DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology

Journal of Leukocyte Biology

Volumn 71, Issue 6, 2002, Pages 921-931

  Geijtenbeek, Teunis B H ^a   Engering, Anneke ^a   Van Kooyk, Yvette ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Adhesion; Antigen receptor; Carbohydrates; HIV 1; ICAM 2; ICAM 3

Indexed keywords

CARBOHYDRATE; GLYCOPROTEIN GP 120; INTERCELLULAR ADHESION MOLECULE 2; INTERCELLULAR ADHESION MOLECULE 3; LECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANTIGEN BINDING; ANTIGEN PRESENTATION; BINDING SITE; CARBOHYDRATE ANALYSIS; CELL MIGRATION; CYTOLOGY; DENDRITIC CELL; ENDOSOME; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNITY; LYMPHOID TISSUE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; CELL ADHESION MOLECULES; DENDRITIC CELLS; HUMANS; LECTINS; LECTINS, C-TYPE; MICE; RECEPTORS, ANTIGEN; RECEPTORS, CELL SURFACE; RECEPTORS, HIV;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036623112     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
2. Sallusto, F., Lanzavecchia, A. (1999) Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J. Exp. Med. 189, 611-614.
3. Geijtenbeek, T. B. H., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Adema, G. J., van Kooyk, Y., Figdor, C. G. (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100, 575-585.
4. Bleijs, D. A., Geijtenbeek, T. B. H., Figdor, C. G., van Kooyk, Y. (2001) DC-SIGN and LFA-1: a battle for ligand. Trends Immunol. 22, 457-463.
5. Curtis, B. M., Scharnowske, S., Watson, A. J. (1992) Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. Proc. Natl. Acad. Sci. USA 89, 8356-8360.
6. Sallusto, F., Cella, M., Danieli, C., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
7. Kato, M., Neil, T. K., Fearnley, D. B., McLellan, A. D., Vuckovic, S., Hart, D. N. (2000) Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Int. Immunol. 12, 1511-1519.
8. Feinberg, H., Mitchell, D. A., Drickamer, K., Weis, W. I. (2001) Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science 294, 2163-2166.
9. Geijtenbeek, T. B. H., Krooshoop, D. J. E. B., Bleijs, D. A., vanVliet, S. J., vanDuijnhoven, G. C. F., Grabovsky, V., Alon, R., Figdor, C. G., vanKooyk, Y. (2000) DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nat. Immunol. 1, 353-357.
10. Soilleux, E. J., Morris, L. S., Lee, B., Pohlmann, S., Trowsdale, J., Doms, R. W., Coleman, N. (2001) Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J. Pathol. 195, 586-592.
11. Geijtenbeek, T. B. H., van Vliet, S. J., van Duijnhoven, G. C. F., Figdor, C. G., van Kooyk, Y. (2001) DC-SIGN, a dendritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review. Placenta 22, S19-S23.
12. Lee, B., Leslie, G., Soilleux, E., O'Doherty, U., Baik, S., Levroney, E., Flummerfelt, K., Swiggard, W., Coleman, N., Malim, M., Doms, R. W. (2001) cis expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor. J. Virol. 75, 12028-12038.
13. Soilleux, E. J., Morris, L. S., Leslie, G. Chehimi, J., Luo, Q., Levroney, E., Trowsdale, J., Montaner, L. J., Doms, R. W., Weissman, D., Coleman, N., Lee, B. (2002) Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J. Leukoc. Biol. 71, 445-457.
14. Mitchell, D. A., Fadden, A. J., Drickamer, K. (2001) A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J. Biol. Chem. 276, 28939-28945.
15. Funatsu, O., Sato, T., Kotovuori, P., Gahmberg, C. G., Ikekita, M., Furukawa, K. (2001) Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). Eur. J. Biochem. 268, 1020-1029.
16. Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Krieger, E., Vriend, G., Figdor, C. G., van Kooyk, Y. (2002) Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for ICAM-3 and HIV-1. J. Biol. Chem., 277, 11314-11320.
17. Springer, T. A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
18. Vestweber, D., Blanks, J. E. (1999) Mechanisms that regulate the function of the selectins and their ligands. Physiol. Rev. 79, 181-213.
19. Leteux, C., Chai, W., Loveless, R. W., Yuen, C. T., Uhlin-Hansen, L., Combarnous, Y., Jankovic, M., Maric, S. C., Misulovin, Z., Nussenzweig, M. C., Ten Feizi (2000) The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. J. Exp. Med. 191, 1117-1126.
20. Irjala, H., Johansson, E. L., Grenman, R., Alanen, K., Salmi, M., Jalkanen, S. (2001) Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. J. Exp. Med. 194, 1033-1042.
