Paracetamol-inhibitable COX-2

Journal of Physiology and Pharmacology

Volumn 51, Issue 4, 2000, Pages 609-618

  Botting, R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

COX 1; COX 2; NSAID induced variant enzyme; Paracetamol; Prostaglandins

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PROSTAGLANDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEVER; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG FIBROBLAST; MOUSE; NONHUMAN; PAIN; PROSTAGLANDIN SYNTHESIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; ENZYME INDUCTION; HUMANS; MACROPHAGES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS;

EID: 0034526729     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (65)

1. Beitrage zur Kenntniss der antipyretica
2. The estimation of acetanilide and its metabolic products, aniline, n-acetyl-p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues
3. The fate of acetophenetidin (phenacetin) in man and methods for the estimation of acetophenetidin and its metabolites in biological material
4. The hepatic side effects of drugs
5. Acetylsalicylic acid versus paracetamol: Effects on post-operative course
6. Paracetamol versus placebo: Effects on post-operative course
7. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
8. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase)
9. Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence
10. Expression of amitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
11. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin-synthase/ cyclooxygenase homologue
12. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
13. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
14. Cyclooxygenases 1 and 2
15. Comparative efficacy of aspirin and acetaminophen in the reduction of fever in children
16. Review of comparative antipyretic activity in children
17. Use of antipyretic analgesics in the pediatric patient
18. Antipyretic therapy in the febrile child
19. Evaluation of the antipyretic effect of ketorolac, acetaminophen and placebo in endotoxin-induced fever
20. The effect of pyrogen and antipyretics on prostagandin activity in cisternal CSF of unanaesthetized cats
21. Endogenous pyrogen fever, prostaglandin release and prostaglandin synthetase inhibitors
22. Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat
23. Prostaglandins, endotoxin and lipid A on body temperature in rats
24. Eugenol: Antipyretic activity in rabbits
25. The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2∓, but not in cyclooxygenase-1∓ mice
26. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: Light and electron microscopic immunocytochemical studies
27. Interleukin-1β in immune cells of the abdominal vagus nerve: A link between the immune and nervous systems?
28. Cytokine-to-brain communication: A review and analysis of alternative mechanisms
29. Blockade of lipopolysaccharide-induced fever by subdiaphragmatic vagotomy in guinea pigs
30. Peripherally acting analgesics
31. Impact of non-narcotic oral analgesics on pain management
32. Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin-evoked visceral pain
33. The abdominal constriction response and its suppression by analgesic drugs in the mouse
34. Comparison of the relative effects of aspirin, mefenamic acid, dihydrocodeine, dextropropoxyphene and paracetamol on visceral pain, respiratory rate and prostaglandin biosynthesis
35. 2 levels in mouse brain
36. Central analgesic effect of acetaminophen but not of aspirin
37. Naloxone-reversible antinociception by paracetamol in the rat
38. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs
39. Comparative effects of aspirin and acetaminophen on hemostasis
40. Effects of aspirin and paracetamol in gastrointestinal hemorrhage. Results from the Boston Collaborative Drug Surveillance Program
41. Comparison of the acute effects of regular aspirin, Bufferin and paracetamol on human gastroduodenal mucosa
42. The effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa
43. Comparison of plain and buffered aspirin with paracetamol in regard to gastrointestinal bleeding
44. Gastrointestinal blood loss: Effect of aspirin, fenoprofen and paracetamol in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers
45. Aspirin and gastrointestinal bleeding. Chromate blood loss studies
46. Distribution of prostaglandins in gastric and duodenal ulcer patients: Effects of aspirin and paracetamol
47. Stimulation and inhibition of prostacyclin formation in the gastric mucosa and ileum in vitro by anti-inflammatory agents
48. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)
49. Tissue selectivity and variability of effects of acetaminophen on arachidonic acid metabolism
50. Interaction between aspirin and paracetamol on the production of prostaglandins in the rat gastric mucosa
51. Effects of aspirin, indomethacin, flufenamic acid and paracetamol on prostaglandin output from rat stomach and renal papilla in-vitro and ex-vivo
52. Mechanism of inhibition of renal prostaglandin production by acetaminophen
53. Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol)
54. The effect of acetaminophen on prostacyclin production in pregnant women
55. Effects of acetylsalicylic acid and paracetamol alone and in combination on prostanoid synthesis in man
56. Paracetamol (acetaminophen) stimulates and inhibits COX activity in cell and tissue homogenates
57. Expression of prostaglandin G/H synthase type 1, but not type 2, in human ovarian adenocarcinomas
58. Over-the-counter analgesics and risk of ovarian cancer
59. Paracetamol and risk of ovarian cancer mortality in a prospective study of women in the USA
60. The effect of 4-acetamidophenol on prostaglandin synthetase activity in bovine and ram seminal vesicle microsomes
61. Paracetamol potentiates acetylsalicylate in inhibiting prostaglandin synthesis
62. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid anti-inflammatory drugs
63. Inducible cyclooxygenase may have anti-inflammatory properties
64. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of iκB kinase
65. 2 inhibits multiple steps in the NF-kB signaling pathway