Bone marrow-derived immature dendritic cells prime in vivo alloreactive T cells for interleukin-4-dependent rejection of major histocompatibility complex class II antigen-disparate cardiac allograft

Transplantation

Volumn 75, Issue 3, 2003, Pages 407-413

  Buonocore, Sofia ^a   Flamand, Véronique ^a   Goldman, Michel ^a   Braun, Michel Y ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSTIMULATING AGENT; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ACUTE GRAFT REJECTION; ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; CELL TRANSPLANTATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; IMMUNIZATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH2 CELL; TISSUE FIXATION;

ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; CHRONIC DISEASE; DENDRITIC CELLS; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS;

EID: 0037442266     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000044172.19087.22     Document Type: Article

References (40)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245.
2. Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med 1996; 183: 1789.
3. + dendritic cells prolong the survival of vascularized heart allografts. J Immunol 2002; 168: 143.
4. +, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995; 60: 1539.
5. Lutz MB, Kukutsch NA, Menges M, et al. Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur J Immunol 2000; 30: 1048.
6. Lutz MB, Kukutsch N, Ogilvie ALJ, et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999; 223: 77.
7. Lutz MB, Suri RM, Niimi M, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 2000; 30: 1813.
8. -) prolong cardiac allograft survival in non immunosuppressed recipients. Transplantation 1996; 62: 659.
9. Khanna A, Morelli AE, Zhong C, et al. Effects of liver-derived dendritic cell progenitors on Th1-and Th2-like cytokine responses in vitro and in vivo. J Immunol 2000; 164: 1346.
10. Morelli AE, O'Connell PJ, Khanna A, et al. Preferential induction of Th1 responses by functionally mature hepatic (CD8alpha- and CD8alpha+) dendritic cells: association with conversion from liver transplant tolerance to acute rejection. Transplantation 2000; 69: 2647.
11. Coudert JD, Foucras G, Demur C, et al. Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC class I-T-cell interactions. J Clin Invest 2000; 105: 1125.
12. + T lymphocytes down-regulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med 1997; 186: 421.
13. + T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur J Immunol 1997; 27: 3341.
14. + T cells. Eur J Immunol 1997; 27: 2657.
15. Foucras G, Coudert JD, Coureau C, et al. Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation. J Immunol 2000; 165: 4994.
16. Shirwan H, Barwari L, Khan NS. Predominant expression of T helper 2 cytokines and altered expression of T helper 1 cytokines in long-term allograft survival induced by intrathymic immune modulation with donor class I major histocompatibility complex peptides. Transplantation 1998; 66: 1802.
17. Olthoff KM, Judge TA, Gelman AE, et al. Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med 1998; 4: 194.
18. Donckier V, Flamand V, Abramowicz D, et al. Increased IL-4 production and decreased CD40L expression by newborn T cells contribute to transplantation tolerance. Transplant Proc 1999; 31: 782.
19. Donckier V, Flamand V, Desalle F, et al. IL-12 prevents neonatal induction of transplantation tolerance in mice. Eur J Immunol 1998; 28: 1426.
20. Plain KM, Chen J, Merten S, et al. Induction of specific tolerance to allografts in rats by therapy with non-mitogenic, non-depleting anti-CD3 monoclonal antibody: association with TH2 cytokines not anergy. Transplantation 1999; 67: 605.
21. + T cells in the antitumor immune response. J Exp Med 1998; 188: 2357.
22. + T cells or B cells. J Immunol 1998; 161: 1868.
23. + T cells. J Immunol 1998;161:5236.
24. Le Moine A, Flamand V, Demoor FX, et al. Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. J Clin Invest 1999; 103: 1659.
25. Le Moine A, Surquin M, Demoor FX, et al. IL-5 mediates eosinophilic rejection of MHC class II-disparate skin allografts in mice. J Immunol 1999;16:3778.
26. + T lymphocytes and IFN-gamma. Eur J Immunol 2000; 30: 1290.
27. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995; 59: 1155.
28. Nagano H, Mitchell RN, Taylor MK, et al. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997; 100: 550.
29. Fischbein MP, Yun J, Laks H, et al. CD8+ lymphocytes augment chronic rejection in a MHC class II mismatched model. Transplantation 2001; 71: 1146.
30. Marone G, Patella V, de Crescenzo G, et al. Immunological interactions between human eosinophils and cardiac mast cells. Chem Immunol 2000; 76: 118.
31. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 1995; 4: 15.
32. Ring GH, Saleem S, Dai Z, et al. Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplantation 1999; 67: 1362.
33. Schleimer RP, Sterbinsky SA, Kaiser J, et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol 1992; 148: 1086.
34. + T cell infiltration. J Immunol 1992; 149: 2954.
35. Teran LM. CCL chemokines and asthma. Immunol Today 2000; 21: 235.
36. Gutierrez-Ramos JC, Lloyd C, Kapsenberg ML, et al. Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung. Immunol Rev 2000; 177: 31.
37. Erb KJ, Ruger B, von Brevern M, et al. Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice. J Exp Med 1997; 185: 329.
38. Schuler T, Qin Z, Ibe S, et al. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice. J Exp Med 1999; 189: 803.
39. Bagley J, Sawada T, Wu Y, et al. A critical role for interleukin 4 in activating alloreactive CD4 T cells. Nature Immunol 2000; 1: 257.
40. Biedermann T, Zimmermann S, Himmelrich H, et al. IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat Immunol 2001; 2: 1054.