21. Hemmerich, S., Bistrup, A., Singer, M. S., van Zante, A., Lee, J. K., Tsay, D., Peters, M., Carminati, J. L., Brennan, T. J., Carver-Moore, K., Leviten, M., Fuentes, M. E., Ruddle, N. H., Rosen, S. D. (2001) Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity 15, 237-247.
22. Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Gunther, G., Johnston, I., Lanzavecchia, A., Nagasaka, T., Okada, T., Vermi, W., Winkels, G., Yamamoto, T., Zysk, M., Yamaguchi, Y., Schmitz, J. (2001) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J. Exp. Med. 194, 1823-1834.
23. Valladeau, J., Duvert-Frances, V., Pin, J. J., Kleijmeer, M. J., Ait-Yahia, S., Ravel, O., Vincent, C., Vega Jr., F., Helms, A., Gorman, D., Zurawski, S. M., Zurawski, G., Ford, J., Saeland, S. (2001) Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis. J. Immunol. 167, 5767-5774.
24. Drickamer, K. (1995) Increasing diversity of animal lectin structures. Curr. Opin. Struct. Biol. 5, 612-616.
25. Stahl, P. D. (1992) The mannose receptor and other macrophage lectins. Curr. Opin. Immunol. 4, 49-52.
26. Ezekowitz, R. A., Sastry, K., Bailly, P., Warner, A. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med. 172, 1785-1794.
27. Engering, A. J., Cella, M., Fluitsma, D., Brockhaus, M., Hoefsmit, E. C., Lanzavecchia, A., Pieters, J. (1997) The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur. J. Immunol. 27, 2417-2425.
28. Tan, M. C., Mommaas, A. M., Drijfhout, J. W., Jordens, R., Onderwater, J. J., Verwoerd, D., Mulder, A. A., van der Heiden, A. N., Scheidegger, D., Oomen, L. C., Ottenhoff, T. H., Tulp, A., Neefjes, J. J., Koning, F. (1997) Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells. Eur. J. Immunol. 27, 2426-2435.
29. Engering, A., Geijtenbeek, T. B., van Vliet, S. J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J., Figdor, C. G., Piguet, V., van Kooyk, Y. (2002) The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J. Immunol. 168, 2118-2126.
30. Lanier, L. L., Bakker, A. B. (2000) The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today 21, 611-614.
31. Monks, C. R., Freiberg, B. A., Kupfer, H., Sciaky, N., Kupfer, A. (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86.
32. Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., Dustin, M. L. (1999) The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221-227.
33. Dustin, M. L., Chan, A. C. (2000) Signaling takes shape in the immune system. Cell 103, 283-294.
34. Xu, H., Tong, I. L., De Fougerolles, A. R., Springer, T. A. (1992) Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. J. Immunol. 149, 2650-2655.
35. Vilella, R., Mila, J., Lozano, F., Alberola-Ila, J., Places, L., Vives, J. (1990) Involvement of the CDw50 molecule in allorecognition. Tissue Antigens 36, 203-210.
36. Starling, G. C., McLellan, A. D., Egner, W., Sorg, R. V., Fawcett, J., Simmons, D. L., Hart, D. N. (1995) Intercellular adhesion molecule-3 is the predominant co-stimulatory ligand for leukocyte function antigen-1 on human blood dendritic cells. Eur. J. Immunol. 25, 2528-2532.
37. Hauss, P., Selz, F., Cavazzana-Calvo, M., Fischer, A. (1995) Characteristics of antigen-independent and antigen-dependent interaction of dendritic cells with CD4+ T cells. Eur. J. Immunol. 25, 2285-2294.
38. Montoya, M. C., Sancho, D., Bonello, G., Collette, Y., Langlet, C., He, H. T., Aparicio, P., Alcover, A., Olive, D., Sanchez-Madrid, F. (2002) Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat. Immunol. 3, 159-168.
39. Ariizumi, K., Shen, G. L., Shikano, S., Xu, S., Ritter 3rd, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R., Takashima, A. (2000) Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275, 20157-20167.
40. Willment, J. A., Gordon, S., Brown, G. D. (2001) Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. J. Biol. Chem. 276, 43818-43823.
41. Geijtenbeek, T. B. H., Kwon, D. S., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Middel, J., Cornelissen, I. L., Nottet, H. S., KewalRamani, V. N., Littman, D. R., Figdor, C. G., van Kooyk, Y. (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100, 587-597.
42. Cameron, P. U., Freudenthal, P. S., Barker, J. M., Gezelter, S., Inaba, K., Steinman, R. M. (1992) Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257, 383-397.
43. Pope, M., Betjes, M. G., Romani, N., Hirmand, H., Cameron, P. U., Hoffman, L., Gezelter, S., Schuler, G., Steinman, R. M. (1994) Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78, 389-398.
44. Pohlmann, S., Baribaud, F., Lee, B., Leslie, G. J., Sanchez, M. D., Hiebenthal-Millow, K., Munch, J., Kirchhoff, F., Doms, R. W. (2001) DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 75, 4664-4672.
