+ cells. Science 257:383.
11. + T cells clonal expansion. Clin. Exp. Immunol. 88:226.
12. Blauvelt, A., M. Clerici, D. R. Lucey, S. M. Steinberg, R. Yarchoan, R. Walker, G. M. Shearer, and S. I. Katz. 1995. Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. J. Immunol. 154:3506.
13. Blauvelt, A., C. Chougnet, G. M. Shearer, and S. I. Katz. 1996. Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12. J. Clin. Invest. 97:1550.
14. Canque, B., M. Rosenzwaig, S. Camus, M. Yagello, M. L. Bonnet, M. Guigon, and J. C. Gluckman. 1996. The effect of in vitro human immunodeficiency virus infection on dendritic cell differentiation and function. Blood 88:4215.
15. Blauvelt, A., H. Asada, M. W. Saville, V. Klaus-Kovtun, D. J. Altman, R. Yarchoan, and S. I. Katz. 1997. Productive infection of dendritic cells by HIV-I and their ability to capture virus are mediated through separate pathways. J. Clin. Invest. 100:2043.
16. Fan, Z., X. L. Huang, L. Zheng, C. Wilson, L. Borowski, J. Liebmann, P. Gupta, J. Margolick, and C. Rinaldo. 1997. Cultured blood dendritic cells retain HIV-1 antigen-presenting capacity for memory CTL during progressive HIV-I infection. J. Immunol. 159:4973.
17. Chougnet, C., S. S. Cohen, T. Kawamura, A. L. Landay, H. A. Kessler, E. Thomas, A. Blauvelt, and G. M. Shearer. 1999. Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy. J. Immunol. 163:1666.
18. Sapp, M., J. Engelmayer, M. Larsson, A. Granelli-Pipemo, R. Steinman, and N. Bhardwaj. 1999. Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses. Immunol. Lett. 66:121.
19. Fan, Z., X. L. Huang, L. Borowski, J. W. Mellors, and C. R. Rinaldo, Jr. 2001. Restoration of anti-human immunodeficiency virus type 1 (HIV-1) responses in CD8+ T cells from late-stage patients on prolonged antiretroviral therapy by stimulation in vitro with HIV-1 protein-loaded dendritic cells. J. Virol. 75:4413.
20. Feldman, S., D. Stein, S. Amrute, T. Denny, Z. Garcia, P. Kloser, Y. Sun, N. Megjugorac, and P. Fitzgerald-Bocarsly. 2001. Decreased interferon-α production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin. Immunol. 101:201.
21. Chehimi, J., D. E. Campbell, L. Azzoni, D. Bacheller, E. Papasavvas, G. Jerandi, K. Mounzer, J. Kostman, G. Trinchieri, and L. J. Montaner. 2002. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J. Immunol. 168:4796.
22. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
23. Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83.
24. Yoshimura, K., R. Kato, K. Yusa, M. F. Kavlick, V. Maroun, A. Nguyen, T. Mimoto, T. Ueno, M. Shintani, J. Falloon, et al. 1999. JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc. Natl. Acad. Sci. USA 96:8675.
25. Gatanaga, H., Y. Suzuki, H. Tsang, K. Yoshimura, M. F. Kavlick, K. Nagashima, R. J. Gorelick, S. Mardy, C. Tang, M. F. Summers, and H. Mitsuya. 2002. Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-I resistance against protease inhibitors. J. Biol. Chem. 277:5952.
26. Kawamura. T., M. Qualbani, E. K. Thomas, J. M. Orenstein, and A. Blauvelt. 2001. Low levels of productive HIV infection in Langerhans cell-like dendritic cells differentiated in the presence of TGF-β1 and increased viral replication with CD40 ligand-induced maturation. Eur. J. Immunol. 31:360.
27. Hochberg, Y. 1988. A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75:800.
28. Sei, S., Q. E. Yang, D. O'Neill, K. Yoshimara, K. Nagashima, and H. Mitsuya. 2000. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain. J. Virol. 74:4621.
