Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E2, interleukin-1β, and nitric oxide synthesis by activated microglia

Journal of Neuroscience Research

Volumn 66, Issue 4, 2001, Pages 715-722

  Ajmone Cat, Maria Antonietta ^a   Nicolini, Alessia ^a   Minghetti, Luisa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Brain macrophages; Cyclooxygenase 2; Inducible nitric oxide synthase

Indexed keywords

FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; INTERLEUKIN 1BETA; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DRUG MECHANISM; ENCEPHALITIS; GASTROINTESTINAL TOXICITY; MACROPHAGE; MICROGLIA; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CELL SURVIVAL; CELLS, CULTURED; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENCEPHALITIS; FLURBIPROFEN; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICROGLIA; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRITES; NITROSO COMPOUNDS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS;

EID: 0035889551     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10038     Document Type: Article

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