45. Pohlmann, S., Leslie, G. J., Edwards, T. G., Macfarlan, T., Reeves, J. D., Hiebenthal-Millow, K., Kirchhoff, F., Baribaud, F., Doms, R. W. (2001) DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions. J. Virol. 75, 10523-10526.
46. Kwon, D. S., Gregorio, G., Bitton, N., Hendrickson, W. A., Littman, D. R. (2002) DC-SIGN-mediated internalization of HIV is required for transenhancement of T cell infection. Immunity 16, 135-144.
47. Petit, C., Buseyne, F., Boccaccio, C., Abastado, J. P., Heard, J. M., Schwartz, O. (2001) Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes. Virology 286, 225-236.
48. Piguet, V., Gu, F., Foti, M., Demaurex, N., Gruenberg, J., Carpentier, J. L., Trono, D. (1999) Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 97, 63-73.
49. Sol-Foulon, N., Moris, A., Nobile, C., Boccaccio, C., Engering, A., Abastado, P., Heard, J-M., van Kooyk, Y., Schwartz, O. (2002) HIV-1 Nef induced up-regulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 16, 145-155.
50. Leonard, C. K., Spellman, M. W., Riddle, L., Harris, R. J., Thomas, J. N., Gregory, T. J. (1990) Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. J. Biol. Chem. 265, 10373-10382.
51. Mizuochi, T., Spellman, M. W., Larkin, M., Solomon, J., Basa, L. J., Feizi, T. (1988) Carbohydrate structures of the human-immunodeficiency-virus (HIV) recombinant envelope glycoprotein gp120 produced in Chinesehamster ovary cells. Biochem. J. 254, 599-603.
52. Weis, W. I., Taylor, M. E., Drickamer, K. (1998) The C-type lectin superfamily in the immune system. Immunol. Rev. 163, 19-34.
53. Bashirova, A. A., Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Eilering, J. B., Martin, M. P., Wu, L., Martin, T. D., Viebig, N., Knolle, P. A., KewalRamani, V. N., van Kooyk, Y., Carrington, M. (2001) A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 193, 671-678.
54. Soilleux, E. J., Barten, R., Trowsdale, J. (2000) Cutting edge: DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 165, 2937-2942.
55. Pohlmann, S., Soilleux, E. J., Baribaud, F., Leslie, G. J., Morris, L. S., Trosdale, J., Lee, B., Coleman, N., Doms, R. W. (2001) DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc. Natl. Acad. Sci. USA 98, 2670-2675.
56. Baribaud, F., Pohlmann, S., Sparwasser, T., Kimata, M. T., Choi, Y. K., Haggarty, B. S., Ahmad, N., Macfarlan, T., Edwards, T. G., Leslie, G. J., Arnason, J., Reinhart, T. A., Kimata, J. T., Littman, D. R., Hoxie, J. A., Doms, R. W. (2001) Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J. Virol. 75, 10281-10289.
57. Geijtenbeek, T. B. H., Koopman, G., van Duijnhoven, G. C., van Vliet, S. J., van Schijndel, A. C., Engering, A., Heeney, J. L., van Kooyk, Y. (2001) Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN. Immunol. Lett. 79, 101-107.
58. Jameson, B., Baribaud, F., Pohlmann, S., Ghavimi, D., Mortari, F., Doms, R. W., Iwasaki, A. (2002) Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques. J. Virol. 76, 1866-1875.
59. Park, C. G., Takahara, K., Umemoto, E., Yashima, Y., Matsubara, K., Matsuda, Y., Clausen, B. E., Inaba, K., Steinman, R. M. (2001) Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13, 1283-1290.
60. Caminschi, I., Lucas, K. M., O'Keeffe, M. A., Hochrein, H., Laabi, Y., Brodnicki, T. C., Lew, A. M., Shortman, K., Wright, M. D. (2001) Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells. Mol. Immunol. 38, 365-373.
61. Mummidi, S., Catano, G., Lam, L., Hoefle, A., Telles, V., Begum, K., Jimenez, F., Ahuja, S. S., Ahuja, S. K. (2001) Extensive repertoire of membrane-bound and soluble DC-SIGN1 and DC-SIGN2 isoforms: interindividual variation in expression of DC-SIGN transcripts. J. Biol. Chem. 276, 33196-33212.
62. Knolle, P. A., Gerken, G. (2000) Local control of the immune response in the liver. Immunol. Rev. 174, 21-34.
63. Moffatt, O. D., Devitt, A., Bell, E. D., Simmons, D. L., Gregory, C. D. (1999) Macrophage recognition of ICAM-3 on apoptotic leukocytes. J. Immunol. 162, 6800-6810.
64. Steffan, A. M., Lafon, M. E., Gendrault, J. L., Schweitzer, C., Royer, C., Jaeck, D., Arnaud, J. P., Schmitt, M. P., Aubertin, A. M., Kirn, A. (1992) Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 89, 1582-1586.
65. Xu, H., Bickford, J. K., Luther, E., Carpenito, C., Takei, F., Springer, T. A. (1996) Characterization of murine intercellular adhesion molecule-2. J. Immunol. 156, 4909-4914.