29. Kawamura, T., S. S. Cohen, D. L. Borris, E. A. Aquilino, S. Glushakova, L. B. Margolis, J. M. Orenstein, R. E. Offord, A. R. Neurath, and A. Blauvelt. 2000. Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. J. Exp. Med. 192:1491.
30. Akridge, R. E., L. K. M. Oyafuso, and S. G. Reed. 1994. IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. J. Immunol. 153:5782.
31. Chehimi, J., S. E. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361.
32. Yoo, J., H. Chen, T. Kraus, D. Hirsch, S. Polyak, I. George, and K. Sperber. 1996. Altered cytokine production and accessory cell function after HIV-1 infection. J. Immunol. 157:1313.
33. Piguet, V., F. Gu, M. Foti, N. Demaurex, J. Gruenberg, J. L. Carpentier, and D. Trono. 1999. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes. Cell 97:63.
34. Sartori, A., M. A. Oliveira, P. Scott, and G. Trinchieri. 1997. Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells. J. Immunol. 159:2849.
35. von Stebut, E., Y. Belkaid, T. Jakob, D. L. Sacks, and M. C. Udey. 1998. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J. Exp. Med. 188:1547.
36. Hickman, S. P., J. Chan, and P. Salgame. 2002. Mycobacterium tuberculosis induces differential cytokine production from dendritic cells and macrophages with divergent effects on naive T cell polarization. J. Immunol. 168:4636.
37. + T cell function by the HIV envelope protein, gp120. J. Immunol. 141:3715.
38. + T lymphocytes by inhibiting interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA 87:2379.
39. Chirmule, N., V. S. Kalyanaraman, N. Oyaizu, H. B. Slade, and S. Pahwa. 1990. Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus. Blood 75:152.
40. Cefai, D., P. Debre, M. Kaczorek, T. Idziorek, B. Autran, and G. Bismuth. 1990. Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. J. Clin. Invest. 86:2117.
41. + cell function down-regulation in AIDS patients. J. Immunol. 148:2709.
42. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat. Med. 5:518.
43. + T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease. J. Infect. Dis. 182:792.
44. + T-cell responses: relationship to viral load in untreated HIV infection. J. Virol. 75:11983.
45. + T cell proliferation. Proc. Natl. Acad. Sci. USA 98:13878.
46. + T cells and HIV-1- specific lymphoproliferation in HIV-1-infected subjects with active viral replication. J. Virol. 76:5925.
47. Clerici, M., R. Yarchoan, S. Blatt, C. W. Hendrix, A. J. Ammann, S. Broder, and G. M. Shearer. 1993. Effect of a recombinant CD4-IgG on in vitro T helper cell function: data from a phase I/II study of patients with AIDS. J. Infect. Dis. 168:1012.
48. Davey, R. T., Jr., C. M. Boenning, B. R. Herpin, D. H. Batts, J. A. Metcalf, L. Wathen, S. R. Cox, M. A. Polis, J. A. Kovacs, J. Falloon, et al. 1994. Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus. J. Infect. Dis. 170:1180.
49. Schacker, T., R. W. Coombs, A. C. Collier, J. E. Zeh, I. Fox, J. Alam, K. Nelson, E. Eggert, and L. Corey. 1994. The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia. J. Infect. Dis. 169:37.
50. Schacker, T., A. C. Collier, R. Coombs, J. D. Unadkat. I. Fox, J. Alam, J. P. Wang, E. Eggert, and L. Corey. 1995. Phase I study of high-dose, intravenous rsCD4 in subjects with advanced HIV-1 infection. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 9:145.
51. Meng, T. C., M. A. Fischl, S. H. Cheeseman, S. A. Spector, L. Resnick, A. Boota, T. Petrakis, B. Wright, and D. D. Richman. 1995. Combination therapy with recombinant human soluble CD4-immunoglobulin G and zidovudine in patients with HIV infection: a phase I study. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 8:152.